PMC Links for Gene (Select 850633) - PMC

Gong-Her Wu, Patrick G. Mitchell, Jesus G. Galaz-Montoya, Corey W. Hecksel, Emily M. Sontag, Vimal Gangadharan, Jeffrey Marshman, David Mankus, Margaret E. Bisher, Abigail K. R. Lytton-Jean, Judith Frydman, Kirk Czymmek, Wah Chiu

Structure. Author manuscript; available in PMC 2021 Nov 3.

Published in final edited form as: Structure. 2020 Nov 3; 28(11): 1231–1237.e3. Published online 2020 Aug 18. doi: 10.1016/j.str.2020.07.017

PMCID:: PMC7642057

Abstract Article PDF–1.8M

Select item 71967725.

Structural and kinetic basis for the regulation and potentiation of Hsp104 function

Xiang Ye, JiaBei Lin, Leland Mayne, James Shorter, S. Walter Englander

Proc Natl Acad Sci U S A. 2020 Apr 28; 117(17): 9384–9392. Published online 2020 Apr 10. doi: 10.1073/pnas.1921968117

PMCID:: PMC7196772

Abstract Article PDF–1.7M

Select item 70642146.

Functional analysis of proposed substrate-binding residues of Hsp104

Matthew K. Howard, Brian S. Sohn, Julius von Borcke, Andy Xu, Meredith E. Jackrel

PLoS One. 2020; 15(3): e0230198. Published online 2020 Mar 10. doi: 10.1371/journal.pone.0230198

PMCID:: PMC7064214

Abstract Article PDF–2.1M

Select item 70083827.

Structural and mechanistic insights into Hsp104 function revealed by synchrotron X-ray footprinting

Elizabeth A. Sweeny, Amber Tariq, Esin Gurpinar, Michelle S. Go, Matthew A. Sochor, Zhong-Yuan Kan, Leland Mayne, S. Walter Englander, James Shorter

J Biol Chem. 2020 Feb 7; 295(6): 1517–1538. Published online 2019 Dec 27. doi: 10.1074/jbc.RA119.011577

PMCID:: PMC7008382

Abstract Article PDF–5.1M

Select item 67527728.

Osmolytes ameliorate the effects of stress in the absence of the heat shock protein Hsp104 in Saccharomyces cerevisiae

Arnab Bandyopadhyay, Indrani Bose, Krishnananda Chattopadhyay

PLoS One. 2019; 14(9): e0222723. Published online 2019 Sep 19. doi: 10.1371/journal.pone.0222723

PMCID:: PMC6752772

Abstract Article PDF–1.9M

Select item 66430439.

Engineered protein disaggregases mitigate toxicity of aberrant prion-like fusion proteins underlying sarcoma

Jeremy J. Ryan, Macy L. Sprunger, Kayla Holthaus, James Shorter, Meredith E. Jackrel

J Biol Chem. 2019 Jul 19; 294(29): 11286–11296. Published online 2019 Jun 5. doi: 10.1074/jbc.RA119.009494

Correction in:: J Biol Chem. 2019 Nov 15; 294(46): 17707.

PMCID:: PMC6643043

Abstract Article PDF–2.7M

Select item 656654110.

Hsp104 facilitates the endoplasmic‐reticulum–associated degradation of disease‐associated and aggregation‐prone substrates

Lynley M. Doonan, Christopher J. Guerriero, G. Michael Preston, Teresa M. Buck, Netaly Khazanov, Edward A. Fisher, Hanoch Senderowitz, Jeffrey L. Brodsky

Protein Sci. 2019 Jul; 28(7): 1290–1306. Published online 2019 May 20. doi: 10.1002/pro.3636

PMCID:: PMC6566541

Abstract Article PDF–2.1M

Select item 646210111.

Hydrogen exchange reveals Hsp104 architecture, structural dynamics, and energetics in physiological solution

Xiang Ye, Jiabei Lin, Leland Mayne, James Shorter, S. Walter Englander

Proc Natl Acad Sci U S A. 2019 Apr 9; 116(15): 7333–7342. Published online 2019 Mar 27. doi: 10.1073/pnas.1816184116

PMCID:: PMC6462101

Abstract Article PDF–2.5M

Select item 577023812.

Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104

Stephanie N. Gates, Adam L. Yokom, JiaBei Lin, Meredith E. Jackrel, Alexandrea N. Rizo, Nathan M. Kendsersky, Courtney E. Buell, Elizabeth A. Sweeny, Korrie L. Mack, Edward Chuang, Mariana P. Torrente, Min Su, James Shorter, Daniel R. Southworth

Science. Author manuscript; available in PMC 2018 Jan 16.

Published in final edited form as: Science. 2017 Jul 21; 357(6348): 273–279. Published online 2017 Jun 15. doi: 10.1126/science.aan1052

PMCID:: PMC5770238

Abstract Article PDF–3.8M

Select item 574183113.

Structural determinants for protein unfolding and translocation by the Hsp104 protein disaggregase

Jungsoon Lee, Nuri Sung, Lythou Yeo, Changsoo Chang, Sukyeong Lee, Francis T.F. Tsai

Biosci Rep. 2017 Dec 22; 37(6): BSR20171399. Prepublished online 2017 Nov 24. Published online 2017 Dec 22. doi: 10.1042/BSR20171399

PMCID:: PMC5741831

Abstract Article PDF–1.8M

Select item 564936214.

Avidity for Polypeptide Binding by Nucleotide-Bound Hsp104 Structures

Clarissa L. Weaver, Elizabeth C. Duran, Korrie L. Mack, JiaBei Lin, Meredith E. Jackrel, Elizabeth A. Sweeny, James Shorter, Aaron L. Lucius

Biochemistry. Author manuscript; available in PMC 2017 Oct 20.

Published in final edited form as: Biochemistry. 2017 Apr 18; 56(15): 2071–2075. Published online 2017 Apr 10. doi: 10.1021/acs.biochem.7b00225

PMCID:: PMC5649362

Abstract Article PDF–629K

Select item 559392715.

Overlapping and Specific Functions of the Hsp104 N Domain Define Its Role in Protein Disaggregation

Jungsoon Lee, Nuri Sung, Jonathan M. Mercado, Corey F. Hryc, Changsoo Chang, Sukyeong Lee, Francis T. F. Tsai

Sci Rep. 2017; 7: 11184. Published online 2017 Sep 11. doi: 10.1038/s41598-017-11474-9

PMCID:: PMC5593927

Abstract Article PDF–3.9M

Select item 550943516.

Spiral architecture of the Hsp104 disaggregase reveals the structural basis for polypeptide translocation

Adam L. Yokom, Stephanie Gates, Meredith E. Jackrel, Korrie L. Mack, Min Su, James Shorter, Daniel R. Southworth

Nat Struct Mol Biol. Author manuscript; available in PMC 2017 Sep 1.

Published in final edited form as: Nat Struct Mol Biol. 2016 Sep; 23(9): 830–837. Published online 2016 Aug 1. doi: 10.1038/nsmb.3277

PMCID:: PMC5509435

Abstract Article PDF–2.5M

Select item 483378017.

Kinetics of Formation and Asymmetrical Distribution of Hsp104-Bound Protein Aggregates in Yeast

Camille Paoletti, Sophie Quintin, Audrey Matifas, Gilles Charvin

Biophys J. 2016 Apr 12; 110(7): 1605–1614. Published online 2016 Apr 12. doi: 10.1016/j.bpj.2016.02.034

PMCID:: PMC4833780

Abstract Article PDF–2.9M

Select item 477784518.

Mechanistic Insights into Hsp104 Potentiation

Mariana P. Torrente, Edward Chuang, Megan M. Noll, Meredith E. Jackrel, Michelle S. Go, James Shorter

J Biol Chem. 2016 Mar 4; 291(10): 5101–5115. Published online 2016 Jan 8. doi: 10.1074/jbc.M115.707976

PMCID:: PMC4777845

Abstract Article PDF–3.3M

Select item 454657119.

Repurposing Hsp104 to antagonize seminal amyloid and counter HIV infection

Laura M. Castellano, Stephen M. Bart, Veronica M. Holmes, Drew Weissman, James Shorter

Chem Biol. Author manuscript; available in PMC 2016 Aug 20.

Published in final edited form as: Chem Biol. 2015 Aug 20; 22(8): 1074–1086. Published online 2015 Aug 6. doi: 10.1016/j.chembiol.2015.07.007

PMCID:: PMC4546571

Abstract Article PDF–1.1M

Select item 419254520.

Suramin Inhibits Hsp104 ATPase and Disaggregase Activity

Mariana P. Torrente, Laura M. Castellano, James Shorter

PLoS One. 2014; 9(10): e110115. Published online 2014 Oct 9. doi: 10.1371/journal.pone.0110115

PMCID:: PMC4192545

Abstract Article PDF–1.6M

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