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Select item 83827841.

Cryo-EM structures of the endoplasmic reticulum membrane complex

Lin Bai, Huilin Li

FEBS J. Author manuscript; available in PMC 2023 Jan 1.

Published in final edited form as: FEBS J. 2022 Jan; 289(1): 102–112. Published online 2021 Mar 6. doi: 10.1111/febs.15786

PMCID:: PMC8382784

Abstract Article PDF–2.5M

Select item 57669672.

The Sec61/SecY complex is inherently deficient in translocating intrinsically disordered proteins

Anika Gonsberg, Sebastian Jung, Sarah Ulbrich, Andrea Origi, Anke Ziska, Michael Baier, Hans-Georg Koch, Richard Zimmermann, Konstanze F. Winklhofer, Jörg Tatzelt

J Biol Chem. 2017 Dec 29; 292(52): 21383–21396. Published online 2017 Oct 30. doi: 10.1074/jbc.M117.788067

PMCID:: PMC5766967

Abstract Article PDF–1.7M

Select item 43599253.

Decatransin, a new natural product inhibiting protein translocation at the Sec61/SecYEG translocon

Tina Junne, Joanne Wong, Christian Studer, Thomas Aust, Benedikt W. Bauer, Martin Beibel, Bhupinder Bhullar, Robert Bruccoleri, Jürg Eichenberger, David Estoppey, Nicole Hartmann, Britta Knapp, Philipp Krastel, Nicolas Melin, Edward J. Oakeley, Lukas Oberer, Ralph Riedl, Guglielmo Roma, Sven Schuierer, Frank Petersen, John A. Tallarico, Tom A. Rapoport, Martin Spiess, Dominic Hoepfner

J Cell Sci. 2015 Mar 15; 128(6): 1217–1229. doi: 10.1242/jcs.165746

PMCID:: PMC4359925

Abstract Article

Select item 41409384.

Structural and Functional Profiling of the Lateral Gate of the Sec61 Translocon

Johannes H. Reithinger, Chewon Yim, Sungmin Kim, Hunsang Lee, Hyun Kim

J Biol Chem. 2014 May 30; 289(22): 15845–15855. Published online 2014 Apr 21. doi: 10.1074/jbc.M113.533794

PMCID:: PMC4140938

Abstract Article PDF–1.8M

Select item 38979195.

ERAD and protein import defects in a sec61 mutant lacking ER-lumenal loop 7

Thomas Tretter, Fábio P Pereira, Ozlem Ulucan, Volkhard Helms, Susanne Allan, Kai-Uwe Kalies, Karin Römisch

BMC Cell Biol. 2013; 14: 56. Published online 2013 Dec 6. doi: 10.1186/1471-2121-14-56

PMCID:: PMC3897919

Abstract Article PDF–1.2M

Select item 38396966.

Functional asymmetry within the Sec61p translocon

Erhan Demirci, Tina Junne, Sefer Baday, Simon Bernèche, Martin Spiess

Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47): 18856–18861. Published online 2013 Nov 4. doi: 10.1073/pnas.1318432110

PMCID:: PMC3839696

Abstract Article PDF–1.5M

Select item 35182257.

A gating motif in the translocation channel sets the hydrophobicity threshold for signal sequence function

Steven F. Trueman, Elisabet C. Mandon, Reid Gilmore

J Cell Biol. 2012 Dec 10; 199(6): 907–918. doi: 10.1083/jcb.201207163

PMCID:: PMC3518225

Abstract Article PDF–2.3M

Select item 21147728.

A yeast mutant defective at an early stage in import of secretory protein precursors into the endoplasmic reticulum

J Cell Biol. 1987 Aug 1; 105(2): 633–645. doi: 10.1083/jcb.105.2.633

PMCID:: PMC2114772

Summary PDF–1.9M

Select item 15563859.

The Plug Domain of Yeast Sec61p Is Important for Efficient Protein Translocation, but Is Not Essential for Cell Viability

Tina Junne, Torsten Schwede, Veit Goder, Martin Spiess

Mol Biol Cell. 2006 Sep; 17(9): 4063–4068. doi: 10.1091/mbc.E06-03-0200

PMCID:: PMC1556385

Abstract Article PDF–631K

Select item 117008010.

Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation.

M Pilon, R Schekman, K Römisch

EMBO J. 1997 Aug 1; 16(15): 4540–4548. doi: 10.1093/emboj/16.15.4540

PMCID:: PMC1170080

Summary PDF–343K

Select item 36316911.

Sec61p Contributes to Signal Sequence Orientation According to the Positive-Inside Rule

Veit Goder, Tina Junne, Martin Spiess

Mol Biol Cell. 2004 Mar; 15(3): 1470–1478. doi: 10.1091/mbc.E03-08-0599

PMCID:: PMC363169

Abstract Article PDF–517K

Select item 27551312.

Protein translocation mutants defective in the insertion of integral membrane proteins into the endoplasmic reticulum.

C J Stirling, J Rothblatt, M Hosobuchi, R Deshaies, R Schekman

Mol Biol Cell. 1992 Feb; 3(2): 129–142. doi: 10.1091/mbc.3.2.129

PMCID:: PMC275513

Summary Page Browse PDF–3.3M

Select item 1828013.

The protein translocation channel mediates glycopeptide export across the endoplasmic reticulum membrane

Pauline Gillece, Marinus Pilon, Karin Römisch

Proc Natl Acad Sci U S A. 2000 Apr 25; 97(9): 4609–4614. Published online 2000 Apr 11. doi: 10.1073/pnas.090083497

PMCID:: PMC18280

Abstract Article PDF–228K

Select item 994733314.

Sec61 channel subunit Sbh1/Sec61β promotes ER translocation of proteins with suboptimal targeting sequences and is fine-tuned by phosphorylation

Guido Barbieri, Julien Simon, Cristina R. Lupusella, Fabio Pereira, Francesco Elia, Hadar Meyer, Maya Schuldiner, Steven D. Hanes, Duy Nguyen, Volkhard Helms, Karin Römisch

J Biol Chem. 2023 Mar; 299(3): 102895. Published online 2023 Jan 11. doi: 10.1016/j.jbc.2023.102895

PMCID:: PMC9947333

Abstract Article PDF–1.7M

Select item 843946515.

Cancer associated mutations in Sec61γ alter the permeability of the ER translocase

Christopher M. Witham, Aleshanee L. Paxman, Lamprini Baklous, Robert F. L. Steuart, Benjamin L. Schulz, Carl J. Mousley

PLoS Genet. 2021 Aug; 17(8): e1009780. Published online 2021 Aug 30. doi: 10.1371/journal.pgen.1009780

PMCID:: PMC8439465

Abstract Article PDF–2.6M

Select item 702911616.

The conserved C-terminus of Sss1p is required to maintain the endoplasmic reticulum permeability barrier

Christopher M. Witham, Hasindu G. Dassanayake, Aleshanee L. Paxman, Kofi L. P. Stevens, Lamprini Baklous, Paris F. White, Amy L. Black, Robert F. L. Steuart, Colin J. Stirling, Benjamin L. Schulz, Carl J. Mousley

J Biol Chem. 2020 Feb 14; 295(7): 2125–2134. Published online 2019 Dec 17. doi: 10.1074/jbc.RA119.010378