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Select item 1179301.

MEC3, MEC1, and DDC2 Are Essential Components of a Telomere Checkpoint Pathway Required for Cell Cycle Arrest during Senescence in Saccharomyces cerevisiae

Shinichiro Enomoto, Lynn Glowczewski, Judith Berman

Mol Biol Cell. 2002 Aug; 13(8): 2626–2638. doi: 10.1091/mbc.02-02-0012

PMCID:: PMC117930

Abstract Article PDF–456K

Select item 18999712.

Function of a Conserved Checkpoint Recruitment Domain in ATRIP Proteins

Heather L. Ball, Mark R. Ehrhardt, Daniel A. Mordes, Gloria G. Glick, Walter J. Chazin, David Cortez

Mol Cell Biol. 2007 May; 27(9): 3367–3377. Published online 2007 Mar 5. doi: 10.1128/MCB.02238-06

PMCID:: PMC1899971

Abstract Article PDF–793K

Select item 870543.

Characterization of mec1 Kinase-Deficient Mutants and of New Hypomorphic mec1 Alleles Impairing Subsets of the DNA Damage Response Pathway

Vera Paciotti, Michela Clerici, Maddalena Scotti, Giovanna Lucchini, Maria Pia Longhese

Mol Cell Biol. 2001 Jun; 21(12): 3913–3925. doi: 10.1128/MCB.21.12.3913-3925.2001

PMCID:: PMC87054

Abstract Article PDF–1005K

Select item 64158664.

Live cell monitoring of double strand breaks in S. cerevisiae

David P. Waterman, Felix Zhou, Kevin Li, Cheng-Sheng Lee, Michael Tsabar, Vinay V. Eapen, Allison Mazzella, James E. Haber

PLoS Genet. 2019 Mar; 15(3): e1008001. Published online 2019 Mar 1. doi: 10.1371/journal.pgen.1008001

PMCID:: PMC6415866

Abstract Article PDF–2.9M

Select item 25962335.

Dpb11 activates the Mec1–Ddc2 complex

Daniel A. Mordes, Edward A. Nam, David Cortez

Proc Natl Acad Sci U S A. 2008 Dec 2; 105(48): 18730–18734. Published online 2008 Nov 21. doi: 10.1073/pnas.0806621105

PMCID:: PMC2596233

Abstract Article PDF–702K

Select item 24131906.

Break dosage, cell cycle stage and DNA replication influence DNA double strand break response

Christian Zierhut, John F X Diffley

EMBO J. 2008 Jul 9; 27(13): 1875–1885. Published online 2008 May 29. doi: 10.1038/emboj.2008.111

PMCID:: PMC2413190

Abstract Article PDF–468K

Select item 3792617.

Mutant Telomere Sequences Lead to Impaired Chromosome Separation and a Unique Checkpoint Response

Jue Lin, Dana L. Smith, Elizabeth H. Blackburn

Mol Biol Cell. 2004 Apr; 15(4): 1623–1634. doi: 10.1091/mbc.E03-10-0740

PMCID:: PMC379261

Abstract Article PDF–718K

Select item 866678.

Pie1, a Protein Interacting with Mec1, Controls Cell Growth and Checkpoint Responses in Saccharomyces cerevisiae

Tatsushi Wakayama, Tae Kondo, Seiko Ando, Kunihiro Matsumoto, Katsunori Sugimoto

Mol Cell Biol. 2001 Feb; 21(3): 755–764. doi: 10.1128/MCB.21.3.755-764.2001

PMCID:: PMC86667

Abstract Article PDF–1.9M

Select item 80273559.

Rad9, a 53BP1 Ortholog of Budding Yeast, Is Insensitive to Spo11-Induced Double-Strand Breaks During Meiosis

Takehiko Usui, Akira Shinohara

Front Cell Dev Biol. 2021; 9: 635383. Published online 2021 Mar 25. doi: 10.3389/fcell.2021.635383

PMCID:: PMC8027355

Abstract Article PDF–1.4M

Select item 785523310.

Mechanism of Auto-inhibition and Activation of Mec1^ATR Checkpoint Kinase

Elias A. Tannous, Luke A. Yates, Xiaodong Zhang, Peter M. Burgers

Nat Struct Mol Biol. Author manuscript; available in PMC 2021 May 9.

Published in final edited form as: Nat Struct Mol Biol. 2021 Jan; 28(1): 50–61. Published online 2020 Nov 9. doi: 10.1038/s41594-020-00522-0

PMCID:: PMC7855233

Abstract Article PDF–7.5M

Select item 570656211.

Yeast PP4 Interacts with ATR Homolog Ddc2-Mec1 and Regulates Checkpoint Signaling

Nicole Hustedt, Andrew Seeber, Ragna Sack, Monika Tsai-Pflugfelder, Bhupinder Bhullar, Hanneke Vlaming, Fred van Leeuwen, Aude Guénolé, Haico van Attikum, Rohith Srivas, Trey Ideker, Kenji Shimada, Susan M. Gasser

Mol Cell. Author manuscript; available in PMC 2017 Nov 29.

Published in final edited form as: Mol Cell. 2015 Jan 22; 57(2): 273–289. Published online 2014 Dec 18. doi: 10.1016/j.molcel.2014.11.016

PMCID:: PMC5706562

Abstract Article PDF–1.2M

Select item 261081112.

Acetylated lysine 56 on histone H3 drives chromatin assembly after repair, signaling for the completion of repair

Chin-Chuan Chen, Joshua J. Carson, Jason Feser, Beth Tamburini, Susan Zabaronick, Jeffrey Linger, Jessica K. Tyler

Cell. Author manuscript; available in PMC 2009 Jul 25.

Published in final edited form as: Cell. 2008 Jul 25; 134(2): 231–243. doi: 10.1016/j.cell.2008.06.035

PMCID:: PMC2610811

Abstract Article PDF–2.4M

Select item 241858413.

TopBP1 activates ATR through ATRIP and a PIKK regulatory domain

Daniel A. Mordes, Gloria G. Glick, Runxiang Zhao, David Cortez

Genes Dev. 2008 Jun 1; 22(11): 1478–1489. doi: 10.1101/gad.1666208

PMCID:: PMC2418584

Abstract Article PDF–470K

Select item 239623814.

Mrc1, Tof1 and Csm3 inhibit CAG CTG repeat instability by at least two mechanisms

David F. Razidlo, Robert S. Lahue

DNA Repair (Amst) Author manuscript; available in PMC 2009 Apr 2.

Published in final edited form as: DNA Repair (Amst). 2008 Apr 2; 7(4): 633–640. Published online 2008 Mar 5. doi: 10.1016/j.dnarep.2008.01.009

PMCID:: PMC2396238

Abstract Article PDF–640K

Select item 126642115.

Role of the C Terminus of Mec1 Checkpoint Kinase in Its Localization to Sites of DNA Damage

Daisuke Nakada, Yukinori Hirano, Yuya Tanaka, Katsunori Sugimoto

Mol Biol Cell. 2005 Nov; 16(11): 5227–5235. doi: 10.1091/mbc.E05-05-0405

PMCID:: PMC1266421

Abstract Article PDF–398K

Select item 31685816.

The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast

Vera Paciotti, Michela Clerici, Giovanna Lucchini, Maria Pia Longhese

Genes Dev. 2000 Aug 15; 14(16): 2046–2059.

PMCID:: PMC316858

Abstract Article PDF–4.9M

Select item 1008355517.

A DNA damage–induced phosphorylation circuit enhances Mec1^ATR Ddc2^ATRIP recruitment to Replication Protein A

Luke A. Yates, Elias A. Tannous, R. Marc Morgan, Peter M. Burgers, Xiaodong Zhang

Proc Natl Acad Sci U S A. 2023 Apr 4; 120(14): e2300150120. Published online 2023 Mar 30. doi: 10.1073/pnas.2300150120

PMCID:: PMC10083555

Abstract Article PDF–2.3M

Select item 747466018.

Yeast ATM and ATR kinases use different mechanisms to spread histone H2A phosphorylation around a DNA double-strand break

Kevin Li, Gabriel Bronk, Jane Kondev, James E. Haber

Proc Natl Acad Sci U S A. 2020 Sep 1; 117(35): 21354–21363. Published online 2020 Aug 17. doi: 10.1073/pnas.2002126117

PMCID:: PMC7474660

Abstract Article PDF–1.8M

Select item 491943219.

The Dimeric Architecture of Checkpoint Kinases Mec1^ATR and Tel1^ATM Reveal a Common Structural Organization

Marta Sawicka, Paulina H. Wanrooij, Vidya C. Darbari, Elias Tannous, Sarem Hailemariam, Daniel Bose, Alena V. Makarova, Peter M. Burgers, Xiaodong Zhang

J Biol Chem. 2016 Jun 24; 291(26): 13436–13447. Published online 2016 Apr 28. doi: 10.1074/jbc.M115.708263