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Items: 1 to 20 of 399

1.
Hydroxyurea and inactivation of checkpoint kinase MEC1 inhibit transcription termination and pre-mRNA cleavage at polyadenylation sites in budding yeast
Pritpal Kaur, Shreya Nagar, Riddhi Mehta, Kyle Sahadeo, Ales Vancura
Sci Rep. 2023; 13: 13106. Published online 2023 Aug 11. doi: 10.1038/s41598-023-40294-3
PMCID:
PMC10421882
AbstractArticlePDF–4.5M
2.
Separable roles for Mec1/ATR in genome maintenance, DNA replication, and checkpoint signaling
Michael Charles Lanz, Susannah Oberly, Ethan James Sanford, Sushma Sharma, Andrei Chabes, Marcus Bustamante Smolka
Genes Dev. 2018 Jun 1; 32(11-12): 822–835. doi: 10.1101/gad.308148.117
PMCID:
PMC6049512
AbstractArticlePDF–2.2M
3.
ATR-like kinase Mec1 facilitates both chromatin accessibility at DNA replication forks and replication fork progression during replication stress
Jairo Rodriguez, Toshio Tsukiyama
Genes Dev. 2013 Jan 1; 27(1): 74–86. doi: 10.1101/gad.202978.112
PMCID:
PMC3553285
AbstractArticlePDF–1.1M
4.
Activation of dormant origins of DNA replication in budding yeast
Corrado Santocanale, Karuna Sharma, John F.X. Diffley
Genes Dev. 1999 Sep 15; 13(18): 2360–2364. doi: 10.1101/gad.13.18.2360
PMCID:
PMC317032
AbstractArticlePDF–780K
5.
An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae.
R Kato, H Ogawa
Nucleic Acids Res. 1994 Aug 11; 22(15): 3104–3112. doi: 10.1093/nar/22.15.3104
PMCID:
PMC310282
SummaryPage BrowsePDF–2.2M
6.
The Saccharomyces cerevisiae MEC1 gene, which encodes a homolog of the human ATM gene product, is required for G1 arrest following radiation treatment.
W Siede, J B Allen, S J Elledge, E C Friedberg
J Bacteriol. 1996 Oct; 178(19): 5841–5843. doi: 10.1128/jb.178.19.5841-5843.1996
PMCID:
PMC178434
SummaryPDF–177K
7.
Deletion of MEC1 suppresses the replicative senescence of the cdc13-2 mutant in Saccharomyces cerevisiae
Yue Yao, Enikő Fekete-Szücs, Fernando R Rosas Bringas, Michael Chang
G3 (Bethesda) 2023 May; 13(5): jkad065. Published online 2023 Mar 22. doi: 10.1093/g3journal/jkad065
PMCID:
PMC10151410
AbstractArticlePDF–470K
8.
Mec1 Modulates Interhomolog Crossover and Interplays with Tel1 at Post Double-Strand Break Stages
Min-Su Lee, Jung Whan Joo, Hyungseok Choi, Hyun Ah Kang, Keunpil Kim
J Microbiol Biotechnol. 2020 Mar 28; 30(3): 469–475. Published online 2019 Dec 4. doi: 10.4014/jmb.1909.09020
PMCID:
PMC9728206
AbstractArticlePDF–5.0M
9.
Distinct Functions in Regulation of Meiotic Crossovers for DNA Damage Response Clamp Loader Rad24(Rad17) and Mec1(ATR) Kinase
Miki Shinohara, Douglas K. Bishop, Akira Shinohara
Genetics. 2019 Dec; 213(4): 1255–1269. Published online 2019 Oct 9. doi: 10.1534/genetics.119.302427
Correction in:
Genetics. 2020 Dec; 216(4): 1239–1241.
PMCID:
PMC6893372
AbstractArticlePDF–1.6M
10.
S phase block following MEC1ATR inactivation occurs without severe dNTP depletion
Caroline Earp, Samuel Rowbotham, Gábor Merényi, Andrei Chabes, Rita S. Cha
Biol Open. 2015 Dec 15; 4(12): 1739–1743. Published online 2015 Nov 24. doi: 10.1242/bio.015347
PMCID:
PMC4736042
AbstractArticlePDF–660K
11.
Distribution and Dynamics of Chromatin Modification Induced by a Defined DNA Double-Strand Break
Robert Shroff, Ayelet Arbel-Eden, Duane Pilch, Grzegorz Ira, William M. Bonner, John H. Petrini, James E. Haber, Michael Lichten
Curr Biol. Author manuscript; available in PMC 2015 Jul 7.
Published in final edited form as: Curr Biol. 2004 Oct 5; 14(19): 1703–1711. doi: 10.1016/j.cub.2004.09.047
PMCID:
PMC4493763
AbstractArticlePDF–1.0M
12.
Gradual Implementation of the Meiotic Recombination Program via Checkpoint Pathways Controlled by Global DSB Levels
Neeraj Joshi, M. Scott Brown, Douglas K. Bishop, G. Valentin Börner
Mol Cell. Author manuscript; available in PMC 2016 Mar 5.
Published in final edited form as: Mol Cell. 2015 Mar 5; 57(5): 797–811. Published online 2015 Feb 5. doi: 10.1016/j.molcel.2014.12.027
PMCID:
PMC4392720
AbstractArticlePDF–1.0M
13.
Dynamics of yeast histone H2A and H2B phosphorylation in response to a double-strand break
Cheng-Sheng Lee, Kihoon Lee, Gaelle Legube, James E. Haber
Nat Struct Mol Biol. Author manuscript; available in PMC 2014 Jul 1.
Published in final edited form as: Nat Struct Mol Biol. 2014 Jan; 21(1): 103–109. Published online 2013 Dec 15. doi: 10.1038/nsmb.2737
PMCID:
PMC3889172
AbstractArticlePDF–2.4M
14.
A tale of two tails: Activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1
Vasundhara M. Navadgi-Patil, Peter M. Burgers
DNA Repair (Amst) Author manuscript; available in PMC 2010 Sep 2.
Published in final edited form as: DNA Repair (Amst). 2009 Sep 2; 8(9): 996–1003. Published online 2009 May 22. doi: 10.1016/j.dnarep.2009.03.011
PMCID:
PMC2725207
AbstractArticlePDF–1.2M
15.
High Rates of “Unselected” Aneuploidy and Chromosome Rearrangements in tel1 mec1 Haploid Yeast Strains
Michael Vernon, Kirill Lobachev, Thomas D. Petes
Genetics. 2008 May; 179(1): 237–247. doi: 10.1534/genetics.107.086603
PMCID:
PMC2390603
AbstractArticlePDF–966K
16.
Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes.
Rolf J Craven, Patricia W Greenwell, Margaret Dominska, Thomas D Petes
Genetics. 2002 Jun; 161(2): 493–507. doi: 10.1093/genetics/161.2.493
PMCID:
PMC1462148
SummaryPDF–294K
17.
Evidence of Meiotic Crossover Control in Saccharomyces cerevisiae Through Mec1-Mediated Phosphorylation of Replication Protein A
Amy J. Bartrand, Dagmawi Iyasu, Suzanne M. Marinco, George S. Brush
Genetics. 2006 Jan; 172(1): 27–39. doi: 10.1534/genetics.105.047845
PMCID:
PMC1456154
AbstractArticlePDF–334K
18.
Esc4p, a new target of Mec1p (ATR), promotes resumption of DNA synthesis after DNA damage
John Rouse
EMBO J. 2004 Mar 10; 23(5): 1188–1197. Published online 2004 Feb 26. doi: 10.1038/sj.emboj.7600129
Correction in:
EMBO J. 2004 Jul 21; 23(14): 2914.
PMCID:
PMC380984
AbstractArticlePDF–328K
19.
Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function.
G L Kiser, T A Weinert
Mol Biol Cell. 1996 May; 7(5): 703–718. doi: 10.1091/mbc.7.5.703
PMCID:
PMC275924
SummaryPage BrowsePDF–2.9M
20.
DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1
Jennifer A. Cobb, Lotte Bjergbaek, Kenji Shimada, Christian Frei, Susan M. Gasser
EMBO J. 2003 Aug 15; 22(16): 4325–4336. doi: 10.1093/emboj/cdg391
PMCID:
PMC175781
AbstractArticlePDF–404K

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