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Select item 84214111.

Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5

Andrzej Harris, Manuel Wagner, Dijun Du, Stefanie Raschka, Lea-Marie Nentwig, Holger Gohlke, Sander H. J. Smits, Ben F. Luisi, Lutz Schmitt

Nat Commun. 2021; 12: 5254. Published online 2021 Sep 6. doi: 10.1038/s41467-021-25574-8

PMCID:: PMC8421411

Abstract Article PDF–8.8M

Select item 81485202.

Involvement of a Multidrug Efflux Pump and Alterations in Cell Surface Structure in the Synergistic Antifungal Activity of Nagilactone E and Anethole against Budding Yeast Saccharomyces cerevisiae

Yuki Ueda, Yuhei O. Tahara, Makoto Miyata, Akira Ogita, Yoshihiro Yamaguchi, Toshio Tanaka, Ken-ichi Fujita

Antibiotics (Basel) 2021 May; 10(5): 537. Published online 2021 May 6. doi: 10.3390/antibiotics10050537

PMCID:: PMC8148520

Abstract Article PDF–11M

Select item 74556623.

β-Lapachone enhances the antifungal activity of fluconazole against a Pdr5p-mediated resistant Saccharomyces cerevisiae strain

Daniel Clemente de Moraes, Karina Martins Cardoso, Levy Tenório Sousa Domingos, Maria do Carmo Freire Ribeiro Pinto, Robson Q. Monteiro, Antônio Ferreira-Pereira

Braz J Microbiol. 2020 Sep; 51(3): 1051–1060. Published online 2020 Mar 10. doi: 10.1007/s42770-020-00254-9

PMCID:: PMC7455662

Abstract Article PDF–653K

Select item 69450314.

Nonsynonymous Mutations in Linker-2 of the Pdr5 Multidrug Transporter Identify a New RNA Stability Element

Hadiar Rahman, Andrew Rudrow, Joshua Carneglia, Sister Stephen Patrick Joly, Dante Nicotera, Michael Naldrett, John Choy, Suresh V. Ambudkar, John Golin

G3 (Bethesda) 2020 Jan; 10(1): 357–369. Published online 2019 Nov 22. doi: 10.1534/g3.119.400863

PMCID:: PMC6945031

Abstract Article PDF–2.1M

Select item 68007725.

An A666G mutation in transmembrane-helix 5 of the yeast multidrug transporter Pdr5 increases drug efflux by enhancing cooperativity between transport sites

Nidhi Arya, Hadiar Rahman, Andrew Rudrow, Manuel Wagner, Lutz Schmitt, Suresh V. Ambudkar, John Golin

Mol Microbiol. Author manuscript; available in PMC 2020 Oct 1.

Published in final edited form as: Mol Microbiol. 2019 Oct; 112(4): 1131–1144. Published online 2019 Jul 23. doi: 10.1111/mmi.14351

PMCID:: PMC6800772

Abstract Article PDF–1.1M

Select item 65333086.

In vitro NTPase activity of highly purified Pdr5, a major yeast ABC multidrug transporter

Manuel Wagner, Sander H. J. Smits, Lutz Schmitt

Sci Rep. 2019; 9: 7761. Published online 2019 May 23. doi: 10.1038/s41598-019-44327-8

PMCID:: PMC6533308

Abstract Article PDF–1.6M

Select item 64769597.

Novel 3,4-Dihydroisocoumarins Inhibit Human P-gp and BCRP in Multidrug Resistant Tumors and Demonstrate Substrate Inhibition of Yeast Pdr5

Julia Sachs, Katja Döhl, Anja Weber, Michele Bonus, Ferdinand Ehlers, Edmond Fleischer, Anette Klinger, Holger Gohlke, Jörg Pietruszka, Lutz Schmitt, Nicole Teusch

Front Pharmacol. 2019; 10: 400. Published online 2019 Apr 16. doi: 10.3389/fphar.2019.00400

PMCID:: PMC6476959

Abstract Article PDF–2.7M

Select item 63252348.

FK506 Resistance of Saccharomyces cerevisiae Pdr5 and Candida albicans Cdr1 Involves Mutations in the Transmembrane Domains and Extracellular Loops

Koichi Tanabe, Michele Bonus, Susumu Tomiyama, Kunji Miyoshi, Minoru Nagi, Kyoko Niimi, Ariya Chindamporn, Holger Gohlke, Lutz Schmitt, Richard D. Cannon, Masakazu Niimi, Erwin Lamping

Antimicrob Agents Chemother. 2019 Jan; 63(1): e01146-18. Prepublished online 2018 Oct 22. Published online 2018 Dec 21. doi: 10.1128/AAC.01146-18

PMCID:: PMC6325234

Abstract Article PDF–3.0M

Select item 62930129.

Measuring Single-Cell Phenotypic Growth Heterogeneity Using a Microfluidic Cell Volume Sensor

Wenyang Jing, Brendan Camellato, Ian J. Roney, Mads Kaern, Michel Godin

Sci Rep. 2018; 8: 17809. Published online 2018 Dec 13. doi: 10.1038/s41598-018-36000-3

PMCID:: PMC6293012

Abstract Article PDF–1.2M

Select item 593255710.

Robust, pleiotropic drug resistance 5 (Pdr5)-mediated multidrug resistance is vigorously maintained in Saccharomyces cerevisiae cells during glucose and nitrogen limitation

Hadiar Rahman, Joshua Carneglia, Molly Lausten, Michael Robertello, John Choy, John Golin

FEMS Yeast Res. 2018 Jun; 18(4): foy029. Published online 2018 Apr 16. doi: 10.1093/femsyr/foy029

PMCID:: PMC5932557

Abstract Article PDF–1.5M

Select item 581506611.

Mutations of charged amino acids at the cytoplasmic end of transmembrane helix 2 affect transport activity of the budding yeast multidrug resistance protein Pdr5p

Weiwang Dou, Jianhua Zhu, Tanjun Wang, Wei Wang, Han Li, Xin Chen, Wenjun Guan

FEMS Yeast Res. 2016 Jun 1; 16(4): fow031. Published online 2016 Apr 19. doi: 10.1093/femsyr/fow031

PMCID:: PMC5815066

Abstract Article PDF–3.2M

Select item 575209812.

Efflux Pump Control Alters Synthetic Gene Circuit Function

Junchen Diao, Daniel A. Charlebois, Dmitry Nevozhay, Zoltán Bódi, Csaba Pál, Gábor Balázsi

ACS Synth Biol. Author manuscript; available in PMC 2018 Jan 3.

Published in final edited form as: ACS Synth Biol. 2016 Jul 15; 5(7): 619–631. Published online 2016 May 4. doi: 10.1021/acssynbio.5b00154

PMCID:: PMC5752098

Abstract Article PDF–2.0M

Select item 478496213.

The multidrug transporter Pdr5 on the 25th anniversary of its discovery: an important model for the study of asymmetric ABC transporters

John Golin, Suresh V. Ambudkar

Biochem J. Author manuscript; available in PMC 2016 Mar 9.

Published in final edited form as: Biochem J. 2015 May 1; 467(3): 353–363. doi: 10.1042/BJ20150042

PMCID:: PMC4784962

Abstract Article PDF–651K

Select item 422250114.

Synthetic organotelluride compounds induce the reversal of Pdr5p mediated fluconazole resistance in Saccharomyces cerevisiae

Leandro Figueira Reis de Sá, Fabiano Travanca Toledo, Bruno Artur de Sousa, Augusto César Gonçalves, Ana Claudia Tessis, Edison P Wendler, João V Comasseto, Alcindo A Dos Santos, Antonio Ferreira-Pereira

BMC Microbiol. 2014; 14: 201. Published online 2014 Jul 26. doi: 10.1186/s12866-014-0201-y