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Select item 55291071.

Evidence that Mediator is essential for Pol II transcription, but is not a required component of the preinitiation complex in vivo

Natalia Petrenko, Yi Jin, Koon Ho Wong, Kevin Struhl

eLife. 2017; 6: e28447. Published online 2017 Jul 12. doi: 10.7554/eLife.28447

Correction in:: eLife. 2017; 6: e32061.

PMCID:: PMC5529107

Abstract Article PDF–1.0M

Select item 150942.

Mediator protein mutations that selectively abolish activated transcription

Lawrence C. Myers, Claes M. Gustafsson, Kathleen C. Hayashibara, Patrick O. Brown, Roger D. Kornberg

Proc Natl Acad Sci U S A. 1999 Jan 5; 96(1): 67–72. doi: 10.1073/pnas.96.1.67

PMCID:: PMC15094

Abstract Article PDF–157K

Select item 51276433.

Dynamic control of Hsf1 during heat shock by a chaperone switch and phosphorylation

Xu Zheng, Joanna Krakowiak, Nikit Patel, Ali Beyzavi, Jideofor Ezike, Ahmad S Khalil, David Pincus

eLife. 2016; 5: e18638. Published online 2016 Nov 10. doi: 10.7554/eLife.18638

PMCID:: PMC5127643

Abstract Article PDF–2.2M

Select item 864884.

In Vivo Requirement of Activator-Specific Binding Targets of Mediator

Jin Mo Park, Hye-Suk Kim, Sang Jun Han, Moon-Sun Hwang, Young Chul Lee, Young-Joon Kim

Mol Cell Biol. 2000 Dec; 20(23): 8709–8719. doi: 10.1128/mcb.20.23.8709-8719.2000

PMCID:: PMC86488

Abstract Article PDF–2.1M

Select item 36369035.

Mediator Recruitment to Heat Shock Genes Requires Dual Hsf1 Activation Domains and Mediator Tail Subunits Med15 and Med16

Sunyoung Kim, David S. Gross

J Biol Chem. 2013 Apr 26; 288(17): 12197–12213. Published online 2013 Feb 27. doi: 10.1074/jbc.M112.449553

PMCID:: PMC3636903

Abstract Article PDF–5.0M

Select item 3441856.

Two Cyclin-Dependent Kinases Promote RNA Polymerase II Transcription and Formation of the Scaffold Complex

Ying Liu, Charles Kung, James Fishburn, Aseem Z. Ansari, Kevan M. Shokat, Steven Hahn

Mol Cell Biol. 2004 Feb; 24(4): 1721–1735. doi: 10.1128/MCB.24.4.1721-1735.2004

Correction in:: Mol Cell Biol. 2023; 43(9): 481–483.

PMCID:: PMC344185

Abstract Article PDF–857K

Select item 151447.

The Med1 subunit of the yeast mediator complex is involved in both transcriptional activation and repression

Darius Balciunas, Cecilia Gälman, Hans Ronne, Stefan Björklund

Proc Natl Acad Sci U S A. 1999 Jan 19; 96(2): 376–381. doi: 10.1073/pnas.96.2.376

Correction in:: Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6): 3330.

PMCID:: PMC15144

Abstract Article PDF–227K

Select item 26738078.

Mediator Structural Conservation and Implications for the Regulation Mechanism

Gang Cai, Tsuyoshi Imasaki, Yuichiro Takagi, Francisco J. Asturias

Structure. Author manuscript; available in PMC 2010 Apr 15.

Published in final edited form as: Structure. 2009 Apr 15; 17(4): 559–567. doi: 10.1016/j.str.2009.01.016

PMCID:: PMC2673807

Abstract Article PDF–2.7M

Select item 31523629.

Mediator head subcomplex Med11/22 contains a common helix bundle building block with a specific function in transcription initiation complex stabilization

Martin Seizl, Laurent Larivière, Toni Pfaffeneder, Larissa Wenzeck, Patrick Cramer

Nucleic Acids Res. 2011 Aug; 39(14): 6291–6304. Published online 2011 Apr 15. doi: 10.1093/nar/gkr229

PMCID:: PMC3152362

Abstract Article PDF–14M

Select item 10912110.

Requirement for a Functional Interaction between Mediator Components Med6 and Srb4 in RNA Polymerase II Transcription

Young Chul Lee, Young-Joon Kim

Mol Cell Biol. 1998 Sep; 18(9): 5364–5370. doi: 10.1128/mcb.18.9.5364

PMCID:: PMC109121

Abstract Article PDF–1.4M

Select item 353171811.

Mediator Phosphorylation Prevents Stress Response Transcription During Non-stress Conditions

Christian Miller, Ivan Matic, Kerstin C. Maier, Björn Schwalb, Susanne Roether, Katja Strässer, Achim Tresch, Matthias Mann, Patrick Cramer

J Biol Chem. 2012 Dec 28; 287(53): 44017–44026. Published online 2012 Nov 7. doi: 10.1074/jbc.M112.430140

PMCID:: PMC3531718

Abstract Article PDF–2.1M

Select item 8409112.

An Activator Binding Module of Yeast RNA Polymerase II Holoenzyme

Young Chul Lee, Jin Mo Park, Soyoung Min, Sang Jun Han, Young-Joon Kim

Mol Cell Biol. 1999 Apr; 19(4): 2967–2976. doi: 10.1128/mcb.19.4.2967

PMCID:: PMC84091

Abstract Article PDF–1.7M

Select item 408576313.

Redefining the modular organization of the core Mediator complex

Xuejuan Wang, Qianqian Sun, Zhenrui Ding, Jinhua Ji, Jianye Wang, Xiao Kong, Jianghong Yang, Gang Cai

Cell Res. 2014 Jul; 24(7): 796–808. Published online 2014 May 9. doi: 10.1038/cr.2014.64

PMCID:: PMC4085763

Abstract Article PDF–1.0M

Select item 383480714.

Mediator is an intrinsic component of the basal RNA polymerase II machinery in vivo

Thierry Lacombe, Siew Lay Poh, Régine Barbey, Laurent Kuras

Nucleic Acids Res. 2013 Nov; 41(21): 9651–9662. Published online 2013 Aug 20. doi: 10.1093/nar/gkt701

PMCID:: PMC3834807

Abstract Article PDF–804K

Select item 819133215.

The Cdk8 kinase module regulates interaction of the mediator complex with RNA polymerase II

Sara Osman, Eusra Mohammad, Michael Lidschreiber, Alexandra Stuetzer, Fanni Laura Bazsó, Kerstin C. Maier, Henning Urlaub, Patrick Cramer

J Biol Chem. 2021 Jan-Jun; 296: 100734. Published online 2021 Apr 30. doi: 10.1016/j.jbc.2021.100734

PMCID:: PMC8191332

Abstract Article PDF–2.6M

Select item 336792616.

Med5(Nut1) and Med17(Srb4) Are Direct Targets of Mediator Histone H4 Tail Interactions

Zhongle Liu, Lawrence C. Myers

PLoS One. 2012; 7(6): e38416. Published online 2012 Jun 5. doi: 10.1371/journal.pone.0038416

PMCID:: PMC3367926

Abstract Article PDF–1.8M

Select item 227919817.

Structure–system correlation identifies a gene regulatory Mediator submodule

Laurent Larivière, Martin Seizl, Sake van Wageningen, Susanne Röther, Loes van de Pasch, Heidi Feldmann, Katja Sträßer, Steve Hahn, Frank C.P. Holstege, Patrick Cramer

Genes Dev. 2008 Apr 1; 22(7): 872–877. doi: 10.1101/gad.465108

PMCID:: PMC2279198

Abstract Article PDF–435K

Select item 31640218.

The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain

Lawrence C. Myers, Claes M. Gustafsson, David A. Bushnell, Mary Lui, Hediye Erdjument-Bromage, Paul Tempst, Roger D. Kornberg

Genes Dev. 1998 Jan 1; 12(1): 45–54. doi: 10.1101/gad.12.1.45

PMCID:: PMC316402

Abstract Article PDF–517K

Select item 506661719.

Functional interplay between Mediator and TFIIB in preinitiation complex assembly in relation to promoter architecture

Thomas Eychenne, Elizaveta Novikova, Marie-Bénédicte Barrault, Olivier Alibert, Claire Boschiero, Nuno Peixeiro, David Cornu, Virginie Redeker, Laurent Kuras, Pierre Nicolas, Michel Werner, Julie Soutourina

Genes Dev. 2016 Sep 15; 30(18): 2119–2132. doi: 10.1101/gad.285775.116