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Select item 110098681.

RUNX1 mutations mitigate quiescence to promote transformation of hematopoietic progenitors in Fanconi anemia

William Marion, Tiago Koppe, Chun-Chin Chen, Dahai Wang, Katie Frenis, Sara Fierstein, Prerana Sensharma, Olivia Aumais, Michael Peters, Sonya Ruiz-Torres, Tafadzwa Chihanga, Steffen Boettcher, Akiko Shimamura, Daniel E. Bauer, Thorsten Schlaeger, Susanne I. Wells, Benjamin L. Ebert, Daniel Starczynowski, Edroaldo Lummertz da Rocha, R. Grant Rowe

Leukemia. Author manuscript; available in PMC 2024 Jun 1.

Published in final edited form as: Leukemia. 2023 Aug; 37(8): 1698–1708. Published online 2023 Jun 30. doi: 10.1038/s41375-023-01945-6

PMCID:: PMC11009868

Abstract Article PDF–1.0M

Select item 109979142.

Altered platelet-megakaryocyte endocytosis and trafficking of albumin and fibrinogen in RUNX1 haplodeficiency

Fabiola Del Carpio-Cano, Guangfen Mao, Lawrence E. Goldfinger, Jeremy Wurtzel, Liying Guan, Mohammad Afaque Alam, Kiwon Lee, Mortimer Poncz, A. Koneti Rao

Blood Adv. 2024 Apr 9; 8(7): 1699–1714. Published online 2024 Feb 10. doi: 10.1182/bloodadvances.2023011098

PMCID:: PMC10997914

Abstract Article PDF–4.8M

Select item 108371963.

Genomic landscape of patients with germline RUNX1 variants and familial platelet disorder with myeloid malignancy

Kai Yu, Natalie Deuitch, Matthew Merguerian, Lea Cunningham, Joie Davis, Erica Bresciani, Jamie Diemer, Elizabeth Andrews, Alice Young, Frank Donovan, Raman Sood, Kathleen Craft, Shawn Chong, Settara Chandrasekharappa, Jim Mullikin, Paul P. Liu

Blood Adv. 2024 Jan 23; 8(2): 497–511. Published online 2023 Nov 29. doi: 10.1182/bloodadvances.2023011165

PMCID:: PMC10837196

Abstract Article PDF–2.7M

Select item 107674004.

Hematopoietic Transcription Factor RUNX1 is Essential for Promoting Macrophage–Myofibroblast Transition in Non‐Small‐Cell Lung Carcinoma

Philip Chiu‐Tsun Tang, Max Kam‐Kwan Chan, Jeff Yat‐Fai Chung, Alex Siu‐Wing Chan, Dongmei Zhang, Chunjie Li, Kam‐Tong Leung, Calvin Sze‐Hang Ng, Yi Wu, Ka‐Fai To, Hui‐Yao Lan, Patrick Ming‐Kuen Tang

Adv Sci (Weinh) 2024 Jan; 11(1): 2302203. Published online 2023 Nov 15. doi: 10.1002/advs.202302203

PMCID:: PMC10767400

Abstract Article PDF–27M

Select item 107021245.

RUNX1 knockdown induced apoptosis and impaired EMT in high-grade serous ovarian cancer cells

Yuanzhi Chen, Zhicheng He, Shuting Yang, Cheng Chen, Wenyong Xiong, YingYing He, Shubai Liu

J Transl Med. 2023; 21: 886. Published online 2023 Dec 6. doi: 10.1186/s12967-023-04762-8

PMCID:: PMC10702124

Abstract Article PDF–4.3M

Select item 104814936.

RUN(X) out of blood: emerging RUNX1 functions beyond hematopoiesis and links to Down syndrome

Esteban J. Rozen, Christopher D. Ozeroff, Mary Ann Allen

Hum Genomics. 2023; 17: 83. Published online 2023 Sep 5. doi: 10.1186/s40246-023-00531-2

PMCID:: PMC10481493

Abstract Article PDF–4.6M

Select item 100865517.

RUNX1 Upregulation Causes Mitochondrial Dysfunction via Regulating the PI3K-Akt Pathway in iPSC from Patients with Down Syndrome

Yanna Liu, Yuehua Zhang, Zhaorui Ren, Fanyi Zeng, Jingbin Yan

Mol Cells. 2023 Apr 30; 46(4): 219–230. Published online 2023 Feb 10. doi: 10.14348/molcells.2023.2095

PMCID:: PMC10086551

Abstract Article PDF–136M

Select item 100237368.

RUNX1 isoform disequilibrium promotes the development of trisomy 21–associated myeloid leukemia

Sofia Gialesaki, Daniela Bräuer-Hartmann, Hasan Issa, Raj Bhayadia, Oriol Alejo-Valle, Lonneke Verboon, Anna-Lena Schmell, Stephanie Laszig, Enikő Regényi, Konstantin Schuschel, Maurice Labuhn, Michelle Ng, Robert Winkler, Christian Ihling, Andrea Sinz, Markus Glaß, Stefan Hüttelmaier, Sören Matzk, Lena Schmid, Farina Josepha Strüwe, Sofie-Katrin Kadel, Dirk Reinhardt, Marie-Laure Yaspo, Dirk Heckl, Jan-Henning Klusmann

Blood. 2023 Mar 9; 141(10): 1105–1118. Published online 2022 Dec 13. doi: 10.1182/blood.2022017619

PMCID:: PMC10023736

Abstract Article

Select item 99362979.

RUNX1-deficient human megakaryocytes demonstrate thrombopoietic and platelet half-life and functional defects

Kiwon Lee, Hyun Sook Ahn, Brian Estevez, Mortimer Poncz

Blood. 2023 Jan 19; 141(3): 260–270. Published online 2022 Oct 14. doi: 10.1182/blood.2022017561

PMCID:: PMC9936297

Abstract Article

Select item 925291110.

RUNX1 mutations contribute to the progression of MDS due to disruption of antitumor cellular defense: a study on patients with lower-risk MDS

Monika Kaisrlikova, Jitka Vesela, David Kundrat, Hana Votavova, Michaela Dostalova Merkerova, Zdenek Krejcik, Vladimir Divoky, Marek Jedlicka, Jan Fric, Jiri Klema, Dana Mikulenkova, Marketa Stastna Markova, Marie Lauermannova, Jolana Mertova, Jacqueline Soukupova Maaloufova, Anna Jonasova, Jaroslav Cermak, Monika Belickova

Leukemia. 2022; 36(7): 1898–1906. Published online 2022 May 3. doi: 10.1038/s41375-022-01584-3

PMCID:: PMC9252911

Abstract Article PDF–5.9M

Select item 908813611.

RUNX1 is a promising prognostic biomarker and related to immune infiltrates of cancer-associated fibroblasts in human cancers

Zhouting Tuo, Ying Zhang, Xin Wang, Shuxin Dai, Kun Liu, Dian Xia, Jinyou Wang, Liangkuan Bi

BMC Cancer. 2022; 22: 523. Published online 2022 May 9. doi: 10.1186/s12885-022-09632-y

PMCID:: PMC9088136

Abstract Article PDF–12M

Select item 889232712.

NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer

Josefina Doffo, Stefanos A. Bamopoulos, Hazal Köse, Felix Orben, Chuanbing Zang, Miriam Pons, Alexander T. den Dekker, Rutger W. W. Brouwer, Apoorva Baluapuri, Stefan Habringer, Maximillian Reichert, Anuradha Illendula, Oliver H. Krämer, Markus Schick, Elmar Wolf, Wilfred F. J. van IJcken, Irene Esposito, Ulrich Keller, Günter Schneider, Matthias Wirth

Proc Natl Acad Sci U S A. 2022 Mar 1; 119(9): e2105691119. Published online 2022 Feb 23. doi: 10.1073/pnas.2105691119

PMCID:: PMC8892327

Abstract Article PDF–2.7M

Select item 888540413.

Validation and refinement of a RUNX1 mutation-associated gene expression signature in blast crisis chronic myeloid leukemia

Kian Leong Lee, Tun Kiat Ko, Nicole Y. L. Saw, Asif Javed, Axel M. Hillmer, Charles Chuah, Vaidehi Krishnan, S. Tiong Ong

Leukemia. 2022; 36(3): 892–896. Published online 2022 Feb 4. doi: 10.1038/s41375-022-01508-1

PMCID:: PMC8885404

Article PDF–1.8M

Select item 881935414.

RUNX1 transactivates BCR‐ABL1 expression in Philadelphia chromosome positive acute lymphoblastic leukemia

Tatsuya Masuda, Shintaro Maeda, Sae Shimada, Naoya Sakuramoto, Ken Morita, Asami Koyama, Kensho Suzuki, Yoshihide Mitsuda, Hidemasa Matsuo, Hirohito Kubota, Itaru Kato, Kuniaki Tanaka, Junko Takita, Masahiro Hirata, Tatsuki R Kataoka, Tatsutoshi Nakahata, Souichi Adachi, Hideyo Hirai, Shuichi Mizuta, Kazuhito Naka, Yoichi Imai, Shinya Kimura, Hiroshi Sugiyama, Yasuhiko Kamikubo

Cancer Sci. 2022 Feb; 113(2): 529–539. Published online 2021 Dec 28. doi: 10.1111/cas.15239

PMCID:: PMC8819354

Abstract Article PDF–1.0M

Select item 880738915.

ETV6-RUNX1 and RUNX1 directly regulate RAG1 expression: one more step in the understanding of childhood B-cell acute lymphoblastic leukemia leukemogenesis

Hélène Jakobczyk, Yan Jiang, Lydie Debaize, Benoit Soubise, Stéphane Avner, Aurélien A. Sérandour, Jérémie Rouger-Gaudichon, Anne-Gaëlle Rio, Jason S. Carroll, Hana Raslova, David Gilot, Ziling Liu, Jocelyne Demengeot, Gilles Salbert, Nathalie Douet-Guilbert, Laurent Corcos, Marie-Dominique Galibert, Virginie Gandemer, Marie-Bérengère Troadec

Leukemia. 2022; 36(2): 549–554. Published online 2021 Sep 17. doi: 10.1038/s41375-021-01409-9

PMCID:: PMC8807389

Abstract Article PDF–1.5M

Select item 855097916.

Functional classification of RUNX1 variants in familial platelet disorder with associated myeloid malignancies

Melanie Decker, Tim Lammens, Alina Ferster, Miriam Erlacher, Ayami Yoshimi, Charlotte M. Niemeyer, Martijn P. T. Ernst, Marc H. G. P. Raaijmakers, Nicolas Duployez, Andreas Flaum, Doris Steinemann, Brigitte Schlegelberger, Thomas Illig, Tim Ripperger

Leukemia. 2021; 35(11): 3304–3308. Published online 2021 Mar 10. doi: 10.1038/s41375-021-01200-w

Correction in:: Leukemia. 2022; 36(12): 2949.

PMCID:: PMC8550979

Article PDF–1.3M

Select item 839501617.

Transcriptional Regulation of RUNX1: An Informatics Analysis

Amarni L. Thomas, Judith Marsman, Jisha Antony, William Schierding, Justin M. O’Sullivan, Julia A. Horsfield

Genes (Basel) 2021 Aug; 12(8): 1175. Published online 2021 Jul 29. doi: 10.3390/genes12081175

PMCID:: PMC8395016

Abstract Article PDF–2.4M

Select item 834028018.

RUNX1 can mediate the glucose and O-GlcNAc-driven proliferation and migration of human retinal microvascular endothelial cells

Xindan Xing, Hanying Wang, Tian Niu, Yan Jiang, Xin Shi, Kun Liu

BMJ Open Diabetes Res Care. 2021; 9(1): e001898. Published online 2021 Aug 4. doi: 10.1136/bmjdrc-2020-001898

PMCID:: PMC8340280

Abstract Article PDF–2.2M

Select item 816848819.

RUNX1-EVI1 disrupts lineage determination and the cell cycle by interfering with RUNX1 and EVI1 driven gene regulatory networks

Sophie G. Kellaway, Peter Keane, Ella Kennett, Constanze Bonifer

Haematologica. 2021 Jun 1; 106(6): 1569–1580. Published online 2020 Apr 16. doi: 10.3324/haematol.2019.241885

PMCID:: PMC8168488

Abstract Article PDF–2.5M

Select item 815688220.

The Potential Protective Role of RUNX1 in Nonalcoholic Fatty Liver Disease

Laia Bertran, Angela Pastor, Marta Portillo-Carrasquer, Jessica Binetti, Carmen Aguilar, Salomé Martínez, Margarita Vives, Fàtima Sabench, José Antonio Porras, David Riesco, Daniel Del Castillo, Cristóbal Richart, Teresa Auguet

Int J Mol Sci. 2021 May; 22(10): 5239. Published online 2021 May 15. doi: 10.3390/ijms22105239

PMCID:: PMC8156882

Abstract Article PDF–2.9M

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