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Select item 102890041.

O-GlcNAcylation of RIPK1 rescues red blood cells from necroptosis

Junghwa Seo, Yeolhoe Kim, Suena Ji, Han Byeol Kim, Hyeryeon Jung, Eugene C. Yi, Yong-ho Lee, Injae Shin, Won Ho Yang, Jin Won Cho

Front Immunol. 2023; 14: 1160490. Published online 2023 Jun 9. doi: 10.3389/fimmu.2023.1160490

PMCID:: PMC10289004

Abstract Article PDF–17M

Select item 102033432.

RIPK1-dependent necroptosis promotes vasculogenic mimicry formation via eIF4E in triple-negative breast cancer

Fan Li, Huizhi Sun, Yihui Yu, Na Che, Jiyuan Han, Runfen Cheng, Nan Zhao, Yuhong Guo, Chongbiao Huang, Danfang Zhang

Cell Death Dis. 2023 May; 14(5): 335. Published online 2023 May 22. doi: 10.1038/s41419-023-05841-w

Correction in:: Cell Death Dis. 2023 Sep; 14(9): 607.

PMCID:: PMC10203343

Abstract Article PDF–8.5M

Select item 97164693.

RIPK1 mutations causing infantile-onset IBD with inflammatory and fistulizing features

Mutaz Sultan, Mohammad Adawi, Nitzan Kol, Blake McCourt, Ihda Adawi, Liran Baram, Noa Tal, Lael Werner, Atar Lev, Scott B. Snapper, Ortal Barel, Liza Konnikova, Raz Somech, Dror S. Shouval

Front Immunol. 2022; 13: 1041315. Published online 2022 Nov 18. doi: 10.3389/fimmu.2022.1041315

PMCID:: PMC9716469

Abstract Article PDF–2.5M

Select item 96747084.

Characterization of Novel Pathogenic Variants Leading to Caspase-8 Cleavage-Resistant RIPK1-Induced Autoinflammatory Syndrome

Alfonso José Tapiz i Reula, Alexis-Virgil Cochino, Andreia L. Martins, Diego Angosto-Bazarra, Iñaki Ortiz de Landazuri, Anna Mensa-Vilaró, Marta Cabral, Alberto Baroja-Mazo, María C. Baños, Zulema Lobato-Salinas, Virginia Fabregat, Susana Plaza, Jordi Yagüe, Ferran Casals, Baldomero Oliva, Antonio E. Figueiredo, Pablo Pelegrín, Juan I. Aróstegui

J Clin Immunol. 2022; 42(7): 1421–1432. Published online 2022 Jun 18. doi: 10.1007/s10875-022-01298-2

Correction in:: J Clin Immunol. 2022; 42(7): 1433.

PMCID:: PMC9674708

Abstract Article PDF–1.3M

Select item 89175165.

RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis

Matija Zelic, Fabrizio Pontarelli, Lisa Woodworth, Cheng Zhu, Amy Mahan, Yi Ren, Michael LaMorte, Ross Gruber, Aislinn Keane, Pequita Loring, Lilu Guo, Tai-he Xia, Boyao Zhang, Pontus Orning, Egil Lien, Alexei Degterev, Timothy Hammond, Dimitry Ofengeim

Cell Rep. Author manuscript; available in PMC 2022 Mar 12.

Published in final edited form as: Cell Rep. 2021 May 11; 35(6): 109112. doi: 10.1016/j.celrep.2021.109112

PMCID:: PMC8917516

Abstract Article PDF–2.6M

Select item 87542166.

Opposite Effects of Apoptotic and Necroptotic Cellular Pathways on Rotavirus Replication

Mahmoud Soliman, Ja-Young Seo, Yeong-Bin Baek, Jun-Gyu Park, Mun-Il Kang, Kyoung-Oh Cho, Sang-Ik Park

J Virol. 2022 Jan; 96(1): e01222-21. Prepublished online 2021 Oct 20. Published online 2022 Jan 12. doi: 10.1128/JVI.01222-21

PMCID:: PMC8754216

Abstract Article PDF–6.9M

Select item 80277927.

RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages

Liang Tao, Yuguo Yi, Yuxin Chen, Haibing Zhang, Pontus Orning, Egil Lien, Jiapeng Jie, Weigao Zhang, Qian Xu, Yang Li, Zhao Ding, Chao Wu, Qiurong Ding, Junsong Wang, Jianfa Zhang, Dan Weng

Cell Death Differ. 2021 Apr; 28(4): 1418–1433. Published online 2020 Nov 18. doi: 10.1038/s41418-020-00668-w

PMCID:: PMC8027792

Abstract Article PDF–5.9M

Select item 71469888.

RIPK1 polymorphisms alter the susceptibility to cervical Cancer among the Uyghur population in China

Zulipiyamu Tuoheti, Lili Han, Sulaiya Husaiyin, Xiaoxi Liu, Chunhua Ma, Mayinuer Niyazi

BMC Cancer. 2020; 20: 299. Published online 2020 Apr 9. doi: 10.1186/s12885-020-06779-4

PMCID:: PMC7146988

Abstract Article PDF–498K

Select item 67481139.

The anticonvulsive Phenhydan^® suppresses extrinsic cell death

Caroline Moerke, Isabel Jaco, Christin Dewitz, Tammo Müller, Annette V. Jacobsen, Jérémie Gautheron, Jürgen Fritsch, Jessica Schmitz, Jan Hinrich Bräsen, Claudia Günther, James M. Murphy, Ulrich Kunzendorf, Pascal Meier, Stefan Krautwald

Cell Death Differ. 2019 Sep; 26(9): 1631–1645. Published online 2018 Nov 15. doi: 10.1038/s41418-018-0232-2

PMCID:: PMC6748113

Abstract Article PDF–3.3M

Select item 662788810.

C-Phycocyanin Suppresses the In Vitro Proliferation and Migration of Non-Small-Cell Lung Cancer Cells through Reduction of RIPK1/NF-κB Activity

Shuai Hao, Shuang Li, Jing Wang, Lei Zhao, Yan Yan, Tingting Wu, Jiawen Zhang, Chengtao Wang

Mar Drugs. 2019 Jun; 17(6): 362. Published online 2019 Jun 18. doi: 10.3390/md17060362

PMCID:: PMC6627888

Abstract Article PDF–3.9M

Select item 652935311.

Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis and intestinal inflammation

Delphine Cuchet-Lourenço, Davide Eletto, Changxin Wu, Vincent Plagnol, Olivier Papapietro, James Curtis, Lourdes Ceron-Gutierrez, Chris M. Bacon, Scott Hackett, Badr Alsaleem, Mailis Maes, Miguel Gaspar, Ali Alisaac, Emma Goss, Eman AlIdrissi, Daniela Siegmund, Harald Wajant, Dinakantha Kumararatne, Mofareh S. AlZahrani, Peter D. Arkwright, Mario Abinun, Rainer Doffinger, Sergey Nejentsev

Science. Author manuscript; available in PMC 2019 May 22.

Published in final edited form as: Science. 2018 Aug 24; 361(6404): 810–813. Published online 2018 Jul 19. doi: 10.1126/science.aar2641

PMCID:: PMC6529353

Abstract Article PDF–1.4M

Select item 633885512.

Human RIPK1 deficiency causes combined immunodeficiency and inflammatory bowel diseases

Yue Li, Marita Führer, Ehsan Bahrami, Piotr Socha, Maja Klaudel-Dreszler, Amira Bouzidi, Yanshan Liu, Anna S. Lehle, Thomas Magg, Sebastian Hollizeck, Meino Rohlfs, Raffaele Conca, Michael Field, Neil Warner, Slae Mordechai, Eyal Shteyer, Dan Turner, Rachida Boukari, Reda Belbouab, Christoph Walz, Moritz M. Gaidt, Veit Hornung, Bernd Baumann, Ulrich Pannicke, Eman Al Idrissi, Hamza Ali Alghamdi, Fernando E. Sepulveda, Marine Gil, Geneviève de Saint Basile, Manfred Hönig, Sibylle Koletzko, Aleixo M. Muise, Scott B. Snapper, Klaus Schwarz, Christoph Klein, Daniel Kotlarz

Proc Natl Acad Sci U S A. 2019 Jan 15; 116(3): 970–975. Published online 2018 Dec 27. doi: 10.1073/pnas.1813582116

PMCID:: PMC6338855

Abstract Article PDF–1.7M

Select item 615517313.

RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation

Julian Buchrieser, Maria Jose Oliva-Martin, Michael D. Moore, Joshua C. D. Long, Sally A. Cowley, Jose Antonio Perez-Simón, William James, Jose Luis Venero

Cell Death Dis. 2018 Oct; 9(10): 973. Published online 2018 Sep 24. doi: 10.1038/s41419-018-1053-4

PMCID:: PMC6155173

Abstract Article PDF–3.0M

Select item 610103614.

Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades

Sharan R. Srinivasan, Laura C. Cesa, Xiaokai Li, Olivier Julien, Min Zhuang, Hao Shao, Jooho Chung, Ivan Maillard, James A. Wells, Colin Duckett, Jason E. Gestwicki

Mol Cancer Res. Author manuscript; available in PMC 2019 Jan 1.

Published in final edited form as: Mol Cancer Res. 2018 Jan; 16(1): 58–68. Published online 2017 Sep 28. doi: 10.1158/1541-7786.MCR-17-0408

PMCID:: PMC6101036

Abstract Article PDF–1.3M

Select item 608647615.

Innate immune signaling through differential RIPK1 expression promote tumor progression in head and neck squamous cell carcinoma

Kevin D. McCormick, Arundhati Ghosh, Sumita Trivedi, Lin Wang, Carolyn B. Coyne, Robert L. Ferris, Saumendra N. Sarkar

Carcinogenesis. 2016 May; 37(5): 522–529. Published online 2016 Mar 18. doi: 10.1093/carcin/bgw032

PMCID:: PMC6086476

Abstract Article PDF–5.0M

Select item 599218216.

RIP1 protects melanoma cells from apoptosis induced by BRAF/MEK inhibitors

Fu Xi Lei, Lei Jin, Xiao Ying Liu, Fritz Lai, Xu Guang Yan, Margaret Farrelly, Su Tang Guo, Xin Han Zhao, Xu Dong Zhang

Cell Death Dis. 2018 Jun; 9(6): 679. Published online 2018 Jun 7. doi: 10.1038/s41419-018-0714-7

Correction in:: Cell Death Dis. 2019 Mar; 10(3): 225.

PMCID:: PMC5992182

Abstract Article PDF–2.6M

Select item 552877917.

RIP1 modulates death receptor mediated apoptosis and autophagy in macrophages

Zhenyu Yao, Peng Zhang, Hui Guo, Juan Shi, Shilian Liu, Yanxin Liu, Dexian Zheng

Mol Oncol. 2015 Apr; 9(4): 806–817. Published online 2014 Dec 30. doi: 10.1016/j.molonc.2014.12.004

PMCID:: PMC5528779

Abstract Article PDF–1.6M

Select item 550075518.

Quantitative Phospho-proteomic Analysis of TNFα/NFκB Signaling Reveals a Role for RIPK1 Phosphorylation in Suppressing Necrotic Cell Death

Firaz Mohideen, Joao A. Paulo, Alban Ordureau, Steve P. Gygi, J. Wade Harper

Mol Cell Proteomics. 2017 Jul; 16(7): 1200–1216. Published online 2017 May 24. doi: 10.1074/mcp.M117.068189

PMCID:: PMC5500755

Abstract Article PDF–3.9M

Select item 544247619.

When PERK inhibitors turn out to be new potent RIPK1 inhibitors: critical issues on the specificity and use of GSK2606414 and GSK2656157

Diego Rojas-Rivera, Tinneke Delvaeye, Ria Roelandt, Wim Nerinckx, Koen Augustyns, Peter Vandenabeele, Mathieu J M Bertrand

Cell Death Differ. 2017 Jun; 24(6): 1100–1110. Published online 2017 Apr 28. doi: 10.1038/cdd.2017.58

PMCID:: PMC5442476

Abstract Article PDF–1.3M

Select item 465053420.

Identification of RIP1 as a critical mediator of Smac mimetic-mediated sensitization of glioblastoma cells for Drozitumab-induced apoptosis

S Cristofanon, B A Abhari, M Krueger, A Tchoghandjian, S Momma, C Calaminus, D Vucic, B J Pichler, S Fulda

Cell Death Dis. 2015 Apr; 6(4): e1724. Published online 2015 Apr 16. doi: 10.1038/cddis.2014.592

PMCID:: PMC4650534

Abstract Article PDF–1.4M

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