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Items: 1 to 20 of 57

1.
Genetic disruption of the scaffolding protein, Kinase Suppressor of Ras 1 (KSR1), differentially regulates GM-CSF-stimulated hyperproliferation in hematopoietic progenitors expressing activating PTPN11 mutants D61Y and E76K
Zhenyun Yang, Mia Chen, Sarah A Sitarski, Tirajeh Saadatzadeh, Fuqin Yin, Menggang Yu, Feng-Chun Yang, Rebecca J Chan
Leuk Res. Author manuscript; available in PMC 2012 Jul 1.
Published in final edited form as: Leuk Res. 2011 Jul; 35(7): 961–964. Published online 2011 May 8. doi: 10.1016/j.leukres.2011.04.003
PMCID:
PMC3145485
AbstractArticlePDF–436K
2.
Induction of kinase suppressor of RAS-1(KSR-1) gene by1, α25-dihydroxyvitamin D3 in human leukemia HL60 cells through a vitamin D response element in the 5′-flanking region
X Wang, T-T Wang, JH White, GP Studzinski
Oncogene. Author manuscript; available in PMC 2010 Mar 22.
Published in final edited form as: Oncogene. 2006 Nov 9; 25(53): 7078–7085. Published online 2006 May 29. doi: 10.1038/sj.onc.1209697
PMCID:
PMC2843694
AbstractArticlePDF–972K
3.
KSR1 Modulates the Sensitivity of Mitogen-Activated Protein Kinase Pathway Activation in T Cells without Altering Fundamental System Outputs
Joseph Lin, Angus Harding, Emanuele Giurisato, Andrey S. Shaw
Mol Cell Biol. 2009 Apr; 29(8): 2082–2091. Published online 2009 Feb 2. doi: 10.1128/MCB.01634-08
PMCID:
PMC2663292
AbstractArticlePDF–2.6M
4.
Downregulation of KSR1 in pancreatic cancer xenografts by antisense oligonucleotide correlates with tumor drug uptake
Jianjun Zhang, Mohammad Zafrullah, Xia Yang, Xianglei Yin, Zhigang Zhang, Zvi Fuks, Richard Kolesnick
Cancer Biol Ther. Author manuscript; available in PMC 2008 Oct 30.
Published in final edited form as: Cancer Biol Ther. 2008 Sep; 7(9): 1490–1495. Published online 2008 Sep 15. doi: 10.4161/cbt.7.9.6472
PMCID:
PMC2576298
AbstractArticlePDF–1.2M
5.
Inflammatory bowel disease reveals the kinase activity of KSR1
Richard Kolesnick, H. Rosie Xing
J Clin Invest. 2004 Nov 1; 114(9): 1233–1237. doi: 10.1172/JCI23441
PMCID:
PMC524240
AbstractArticlePDF–329K
6.
SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status
Brianna R. Daley, Heidi M. Vieira, Chaitra Rao, Jacob M. Hughes, Zaria M. Beckley, Dianna H. Huisman, Deepan Chatterjee, Nancy E. Sealover, Katherine Cox, James W. Askew, Robert A. Svoboda, Kurt W. Fisher, Robert E. Lewis, Robert L. Kortum
Proc Natl Acad Sci U S A. 2023 Nov 21; 120(47): e2313137120. Published online 2023 Nov 16. doi: 10.1073/pnas.2313137120
PMCID:
PMC10666034
AbstractArticlePDF–3.4M
7.
Kinase Suppressor of RAS 1 (KSR1) Maintains the Transformed Phenotype of BRAFV600E Mutant Human Melanoma Cells
Zhi Liu, Aleksandar Krstic, Ashish Neve, Cristina Casalou, Nora Rauch, Kieran Wynne, Hilary Cassidy, Amanda McCann, Emma Kavanagh, Brendan McCann, Alfonso Blanco, Jens Rauch, Walter Kolch
Int J Mol Sci. 2023 Jul; 24(14): 11821. Published online 2023 Jul 23. doi: 10.3390/ijms241411821
PMCID:
PMC10380721
AbstractArticlePDF–1.5M
8.
Praja2 suppresses the growth of gastric cancer by ubiquitylation of KSR1 and inhibiting MEK-ERK signal pathways
Zhiwei Zhao, Lin Zhu, Yanwei Xing, Zhenan Zhang
Aging (Albany NY) 2021 Feb 15; 13(3): 3886–3897. Published online 2021 Jan 10. doi: 10.18632/aging.202356
PMCID:
PMC7906149
AbstractArticlePDF–1.5M
9.
Kinase suppressor of Ras 1 and Exo70 promote fatty acid-stimulated neurotensin secretion through ERK1/2 signaling
Stephanie Rock, Xian Li, Jun Song, Courtney M. Townsend, Jr., Heidi L. Weiss, Piotr Rychahou, Tianyan Gao, Jing Li, B. Mark Evers
PLoS One. 2019; 14(3): e0211134. Published online 2019 Mar 27. doi: 10.1371/journal.pone.0211134
PMCID:
PMC6436710
AbstractArticlePDF–1.7M
10.
MicroRNA-497 inhibits tumor growth and increases chemosensitivity to 5-fluorouracil treatment by targeting KSR1
Lin Wang, Cheng-fei Jiang, Dong-mei Li, Xin Ge, Zhu-mei Shi, Chong-yong Li, Xue Liu, Yu Yin, Linlin Zhen, Ling-Zhi Liu, Bing-Hua Jiang
Oncotarget. 2016 Jan 19; 7(3): 2660–2671. Published online 2015 Dec 9. doi: 10.18632/oncotarget.6545
PMCID:
PMC4823062
AbstractArticlePDF–5.9M
11.
SILAC-based phosphoproteomics reveals an inhibitory role of KSR1 in p53 transcriptional activity via modulation of DBC1
H Zhang, Y Xu, A Filipovic, L C Lit, C-Y Koo, J Stebbing, G Giamas
Br J Cancer. 2013 Nov 12; 109(10): 2675–2684. Published online 2013 Oct 15. doi: 10.1038/bjc.2013.628
PMCID:
PMC3833216
AbstractArticlePDF–1.4M
12.
A CC-SAM, for Coiled Coil–Sterile α Motif, Domain Targets the Scaffold KSR-1 to Specific Sites in the Plasma Membrane
Dorothy Koveal, Natasha Schuh-Nuhfer, Daniel Ritt, Rebecca Page, Deborah K. Morrison, Wolfgang Peti
Sci Signal. Author manuscript; available in PMC 2013 Dec 18.
Published in final edited form as: Sci Signal. 2012 Dec 18; 5(255): ra94. Published online 2012 Dec 18. doi: 10.1126/scisignal.2003289
PMCID:
PMC3740349
AbstractArticlePDF–5.1M
13.
Oncoprotein Cot1 Represses Kinase Suppressors of Ras1/2 and 1,25-Dihydroxyvitamin D3-Induced Differentiation of Human Acute Myeloid Leukemia Cells
XUENING WANG, GEORGE P. STUDZINSKI
J Cell Physiol. Author manuscript; available in PMC 2012 Sep 12.
Published in final edited form as: J Cell Physiol. 2011 May; 226(5): 1232–1240. doi: 10.1002/jcp.22449
PMCID:
PMC3440184
AbstractArticlePDF–2.3M
14.
VRK2 anchors KSR1-MEK1 to endoplasmic reticulum forming a macromolecular complex that compartmentalizes MAPK signaling
Isabel F. Fernández, Luis G. Pérez-Rivas, Sandra Blanco, Adrián A. Castillo-Dominguez, José Lozano, Pedro A. Lazo
Cell Mol Life Sci. 2012 Nov; 69(22): 3881–3893. Published online 2012 Jul 4. doi: 10.1007/s00018-012-1056-8
PMCID:
PMC11114894
AbstractArticlePDF–1.1M
15.
Erbin suppresses KSR1-mediated RAS/RAF signaling and tumorigenesis in colorectal cancer
Payton D. Stevens, Yang-An Wen, Xiaopeng Xiong, Yekaterina Y. Zaytseva, Austin T. Li, Chi Wang, Ashley Stevens, Trevor N. Farmer, Tong Gan, Heidi L. Weiss, Masaki Inagaki, Sylvie Marchetto, Jean-Paul Borg, Tianyan Gao
Cancer Res. Author manuscript; available in PMC 2019 May 10.
Published in final edited form as: Cancer Res. 2018 Sep 1; 78(17): 4839–4852. Published online 2018 Jul 6. doi: 10.1158/0008-5472.CAN-17-3629
PMCID:
PMC6510240
AbstractArticlePDF–1.2M
16.
Homozygous KSR1 deletion attenuates morbidity but does not prevent tumor development in a mouse model of RAS-driven pancreatic cancer
Elizabeth A. Germino, Joseph P. Miller, Lauri Diehl, Carter J. Swanson, Steffen Durinck, Zora Modrusan, Jeffrey H. Miner, Andrey S. Shaw
PLoS One. 2018; 13(3): e0194998. Published online 2018 Mar 29. doi: 10.1371/journal.pone.0194998
PMCID:
PMC5875795
AbstractArticlePDF–15M
17.
Phosphorylation of Rap1 by cAMP-dependent Protein Kinase (PKA) Creates a Binding Site for KSR to Sustain ERK Activation by cAMP
Maho Takahashi, Yanping Li, Tara J. Dillon, Philip J. S. Stork
J Biol Chem. 2017 Jan 27; 292(4): 1449–1461. Published online 2016 Dec 21. doi: 10.1074/jbc.M116.768986
PMCID:
PMC5270487
AbstractArticlePDF–1.9M
18.
praja2 regulates KSR1 stability and mitogenic signaling
L Rinaldi, R Delle Donne, M Sepe, M Porpora, C Garbi, F Chiuso, A Gallo, S Parisi, L Russo, V Bachmann, R G Huber, E Stefan, T Russo, A Feliciello
Cell Death Dis. 2016 May; 7(5): e2230. Published online 2016 May 19. doi: 10.1038/cddis.2016.109
PMCID:
PMC4917648
AbstractArticlePDF–1.5M
19.
Caveolin-1 Is Required for Kinase Suppressor of Ras 1 (KSR1)-Mediated Extracellular Signal-Regulated Kinase 1/2 Activation, H-RasV12-Induced Senescence, and Transformation
Robert L. Kortum, Mario R. Fernandez, Diane L. Costanzo-Garvey, Heidi J. Johnson, Kurt W. Fisher, Deanna J. Volle, Robert E. Lewis
Mol Cell Biol. 2014 Sep; 34(18): 3461–3472. doi: 10.1128/MCB.01633-13
PMCID:
PMC4135613
AbstractArticlePDF–3.1M
20.
Kinase Suppressor of Ras (KSR) Is a Scaffold Which Facilitates Mitogen-Activated Protein Kinase Activation In Vivo
AnhCo Nguyen, W. Richard Burack, Jeffrey L. Stock, Robert Kortum, Oleg V. Chaika, Maryam Afkarian, William J. Muller, Kenneth M. Murphy, Deborah K. Morrison, Robert E. Lewis, John McNeish, Andrey S. Shaw
Mol Cell Biol. 2002 May; 22(9): 3035–3045. doi: 10.1128/MCB.22.9.3035-3045.2002
PMCID:
PMC133772
AbstractArticlePDF–504K

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