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Items: 1 to 20 of 45

1.
Charge neutralization of the active site glutamates does not limit substrate binding and transport by small multidrug resistance transporter EmrE
Peyton J. Spreacker, Merissa Brousseau, Grant S. Hisao, Mohammad Soltani, James H. Davis, Jr., Katherine A. Henzler-Wildman
J Biol Chem. 2023 Feb; 299(2): 102805. Published online 2022 Dec 16. doi: 10.1016/j.jbc.2022.102805
PMCID:
PMC9860125
AbstractArticlePDF–2.5M
2.
Activating alternative transport modes in a multidrug resistance efflux pump to confer chemical susceptibility
Peyton J. Spreacker, Nathan E. Thomas, Will F. Beeninga, Merissa Brousseau, Colin J. Porter, Kylie M. Hibbs, Katherine A. Henzler-Wildman
Nat Commun. 2022; 13: 7655. Published online 2022 Dec 10. doi: 10.1038/s41467-022-35410-2
PMCID:
PMC9741644
AbstractArticlePDF–3.0M
3.
Cotranslational folding and assembly of the dimeric Escherichia coli inner membrane protein EmrE
Daphne Mermans, Felix Nicolaus, Klara Fleisch, Gunnar von Heijne
Proc Natl Acad Sci U S A. 2022 Aug 30; 119(35): e2205810119. Published online 2022 Aug 22. doi: 10.1073/pnas.2205810119
PMCID:
PMC9436324
AbstractArticlePDF–1.1M
4.
High-pH structure of EmrE reveals the mechanism of proton-coupled substrate transport
Alexander A. Shcherbakov, Peyton J. Spreacker, Aurelio J. Dregni, Katherine A. Henzler-Wildman, Mei Hong
Nat Commun. 2022; 13: 991. Published online 2022 Feb 18. doi: 10.1038/s41467-022-28556-6
PMCID:
PMC8857205
AbstractArticlePDF–3.1M
5.
Molecular mechanism of proton-coupled ligand translocation by the bacterial efflux pump EmrE
Jakub Jurasz, Maciej Bagiński, Jacek Czub, Miłosz Wieczór
PLoS Comput Biol. 2021 Oct; 17(10): e1009454. Published online 2021 Oct 6. doi: 10.1371/journal.pcbi.1009454
PMCID:
PMC8523053
AbstractArticlePDF–2.6M
6.
Inducing conformational preference of the membrane protein transporter EmrE through conservative mutations
Maureen Leninger, Ampon Sae Her, Nathaniel J Traaseth
eLife. 2019; 8: e48909. Published online 2019 Oct 22. doi: 10.7554/eLife.48909
PMCID:
PMC6805155
AbstractArticlePDF–3.0M
7.
Structure of the EmrE multidrug transporter and its use for inhibitor peptide design
Victor Ovchinnikov, Tracy A. Stone, Charles M. Deber, Martin Karplus
Proc Natl Acad Sci U S A. 2018 Aug 21; 115(34): E7932–E7941. Published online 2018 Aug 6. doi: 10.1073/pnas.1802177115
PMCID:
PMC6112734
AbstractArticlePDF–2.4M
8.
Few Conserved Amino Acids in the Small Multidrug Resistance Transporter EmrE Influence Drug Polyselectivity
Marwah Saleh, Denice C. Bay, Raymond J. Turner
Antimicrob Agents Chemother. 2018 Aug; 62(8): e00461-18. Prepublished online 2018 Jun 4. Published online 2018 Jul 27. doi: 10.1128/AAC.00461-18
PMCID:
PMC6105815
AbstractArticlePDF–1.4M
9.
New free-exchange model of EmrE transport
Anne E. Robinson, Nathan E. Thomas, Emma A. Morrison, Bryan M. Balthazor, Katherine A. Henzler-Wildman
Proc Natl Acad Sci U S A. 2017 Nov 21; 114(47): E10083–E10091. Published online 2017 Nov 7. doi: 10.1073/pnas.1708671114
PMCID:
PMC5703289
AbstractArticlePDF–1.5M
10.
Regulation of multispanning membrane protein topology via post-translational annealing
Reid C Van Lehn, Bin Zhang, Thomas F Miller, III
eLife. 2015; 4: e08697. Published online 2015 Sep 26. doi: 10.7554/eLife.08697
PMCID:
PMC4635508
AbstractArticlePDF–2.4M
11.
A Structured Loop Modulates Coupling between the Substrate-binding and Dimerization Domains in the Multidrug Resistance Transporter EmrE
James R. Banigan, Anindita Gayen, Min-Kyu Cho, Nathaniel J. Traaseth
J Biol Chem. 2015 Jan 9; 290(2): 805–814. Published online 2014 Nov 18. doi: 10.1074/jbc.M114.601963
PMCID:
PMC4294503
AbstractArticlePDF–2.1M
12.
Transported Substrate Determines Exchange Rate in the Multidrug Resistance Transporter EmrE
Emma A. Morrison, Katherine A. Henzler-Wildman
J Biol Chem. 2014 Mar 7; 289(10): 6825–6836. Published online 2014 Jan 21. doi: 10.1074/jbc.M113.535328
PMCID:
PMC3945343
AbstractArticlePDF–2.8M
13.
Transforming a drug/H+ antiporter into a polyamine importer by a single mutation
Shlomo Brill, Ofir Sade Falk, Shimon Schuldiner
Proc Natl Acad Sci U S A. 2012 Oct 16; 109(42): 16894–16899. Published online 2012 Oct 3. doi: 10.1073/pnas.1211831109
PMCID:
PMC3479526
AbstractArticlePDF–498K
14.
Antiparallel EmrE exports drugs by exchanging between asymmetric structures
Emma A. Morrison, Gregory T. DeKoster, Supratik Dutta, Michael W. Clarkson, Reza Vafabakhsh, Arjun Bahl, Dorothee Kern, Taekjip Ha, Katherine A. Henzler-Wildman
Nature. Author manuscript; available in PMC 2012 Jul 5.
Published in final edited form as: Nature. 2012 Jan 5; 481(7379): 45–50. Published online 2011 Dec 18. doi: 10.1038/nature10703
PMCID:
PMC3253143
AbstractArticlePDF–710K
15.
Structure, Dynamics, and Substrate-induced Conformational Changes of the Multidrug Transporter EmrE in Liposomes
Sepan T. Amadi, Hanane A. Koteiche, Sanjay Mishra, Hassane S. Mchaourab
J Biol Chem. 2010 Aug 20; 285(34): 26710–26718. Published online 2010 Jun 15. doi: 10.1074/jbc.M110.132621
PMCID:
PMC2924113
AbstractArticlePDF–3.3M
16.
Electron Crystallography Reveals Plasticity within the Drug Binding Site of the Small Multidrug Transporter EmrE
Vladimir M. Korkhov, Christopher G. Tate
J Mol Biol. 2008 Apr 4; 377(4): 1094–1103. doi: 10.1016/j.jmb.2008.01.056
PMCID:
PMC2726284
AbstractArticle
17.
An emerging consensus for the structure of EmrE
Vladimir M. Korkhov, Christopher G. Tate
Acta Crystallogr D Biol Crystallogr. 2009 Feb 1; 65(Pt 2): 186–192. Published online 2009 Jan 20. doi: 10.1107/S0907444908036640
PMCID:
PMC2631640
AbstractArticlePDF–830K
18.
Lipid bilayer composition influences small multidrug transporters
Kalypso Charalambous, David Miller, Paul Curnow, Paula J Booth
BMC Biochem. 2008; 9: 31. Published online 2008 Nov 25. doi: 10.1186/1471-2091-9-31
PMCID:
PMC2605743
AbstractArticlePDF–791K
19.
Identification of a Glycine Motif Required for Packing in EmrE, a Multidrug Transporter from Escherichia coli
Yael Elbaz, Tal Salomon, Shimon Schuldiner
J Biol Chem. 2008 May 2; 283(18): 12276–12283. doi: 10.1074/jbc.M710338200
PMCID:
PMC2431008
AbstractArticlePDF–581K
20.
Parallel topology of genetically fused EmrE homodimers
Sonia Steiner-Mordoch, Misha Soskine, Dalia Solomon, Dvir Rotem, Ayala Gold, Michal Yechieli, Yoav Adam, Shimon Schuldiner
EMBO J. 2008 Jan 9; 27(1): 17–26. Published online 2007 Dec 6. doi: 10.1038/sj.emboj.7601951
PMCID:
PMC2206133
AbstractArticlePDF–612K

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