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Items: 1 to 20 of 52

1.
Random circular permutation leading to chain disruption within and near α helices in the catalytic chains of aspartate transcarbamoylase: Effects on assembly, stability, and function
Peter T. Beernink, Ying R. Yang, Roney Graf, David S. King, Shaival S. Shah, Howard K. Schachman
Protein Sci. 2001 Mar; 10(3): 528–537. doi: 10.1110/ps.39001
PMCID:
PMC2374132
AbstractArticlePDF–406K
2.
Weakening of the interface between adjacent catalytic chains promotes domain closure in Escherichia coli aspartate transcarbamoylase.
D. P. Baker, L. Fetler, R. T. Keiser, P. Vachette, E. R. Kantrowitz
Protein Sci. 1995 Feb; 4(2): 258–267. doi: 10.1002/pro.5560040212
PMCID:
PMC2143059
SummaryPDF–1.0M
3.
Glu-50 in the catalytic chain of Escherichia coli aspartate transcarbamoylase plays a crucial role in the stability of the R quaternary structure.
P. Tauc, R. T. Keiser, E. R. Kantrowitz, P. Vachette
Protein Sci. 1994 Nov; 3(11): 1998–2004. doi: 10.1002/pro.5560031112
PMCID:
PMC2142631
SummaryPDF–1.5M
4.
Design, synthesis and bioactivity of novel inhibitors of E. coli aspartate transcarbamoylase
Joby Eldo, Sabrina Heng, Evan R. Kantrowitz
Bioorg Med Chem Lett. Author manuscript; available in PMC 2007 Jul 23.
Published in final edited form as: Bioorg Med Chem Lett. 2007 Apr 1; 17(7): 2086–2090. Published online 2006 Dec 21. doi: 10.1016/j.bmcl.2006.12.050
PMCID:
PMC1930159
AbstractArticlePDF–179K
5.
Direct observation in solution of a preexisting structural equilibrium for a mutant of the allosteric aspartate transcarbamoylase
Luc Fetler, Evan R. Kantrowitz, Patrice Vachette
Proc Natl Acad Sci U S A. 2007 Jan 9; 104(2): 495–500. Published online 2007 Jan 3. doi: 10.1073/pnas.0607641104
PMCID:
PMC1766413
AbstractArticlePDF–1.1M
6.
Amino acid sequence of the catalytic subunit of aspartate transcarbamoylase from Escherichia coli.
W H Konigsberg, L Henderson
Proc Natl Acad Sci U S A. 1983 May; 80(9): 2467–2471. doi: 10.1073/pnas.80.9.2467
PMCID:
PMC393846
SummaryPage BrowsePDF–920K
7.
Synthesis of aspartate transcarbamoylase in Escherichia coli: transcriptional regulation of the pyrB-pyrI operon.
M Navre, H K Schachman
Proc Natl Acad Sci U S A. 1983 Mar; 80(5): 1207–1211. doi: 10.1073/pnas.80.5.1207
PMCID:
PMC393563
SummaryPage BrowsePDF–1.1M
8.
Role of the ribosome in suppressing transcriptional termination at the pyrBI attenuator of Escherichia coli K-12.
K L Roland, C G Liu, C L Turnbough, Jr
Proc Natl Acad Sci U S A. 1988 Oct; 85(19): 7149–7153. doi: 10.1073/pnas.85.19.7149
PMCID:
PMC282141
SummaryPage BrowsePDF–1.1M
9.
Assessment of the allosteric mechanism of aspartate transcarbamoylase based on the crystalline structure of the unregulated catalytic subunit
Peter T. Beernink, James A. Endrizzi, Tom Alber, H. K. Schachman
Proc Natl Acad Sci U S A. 1999 May 11; 96(10): 5388–5393. doi: 10.1073/pnas.96.10.5388
PMCID:
PMC21869
AbstractArticlePDF–623K
10.
Metal Ion Involvement in the Allosteric Mechanism of Escherichia coli Aspartate Transcarbamoylase
Gregory M. Cockrell, Evan R. Kantrowitz
Biochemistry. Author manuscript; available in PMC 2013 Sep 11.
Published in final edited form as: Biochemistry. 2012 Sep 11; 51(36): 7128–7137. Published online 2012 Aug 24. doi: 10.1021/bi300920m
PMCID:
PMC3461825
AbstractArticlePDF–2.9M
11.
Trapping and structure determination of an intermediate in the allosteric transition of aspartate transcarbamoylase
Wenyue Guo, Jay M. West, Andrew S. Dutton, Hiro Tsuruta, Evan R. Kantrowitz
Proc Natl Acad Sci U S A. 2012 May 15; 109(20): 7741–7746. Published online 2012 Apr 30. doi: 10.1073/pnas.1119683109
PMCID:
PMC3356622
AbstractArticlePDF–999K
12.
Allosteric Signal Transmission Involves Synergy between Discrete Structural Units of the Regulatory Subunit of Aspartate Transcarbamoylase
Leyuan Liu, Melinda E. Wales, James R. Wild
Arch Biochem Biophys. Author manuscript; available in PMC 2011 Dec 18.
Published in final edited form as: Arch Biochem Biophys. 2000 Jan 15; 373(2): 352–360. doi: 10.1006/abbi.1999.1570
PMCID:
PMC3241997
AbstractArticlePDF–1.6M
13.
The First High pH Structure of Escherichia coli Aspartate Transcarbamoylase
Kimberly A. Stieglitz, Jiarong Xia, Evan Kantrowitz
Proteins. Author manuscript; available in PMC 2010 Aug 11.
Published in final edited form as: Proteins. 2009 Feb 1; 74(2): 318–327. doi: 10.1002/prot.22162
PMCID:
PMC2920061
AbstractArticlePDF–3.2M
14.
Synthesis and In Vitro Evaluation of Aspartate Transcarbamoylase Inhibitors
Laëtitia Coudray, Anne F. Pennebaker, Jean-Luc Montchamp
Bioorg Med Chem. Author manuscript; available in PMC 2010 Nov 15.
Published in final edited form as: Bioorg Med Chem. 2009 Nov 15; 17(22): 7680–7689. Published online 2009 Sep 30. doi: 10.1016/j.bmc.2009.09.045
PMCID:
PMC2783949
AbstractArticlePDF–1.2M
15.
Submicromolar Phosphinic Inhibitors of E. coli Aspartate Transcarbamoylase
Laëtitia Coudray, Evan R. Kantrowitz, Jean-Luc Montchamp
Bioorg Med Chem Lett. Author manuscript; available in PMC 2010 Feb 1.
Published in final edited form as: Bioorg Med Chem Lett. 2009 Feb 1; 19(3): 900–902. Published online 2008 Dec 6. doi: 10.1016/j.bmcl.2008.11.115
PMCID:
PMC2743340
AbstractArticlePDF–319K
16.
Dissecting Enzyme Regulation by Multiple Allosteric Effectors: Nucleotide Regulation of Aspartate Transcarbamoylase
Joshua D. Rabinowitz, Jennifer J. Hsiao, Kimberly R. Gryncel, Evan R. Kantrowitz, Xiao-Jiang Feng, Genyuan Li, Herschel Rabitz
Biochemistry. Author manuscript; available in PMC 2009 Aug 26.
Published in final edited form as: Biochemistry. 2008 May 27; 47(21): 5881–5888. Published online 2008 May 3. doi: 10.1021/bi8000566
PMCID:
PMC2732338
AbstractArticlePDF–673K
17.
Structural Model of the R State of Escherichia coli Aspartate Transcarbamoylase with Substrates Bound
Jie Wang, Joby Eldo, Evan R. Kantrowitz
J Mol Biol. Author manuscript; available in PMC 2009 Aug 3.
Published in final edited form as: J Mol Biol. 2007 Aug 31; 371(5): 1261–1273. Published online 2007 Jun 9. doi: 10.1016/j.jmb.2007.06.011
PMCID:
PMC2720131
AbstractArticlePDF–2.0M
18.
Time Evolution of the Quaternary Structure of Escherichia coli Aspartate Transcarbamoylase upon Reaction with the Natural Substrates and a Slow Tight Binding Inhibitor
Jay M. West, Jiarong Xia, Hiro Tsuruta, Wenyue Guo, Elizabeth M. O’Day, Evan R. Kantrowitz
J Mol Biol. Author manuscript; available in PMC 2009 Dec 5.
Published in final edited form as: J Mol Biol. 2008 Dec 5; 384(1): 206–218. Published online 2008 Sep 16. doi: 10.1016/j.jmb.2008.09.022
PMCID:
PMC2656920
AbstractArticlePDF–1.0M
19.
N-phosphonacetyl-L-isoasparagine a Potent and Specific Inhibitor of E. coli Aspartate Transcarbamoylase
Joby Eldo, James P. Cardia, Elizabeth M. O’Day, Jiarong Xia, Hiro Tsurata, Evan R. Kantrowitz
J Med Chem. Author manuscript; available in PMC 2008 Sep 16.
Published in final edited form as: J Med Chem. 2006 Oct 5; 49(20): 5932–5938. doi: 10.1021/jm0607294
PMCID:
PMC2538380
AbstractArticlePDF–1.0M
20.
Replacement of Asp-162 by Ala prevents the cooperative transition by the substrates while enhancing the effect of the allosteric activator ATP on E. coli aspartate transcarbamoylase
L. Fetler, P. Tauc, D.P. Baker, C.P. Macol, E.R. Kantrowitz, P. Vachette
Protein Sci. 2002 May; 11(5): 1074–1081. doi: 10.1110/ps.4500102
PMCID:
PMC2373563
AbstractArticlePDF–125K

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