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Select item 99769781.

Novel gene–intergenic fusion involving ubiquitin E3 ligase UBE3C causes distal hereditary motor neuropathy

Anthony N Cutrupi, Ramesh K Narayanan, Gonzalo Perez-Siles, Bianca R Grosz, Kaitao Lai, Alexandra Boyling, Melina Ellis, Ruby C Y Lin, Brent Neumann, Di Mao, Motonari Uesugi, Garth A Nicholson, Steve Vucic, Mario A Saporta, Marina L Kennerson

Brain. 2023 Mar; 146(3): 880–897. Published online 2022 Nov 16. doi: 10.1093/brain/awac424

PMCID:: PMC9976978

Abstract Article PDF–1.4M

Select item 49412732.

Ubiquitin ligase UBE3C promotes melanoma progression by increasing epithelial-mesenchymal transition in melanoma cells

Li Tang, Xue-Mei Yi, Jia Chen, Fu-Juan Chen, Wei Lou, Yun-Lu Gao, Jing Zhou, Li-Na Su, Xin Xu, Jia-Qing Lu, Jun Ma, Ning Yu, Yang-Feng Ding

Oncotarget. 2016 Mar 29; 7(13): 15738–15746. Published online 2016 Feb 15. doi: 10.18632/oncotarget.7393

PMCID:: PMC4941273

Abstract Article PDF–7.1M

Select item 43199093.

UBE3C Promotes Growth and Metastasis of Renal Cell Carcinoma via Activating Wnt/β-Catenin Pathway

Ji Ling Wen, Xiao Fei Wen, Rong Bing Li, Yong Chao Jin, Xue Lei Wang, Lan Zhou, Hui Xing Chen

PLoS One. 2015; 10(2): e0115622. Published online 2015 Feb 6. doi: 10.1371/journal.pone.0115622

PMCID:: PMC4319909

Abstract Article PDF–712K

Select item 92847924.

Circular RNA circPOLR2A promotes clear cell renal cell carcinoma progression by facilitating the UBE3C-induced ubiquitination of PEBP1 and, thereby, activating the ERK signaling pathway

Zhipeng Xu, Shuqiu Chen, Ruiji Liu, Hui Chen, Bin Xu, Weizhang Xu, Ming Chen

Mol Cancer. 2022; 21: 146. Published online 2022 Jul 15. doi: 10.1186/s12943-022-01607-8

PMCID:: PMC9284792

Abstract Article PDF–24M

Select item 44640765.

Ubiquitin-protein ligase E3C promotes glioma progression by mediating the ubiquitination and degrading of Annexin A7

Si-Jian Pan, Shi-Kun Zhan, Wei-Zhong Ji, Yi-Xin Pan, Wei Liu, Dian-You Li, Peng Huang, Xiao-Xiao Zhang, Chun-Yan Cao, Jing Zhang, Liu-Guan Bian, Bomin Sun, Qing-Fang Sun

Sci Rep. 2015; 5: 11066. Published online 2015 Jun 11. doi: 10.1038/srep11066

PMCID:: PMC4464076

Abstract Article PDF–2.8M

Select item 38430716.

The E3 Ubiquitin Ligase UBE3C Enhances Proteasome Processivity by Ubiquitinating Partially Proteolyzed Substrates

Bernard W. Chu, Kyle M. Kovary, Johan Guillaume, Ling-chun Chen, Mary N. Teruel, Thomas J. Wandless

J Biol Chem. 2013 Nov 29; 288(48): 34575–34587. Published online 2013 Oct 24. doi: 10.1074/jbc.M113.499350

PMCID:: PMC3843071

Abstract Article PDF–1.2M

Select item 30123797.

The ubiquitin E3 ligase RAUL negatively regulates type I interferon through ubiquitination of the transcription factors IRF7 and IRF3

Yanxing Yu, Gary S. Hayward

Immunity. Author manuscript; available in PMC 2011 Dec 14.

Published in final edited form as: Immunity. 2010 Dec 14; 33(6): 863–877. doi: 10.1016/j.immuni.2010.11.027

PMCID:: PMC3012379

Abstract Article PDF–1.4M

Select item 68513448.

Acute unfolding of a single protein immediately stimulates recruitment of ubiquitin protein ligase E3C (UBE3C) to 26S proteasomes

Colin D. Gottlieb, Airlia C. S. Thompson, Alban Ordureau, J. Wade Harper, Ron R. Kopito

J Biol Chem. 2019 Nov 8; 294(45): 16511–16524. Published online 2019 Aug 2. doi: 10.1074/jbc.RA119.009654

PMCID:: PMC6851344

Abstract Article PDF–1.8M

Select item 14408289.

Molecular determinants of polyubiquitin linkage selection by an HECT ubiquitin ligase

Min Wang, Dongmei Cheng, Junmin Peng, Cecile M Pickart

EMBO J. 2006 Apr 19; 25(8): 1710–1719. Published online 2006 Apr 6. doi: 10.1038/sj.emboj.7601061

PMCID:: PMC1440828

Abstract Article PDF–448K

Select item 791058010.

VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism

Yu-Hsuan Chen, Tzu-Yu Huang, Yu-Tung Lin, Shu-Yu Lin, Wen-Hsin Li, Hsiang-Jung Hsiao, Ruei-Liang Yan, Hong-Wen Tang, Zhao-Qing Shen, Guang-Chao Chen, Kuen-Phon Wu, Ting-Fen Tsai, Ruey-Hwa Chen

Nat Commun. 2021; 12: 1322. Published online 2021 Feb 26. doi: 10.1038/s41467-021-21715-1

PMCID:: PMC7910580

Abstract Article PDF–4.2M

Select item 557555711.

Activity‐Based Probes for HECT E3 Ubiquitin Ligases

Robert Byrne, Dr. Thomas Mund, Dr. Julien D. F. Licchesi

Chembiochem. 2017 Jul 18; 18(14): 1415–1427. Published online 2017 Jun 28. doi: 10.1002/cbic.201700006

PMCID:: PMC5575557

Abstract Article PDF–4.2M

Select item 279492112.

A Genome-Wide Association Study of Citalopram Response in Major Depressive Disorder

Holly A. Garriock, Jeffrey B. Kraft, Stanley I. Shyn, Eric J. Peters, Jennifer S. Yokoyama, Gregory D. Jenkins, Megan S. Reinalda, Susan L. Slager, Patrick J. McGrath, Steven P. Hamilton

Biol Psychiatry. Author manuscript; available in PMC 2011 Jan 15.

Published in final edited form as: Biol Psychiatry. 2010 Jan 15; 67(2): 133–138. doi: 10.1016/j.biopsych.2009.08.029

PMCID:: PMC2794921

Abstract Article PDF–75K

Select item 1018261013.

LINC00963-FOSB-mediated transcription activation of UBE3C enhances radioresistance of breast cancer cells by inducing ubiquitination-dependent protein degradation of TP73

Yansu Wang, Ming Liu, Xiaoqian Liu, Xianling Guo

J Transl Med. 2023; 21: 321. Published online 2023 May 12. doi: 10.1186/s12967-023-04153-z

PMCID:: PMC10182610

Abstract Article PDF–10M

Select item 438664014.

K29-Selective Ubiquitin Binding Domain Reveals Structural Basis of Specificity and Heterotypic Nature of K29 Polyubiquitin

Yosua Adi Kristariyanto, Syed Arif Abdul Rehman, David G. Campbell, Nicholas A. Morrice, Clare Johnson, Rachel Toth, Yogesh Kulathu

Mol Cell. 2015 Apr 2; 58(1): 83–94. doi: 10.1016/j.molcel.2015.01.041

PMCID:: PMC4386640

Abstract Article

Select item 438603115.

Assembly and Specific Recognition of K29- and K33-Linked Polyubiquitin

Martin A. Michel, Paul R. Elliott, Kirby N. Swatek, Michal Simicek, Jonathan N. Pruneda, Jane L. Wagstaff, Stefan M.V. Freund, David Komander

Mol Cell. 2015 Apr 2; 58(1): 95–109. doi: 10.1016/j.molcel.2015.01.042

PMCID:: PMC4386031

Abstract Article

Select item 966472916.

Long noncoding RNA DLGAP1-AS2 promotes tumorigenesis and metastasis by regulating the Trim21/ELOA/LHPP axis in colorectal cancer

Xue Wang, Han Cheng, Jing Zhao, Jiuming Li, Ying Chen, Kaisa Cui, Lu Tian, Jia Zhang, Chaoqun Li, Shengbai Sun, Yuyang Feng, Surui Yao, Zehua Bian, Shenglin Huang, Bojian Fei, Zhaohui Huang

Mol Cancer. 2022; 21: 210. Published online 2022 Nov 14. doi: 10.1186/s12943-022-01675-w

PMCID:: PMC9664729

Abstract Article PDF–20M

Select item 566292417.

Poly r(C) binding protein (PCBP) 1 expression is regulated by the E3 ligase UBE4A in thyroid carcinoma

Ming-Peng Zhang, Wei-San Zhang, Jin Tan, Ming-Hui Zhao, Lin-Juan Lian, Jie Cai

Biosci Rep. 2017 Oct 31; 37(5): BSR20170114. Prepublished online 2017 Sep 29. Published online 2017 Oct 31. doi: 10.1042/BSR20170114

PMCID:: PMC5662924

Abstract Article PDF–548K

Select item 541078418.

Ubiquitinated proteins promote the association of proteasomes with the deubiquitinating enzyme Usp14 and the ubiquitin ligase Ube3c

Chueh-Ling Kuo, Alfred Lewis Goldberg

Proc Natl Acad Sci U S A. 2017 Apr 25; 114(17): E3404–E3413. Published online 2017 Apr 10. doi: 10.1073/pnas.1701734114

PMCID:: PMC5410784

Abstract Article PDF–1.9M

Select item 20448419.

A conserved catalytic residue in the ubiquitin-conjugating enzyme family

Pei-Ying Wu, Mary Hanlon, Michael Eddins, Colleen Tsui, Richard S. Rogers, Jane P. Jensen, Michael J. Matunis, Allan M. Weissman, Cynthia P. Wolberger, Cecile M. Pickart

EMBO J. 2003 Oct 1; 22(19): 5241–5250. doi: 10.1093/emboj/cdg501

Correction in:: EMBO J. 2004 Dec 8; 23(24): 4876.

PMCID:: PMC204484

Abstract Article PDF–324K

Select item 341296520.

A Human Ubiquitin Conjugating Enzyme (E2)-HECT E3 Ligase Structure-function Screen

Yi Sheng, Jenny H. Hong, Ryan Doherty, Tharan Srikumar, Jonathan Shloush, George V. Avvakumov, John R. Walker, Sheng Xue, Dante Neculai, Janet W. Wan, Sung K. Kim, Cheryl H. Arrowsmith, Brian Raught, Sirano Dhe-Paganon

Mol Cell Proteomics. 2012 Aug; 11(8): 329–341. Published online 2012 Apr 10. doi: 10.1074/mcp.O111.013706