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Select item 113815321.

Protein phosphatase 4 maintains the survival of primordial follicles by regulating autophagy in oocytes

Ming-Zhe Dong, Ying-Chun Ouyang, Shi-Cai Gao, Lin-Jian Gu, Jia-Ni Guo, Si-Min Sun, Zhen-Bo Wang, Qing-Yuan Sun

Cell Death Dis. 2024 Sep; 15(9): 658. Published online 2024 Sep 8. doi: 10.1038/s41419-024-07051-4

PMCID:: PMC11381532

Abstract Article PDF–6.1M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 103216683.

MK2 drives progression of pancreas and colon cancers by suppressing CD8⁺ T cell cytotoxic function and is a potential immunotherapy target

Damian Jacenik, Eric J. Lebish, Ellen J. Beswick

Front Immunol. 2023; 14: 1212100. Published online 2023 Jun 21. doi: 10.3389/fimmu.2023.1212100

PMCID:: PMC10321668

Abstract Article PDF–3.9M

Select item 95779424.

The MK2 cascade mediates transient alteration in mGluR‐LTD and spatial learning in a murine model of Alzheimer's disease

Lucia Privitera, Ellen L. Hogg, Marcia Lopes, Luana B. Domingos, Matthias Gaestel, Jürgen Müller, Mark J. Wall, Sonia A. L. Corrêa

Aging Cell. 2022 Oct; 21(10): e13717. Published online 2022 Sep 22. doi: 10.1111/acel.13717

PMCID:: PMC9577942

Abstract Article PDF–1.4M

Select item 92508045.

Gene Therapy with Pellino-1 Improves Perfusion and Decreases Tissue Loss in Flk-1 Heterozygous Mice but Fails in MAPKAP KINASE-2 Knockout Murine Hind Limb Ischemia Model

Mahesh Thirunavukkarasu, Seetur R. Pradeep, Gopi Ukani, Salim Abunnaja, Mark Youssef, Diego Accorsi, Santosh Swaminathan, Sue Ting Lim, Virginia Parker, Jacob Campbell, Muhammad Tipu Rishi, J. Alexander Palesty, Nilanjana Maulik

Microvasc Res. Author manuscript; available in PMC 2023 May 1.

Published in final edited form as: Microvasc Res. 2022 May; 141: 104311. Published online 2022 Jan 7. doi: 10.1016/j.mvr.2022.104311

PMCID:: PMC9250804

Abstract Article PDF–4.8M

Select item 86470226.

Promyelocytic leukemia protein targets MK2 to promote cytotoxicity

I‐Ting Chen, Hsiao‐Chi Chen, Yu‐Hsun Lo, Peng‐Yeh Lai, Fu‐Yi Hsieh, Yung‐Hsuan Wu, Hsiu‐Ming Shih, Ming‐Zong Lai

EMBO Rep. 2021 Dec 6; 22(12): e52254. Published online 2021 Oct 11. doi: 10.15252/embr.202052254

PMCID:: PMC8647022

Abstract Article PDF–3.1M

Select item 83132397.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 80443398.

IL‐3 is essential for ICOS‐L stabilization on mast cells, and sustains the IL‐33‐induced RORγt⁺ T_reg generation via enhanced IL‐6 induction

Sebastian Drube, Sylvia Müller, Franziska Weber, Philine Wegner, Romy Böttcher‐Loschinski, Matthias Gaestel, Andreas Hutloff, Thomas Kamradt, Nico Andreas

Immunology. 2021 May; 163(1): 86–97. Published online 2021 Jan 27. doi: 10.1111/imm.13305

PMCID:: PMC8044339

Abstract Article PDF–901K

Select item 79402029.

MAPKAP Kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model of Inflammation-Induced Colon Cancer

Lucia Suarez-Lopez, Yi Wen Kong, Ganapathy Sriram, Jesse C. Patterson, Samantha Rosenberg, Sandra Morandell, Kevin M. Haigis, Michael B. Yaffe

Front Immunol. 2020; 11: 607891. Published online 2021 Feb 23. doi: 10.3389/fimmu.2020.607891

PMCID:: PMC7940202

Abstract Article PDF–1.8M

Select item 793877010.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 723521211.

The IL-33-induced p38-/JNK1/2-TNFα axis is antagonized by activation of β-adrenergic-receptors in dendritic cells

Christiane Helbig, Franziska Weber, Nico Andreas, Thomas Herdegen, Matthias Gaestel, Thomas Kamradt, Sebastian Drube

Sci Rep. 2020; 10: 8152. Published online 2020 May 18. doi: 10.1038/s41598-020-65072-3

PMCID:: PMC7235212

Abstract Article PDF–1.9M

Select item 720843912.

Substrate-based kinase activity inference identifies MK2 as driver of colitis

Samantha Dale Strasser, Phaedra C. Ghazi, Alina Starchenko, Myriam Boukhali, Amanda Edwards, Lucia Suarez-Lopez, Jesse Lyons, Paul S. Changelian, Joseph B. Monahan, Jon Jacobsen, Douglas K. Brubaker, Brian A. Joughin, Michael B. Yaffe, Wilhelm Haas, Douglas A. Lauffenburger, Kevin M. Haigis

Integr Biol (Camb) Author manuscript; available in PMC 2020 May 8.

Published in final edited form as: Integr Biol (Camb). 2019 Nov 26; 11(7): 301–314. doi: 10.1093/intbio/zyz025

PMCID:: PMC7208439

Abstract Article PDF–1.9M

Select item 713598113.

Tristetraprolin regulates necroptosis during tonic Toll-like receptor 4 (TLR4) signaling in murine macrophages

Ardeshir Ariana, Norah A. Alturki, Stephanie Hajjar, Deborah J. Stumpo, Christopher Tiedje, Emad S. Alnemri, Matthias Gaestel, Perry J. Blackshear, Subash Sad

J Biol Chem. 2020 Apr 3; 295(14): 4661–4672. Published online 2020 Feb 24. doi: 10.1074/jbc.RA119.011633

PMCID:: PMC7135981

Abstract Article PDF–3.4M

Select item 663372614.

Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK2) Contributes to Secondary Damage after Spinal Cord Injury

Nader Ghasemlou, Ruben Lopez-Vales, Claude Lachance, Thusanth Thuraisingam, Matthias Gaestel, Danuta Radzioch, Samuel David

J Neurosci. 2010 Oct 13; 30(41): 13750–13759. doi: 10.1523/JNEUROSCI.2998-10.2010

PMCID:: PMC6633726

Abstract Article PDF–1.4M

Select item 627518815.

Hsp70 Interacts with Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinase 2 To Regulate p38MAPK Stability and Myoblast Differentiation during Skeletal Muscle Regeneration

Wei Fan, Xiu Kui Gao, Xi Sheng Rao, Yin Pu Shi, Xiao Ceng Liu, Fei Ya Wang, Yu Fen Liu, Xiao Xia Cong, Min Yi He, Shui Bo Xu, Wei Liang Shen, Yue Shen, Shi Gui Yan, Yan Luo, Boon Chuan Low, Hongwei Ouyang, Zhang Bao, Li Ling Zheng, Yi Ting Zhou

Mol Cell Biol. 2018 Dec 15; 38(24): e00211-18. Prepublished online 2018 Oct 1. Published online 2018 Nov 28. doi: 10.1128/MCB.00211-18