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Items: 1 to 20 of 29

1.
Inhibition of CK2 Diminishes Fibrotic Scar Formation and Improves Outcomes After Ischemic Stroke via Reducing BRD4 Phosphorylation
Xuemei Li, Qinghuan Yang, Peiran Jiang, Jun Wen, Yue Chen, Jiagui Huang, Mingfen Tian, Jiangxia Ren, Qin Yang
Neurochem Res. 2024; 49(5): 1254–1267. Published online 2024 Feb 21. doi: 10.1007/s11064-024-04112-0
PMCID:
PMC10991067
AbstractArticlePDF–6.6M
2.
Salvianic acid A alleviates chronic alcoholic liver disease by inhibiting HMGB1 translocation via down‐regulating BRD4
Yanwen Lan, Ran Yan, Wen Shan, Junyi Chu, Ruimin Sun, Ruiwen Wang, Yan Zhao, Zhanyu Wang, Ning Zhang, Jihong Yao
J Cell Mol Med. 2020 Aug; 24(15): 8518–8531. Published online 2020 Jun 29. doi: 10.1111/jcmm.15473
PMCID:
PMC7412690
AbstractArticlePDF–2.2M
3.
MiR-101-containing extracellular vesicles bind to BRD4 and enhance proliferation and migration of trophoblasts in preeclampsia
Jinhui Cui, Xinjuan Chen, Shuo Lin, Ling Li, Jianhui Fan, Hongying Hou, Ping Li
Stem Cell Res Ther. 2020; 11: 231. Published online 2020 Jun 11. doi: 10.1186/s13287-020-01720-9
PMCID:
PMC7291671
AbstractArticlePDF–3.4M
4.
The BD2 domain of BRD4 is a determinant in EndoMT and vein graft neointima formation
Mengxue Zhang, Bowen Wang, Go Urabe, Yitao Huang, Jorge Plutzky, K. Craig Kent, Lian-Wang Guo
Cell Signal. Author manuscript; available in PMC 2020 Sep 1.
Published in final edited form as: Cell Signal. 2019 Sep; 61: 20–29. Published online 2019 May 7. doi: 10.1016/j.cellsig.2019.05.005
PMCID:
PMC6561802
AbstractArticlePDF–1.8M
5.
BRD4 inhibition attenuates inflammatory response in microglia and facilitates recovery after spinal cord injury in rats
Jianle Wang, Jiaoxiang Chen, Haiming Jin, Dongdong Lin, Yu Chen, Ximiao Chen, Ben Wang, Sunli Hu, Yan Wu, Yaosen Wu, Yifei Zhou, Naifeng Tian, Weiyang Gao, Xiangyang Wang, Xiaolei Zhang
J Cell Mol Med. 2019 May; 23(5): 3214–3223. Published online 2019 Feb 26. doi: 10.1111/jcmm.14196
PMCID:
PMC6484335
AbstractArticlePDF–1.2M
6.
Function of BRD4 in the pathogenesis of high glucose-induced cardiac hypertrophy
Qian Wang, Yuxin Sun, Tianshu Li, Lianqin Liu, Yunxia Zhao, Liyuan Li, Ling Zhang, Yan Meng
Mol Med Rep. 2019 Jan; 19(1): 499–507. Published online 2018 Nov 21. doi: 10.3892/mmr.2018.9681
PMCID:
PMC6297744
AbstractArticlePDF–1.7M
7.
Structural Mechanism of the Oxygenase JMJD6 Recognition by the Extraterminal (ET) Domain of BRD4
Tsuyoshi Konuma, Di Yu, Chengcheng Zhao, Ying Ju, Rajal Sharma, Chunyan Ren, Qiang Zhang, Ming-Ming Zhou, Lei Zeng
Sci Rep. 2017; 7: 16272. Published online 2017 Nov 24. doi: 10.1038/s41598-017-16588-8
PMCID:
PMC5701133
AbstractArticlePDF–2.2M
8.
Brd4 inhibition attenuates unilateral ureteral obstruction-induced fibrosis by blocking TGF-β-mediated Nox4 expression
Baoshang Zhou, Jiao Mu, Yi Gong, Caibao Lu, Youguang Zhao, Ting He, Zhexue Qin
Redox Biol. 2017 Apr; 11: 390–402. Published online 2016 Dec 30. doi: 10.1016/j.redox.2016.12.031
PMCID:
PMC5219604
AbstractArticlePDF–1.5M
9.
BRD4 Sustains Melanoma Proliferation and Represents a New Target for Epigenetic Therapy
Miguel F. Segura, Bárbara Fontanals-Cirera, Avital Gaziel-Sovran, María V. Guijarro, Doug Hanniford, Guangtao Zhang, Pilar González-Gomez, Marta Morante, Luz Jubierre, Weijia Zhang, Farbod Darvishian, Michael Ohlmeyer, Iman Osman, Ming-Ming Zhou, Eva Hernando
Cancer Res. Author manuscript; available in PMC 2014 Dec 3.
Published in final edited form as: Cancer Res. 2013 Oct 15; 73(20): 6264–6276. Published online 2013 Aug 15. doi: 10.1158/0008-5472.CAN-13-0122-T
PMCID:
PMC4254777
AbstractArticlePDF–987K
10.
Bromodomain 4 protein is a predictor of survival for urothelial carcinoma of bladder
Yang Yan, Feng-Qiang Yang, Hai-Min Zhang, Jun Li, Wei Li, Guang-Chun Wang, Jian-Ping Che, Jun-Hua Zheng, Min Liu
Int J Clin Exp Pathol. 2014; 7(7): 4231–4238. Published online 2014 Jun 15.
PMCID:
PMC4129038
AbstractArticlePDF–600K
11.
The Bromodomain: From Epigenome Reader to Druggable Target
Roberto Sanchez, Jamel Meslamani, Ming-Ming Zhou
Biochim Biophys Acta. Author manuscript; available in PMC 2015 Aug 1.
Published in final edited form as: Biochim Biophys Acta. 2014 Aug; 1839(8): 676–685. Published online 2014 Mar 28. doi: 10.1016/j.bbagrm.2014.03.011
PMCID:
PMC4099289
AbstractArticlePDF–968K
12.
BET Acetyl-Lysine Binding Proteins Control Pathological Cardiac Hypertrophy
Jessica I. Spiltoir, Matthew S. Stratton, Maria A. Cavasin, Kim Demos-Davies, Brian G. Reid, Jun Qi, James E. Bradner, Timothy A. McKinsey
J Mol Cell Cardiol. Author manuscript; available in PMC 2014 Jul 9.
Published in final edited form as: J Mol Cell Cardiol. 2013 Oct; 63: 175–179. Published online 2013 Aug 9. doi: 10.1016/j.yjmcc.2013.07.017
PMCID:
PMC4089995
AbstractArticlePDF–911K
13.
Brd4 and JMJD6-associated Anti-pause Enhancers in Regulation of Transcriptional Pause Release
Wen Liu, Qi Ma, Kaki Wong, Wenbo Li, Kenny Ohgi, Jie Zhang, Aneel Aggarwal, Michael G. Rosenfeld
Cell. Author manuscript; available in PMC 2014 Dec 19.
Published in final edited form as: Cell. 2013 Dec 19; 155(7): 1581–1595. doi: 10.1016/j.cell.2013.10.056
PMCID:
PMC3886918
AbstractArticlePDF–2.7M
14.
The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy
Valentina Proserpio, Raffaella Fittipaldi, James G. Ryall, Vittorio Sartorelli, Giuseppina Caretti
Genes Dev. 2013 Jun 1; 27(11): 1299–1312. doi: 10.1101/gad.217240.113
PMCID:
PMC3690402
AbstractArticlePDF–2.4M
15.
The Bromodomain Protein Brd4 Insulates Chromatin from DNA Damage Signaling
Scott R. Floyd, Michael E. Pacold, Qiuying Huang, Scott M. Clarke, Fred C. Lam, Ian G. Cannell, Bryan D. Bryson, Jonathan Rameseder, Michael J. Lee, Emily J. Blake, Anna Fydrych, Richard Ho, Benjamin A. Greenberger, Grace C. Chen, Amanda Maffa, Amanda M. Del Rosario, David E. Root, Anne E. Carpenter, William C. Hahn, David M. Sabatini, Clark C. Chen, Forest M. White, James E. Bradner, Michael B. Yaffe
Nature. Author manuscript; available in PMC 2013 Dec 13.
Published in final edited form as: Nature. 2013 Jun 13; 498(7453): 246–250. Published online 2013 Jun 2. doi: 10.1038/nature12147
PMCID:
PMC3683358
ArticlePDF–1.4M
16.
Phospho Switch Triggers Brd4 Chromatin Binding and Activator Recruitment for Gene-Specific Targeting
Shwu-Yuan Wu, A-Young Lee, Hsien-Tsung Lai, Hong Zhang, Cheng-Ming Chiang
Mol Cell. Author manuscript; available in PMC 2014 Mar 7.
Published in final edited form as: Mol Cell. 2013 Mar 7; 49(5): 843–857. Published online 2013 Jan 11. doi: 10.1016/j.molcel.2012.12.006
PMCID:
PMC3595396
AbstractArticlePDF–5.5M
17.
Bromodomain-containing Protein 4 (BRD4) Regulates RNA Polymerase II Serine 2 Phosphorylation in Human CD4+ T Cells
Weishi Zhang, Celine Prakash, Calvin Sum, Yue Gong, Yinghui Li, Jeffrey J. T. Kwok, Nina Thiessen, Sven Pettersson, Steven J. M. Jones, Stefan Knapp, Henry Yang, Keh-Chuang Chin
J Biol Chem. 2012 Dec 14; 287(51): 43137–43155. Published online 2012 Oct 19. doi: 10.1074/jbc.M112.413047
PMCID:
PMC3522308
AbstractArticlePDF–5.2M
18.
Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells
Daiji Okamura, Ikuma Maeda, Hirofumi Taniguchi, Yuko Tokitake, Makiko Ikeda, Keiko Ozato, Nathan Mise, Kuniya Abe, Toshiaki Noce, Juan Carlos Izpisua Belmonte, Yasuhisa Matsui
Genes Dev. 2012 Nov 15; 26(22): 2477–2482. doi: 10.1101/gad.202242.112
PMCID:
PMC3505818
AbstractArticlePDF–663K
19.
BRD4 is an atypical kinase that phosphorylates Serine2 of the RNA Polymerase II carboxy-terminal domain
Ballachanda N. Devaiah, Brian A. Lewis, Natasha Cherman, Michael C. Hewitt, Brian K. Albrecht, Pamela G. Robey, Keiko Ozato, Robert J. Sims, III, Dinah S. Singer
Proc Natl Acad Sci U S A. 2012 May 1; 109(18): 6927–6932. Published online 2012 Apr 16. doi: 10.1073/pnas.1120422109
PMCID:
PMC3345009
AbstractArticlePDF–719K
20.
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
Johannes Zuber, Junwei Shi, Eric Wang, Amy R. Rappaport, Harald Herrmann, Edward A. Sison, Daniel Magoon, Jun Qi, Katharina Blatt, Mark Wunderlich, Meredith J. Taylor, Christopher Johns, Agustin Chicas, James C. Mulloy, Scott C. Kogan, Patrick Brown, Peter Valent, James E. Bradner, Scott W. Lowe, Christopher R. Vakoc
Nature. Author manuscript; available in PMC 2012 Apr 17.
Published in final edited form as: Nature. 2011 Aug 3; 478(7370): 524–528. Published online 2011 Aug 3. doi: 10.1038/nature10334
PMCID:
PMC3328300
AbstractArticlePDF–2.0M

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