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Select item 110092531.

Tension activation of mechanosensitive two-pore domain K+ channels TRAAK, TREK-1, and TREK-2

Ben Sorum, Trevor Docter, Vincent Panico, Robert A. Rietmeijer, Stephen G. Brohawn

Nat Commun. 2024; 15: 3142. Published online 2024 Apr 11. doi: 10.1038/s41467-024-47208-5

PMCID:: PMC11009253

Abstract Article PDF–3.7M

Select item 100348482.

Pharmacogenetic Analysis of Genes Implicated in Rodent Models of Antidepressant Response: Association of TREK1 and Treatment Resistance in the STAR*D Study

Roy H Perlis, Priya Moorjani, Jesen Fagerness, Shaun Purcell, Madhukar H Trivedi, Maurizio Fava, A John Rush, Jordan W Smoller

Neuropsychopharmacology. Author manuscript; available in PMC 2023 Mar 23.

Published in final edited form as: Neuropsychopharmacology. 2008 Nov; 33(12): 2810–2819. Published online 2008 Feb 20. doi: 10.1038/npp.2008.6

PMCID:: PMC10034848

Abstract Article PDF–667K

Select item 99989773.

High glucose induced HIF-1α/TREK1 expression and myometrium relaxation during pregnancy

Tengteng Li, Jiajia Fei, Huihui Yu, Xingxing Wang, Jingjing Bai, Fucai Chen, Dan Li, Zongzhi Yin

Front Endocrinol (Lausanne) 2023; 14: 1115619. Published online 2023 Feb 27. doi: 10.3389/fendo.2023.1115619

Correction in:: Front Endocrinol (Lausanne). 2023; 14: 1200774.

PMCID:: PMC9998977

Abstract Article PDF–3.3M

Select item 98294834.

Activation of TREK-1 (K_2P2.1) potassium channels protects against influenza A-induced lung injury

Tatiana Zyrianova, Benjamin Lopez, Kathlyn Zou, Charles Gu, Dayna Pham, Sriharsha Talapaneni, Christopher M. Waters, Riccardo Olcese, Andreas Schwingshackl

Am J Physiol Lung Cell Mol Physiol. 2023 Jan 1; 324(1): L64–L75. Published online 2022 Nov 21. doi: 10.1152/ajplung.00116.2022

PMCID:: PMC9829483

Abstract Article

Select item 83217925.

Human adrenal glomerulosa cells express K2P and GIRK potassium channels that are inhibited by ANG II and ACTH

John J. Enyeart, Judith A. Enyeart

Am J Physiol Cell Physiol. 2021 Jul 1; 321(1): C158–C175. Published online 2021 May 26. doi: 10.1152/ajpcell.00118.2021

PMCID:: PMC8321792

Abstract Article

Select item 75668816.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 73653167.

Trek1 contributes to maintaining nasal epithelial barrier integrity

Jing Jiang, Jiang-Qi Liu, Jing Li, Meng Li, Hong-Bin Chen, Hao Yan, Li-Hua Mo, Shu-Qi Qiu, Zhi-Gang Liu, Ping-Chang Yang

Sci Rep. 2015; 5: 9191. Published online 2015 Mar 17. doi: 10.1038/srep09191

PMCID:: PMC7365316

Abstract Article PDF–924K

Select item 62793588.

TREK-1 channels regulate pressure sensitivity and calcium signaling in trabecular meshwork cells

Oleg Yarishkin, Tam T.T. Phuong, Colin A. Bretz, Kenneth W. Olsen, Jackson M. Baumann, Monika Lakk, Alan Crandall, Catherine Heurteaux, Mary E. Hartnett, David Križaj

J Gen Physiol. 2018 Dec 3; 150(12): 1660–1675. doi: 10.1085/jgp.201812179

PMCID:: PMC6279358

Abstract Article PDF–2.6M

Select item 61485489.

Altered expression and modulation of the two-pore-domain (K_2P) mechanogated potassium channel TREK-1 in overactive human detrusor

Ricardo H. Pineda, Balachandar Nedumaran, Joseph Hypolite, Xiao-Qing Pan, Shandra Wilson, Randall B. Meacham, Anna P. Malykhina

Am J Physiol Renal Physiol. 2017 Aug 1; 313(2): F535–F546. Published online 2017 May 24. doi: 10.1152/ajprenal.00638.2016

PMCID:: PMC6148548

Abstract Article

Select item 596063910.

Adaptive Reduction of Human Myometrium Contractile Activity in Response to Prolonged Uterine Stretch during Term and Twin Pregnancy. Role of TREK-1 Channel

Zongzhi Yin, Wenzhu He, Yun Li, Dan Li, Hongyan Li, Yuanyuan Yang, Zhaolian Wei, Bing Shen, Xi Wang, Yunxia Cao, Raouf A. Khalil

Biochem Pharmacol. Author manuscript; available in PMC 2019 Jun 1.

Published in final edited form as: Biochem Pharmacol. 2018 Jun; 152: 252–263. Published online 2018 Mar 22. doi: 10.1016/j.bcp.2018.03.021

PMCID:: PMC5960639

Abstract Article PDF–1.0M

Select item 577889111.

K_2P2.1(TREK-1):activator complexes reveal a cryptic selectivity filter binding site

Marco Lolicato, Cristina Arrigoni, Takahiro Mori, Yoko Sekioka, Clifford Bryant, Kimberly A. Clark, Daniel L. Minor, Jr.

Nature. Author manuscript; available in PMC 2018 Jan 23.

Published in final edited form as: Nature. 2017 Jul 20; 547(7663): 364–368. Published online 2017 Jul 10. doi: 10.1038/nature22988

PMCID:: PMC5778891

Abstract Article PDF–2.9M

Select item 537675712.

Sodium permeable and “hypersensitive” TREK‐1 channels cause ventricular tachycardia

Niels Decher, Beatriz Ortiz‐Bonnin, Corinna Friedrich, Marcus Schewe, Aytug K Kiper, Susanne Rinné, Gunnar Seemann, Rémi Peyronnet, Sven Zumhagen, Daniel Bustos, Jens Kockskämper, Peter Kohl, Steffen Just, Wendy González, Thomas Baukrowitz, Birgit Stallmeyer, Eric Schulze‐Bahr

EMBO Mol Med. 2017 Apr; 9(4): 403–414. Published online 2017 Feb 27. doi: 10.15252/emmm.201606690

PMCID:: PMC5376757

Abstract Article PDF–1.7M

Select item 502210113.

Over-expressed human TREK-1 inhibits CHO cell proliferation via inhibiting PKA and p38 MAPK pathways and subsequently inducing G₁ arrest

Man Zhang, Hua-jing Yin, Wei-ping Wang, Jiang Li, Xiao-liang Wang

Acta Pharmacol Sin. 2016 Sep; 37(9): 1190–1198. Published online 2016 Jul 11. doi: 10.1038/aps.2016.65

PMCID:: PMC5022101

Abstract Article PDF–1.7M

Select item 471200714.

Alternatively Spliced Human TREK-1 Variants Alter TREK-1 Channel Function and Localization

Chad L. Cowles, Yi-Ying Wu, Scott D. Barnett, Michael T. Lee, Heather R. Burkin, Iain L.O. Buxton

Biol Reprod. 2015 Nov; 93(5): 122. Published online 2015 Sep 23. doi: 10.1095/biolreprod.115.129791

PMCID:: PMC4712007

Abstract Article PDF–918K

Select item 471168115.

Regulation of TWIK-related potassium channel-1 (Trek1) restitutes intestinal epithelial barrier function

Huang Huang, Jiang-Qi Liu, Yong Yu, Li-Hua Mo, Rong-Ti Ge, Huan-Ping Zhang, Zhi-Gang Liu, Peng-Yuan Zheng, Ping-Chang Yang

Cell Mol Immunol. 2016 Jan; 13(1): 110–118. Published online 2015 Feb 16. doi: 10.1038/cmi.2014.137

PMCID:: PMC4711681

Abstract Article PDF–2.2M

Select item 462190316.

Prognostic significance of the TREK-1 K2P potassium channels in prostate cancer

Gui-Ming Zhang, Fang-Ning Wan, Xiao-Jian Qin, Da-Long Cao, Hai-Liang Zhang, Yao Zhu, Bo Dai, Guo-Hai Shi, Ding-Wei Ye

Oncotarget. 2015 Jul 30; 6(21): 18460–18468. Published online 2015 Apr 21. doi: 10.18632/oncotarget.3782

PMCID:: PMC4621903

Abstract Article PDF–2.3M

Select item 442880917.

Two-pore domain potassium channels enable action potential generation in the absence of voltage-gated potassium channels

Georgina MacKenzie, Nicholas P. Franks, Stephen G. Brickley

Pflugers Arch. 2015; 467(5): 989–999. Published online 2014 Dec 9. doi: 10.1007/s00424-014-1660-6

PMCID:: PMC4428809

Abstract Article PDF–1.3M

Select item 429403318.

Modulation of K_2P2.1 and K_2P10.1 K⁺ channel sensitivity to carvedilol by alternative mRNA translation initiation

J Kisselbach, C Seyler, P A Schweizer, R Gerstberger, R Becker, H A Katus, D Thomas

Br J Pharmacol. 2014 Dec; 171(23): 5182–5194. Published online 2014 Aug 28. doi: 10.1111/bph.12596

PMCID:: PMC4294033

Abstract Article PDF–1.5M

Select item 421465719.

Response of the human detrusor to stretch is regulated by TREK-1, a two-pore-domain (K_2P) mechano-gated potassium channel

Qi Lei, Xiao-Qing Pan, Shaohua Chang, S Bruce Malkowicz, Thomas J Guzzo, Anna P Malykhina

J Physiol. 2014 Jul 15; 592(Pt 14): 3013–3030. Published online 2014 May 6. doi: 10.1113/jphysiol.2014.271718

PMCID:: PMC4214657

Abstract Article PDF–2.0M

Select item 416992120.

Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid

Yannick Comoglio, Joshua Levitz, Michael A. Kienzler, Florian Lesage, Ehud Y. Isacoff, Guillaume Sandoz

Proc Natl Acad Sci U S A. 2014 Sep 16; 111(37): 13547–13552. Published online 2014 Sep 2. doi: 10.1073/pnas.1407160111

PMCID:: PMC4169921

Abstract Article PDF–1.1M

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