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Select item 106712761.

C-C Motif Chemokine Ligand 5 (CCL5) Promotes Irradiation-Evoked Osteoclastogenesis

Jing Wang, Fanyu Zhao, Linshan Xu, Jianping Wang, Jianglong Zhai, Li Ren, Guoying Zhu

Int J Mol Sci. 2023 Nov; 24(22): 16168. Published online 2023 Nov 10. doi: 10.3390/ijms242216168

PMCID:: PMC10671276

Abstract Article PDF–67M

Select item 106498912.

TCR-independent CD137 (4–1BB) signaling promotes CD8⁺-exhausted T cell proliferation and terminal differentiation

Andrea C. Pichler, Nadège Carrié, Marine Cuisinier, Samira Ghazali, Allison Voisin, Pierre-Paul Axisa, Marie Tosolini, Céline Mazzotti, Dominic P. Golec, Sabrina Maheo, Laura do Souto, Rüçhan Ekren, Eve Blanquart, Lea Lemaitre, Virginie Feliu, Marie-Véronique Joubert, Jennifer L. Cannons, Camille Guillerey, Hervé Avet-Loiseau, Tania H. Watts, Benoit L. Salomon, Olivier Joffre, Yenkel Grinberg-Bleyer, Pamela L. Schwartzberg, Liliana E. Lucca, Ludovic Martinet

Immunity. Author manuscript; available in PMC 2023 Nov 15.

Published in final edited form as: Immunity. 2023 Jul 11; 56(7): 1631–1648.e10. Published online 2023 Jun 30. doi: 10.1016/j.immuni.2023.06.007

PMCID:: PMC10649891

Abstract Article PDF–3.7M

Select item 106465513.

cIAPs control RIPK1 kinase activity‐dependent and ‐independent cell death and tissue inflammation

Fabian Schorn, J Paul Werthenbach, Mattes Hoffmann, Mila Daoud, Johanna Stachelscheid, Lars M Schiffmann, Ximena Hildebrandt, Su Ir Lyu, Nieves Peltzer, Alexander Quaas, Domagoj Vucic, John Silke, Manolis Pasparakis, Hamid Kashkar

EMBO J. 2023 Nov; 42(22): e113614. Published online 2023 Oct 4. doi: 10.15252/embj.2023113614

PMCID:: PMC10646551

Abstract Article PDF–3.3M

Select item 102328134.

Single cell transcriptomics of bone marrow derived macrophages reveals Ccl5 as a biomarker of direct IFNAR-independent responses to DNA sensing

Emily McCarty, Justin Yu, Van K. Ninh, David M. Calcagno, Jodi Lee, Kevin R. King

Front Immunol. 2023; 14: 1199730. Published online 2023 May 18. doi: 10.3389/fimmu.2023.1199730

PMCID:: PMC10232813

Abstract Article PDF–6.4M

Select item 100722235.

CCL5-producing migratory dendritic cells guide CCR5⁺ monocytes into the draining lymph nodes

Kavita Rawat, Anita Tewari, Xin Li, Arlind B. Mara, William T. King, Sophie L. Gibbings, Chinaza F. Nnam, Fred W. Kolling, Bart N. Lambrecht, Claudia V. Jakubzick

J Exp Med. 2023 Jun 5; 220(6): e20222129. Published online 2023 Mar 22. doi: 10.1084/jem.20222129

PMCID:: PMC10072223

Abstract Article PDF–3.6M

Select item 100159636.

CCL5/CCR5-mediated peripheral inflammation exacerbates blood‒brain barrier disruption after intracerebral hemorrhage in mice

Jie Lin, Ya Xu, Peiwen Guo, Yù-Jié Chen, Jiru Zhou, Min Xia, Binbin Tan, Xin Liu, Hua Feng, Yujie Chen

J Transl Med. 2023; 21: 196. Published online 2023 Mar 14. doi: 10.1186/s12967-023-04044-3

PMCID:: PMC10015963

Abstract Article PDF–9.5M

Select item 98804187.

Metabolic effects of CCL5 deficiency in lean and obese mice

Hui Zhou, Xiyan Liao, Qin Zeng, Haowei Zhang, Jianfeng Song, Wanyu Hu, Xiaoxiao Sun, Yujin Ding, Dandan Wang, Yalun Xiao, Tuo Deng

Front Immunol. 2022; 13: 1059687. Published online 2023 Jan 13. doi: 10.3389/fimmu.2022.1059687

PMCID:: PMC9880418

Abstract Article PDF–4.0M

Select item 98631458.

Convergent transcriptomic and genomic evidence supporting a dysregulation of CXCL16 and CCL5 in Alzheimer’s disease

Xiao Li, Deng-Feng Zhang, Rui Bi, Li-Wen Tan, Xiaogang Chen, Min Xu, Yong-Gang Yao

Alzheimers Res Ther. 2023; 15: 17. Published online 2023 Jan 21. doi: 10.1186/s13195-022-01159-5

PMCID:: PMC9863145

Abstract Article PDF–2.5M

Select item 97905899.

C‐C motif chemokine ligand 5 confines liver regeneration by down‐regulating reparative macrophage‐derived hepatocyte growth factor in a forkhead box O 3a–dependent manner

Miao Huang, Junzhe Jiao, Hao Cai, Yichi Zhang, Yuhan Xia, Jiacheng Lin, Zhi Shang, Yihan Qian, Fang Wang, Hailong Wu, Xiaoni Kong, Jinyang Gu

Hepatology. 2022 Dec; 76(6): 1706–1722. Published online 2022 May 5. doi: 10.1002/hep.32458

PMCID:: PMC9790589

Abstract Article PDF–18M

Select item 969251310.

Adipose Tissue-Derived CCL5 Enhances Local Pro-Inflammatory Monocytic MDSCs Accumulation and Inflammation via CCR5 Receptor in High-Fat Diet-Fed Mice

Pei-Chi Chan, Chieh-Hua Lu, Hung-Che Chien, Yu-Feng Tian, Po-Shiuan Hsieh

Int J Mol Sci. 2022 Nov; 23(22): 14226. Published online 2022 Nov 17. doi: 10.3390/ijms232214226

PMCID:: PMC9692513

Abstract Article PDF–2.7M

Select item 968188711.

SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation

Lingjie Yan, Tao Zhang, Kai Wang, Zezhao Chen, Yuanxin Yang, Bing Shan, Qi Sun, Mengmeng Zhang, Yichi Zhang, Yedan Zhong, Nan Liu, Jinyang Gu, Daichao Xu

Nat Commun. 2022; 13: 7153. Published online 2022 Nov 22. doi: 10.1038/s41467-022-34993-0

PMCID:: PMC9681887

Abstract Article PDF–8.5M

Select item 939232412.

Human induced pluripotent stem cell engineering establishes a humanized mouse platform for pediatric low-grade glioma modeling

Corina Anastasaki, Jit Chatterjee, Olivia Cobb, Shilpa Sanapala, Suzanne M. Scheaffer, Amanda De Andrade Costa, Anna F. Wilson, Chloe M. Kernan, Ameera H. Zafar, Xia Ge, Joel R. Garbow, Fausto J. Rodriguez, David H. Gutmann

Acta Neuropathol Commun. 2022; 10: 120. Published online 2022 Aug 19. doi: 10.1186/s40478-022-01428-2

PMCID:: PMC9392324

Abstract Article PDF–13M

Select item 901228913.

Intrahepatic microbes govern liver immunity by programming NKT cells

Joshua C. Leinwand, Bidisha Paul, Ruonan Chen, Fangxi Xu, Maria A. Sierra, Madan M. Paluru, Sumant Nanduri, Carolina G. Alcantara, Sorin A.A. Shadaloey, Fan Yang, Salma A. Adam, Qianhao Li, Michelle Bandel, Inderdeep Gakhal, Lara Appiah, Yuqi Guo, Mridula Vardhan, Zia Flaminio, Emilie R. Grodman, Ari Mermelstein, Wei Wang, Brian Diskin, Berk Aykut, Mohammad Khan, Gregor Werba, Smruti Pushalkar, Mia McKinstry, Zachary Kluger, Jaimie J. Park, Brandon Hsieh, Kristen Dancel-Manning, Feng-Xia Liang, James S. Park, Anjana Saxena, Xin Li, Neil D. Theise, Deepak Saxena, George Miller

J Clin Invest. 2022 Apr 15; 132(8): e151725. Published online 2022 Apr 15. doi: 10.1172/JCI151725

PMCID:: PMC9012289

Abstract Article PDF–7.0M

Select item 884994514.

CCR5 maintains macrophages in the bone marrow and drives hematopoietic failure in a mouse model of severe aplastic anemia

Allison N. Seyfried, Amanda McCabe, Julianne N. P. Smith, Laura M. Calvi, Katherine C. MacNamara

Leukemia. Author manuscript; available in PMC 2022 Feb 16.

Published in final edited form as: Leukemia. 2021 Nov; 35(11): 3139–3151. Published online 2021 Mar 20. doi: 10.1038/s41375-021-01219-z

PMCID:: PMC8849945

Abstract Article PDF–2.2M

Select item 880912015.

RGMa regulates CCL5 expression via the BMP receptor in experimental autoimmune encephalomyelitis mice and endothelial cells

Shi Tang, Bao Su, Tao Tao, Weiping Yan, Rongrong Zhang, Xinyue Qin, Jinzhou Feng

Mol Med Rep. 2022 Mar; 25(3): 85. Published online 2022 Jan 13. doi: 10.3892/mmr.2022.12601

PMCID:: PMC8809120

Abstract Article PDF–2.2M

Select item 869152516.

Commensal-driven Immune Zonation of the Liver Promotes Host Defense

Anita Gola, Michael G. Dorrington, Emily Speranza, Claudia Sala, Rochelle M. Shih, Andrea J. Radtke, Harikesh S. Wong, Antonio P. Baptista, Jonathan M. Hernandez, Gastone Castellani, Iain D. C. Fraser, Ronald N. Germain

Nature. Author manuscript; available in PMC 2021 Dec 21.

Published in final edited form as: Nature. 2021 Jan; 589(7840): 131–136. Published online 2020 Nov 25. doi: 10.1038/s41586-020-2977-2

PMCID:: PMC8691525

Abstract Article PDF–7.1M

Select item 851189617.

Regulated on Activation, NormalT cell Expressed and Secreted (RANTES) drives the resolution of allergic asthma

Nina Li, Hoomann Mirzakhani, Alexander Kiefer, Julia Koelle, Tytti Vuorinen, Manfred Rauh, Zuqin Yang, Susanne Krammer, Paraskevi Xepapadaki, Anna Lewandowska-Polak, Heikki Lukkarinen, Nan Zhang, Barbara Stanic, Theodor Zimmermann, Marek L. Kowalski, Tuomas Jartti, Claus Bachert, Mübeccel Akdis, Nikolaos G. Papadopoulos, Benjamin A. Raby, Scott T. Weiss, Susetta Finotto

iScience. 2021 Oct 22; 24(10): 103163. Published online 2021 Sep 25. doi: 10.1016/j.isci.2021.103163

PMCID:: PMC8511896

Abstract Article PDF–2.8M

Select item 832735518.

CCL5 via GPX1 activation protects hippocampal memory function after mild traumatic brain injury

Man-Hau Ho, Chia-Hung Yen, Tsung-Hsun Hsieh, Tzu-Jen Kao, Jing-Yuan Chiu, Yung-Hsiao Chiang, Barry J. Hoffer, Wen-Chang Chang, Szu-Yi Chou

Redox Biol. 2021 Oct; 46: 102067. Published online 2021 Jul 17. doi: 10.1016/j.redox.2021.102067

PMCID:: PMC8327355

Abstract Article PDF–13M

Select item 831340619.

Anti-tumor immunity in mismatch repair-deficient colorectal cancers requires type I IFN–driven CCL5 and CXCL10

Courtney Mowat, Shayla R. Mosley, Afshin Namdar, Daniel Schiller, Kristi Baker

J Exp Med. 2021 Sep 6; 218(9): e20210108. Published online 2021 Jul 23. doi: 10.1084/jem.20210108

PMCID:: PMC8313406

Abstract Article PDF–5.6M

Select item 758395120.

Chrysin Inhibits NF-κB-Dependent CCL5 Transcription by Targeting IκB Kinase in the Atopic Dermatitis-Like Inflammatory Microenvironment

Hyunjin Yeo, Young Han Lee, Dongsoo Koh, Yoongho Lim, Soon Young Shin

Int J Mol Sci. 2020 Oct; 21(19): 7348. Published online 2020 Oct 5. doi: 10.3390/ijms21197348

PMCID:: PMC7583951

Abstract Article PDF–2.9M

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