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Items: 1 to 20 of 36

1.
Suppression of Wnt/β-catenin signaling is associated with downregulation of Wnt1, PORCN and Rspo2 in Alzheimer’s disease
Jesse R. Macyczko, Na Wang, Jing Zhao, Yingxue Ren, Wenyan Lu, Tadafumi C. Ikezu, Na Zhao, Chia-Chen Liu, Guojun Bu, Yonghe Li
Mol Neurobiol. Author manuscript; available in PMC 2024 Jan 1.
Published in final edited form as: Mol Neurobiol. 2023 Jan; 60(1): 26–35. Published online 2022 Oct 10. doi: 10.1007/s12035-022-03065-1
PMCID:
PMC9795414
AbstractArticlePDF–1.5M
2.
Identification of a regulatory pathway inhibiting adipogenesis via RSPO2
Hua Dong, Wenfei Sun, Yang Shen, Miroslav Baláz, Lucia Balázová, Lianggong Ding, Mona Löffler, Bradford Hamilton, Nora Klöting, Matthias Blüher, Heike Neubauer, Holger Klein, Christian Wolfrum
Nat Metab. 2022; 4(1): 90–105. Published online 2022 Jan 13. doi: 10.1038/s42255-021-00509-1
PMCID:
PMC8803606
AbstractArticlePDF–24M
3.
RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis
Zhiying Yue, Xin Niu, Zengjin Yuan, Qin Qin, Wenhao Jiang, Liang He, Jingduo Gao, Yi Ding, Yanxi Liu, Ziwei Xu, Zhenxi Li, Zhengfeng Yang, Rong Li, Xiwen Xue, Yankun Gao, Fei Yue, Xiang H.-F. Zhang, Guohong Hu, Yi Wang, Yi Li, Geng Chen, Stefan Siwko, Alison Gartland, Ning Wang, Jianru Xiao, Mingyao Liu, Jian Luo
J Clin Invest. 2022 Jan 18; 132(2): e144579. Published online 2022 Jan 18. doi: 10.1172/JCI144579
PMCID:
PMC8759794
AbstractArticlePDF–9.4M
4.
Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma
Tatenda Mahlokozera, Bhuvic Patel, Hao Chen, Patrick Desouza, Xuan Qu, Diane D. Mao, Daniel Hafez, Wei Yang, Rukayat Taiwo, Mounica Paturu, Afshin Salehi, Amit D. Gujar, Gavin P. Dunn, Nima Mosammaparast, Allegra A. Petti, Hiroko Yano, Albert H. Kim
Nat Commun. 2021; 12: 6321. Published online 2021 Nov 3. doi: 10.1038/s41467-021-26653-6
PMCID:
PMC8566473
AbstractArticlePDF–2.7M
5.
Evaluation of WNT Signaling Pathway Gene Variants WNT7B rs6519955, SFRP4 rs17171229 and RSPO2 rs611744 in Patients with Dupuytren’s Contracture
Gediminas Samulėnas, Alina Smalinskienė, Rytis Rimdeika, Kęstutis Braziulis, Mantas Fomkinas, Rokas Paškevičius
Genes (Basel) 2021 Sep; 12(9): 1293. Published online 2021 Aug 24. doi: 10.3390/genes12091293
PMCID:
PMC8469921
AbstractArticlePDF–237K
6.
Role of R-spondin 2 in arterial lymphangiogenesis and atherosclerosis
Bhupesh Singla, Hui-Ping Lin, Alex Chen, WonMo Ahn, Pushpankur Ghoshal, Mary Cherian-Shaw, Joseph White, Brian K Stansfield, Gábor Csányi
Cardiovasc Res. 2021 Jun 1; 117(6): 1489–1509. Published online 2020 Aug 4. doi: 10.1093/cvr/cvaa244
PMCID:
PMC8152716
AbstractArticlePDF–2.2M
7.
R-Spondins 2 and 3 Are Overexpressed in a Subset of Human Colon and Breast Cancers
Caitlin B. Conboy, Germán L. Vélez-Reyes, Susan K. Rathe, Juan E. Abrahante, Nuri A. Temiz, Michael B. Burns, Reuben S. Harris, Timothy K. Starr, David A. Largaespada
DNA Cell Biol. January 2021; 40(1): 70–79. Published online 2021 Jan 19. doi: 10.1089/dna.2020.5585
PMCID:
PMC7821429
AbstractArticlePDF–612K
8.
A polymorphism within the R-spondin 2 gene predicts outcome in metastatic colorectal cancer patients treated with FOLFIRI/bevacizumab: Data from FIRE-3 and TRIBE trials
Martin D. Berger, Yan Ning, Sebastian Stintzing, Volker Heinemann, Shu Cao, Wu Zhang, Dongyun Yang, Yuji Miyamoto, Mitsukuni Suenaga, Marta Schirripa, Diana L. Hanna, Shivani Soni, Alberto Puccini, Ryuma Tokunaga, Madiha Naseem, Francesca Battaglin, Chiara Cremolini, Alfredo Falcone, Fotios Loupakis, Heinz-Josef Lenz
Eur J Cancer. Author manuscript; available in PMC 2020 Sep 24.
Published in final edited form as: Eur J Cancer. 2020 May; 131: 89–97. Published online 2020 Apr 16. doi: 10.1016/j.ejca.2020.02.048
PMCID:
PMC7513926
AbstractArticlePDF–379K
9.
R-spondin2 signaling is required for oocyte-driven intercellular communication and follicular growth
Marie-Cécile De Cian, Elodie P. Gregoire, Morgane Le Rolle, Simon Lachambre, Magali Mondin, Sheila Bell, Céline J. Guigon, Anne-Amandine Chassot, Marie-Christine Chaboissier
Cell Death Differ. 2020 Oct; 27(10): 2856–2871. Published online 2020 Apr 27. doi: 10.1038/s41418-020-0547-7
PMCID:
PMC7493947
AbstractArticlePDF–20M
10.
R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling
Ramin Dubey, Peter van Kerkhof, Ingrid Jordens, Tomas Malinauskas, Ganesh V Pusapati, Joseph K McKenna, Dan Li, Jan E Carette, Mitchell Ho, Christian Siebold, Madelon Maurice, Andres M Lebensohn, Rajat Rohatgi
eLife. 2020; 9: e54469. Published online 2020 May 20. doi: 10.7554/eLife.54469
PMCID:
PMC7239654
AbstractArticlePDF–2.7M
11.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
12.
R-spondin 2-LGR4 system regulates growth, migration and invasion, epithelial-mesenchymal transition and stem-like properties of tongue squamous cell carcinoma via Wnt/β-catenin signaling
Liping Zhang, Yan Song, Zihang Ling, Yuanyuan Li, Xianyue Ren, Jing Yang, Zhi Wang, Juan Xia, Weizhen Zhang, Bin Cheng
EBioMedicine. 2019 Jun; 44: 275–288. Published online 2019 May 13. doi: 10.1016/j.ebiom.2019.03.076
PMCID:
PMC6603804
AbstractArticlePDF–7.4M
13.
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei
Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck
Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924
PMCID:
PMC6166682
AbstractArticlePDF–3.8M
14.
Identification of RSPO2 Fusion Mutations and Target Therapy Using a Porcupine Inhibitor
Chong Li, Jing Cao, Ning Zhang, Meiqing Tu, Fengwei Xu, Shuang Wei, Xiaojing Chen, Yuhong Xu
Sci Rep. 2018; 8: 14244. Published online 2018 Sep 24. doi: 10.1038/s41598-018-32652-3
PMCID:
PMC6155119
AbstractArticlePDF–4.1M
15.
The Matricellular Protein R-Spondin 2 Promotes Midbrain Dopaminergic Neurogenesis and Differentiation
Daniel Gyllborg, Maqsood Ahmed, Enrique M. Toledo, Spyridon Theofilopoulos, Shanzheng Yang, Charles ffrench-Constant, Ernest Arenas
Stem Cell Reports. 2018 Sep 11; 11(3): 651–664. Published online 2018 Aug 23. doi: 10.1016/j.stemcr.2018.07.014
PMCID:
PMC6135723
AbstractArticlePDF–2.5M
16.
Differential activities and mechanisms of the four R-spondins in potentiating Wnt/β-catenin signaling
Soohyun Park, Jie Cui, Wangsheng Yu, Ling Wu, Kendra S. Carmon, Qingyun J. Liu
J Biol Chem. 2018 Jun 22; 293(25): 9759–9769. Published online 2018 May 11. doi: 10.1074/jbc.RA118.002743
PMCID:
PMC6016459
AbstractArticlePDF–2.2M
17.
R-spondin2, a novel target of NOBOX: identification of variants in a cohort of women with primary ovarian insufficiency
Justine Bouilly, Isabelle Beau, Sara Barraud, Valérie Bernard, Brigitte Delemer, Jacques Young, Nadine Binart
J Ovarian Res. 2017; 10: 51. Published online 2017 Jul 25. doi: 10.1186/s13048-017-0345-0
PMCID:
PMC5526297
AbstractArticlePDF–675K
18.
RSPOs facilitated HSC activation and promoted hepatic fibrogenesis
Xinguang Yin, Huixing Yi, Linlin Wang, Wanxin Wu, Xiaojun Wu, Linghua Yu
Oncotarget. 2016 Sep 27; 7(39): 63767–63778. Published online 2016 Aug 27. doi: 10.18632/oncotarget.11654
PMCID:
PMC5325402
AbstractArticlePDF–7.2M
19.
Rspo2 suppresses CD36-mediated apoptosis in oxidized low density lipoprotein-induced macrophages
Hui Yan, Shuai Wang, Zhenwei Li, Zewei Sun, Jie Zan, Wenting Zhao, Yanyun Pan, Zhen Wang, Mingjie Wu, Jianhua Zhu
Mol Med Rep. 2016 Oct; 14(4): 2945–2952. Published online 2016 Aug 19. doi: 10.3892/mmr.2016.5642
PMCID:
PMC5042761
AbstractArticlePDF–1.1M
20.
Identification and Functional Characterization of RSPO2 as a Susceptibility Gene for Ossification of the Posterior Longitudinal Ligament of the Spine
Masahiro Nakajima, Ikuyo Kou, Hirofumi Ohashi, Genetic Study Group of the Investigation Committee on the Ossification of Spinal Ligaments, Shiro Ikegawa
Am J Hum Genet. 2016 Jul 7; 99(1): 202–207. Published online 2016 Jun 30. doi: 10.1016/j.ajhg.2016.05.018
PMCID:
PMC5005442
AbstractArticlePDF–993K

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