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Items: 1 to 20 of 28

1.
Identification and experimental validation of KMO as a critical immune-associated mitochondrial gene in unstable atherosclerotic plaque
Fu-Jun Liao, Shao-Liang Shen, Hai-Long Bao, Hui Li, Quan-Wei Zhao, Long Chen, Cai-Wei Gong, Cheng-Zhu Xiong, Wu-Peng Liu, Wei Li, Da-Nan Liu
J Transl Med. 2024; 22: 668. Published online 2024 Jul 18. doi: 10.1186/s12967-024-05464-5
PMCID:
PMC11256392
AbstractArticlePDF–10M
2.
Enzymology of NAD+ homeostasis in man
G. Magni, A. Amici, M. Emanuelli, G. Orsomando, N. Raffaelli, S. Ruggieri
Cell Mol Life Sci. 2004 Jan; 61(1): 19–34. doi: 10.1007/s00018-003-3161-1
PMCID:
PMC11138864
AbstractArticlePDF–291K
3.
FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia
Xiao-Na Zhu, Yu-Sheng Wei, Qian Yang, Hao-Ran Liu, Zhe Zhi, Di Zhu, Li Xia, Deng-Li Hong, Yun Yu, Guo-Qiang Chen
J Hematol Oncol. 2023; 16: 9. Published online 2023 Feb 11. doi: 10.1186/s13045-023-01400-0
PMCID:
PMC9922468
AbstractArticlePDF–4.9M
4.
The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors
Tamera D. Hughes, Osman F. Güner, Emma Carine Iradukunda, Robert S. Phillips, J. Phillip Bowen
Molecules. 2022 Jan; 27(1): 273. Published online 2022 Jan 2. doi: 10.3390/molecules27010273
PMCID:
PMC8747024
AbstractArticlePDF–2.8M
5.
Kynurenine Monooxygenase Expression and Activity in Human Astrocytomas
Gustavo Ignacio Vázquez Cervantes, Benjamín Pineda, Daniela Ramírez Ortega, Alelí Salazar, Dinora Fabiola González Esquivel, Daniel Rembao, Sergio Zavala Vega, Saúl Gómez-Manzo, Gonzalo Pérez de la Cruz, Verónica Pérez de la Cruz
Cells. 2021 Aug; 10(8): 2028. Published online 2021 Aug 8. doi: 10.3390/cells10082028
PMCID:
PMC8393384
AbstractArticlePDF–3.4M
6.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
7.
A novel role for kynurenine 3-monooxygenase in mitochondrial dynamics
Daniel C. Maddison, Mónica Alfonso-Núñez, Aisha M. Swaih, Carlo Breda, Susanna Campesan, Natalie Allcock, Anna Straatman-Iwanowska, Charalambos P. Kyriacou, Flaviano Giorgini
PLoS Genet. 2020 Nov; 16(11): e1009129. Published online 2020 Nov 10. doi: 10.1371/journal.pgen.1009129
PMCID:
PMC7654755
AbstractArticlePDF–2.7M
8.
Dysregulation at multiple points of the kynurenine pathway is a ubiquitous feature of renal cancer: implications for tumour immune evasion
Nick Hornigold, Karen R. Dunn, Rachel A. Craven, Alexandre Zougman, Sebastian Trainor, Rebecca Shreeve, Joanne Brown, Helen Sewell, Michael Shires, Margaret Knowles, Tsutomu Fukuwatari, Eamonn R. Maher, Julie Burns, Selina Bhattarai, Mini Menon, Alvis Brazma, Ghislaine Scelo, Lara Feulner, Yasser Riazalhosseini, Mark Lathrop, Adrian Harris, Peter J. Selby, Rosamonde E. Banks, Naveen S. Vasudev
Br J Cancer. 2020 Jul 7; 123(1): 137–147. Published online 2020 May 11. doi: 10.1038/s41416-020-0874-y
PMCID:
PMC7341846
AbstractArticlePDF–1.3M
9.
Kynurenine 3-monooxygenase upregulates pluripotent genes through β-catenin and promotes triple-negative breast cancer progression
Tzu-Ting Huang, Ling-Ming Tseng, Ji-Lin Chen, Pei-Yi Chu, Chia-Han Lee, Chun-Teng Huang, Wan-Lun Wang, Ka-Yi Lau, Mei-Fang Tseng, Yuan-Ya Chang, Tzu-Yi Chiang, Yune-Fang Ueng, Hsin-Chen Lee, Ming-Shen Dai, Chun-Yu Liu
EBioMedicine. 2020 Apr; 54: 102717. Published online 2020 Apr 27. doi: 10.1016/j.ebiom.2020.102717
PMCID:
PMC7191260
AbstractArticlePDF–5.3M
10.
Endogenous Cell Type-Specific DISC1 Interactomes Reveal Protein Networks Associated to Neurodevelopmental Disorders
Brent Wilkinson, Oleg Evgrafov, DongQing Zheng, Nicolas Hartel, James A. Knowles, Nicholas A. Graham, Justin Ichida, Marcelo P. Coba
Biol Psychiatry. Author manuscript; available in PMC 2020 Feb 15.
Published in final edited form as: Biol Psychiatry. 2019 Feb 15; 85(4): 305–316. Published online 2018 May 23. doi: 10.1016/j.biopsych.2018.05.009
PMCID:
PMC6251761
AbstractArticlePDF–1.6M
11.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M
12.
Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease
Felipe Roberti Teixeira, Suzanne J. Randle, Shachi P. Patel, Tycho E.T. Mevissen, Grasilda Zenkeviciute, Tie Koide, David Komander, Heike Laman
Biochem J. 2016 Oct 15; 473(20): 3563–3580. Prepublished online 2016 Aug 8. Published online 2016 Oct 11. doi: 10.1042/BCJ20160387
PMCID:
PMC5260939
AbstractArticlePDF–1.1M
13.
Loss of Kynurenine 3-Mono-oxygenase Causes Proteinuria
Ron Korstanje, Konstantin Deutsch, Patricia Bolanos-Palmieri, Nils Hanke, Patricia Schroder, Lynne Staggs, Jan H. Bräsen, Ian S.D. Roberts, Susan Sheehan, Holly Savage, Hermann Haller, Mario Schiffer
J Am Soc Nephrol. 2016 Nov; 27(11): 3271–3277. Published online 2016 Mar 28. doi: 10.1681/ASN.2015070835
PMCID:
PMC5084883
AbstractArticle
14.
A genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder
CM Sellgren, ME Kegel, SE Bergen, CJ Ekman, S Olsson, M Larsson, MP Vawter, L Backlund, PF Sullivan, P Sklar, JW Smoller, PKE Magnusson, CM Hultman, L Walther-Jallow, CI Svensson, P Lichtenstein, M Schalling, G Engberg, S Erhardt, M Landén
Mol Psychiatry. Author manuscript; available in PMC 2016 Aug 18.
Published in final edited form as: Mol Psychiatry. 2014 Mar; 19(3): 334–341. Published online 2013 Mar 5. doi: 10.1038/mp.2013.11
PMCID:
PMC4990004
AbstractArticlePDF–556K
15.
Kynurenine–3–monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis
Damian J Mole, Scott P Webster, Iain Uings, Xiaozhong Zheng, Margaret Binnie, Kris Wilson, Jonathan P Hutchinson, Olivier Mirguet, Ann Walker, Benjamin Beaufils, Nicolas Ancellin, Lionel Trottet, Véronique Bénéton, Christopher G Mowat, Martin Wilkinson, Paul Rowland, Carl Haslam, Andrew McBride, Natalie ZM Homer, James E Baily, Matthew GF Sharp, O James Garden, Jeremy Hughes, Sarah EM Howie, Duncan S Holmes, John Liddle, John P Iredale
Nat Med. Author manuscript; available in PMC 2016 Jul 11.
Published in final edited form as: Nat Med. 2016 Feb; 22(2): 202–209. Published online 2016 Jan 11. doi: 10.1038/nm.4020
PMCID:
PMC4871268
AbstractArticlePDF–1.1M
16.
Overexpression of human kynurenine-3-monooxygenase protects against 3-hydroxykynurenine-mediated apoptosis through bidirectional nonlinear feedback
K Wilson, M Auer, M Binnie, X Zheng, N T Pham, J P Iredale, S P Webster, D J Mole
Cell Death Dis. 2016 Apr; 7(4): e2197. Published online 2016 Apr 14. doi: 10.1038/cddis.2016.87
PMCID:
PMC4855666
AbstractArticlePDF–2.2M
17.
Influence of kynurenine 3-monooxygenase (KMO) gene polymorphism on cognitive function in schizophrenia
Ikwunga Wonodi, Robert P. McMahon, Nithin Krishna, Braxton D. Mitchell, Judy Liu, Matthew Glassman, L. Elliot Hong, James M. Gold
Schizophr Res. Author manuscript; available in PMC 2015 Dec 1.
Published in final edited form as: Schizophr Res. 2014 Dec; 160(0): 80–87. Published online 2014 Nov 14. doi: 10.1016/j.schres.2014.10.026
PMCID:
PMC4516229
AbstractArticlePDF–1004K
18.
Prognostic significance of kynurenine 3-monooxygenase and effects on proliferation, migration, and invasion of human hepatocellular carcinoma
Haojie Jin, Yurong Zhang, Haiyan You, Xuemei Tao, Cun Wang, Guangzhi Jin, Ning Wang, Haoyu Ruan, Dishui Gu, Xisong Huo, Wenming Cong, Wenxin Qin
Sci Rep. 2015; 5: 10466. Published online 2015 Jun 23. doi: 10.1038/srep10466
PMCID:
PMC4479133
AbstractArticlePDF–1.9M
19.
Bacterial expression of human kynurenine 3-monooxygenase: Solubility, activity, purification
K. Wilson, D.J. Mole, M. Binnie, N.Z.M. Homer, X. Zheng, B.A. Yard, J.P. Iredale, M. Auer, S.P. Webster
Protein Expr Purif. 2014 Mar; 95(100): 96–103. doi: 10.1016/j.pep.2013.11.015
PMCID:
PMC3969302
AbstractArticle
20.
Downregulated Kynurenine 3-Monooxygenase Gene Expression and Enzyme Activity in Schizophrenia and Genetic Association With Schizophrenia Endophenotypes
Ikwunga Wonodi, O. Colin Stine, Korrapati V. Sathyasaikumar, Rosalinda C. Roberts, Braxton D. Mitchell, L. Elliot Hong, Yasushi Kajii, Gunvant K. Thaker, Robert Schwarcz
Arch Gen Psychiatry. Author manuscript; available in PMC 2013 Dec 7.
Published in final edited form as: Arch Gen Psychiatry. 2011 Jul; 68(7): 10.1001/archgenpsychiatry.2011.71. doi: 10.1001/archgenpsychiatry.2011.71
PMCID:
PMC3855543
AbstractArticlePDF–429K

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