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Select item 112376691.

GRP78 recognizes EV-F 3D protein and activates NF-κB to repress virus replication by interacting with CHUK/IKBKB

Xiaoran Chang, Yidi Guo, Qun Zhang, Xuebo Zheng, Xuyuan Cui, Junying Hu, Zhiyuan Zhang, Fan Zhang, Xinping Wang

J Virol. 2024 Jun; 98(6): e00268-24. Published online 2024 May 22. doi: 10.1128/jvi.00268-24

PMCID:: PMC11237669

Abstract Article PDF–4.0M

Select item 111132972.

Anna Senegas, Jérémie Gautheron, Alice Gentil Dit Maurin, Gilles Courtois

Cell Mol Life Sci. 2015 Apr; 72(7): 1275–1287. Published online 2014 Nov 29. doi: 10.1007/s00018-014-1793-y

Correction in:: Cell Mol Life Sci. 2015 Apr; 72(7): 1289.

PMCID:: PMC11113297

Abstract Article PDF–1.4M

Select item 111094833.

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors

Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer

Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740

PMCID:: PMC11109483

Abstract Article PDF–2.9M

Select item 107834334.

IκB kinase phosphorylates cytoplasmic TDP-43 and promotes its proteasome degradation

Yohei Iguchi, Yuhei Takahashi, Jiayi Li, Kunihiko Araki, Yoshinobu Amakusa, Yu Kawakami, Kenta Kobayashi, Satoshi Yokoi, Masahisa Katsuno

J Cell Biol. 2024 Feb 5; 223(2): e202302048. Published online 2024 Jan 10. doi: 10.1083/jcb.202302048

PMCID:: PMC10783433

Abstract Article PDF–6.5M

Select item 102443835.

IKK-mediated TRAF6 and RIPK1 interaction stifles cell death complex assembly leading to the suppression of TNF-α-induced cell death

Choong-Sil Lee, Gyuho Hwang, Young Woo Nam, Chi Hyun Hwang, Jaewhan Song

Cell Death Differ. 2023 Jun; 30(6): 1575–1584. Published online 2023 Apr 21. doi: 10.1038/s41418-023-01161-w

PMCID:: PMC10244383

Abstract Article PDF–2.8M

Select item 102374226.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 101368387.

IKKβ Inhibition Attenuates Epithelial Mesenchymal Transition of Human Stem Cell-Derived Retinal Pigment Epithelium

Srinivasa R. Sripathi, Ming-Wen Hu, Ravi Chakra Turaga, Rebekah Mikeasky, Ganesh Satyanarayana, Jie Cheng, Yukan Duan, Julien Maruotti, Karl J. Wahlin, Cynthia A. Berlinicke, Jiang Qian, Noriko Esumi, Donald J. Zack

Cells. 2023 Apr; 12(8): 1155. Published online 2023 Apr 13. doi: 10.3390/cells12081155

PMCID:: PMC10136838

Abstract Article PDF–5.7M

Select item 100729068.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 100621309.

Molluscum Contagiosum Virus Protein MC008 Targets NF-κB Activation by Inhibiting Ubiquitination of NEMO

Thomas Phelan, Clara Lawler, Andreas Pichlmair, Mark A. Little, Andrew G. Bowie, Gareth Brady

J Virol. 2023 Mar; 97(3): e00108-23. Published online 2023 Mar 14. doi: 10.1128/jvi.00108-23

PMCID:: PMC10062130

Abstract Article PDF–2.4M

Select item 1000942410.

SARS-CoV-2 ORF3a positively regulates NF-κB activity by enhancing IKKβ-NEMO interaction

Ying Nie, Lumin Mou, Qizhou Long, Dongqing Deng, Rongying Hu, Jinzhi Cheng, Jiahong Wu

Virus Res. 2023 Apr 15; 328: 199086. Published online 2023 Mar 13. doi: 10.1016/j.virusres.2023.199086

PMCID:: PMC10009424

Abstract Article PDF–3.3M

Select item 1000869011.

Phosphorylation by IKKβ Promotes the Degradation of HMGCL via NEDD4 in Lung Cancer

Chenxi Zhong, Guosheng Xiong, Haitang Yang, Xiaohua Du, Jiankui Du, Feng Yao, Wentao Fang, Yuezhen Deng

Int J Biol Sci. 2023; 19(4): 1110–1122. Published online 2023 Feb 5. doi: 10.7150/ijbs.82015

PMCID:: PMC10008690

Abstract Article PDF–6.9M

Select item 988991612.

Linear ubiquitination induces NEMO phase separation to activate NF-κB signaling

Simran Goel, Rosario Oliva, Sadasivam Jeganathan, Verian Bader, Laura J Krause, Simon Kriegler, Isabelle D Stender, Chadwick W Christine, Ken Nakamura, Jan-Erik Hoffmann, Roland Winter, Jörg Tatzelt, Konstanze F Winklhofer

Life Sci Alliance. 2023 Apr; 6(4): e202201607. Published online 2023 Jan 31. doi: 10.26508/lsa.202201607

PMCID:: PMC9889916

Abstract Article PDF–2.9M

Select item 984344013.

The inhibitor of κB kinase β (IKKβ) phosphorylates IκBα twice in a single binding event through a sequential mechanism

Anthony A. Stephenson, David J. Taggart, Guozhou Xu, Jason D. Fowler, Hao Wu, Zucai Suo

J Biol Chem. 2023 Jan; 299(1): 102796. Published online 2022 Dec 14. doi: 10.1016/j.jbc.2022.102796

PMCID:: PMC9843440

Abstract Article PDF–1.7M

Select item 972467114.

Human ZBP1 induces cell death‐independent inflammatory signaling via RIPK3 and RIPK1

Ruoshi Peng, Chris Kedong Wang, Xuan Wang‐Kan, Manja Idorn, Majken Kjær, Felix Y Zhou, Berthe Katrine Fiil, Frederik Timmermann, Susana L Orozco, Julia McCarthy, Carol S Leung, Xin Lu, Katrin Bagola, Jan Rehwinkel, Andrew Oberst, Jonathan Maelfait, Søren R Paludan, Mads Gyrd‐Hansen

EMBO Rep. 2022 Dec; 23(12): e55839. Published online 2022 Oct 21. doi: 10.15252/embr.202255839

PMCID:: PMC9724671

Abstract Article PDF–1.8M

Select item 970452715.

Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC

Tom Snelling, Natalia Shpiro, Robert Gourlay, Frederic Lamoliatte, Philip Cohen

Biochem J. 2022 Oct 28; 479(20): 2195–2216. Published online 2022 Oct 21. doi: 10.1042/BCJ20220401

PMCID:: PMC9704527

Abstract Article PDF–7.7M

Select item 969411416.

Stress response protein REDD1 promotes diabetes-induced retinal inflammation by sustaining canonical NF-κB signaling

Siddharth Sunilkumar, Allyson L. Toro, Christopher M. McCurry, Ashley M. VanCleave, Shaunaci A. Stevens, William P. Miller, Scot R. Kimball, Michael D. Dennis

J Biol Chem. 2022 Dec; 298(12): 102638. Published online 2022 Oct 26. doi: 10.1016/j.jbc.2022.102638

PMCID:: PMC9694114

Abstract Article PDF–2.0M

Select item 967639617.

HBV X Protein Induces Degradation of UBXN7, a Novel Negative Regulator of NF-κB Signaling, to Promote HBV Replication

Sen Yuan, Jiaqi Xu, Min Wang, Junsong Huang, Shuangshuang Ma, Yang Liu, Yujia Ke, Xianhuang Zeng, Kangwei Wu, Jingwen Wang, Xuezhang Tian, Dandan Zheng, Tanzeel Yousaf, Wajeeha Naz, Junwei Sun, Lang Chen, Deyin Guo, Mingxiong Guo, Guihong Sun

Cell Mol Gastroenterol Hepatol. 2023; 15(1): 179–195. Published online 2022 Sep 9. doi: 10.1016/j.jcmgh.2022.09.003

PMCID:: PMC9676396

Abstract Article PDF–5.0M

Select item 951717318.

Crosstalk of the IκB kinase with spliced X-box binding protein 1 couples inflammation with glucose metabolic reprogramming in epithelial-mesenchymal transition

Yingxin Zhao, Jing Zhang, Hong Sun, Allan R Brasier

J Proteome Res. Author manuscript; available in PMC 2022 Sep 28.

Published in final edited form as: J Proteome Res. 2021 Jul 2; 20(7): 3475–3488. Published online 2021 Jun 14. doi: 10.1021/acs.jproteome.1c00093

PMCID:: PMC9517173

Abstract Article PDF–2.1M

Select item 934596119.

Targeting HECTD3-IKKα axis inhibits inflammation-related metastasis

Fubing Li, Huichun Liang, Hua You, Ji Xiao, Houjun Xia, Xi Chen, Maobo Huang, Zhuo Cheng, Chuanyu Yang, Wenjing Liu, Hailin Zhang, Li Zeng, Yingying Wu, Fei Ge, Zhen Li, Wenhui Zhou, Yi Wen, Zhongmei Zhou, Rong Liu, Dewei Jiang, Ni Xie, Bin Liang, Zhenzhen Liu, Yanjie Kong, Ceshi Chen

Signal Transduct Target Ther. 2022; 7: 264. Published online 2022 Aug 3. doi: 10.1038/s41392-022-01057-0

PMCID:: PMC9345961

Abstract Article PDF–6.4M

Select item 929541720.

A Central Region of NEMO is Required for IKKβ-Induced Conformational Change and for Signal Propagation

Robert Shaffer, Anthony M. DeMaria, Larisa Kagermazova, Yuekun Liu, Milad Babaei, Suhaily Penix, Arisdelsy Cervantes, Stefan Jehle, Lee Makowski, Thomas D. Gilmore, Adrian Whitty, Karen N. Allen

Biochemistry. Author manuscript; available in PMC 2022 Jul 19.

Published in final edited form as: Biochemistry. 2019 Jul 2; 58(26): 2906–2920. Published online 2019 Jun 18. doi: 10.1021/acs.biochem.8b01316