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Select item 111121251.

DLC1 promotes mechanotransductive feedback for YAP via RhoGAP-mediated focal adhesion turnover

Aukie Hooglugt, Miesje M. van der Stoel, Apeksha Shapeti, Beau F. Neep, Annett de Haan, Hans van Oosterwyck, Reinier A. Boon, Stephan Huveneers

J Cell Sci. 2024 Apr 15; 137(8): jcs261687. Published online 2024 Apr 30. doi: 10.1242/jcs.261687

PMCID:: PMC11112125

Abstract Article

Select item 89431372.

Proteasomal turnover of the RhoGAP tumor suppressor DLC1 is regulated by HECTD1 and USP7

Yannick Frey, Mirita Franz-Wachtel, Boris Macek, Monilola A. Olayioye

Sci Rep. 2022; 12: 5036. Published online 2022 Mar 23. doi: 10.1038/s41598-022-08844-3

PMCID:: PMC8943137

Abstract Article PDF–2.1M

Select item 85619243.

The tumor suppressor activity of DLC1 requires the interaction of its START domain with Phosphatidylserine, PLCD1, and Caveolin-1

Beatriz Sanchez-Solana, Dunrui Wang, Xiaolan Qian, Parthibane Velayoudame, Dhirendra K. Simanshu, Jairaj K. Acharya, Douglas R. Lowy

Mol Cancer. 2021; 20: 141. Published online 2021 Nov 2. doi: 10.1186/s12943-021-01439-y

PMCID:: PMC8561924

Abstract Article PDF–5.1M

Select item 84124394.

Cancer-associated point mutations in the DLC1 tumor suppressor and other Rho-GAPs occur frequently and are associated with decreased function

Dunui Wang, Xiaolan Qian, Beatriz Sanchez-Solana, Brajendra K. Tripathi, Marian E. Durkin, Douglas R. Lowy

Cancer Res. Author manuscript; available in PMC 2021 Sep 2.

Published in final edited form as: Cancer Res. 2020 Sep 1; 80(17): 3568–3579. Published online 2020 Jun 30. doi: 10.1158/0008-5472.CAN-19-3984

PMCID:: PMC8412439

Abstract Article PDF–1.1M

Select item 82761165.

DLC1 deficiency and YAP signaling drive endothelial cell contact inhibition of growth and tumorigenesis

Lisa Ritchey, Taekyu Ha, Atsushi Otsuka, Kenji Kabashima, Dunrui Wang, Yuyi Wang, Douglas R. Lowy, Giovanna Tosato

Oncogene. Author manuscript; available in PMC 2021 Jul 13.

Published in final edited form as: Oncogene. 2019 Nov; 38(45): 7046–7059. Published online 2019 Aug 13. doi: 10.1038/s41388-019-0944-x

PMCID:: PMC8276116

Abstract Article PDF–3.6M

Select item 81989166.

Oncogenic Role of miR-200c-3p in High-Grade Serous Ovarian Cancer Progression via Targeting the 3′-Untranslated Region of DLC1

Sheril June Ankasha, Mohamad Nasir Shafiee, Norhazlina Abdul Wahab, Raja Affendi Raja Ali, Norfilza Mohd Mokhtar

Int J Environ Res Public Health. 2021 Jun; 18(11): 5741. Published online 2021 May 27. doi: 10.3390/ijerph18115741

PMCID:: PMC8198916

Abstract Article PDF–1.4M

Select item 81650307.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80936158.

MIR-301b-3p Promotes Lung Adenocarcinoma Cell Proliferation, Migration and Invasion by Targeting DLC1

Haitao Liu, Xingjie Ma, Niu Niu, Junjie Zhao, Chao Lu, Fan Yang, Weibo Qi

Technol Cancer Res Treat. 2021; 20: 1533033821990036. Published online 2021 Mar 23. doi: 10.1177/1533033821990036

PMCID:: PMC8093615

Abstract Article PDF–1.0M

Select item 79502619.

TMEM106C contributes to the malignant characteristics and poor prognosis of hepatocellular carcinoma

Jicheng Duan, Youwen Qian, Xiaohui Fu, Meiling Chen, Kai Liu, Hu Liu, Jiahe Yang, Chen Liu, Yanxin Chang

Aging (Albany NY) 2021 Feb 28; 13(4): 5585–5606. Published online 2021 Feb 11. doi: 10.18632/aging.202487

PMCID:: PMC7950261

Abstract Article PDF–2.2M

Select item 775805010.

In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators

Jennifer L. Franks, Raquel C. Martinez-Chacin, Xianxi Wang, Rochelle L. Tiedemann, Thomas Bonacci, Rajarshi Choudhury, Derek L. Bolhuis, Taylor P. Enrico, Ryan D. Mouery, Jeffrey S. Damrauer, Feng Yan, Joseph S. Harrison, M. Ben Major, Katherine A. Hoadley, Aussie Suzuki, Scott B. Rothbart, Nicholas G. Brown, Michael J. Emanuele

PLoS Biol. 2020 Dec; 18(12): e3000975. Published online 2020 Dec 11. doi: 10.1371/journal.pbio.3000975

PMCID:: PMC7758050

Abstract Article PDF–4.2M

Select item 773888811.

Circular RNA circDLC1 inhibits MMP1-mediated liver cancer progression via interaction with HuR

Hailing Liu, Tian Lan, Hui Li, Lin Xu, Xing Chen, Haotian Liao, Xiangzheng Chen, Jinpeng Du, Yunshi Cai, Jinju Wang, Xuefeng Li, Jiwei Huang, Kefei Yuan, Yong Zeng

Theranostics. 2021; 11(3): 1396–1411. Published online 2021 Jan 1. doi: 10.7150/thno.53227

PMCID:: PMC7738888

Abstract Article PDF–3.8M

Select item 766265412.

Identifying Cancer-Relevant Mutations in the DLC START Domain Using Evolutionary and Structure-Function Analyses

Ashton S. Holub, Renee A. Bouley, Ruben C. Petreaca, Aman Y. Husbands

Int J Mol Sci. 2020 Nov; 21(21): 8175. Published online 2020 Oct 31. doi: 10.3390/ijms21218175

PMCID:: PMC7662654

Abstract Article PDF–3.6M

Select item 752126613.

Curcumin inhibits the growth of triple‐negative breast cancer cells by silencing EZH2 and restoring DLC1 expression

Xueliang Zhou, Dechao Jiao, Mengmeng Dou, Weijie Zhang, Liying Lv, Jianjian Chen, Lifeng Li, Liuxing Wang, Xinwei Han

J Cell Mol Med. 2020 Sep; 24(18): 10648–10662. Published online 2020 Jul 28. doi: 10.1111/jcmm.15683

PMCID:: PMC7521266

Abstract Article PDF–3.3M

Select item 747739314.

Inactivation of the Dlc1 gene cooperates with down-regulation of p15^INK4b and p16^Ink4a leading to neoplastic transformation and poor prognosis in human cancer

Xiaolan Qian, Marian E. Durkin, Dunrui Wang, Brajendra K. Tripathi, Lyra Olson, Xu-yu Yang, William C. Vass, Nicholas C. Popescu, Douglas R. Lowy

Cancer Res. Author manuscript; available in PMC 2020 Sep 8.

Published in final edited form as: Cancer Res. 2012 Nov 15; 72(22): 5900–5911. Published online 2012 Sep 25. doi: 10.1158/0008-5472.CAN-12-2368

PMCID:: PMC7477393

Abstract Article PDF–2.3M

Select item 722086915.

Nuclear DLC1 exerts oncogenic function through association with FOXK1 for cooperative activation of MMP9 expression in melanoma

Xintao Yang, Feng Hu, Jessica Aijia Liu, Shan Yu, May Pui Lai Cheung, Xuelai Liu, Irene Oi-Lin Ng, Xin-Yuan Guan, Kelvin K. W. Wong, Rakesh Sharma, Hong Lok Lung, Yufei Jiao, Leo Tsz On Lee, Martin Cheung

Oncogene. 2020; 39(20): 4061–4076. Published online 2020 Mar 25. doi: 10.1038/s41388-020-1274-8

PMCID:: PMC7220869

Abstract Article PDF–7.5M

Select item 721532016.

Inhibition of miR-141 and miR-200a Increase DLC-1 and ZEB2 Expression, Enhance Migration and Invasion in Metastatic Serous Ovarian Cancer

Norhazlina Abdul Wahab, Zahreena Othman, Noor Wahidah Mohd Nasri, Mohd Helmy Mokhtar, Siti Fatimah Ibrahim, Adila A. Hamid, Raja Affendi Raja Ali, Norfilza Mohd Mokhtar

Int J Environ Res Public Health. 2020 Apr; 17(8): 2766. Published online 2020 Apr 17. doi: 10.3390/ijerph17082766

PMCID:: PMC7215320

Abstract Article PDF–2.4M

Select item 695652517.

DLC1 SAM domain-binding peptides inhibit cancer cell growth and migration by inactivating RhoA

Rakesh Joshi, Lyugao Qin, Xuan Cao, Shanshan Zhong, Courtney Voss, Weiping Min, Shawn S. C. Li

J Biol Chem. 2020 Jan 10; 295(2): 645–656. Published online 2019 Dec 5. doi: 10.1074/jbc.RA119.011929

PMCID:: PMC6956525

Abstract Article PDF–2.7M

Select item 684911218.

Sequencing Analysis at 8p23 Identifies Multiple Rare Variants in DLC1 Associated with Sleep-Related Oxyhemoglobin Saturation Level

Jingjing Liang, Brian E. Cade, Karen Y. He, Heming Wang, Jiwon Lee, Tamar Sofer, Stephanie Williams, Ruitong Li, Han Chen, Daniel J. Gottlieb, Daniel S. Evans, Xiuqing Guo, Sina A. Gharib, Lauren Hale, David R. Hillman, Pamela L. Lutsey, Sutapa Mukherjee, Heather M. Ochs-Balcom, Lyle J. Palmer, Jessica Rhodes, Shaun Purcell, Sanjay R. Patel, Richa Saxena, Katie L. Stone, Weihong Tang, Gregory J. Tranah, Eric Boerwinkle, Xihong Lin, Yongmei Liu, Bruce M. Psaty, Ramachandran S. Vasan, Michael H. Cho, Ani Manichaikul, Edwin K. Silverman, R. Graham Barr, Stephen S. Rich, Jerome I. Rotter, James G. Wilson, NHLBI Trans-Omics for Precision Medicine (TOPMed), TOPMed Sleep Working Group, Susan Redline, Xiaofeng Zhu

Am J Hum Genet. 2019 Nov 7; 105(5): 1057–1068. Published online 2019 Oct 24. doi: 10.1016/j.ajhg.2019.10.002

PMCID:: PMC6849112

Abstract Article PDF–2.1M

Select item 671944219.

SRC and ERK cooperatively phosphorylate DLC1 and attenuate its Rho-GAP and tumor suppressor functions

Brajendra K. Tripathi, Meghan F. Anderman, Xiaolan Qian, Ming Zhou, Dunrui Wang, Alex G. Papageorge, Douglas R. Lowy

J Cell Biol. 2019 Sep 2; 218(9): 3060–3076. Published online 2019 Jul 15. doi: 10.1083/jcb.201810098

PMCID:: PMC6719442

Abstract Article PDF–4.3M

Select item 626479320.

Functional interaction of tumor suppressor DLC1 and caveolin-1 in cancer cells

Xiaoli Du, Xiaolan Qian, Alex Papageorge, Aaron J. Schetter, William C. Vass, Xi Liu, Richard Braverman, Ana I. Robles, Douglas R. Lowy

Cancer Res. Author manuscript; available in PMC 2018 Nov 29.

Published in final edited form as: Cancer Res. 2012 Sep 1; 72(17): 4405–4416. Published online 2012 Jun 12. doi: 10.1158/0008-5472.CAN-12-0777

PMCID:: PMC6264793

Abstract Article PDF–3.5M

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