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Select item 102374221.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 100824802.

Proinflammatory plasticity towards Th17 paradigm of regulatory T cells consistent with elevated prevalence of TGFBR2 variants in elderly patients with primary immune thrombocytopenia

Jingjing Cao, Yanxia Zhan, Lili Ji, Pu Chen, Luya Cheng, Feng Li, Xibing Zhuang, Zhihui Min, Lihua Sun, Fanli Hua, Hao Chen, Boting Wu, Yunfeng Cheng

BMC Immunol. 2023; 24: 6. Published online 2023 Apr 7. doi: 10.1186/s12865-023-00541-8

PMCID:: PMC10082480

Abstract Article PDF–1.9M

Select item 100653253.

Clinical utility of TGFB1 and its receptors (TGFBR1 and TGFBR2) in thyroid nodules: evaluation based on single nucleotide polymorphisms and mRNA analysis

Karina Colombera Peres, Larissa Teodoro, Laís Helena Pereira Amaral, Elisângela Souza Teixeira, Icléia Siqueira Barreto, Leandro Luiz Lopes de Freitas, Valdemar Maximo, Lígia V. Montalli Assumpção, Natassia Elena Bufalo, Laura Sterian Ward

Arch Endocrinol Metab. 2021 Mar-Apr; 65(2): 172–184. Published online 2021 Feb 25. doi: 10.20945/2359-3997000000330

PMCID:: PMC10065325

Abstract Article PDF–421K

Select item 99901784.

Therapeutic potency of compound RMY-205 for pulmonary fibrosis induced by SARS-CoV-2 nucleocapsid protein

Zhi-yuan Zhang, Cui-yu Ju, Liu-zheng Wu, Han Yan, Wen-bin Hong, Hang-zi Chen, Peng-bo Yang, Bao-Rui Wang, Tong Gou, Xiao-yan Chen, Zhi-hong Jiang, Wei-jia Wang, Tianwei Lin, Fu-nan Li, Qiao Wu

Cell Chem Biol. 2023 Mar 16; 30(3): 261–277.e8. Published online 2023 Mar 7. doi: 10.1016/j.chembiol.2023.02.004

PMCID:: PMC9990178

Abstract Article PDF–6.9M

Select item 98593225.

Loss of Function TGFBR2 Variant as a Contributing Factor in Generalized Pustular Psoriasis and Adult-Onset Immunodeficiency

Piranit Kantaputra, Teerada Daroontum, Mati Chuamanochan, Suteeraporn Chaowattanapanit, Worrachet Intachai, Bjorn Olsen, Thanapat Sastraruji, Sissades Tongsima, Chumpol Ngamphiw, Jatupol Kampuansai, Timothy C. Cox, Salin Kiratikanon

Genes (Basel) 2023 Jan; 14(1): 103. Published online 2022 Dec 29. doi: 10.3390/genes14010103

PMCID:: PMC9859322

Abstract Article PDF–13M

Select item 96698956.

Enzalutamide-induced and PTH1R-mediated TGFBR2 degradation in osteoblasts confers resistance in prostate cancer bone metastases

Shang Su, Jingchen Cao, Xiangqi Meng, Ruihua Liu, Alexandra Vander Ark, Erica Woodford, Reian Zhang, Isabelle Stiver, Xiaotun Zhang, Zachary B. Madaj, Megan J. Bowman, Yingying Wu, H. Eric Xu, Bin Chen, Haiquan Yu, Xiaohong Li

Cancer Lett. Author manuscript; available in PMC 2023 Jan 28.

Published in final edited form as: Cancer Lett. 2022 Jan 28; 525: 170–178. Published online 2021 Nov 6. doi: 10.1016/j.canlet.2021.10.042

PMCID:: PMC9669895

Abstract Article PDF–1.6M

Select item 93795537.

USP8 promotes cancer progression and extracellular vesicle‐mediated CD8+ T cell exhaustion by deubiquitinating the TGF‐β receptor TβRII

Feng Xie, Xiaoxue Zhou, Heyu Li, Peng Su, Sijia Liu, Ran Li, Jing Zou, Xiang Wei, Chen Pan, Zhengkui Zhang, Min Zheng, Zhuang Liu, Xuli Meng, Huib Ovaa, Peter ten Dijke, Fangfang Zhou, Long Zhang

EMBO J. 2022 Aug; 41(16): e108791. Published online 2022 Jul 11. doi: 10.15252/embj.2021108791

PMCID:: PMC9379553

Abstract Article PDF–5.6M

Select item 93794128.

Decrease of circARID1A retards glioblastoma invasion by modulating miR-370-3p/ TGFBR2 pathway

Baisheng Li, Jiansheng Chen, Yi Wu, Honghai Luo, Yiquan Ke

Int J Biol Sci. 2022; 18(13): 5123–5135. Published online 2022 Aug 8. doi: 10.7150/ijbs.66673

PMCID:: PMC9379412

Abstract Article PDF–1.8M

Select item 93436119.

Breast cancer cell-derived extracellular vesicles promote CD8⁺ T cell exhaustion via TGF-β type II receptor signaling

Feng Xie, Xiaoxue Zhou, Peng Su, Heyu Li, Yifei Tu, Jinjin Du, Chen Pan, Xiang Wei, Min Zheng, Ke Jin, Liyan Miao, Chao Wang, Xuli Meng, Hans van Dam, Peter ten Dijke, Long Zhang, Fangfang Zhou

Nat Commun. 2022; 13: 4461. Published online 2022 Aug 1. doi: 10.1038/s41467-022-31250-2

PMCID:: PMC9343611

Abstract Article PDF–3.2M

Select item 921752610.

Transforming Growth Factor Beta Receptor 2 (TGFBR2) Promoter Region Polymorphisms May Be Involved in Mandibular Retrognathism

Margarita Kirschneck, Nermien Zbidat, Eva Paddenberg, Caio Luiz Bitencourt Reis, Isabela Ribeiro Madalena, Maria Angélica Hueb de Menezes-Oliveira, César Penazzo Lepri, Peter Proff, Christian Kirschneck, Erika Calvano Küchler

Biomed Res Int. 2022; 2022: 1503052. Published online 2022 Jun 15. doi: 10.1155/2022/1503052

PMCID:: PMC9217526

Abstract Article PDF–465K

Select item 920157211.

Shenkang Injection for Treating Renal Fibrosis-Metabonomics and Regulation of E3 Ubiquitin Ligase Smurfs on TGF-β/Smads Signal Transduction

Junju Zou, Xiaotao Zhou, Xian Chen, Yuerong Ma, Rong Yu

Front Pharmacol. 2022; 13: 849832. Published online 2022 Jun 2. doi: 10.3389/fphar.2022.849832

PMCID:: PMC9201572

Abstract Article PDF–7.1M

Select item 909732512.

GABPA-activated TGFBR2 transcription inhibits aggressiveness but is epigenetically erased by oncometabolites in renal cell carcinoma

Zhiqing Fang, Ning Zhang, Xiaotian Yuan, Xiangling Xing, Xiaofeng Li, Xin Qin, Zhengfang Liu, Shiyong Neo, Cheng Liu, Feng Kong, Magnus Björkholm, Yidong Fan, Dawei Xu

J Exp Clin Cancer Res. 2022; 41: 173. Published online 2022 May 12. doi: 10.1186/s13046-022-02382-6

PMCID:: PMC9097325

Abstract Article PDF–9.1M

Select item 903604713.

HTR1A Inhibits the Progression of Triple‐Negative Breast Cancer via TGF‐β Canonical and Noncanonical Pathways

Qiqi Liu, Hefen Sun, Yang Liu, Xuan Li, Baojin Xu, Liangdong Li, Wei Jin

Adv Sci (Weinh) 2022 Apr; 9(12): 2105672. Published online 2022 Feb 24. doi: 10.1002/advs.202105672

PMCID:: PMC9036047

Abstract Article PDF–12M

Select item 892894814.

Influence of TGFBR2, TGFB3, DNMT1, and DNMT3A Knockdowns on CTGF, TGFBR2, and DNMT3A in Neonatal and Adult Human Dermal Fibroblasts Cell Lines

Katarzyna Tomela, Justyna A. Karolak, Barbara Ginter-Matuszewska, Michal Kabza, Marzena Gajecka

Curr Issues Mol Biol. 2021 Jun; 43(1): 276–285. Published online 2021 Jun 3. doi: 10.3390/cimb43010023

PMCID:: PMC8928948

Abstract Article PDF–1.2M

Select item 875267215.

SMURF2 phosphorylation at Thr249 modifies glioma stemness and tumorigenicity by regulating TGF-β receptor stability

Manami Hiraiwa, Kazuya Fukasawa, Takashi Iezaki, Hemragul Sabit, Tetsuhiro Horie, Kazuya Tokumura, Sayuki Iwahashi, Misato Murata, Masaki Kobayashi, Akane Suzuki, Gyujin Park, Katsuyuki Kaneda, Tomoki Todo, Atsushi Hirao, Mitsutoshi Nakada, Eiichi Hinoi

Commun Biol. 2022; 5: 22. Published online 2022 Jan 11. doi: 10.1038/s42003-021-02950-0

PMCID:: PMC8752672

Abstract Article PDF–3.3M

Select item 869096716.

Upregulated expression of transforming growth factor-β receptor I/II in an endemic Osteoarthropathy in China

Ying Zhang, Yudong Mu, Ying He, Zhengzheng Li, Ge Mi, Yinan Liu, Meng Zhang, Hui Wang, Yiping Feng, Qian Fang, Tianyou Ma, Xianghua Deng, Jinghong Chen

BMC Musculoskelet Disord. 2021; 22: 1051. Published online 2021 Dec 20. doi: 10.1186/s12891-021-04939-6

PMCID:: PMC8690967

Abstract Article PDF–1.7M

Select item 865781717.

Splice-Variant Knock-Out of TGFβ Receptors Perturbates the Proteome of Ovarian Carcinoma Cells

Liora Jacobs Catane, Ofra Moshel, Yoav Smith, Ben Davidson, Reuven Reich

Int J Mol Sci. 2021 Dec; 22(23): 12647. Published online 2021 Nov 23. doi: 10.3390/ijms222312647

PMCID:: PMC8657817

Abstract Article PDF–2.7M

Select item 846124918.

A Novel Splice Variant of Human TGF-β Type II Receptor Encodes a Soluble Protein and Its Fc-Tagged Version Prevents Liver Fibrosis in vivo

Marcela Soledad Bertolio, Anabela La Colla, Alejandra Carrea, Ana Romo, Gabriela Canziani, Stella Maris Echarte, Sabrina Campisano, German Patricio Barletta, Alexander Miguel Monzon, Tania Melina Rodríguez, Andrea Nancy Chisari, Ricardo Alfredo Dewey

Front Cell Dev Biol. 2021; 9: 690397. Published online 2021 Sep 10. doi: 10.3389/fcell.2021.690397

PMCID:: PMC8461249

Abstract Article PDF–3.3M

Select item 820174419.

Long non-coding RNA CDKN2B-AS1 enhances LPS-induced apoptotic and inflammatory damages in human lung epithelial cells via regulating the miR-140-5p/TGFBR2/Smad3 signal network

Bing Wang, Qi Sun, Wen Ye, Lianghai Li, Ping Jin

BMC Pulm Med. 2021; 21: 200. Published online 2021 Jun 14. doi: 10.1186/s12890-021-01561-z

PMCID:: PMC8201744

Abstract Article PDF–4.3M

Select item 816503020.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

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