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Select item 112370791.

Silencing CK19 regulates ferroptosis by affecting the expression of GPX4 and ACSL4 in oral squamous cell carcinoma in vivo and in vitro

Yong Rao, Jingying Li, Lijuan Shi, Xiao Chen, Yun Hu, Yalin Mao, Xiaoyan Zhang, Xuqian Liu

Sci Rep. 2024; 14: 15968. Published online 2024 Jul 10. doi: 10.1038/s41598-024-65079-0

PMCID:: PMC11237079

Abstract Article PDF–6.2M

Select item 111602252.

Fatty acid‐CoA ligase 4 is overexpressed in human hepatocellular carcinoma

Young Kwan Sung, Sun Young Hwang, Mi Kyung Park, Han Ik Bae, Woo Ho Kim, Jung‐Chul Kim, Moonkyu Kim

Cancer Sci. 2003 May; 94(5): 421–424. Published online 2005 Aug 19. doi: 10.1111/j.1349-7006.2003.tb01458.x

PMCID:: PMC11160225

Abstract Article PDF–456K

Select item 110993253.

Long-chain acyl-CoA synthetase-4 regulates endometrial decidualization through a fatty acid β-oxidation pathway rather than lipid droplet accumulation

Hongshuo Zhang, Qianyi Sun, Haojie Dong, Zeen Jin, Mengyue Li, Shanyuan Jin, Xiaolan Zeng, Jianhui Fan, Ying Kong

Mol Metab. 2024 Jun; 84: 101953. Published online 2024 May 4. doi: 10.1016/j.molmet.2024.101953

PMCID:: PMC11099325

Abstract Article PDF–5.2M

Select item 110728144.

New inhibitor targeting Acyl-CoA synthetase 4 reduces breast and prostate tumor growth, therapeutic resistance and steroidogenesis

Ana F. Castillo, Ulises D. Orlando, Paula M. Maloberti, Jesica G. Prada, Melina A. Dattilo, Angela R. Solano, María M. Bigi, Mayra A. Ríos Medrano, María T. Torres, Sebastián Indo, Graciela Caroca, Hector R. Contreras, Belkis E. Marelli, Facundo J. Salinas, Natalia R. Salvetti, Hugo H. Ortega, Pablo Lorenzano Menna, Sergio Szajnman, Daniel E. Gomez, Juan B. Rodríguez, Ernesto J. Podesta

Cell Mol Life Sci. 2021 Mar; 78(6): 2893–2910. Published online 2020 Oct 17. doi: 10.1007/s00018-020-03679-5

PMCID:: PMC11072814

Abstract Article PDF–3.6M

Select item 109271105.

Autocrine phosphatase PDP2 inhibits ferroptosis by dephosphorylating ACSL4 in the Luminal A Breast Cancer

Jun-Jie Zhu, Feng-Ying Huang, Hengyu Chen, Yun-long Zhang, Ming-Hui Chen, Ri-Hong Wu, Shu-Zhen Dai, Gui-Sheng He, Guang-Hong Tan, Wu-Ping Zheng

PLoS One. 2024; 19(3): e0299571. Published online 2024 Mar 11. doi: 10.1371/journal.pone.0299571

PMCID:: PMC10927110

Abstract Article PDF–3.5M

Select item 108447646.

Loss of nephric augmenter of liver regeneration facilitates acute kidney injury via ACSL4‐mediated ferroptosis

Lili Huang, Ling Zhang, Zheng Zhang, Fangyan Tan, Yixin Ma, Xujia Zeng, Dan Cao, Lili Deng, Qi Liu, Hang Sun, Bingbing Shen, Xiaohui Liao

J Cell Mol Med. 2024 Feb; 28(3): e18076. Published online 2023 Dec 13. doi: 10.1111/jcmm.18076

PMCID:: PMC10844764

Abstract Article PDF–28M

Select item 107833777.

Serum ACSL4 levels in patients with ST-segment elevation myocardial infarction (STEMI) and its association with one-year major adverse cardiovascular events (MACE): A prospective cohort study

Yun Hu, Qingye Li, Yinglin Wang

Medicine (Baltimore) 2024 Jan 12; 103(2): e36870. Published online 2024 Jan 12. doi: 10.1097/MD.0000000000036870

PMCID:: PMC10783377

Abstract Article PDF–1.2M

Select item 107774668.

SENP1 inhibits ferroptosis and promotes head and neck squamous cell carcinoma by regulating ACSL4 protein stability via SUMO1

Xianzhi Xu, Yiting Mao, Zhaowei Feng, Feng Dai, Teng Gu, Jiwei Zheng

Oncol Rep. 2024 Feb; 51(2): 34. Published online 2023 Dec 28. doi: 10.3892/or.2023.8693

PMCID:: PMC10777466

Abstract Article PDF–17M

Select item 107295639.

miRNA-211 maintains metabolic homeostasis in medulloblastoma through its target gene long-chain acyl-CoA synthetase 4

Menglang Yuan, Iqbal Mahmud, Keisuke Katsushima, Kandarp Joshi, Olivier Saulnier, Rudramani Pokhrel, Bongyong Lee, Wathsala Liyanage, Haritha Kunhiraman, Stacie Stapleton, Ignacio Gonzalez-Gomez, Rangaramanujam M. Kannan, Tanja Eisemann, Elayaraja Kolanthai, Sudipta Seal, Timothy J. Garrett, Saed Abbasi, Kimberly Bockley, Justin Hanes, Prem Chapagain, George Jallo, Robert J. Wechsler-Reya, Michael D. Taylor, Charles G. Eberhart, Animesh Ray, Ranjan J. Perera

Acta Neuropathol Commun. 2023; 11: 203. Published online 2023 Dec 19. doi: 10.1186/s40478-023-01684-w

PMCID:: PMC10729563

Abstract Article PDF–9.5M

Select item 1059181810.

MMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated phosphatidylinositol remodeling and susceptibility to ferroptosis

Vaishnavi V. Phadnis, Jamie Snider, Venkateshwari Varadharajan, Iyappan Ramachandiran, Amy A. Deik, Zon Weng Lai, Tenzin Kunchok, Elinor Ng Eaton, Carolin Sebastiany, Anna Lyakisheva, Kyle D. Vaccaro, Juliet Allen, Zhong Yao, Victoria Wong, Betty Geng, Kipp Weiskopf, Clary B. Clish, J. Mark Brown, Igor Stagljar, Robert A. Weinberg, Whitney S. Henry

Cell Rep. Author manuscript; available in PMC 2023 Oct 23.

Published in final edited form as: Cell Rep. 2023 Sep 26; 42(9): 113023. Published online 2023 Sep 8. doi: 10.1016/j.celrep.2023.113023

PMCID:: PMC10591818

Abstract Article PDF–2.2M

Select item 1047785511.

Inhibition of CDK1 Overcomes Oxaliplatin Resistance by Regulating ACSL4‐mediated Ferroptosis in Colorectal Cancer

Kaixuan Zeng, Weihao Li, Yue Wang, Zifei Zhang, Linjie Zhang, Weili Zhang, Yue Xing, Chi Zhou

Adv Sci (Weinh) 2023 Sep; 10(25): 2301088. Published online 2023 Jul 10. doi: 10.1002/advs.202301088

PMCID:: PMC10477855

Abstract Article PDF–7.1M

Select item 1045727112.

Inhibition of ACSL4 Alleviates Parkinsonism Phenotypes by Reduction of Lipid Reactive Oxygen Species

Fei Tang, Liu-yao Zhou, Ping Li, Ling-ling Jiao, Kang Chen, Yu-jie Guo, Xu-long Ding, Si-yu He, Biao Dong, Ru-xiang Xu, Huan Xiong, Peng Lei

Neurotherapeutics. 2023 Jul; 20(4): 1154–1166. Published online 2023 May 3. doi: 10.1007/s13311-023-01382-4

PMCID:: PMC10457271

Abstract Article PDF–7.4M

Select item 1027991313.

AdipoR2 recruits protein interactors to promote fatty acid elongation and membrane fluidity

Mario Ruiz, Ranjan Devkota, Delaney Kaper, Hanna Ruhanen, Kiran Busayavalasa, Uroš Radović, Marcus Henricsson, Reijo Käkelä, Jan Borén, Marc Pilon

J Biol Chem. 2023 Jun; 299(6): 104799. Published online 2023 May 8. doi: 10.1016/j.jbc.2023.104799

PMCID:: PMC10279913

Abstract Article PDF–4.1M

Select item 1023742214.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1015161515.

Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell

Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low

Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120

PMCID:: PMC10151615

Abstract Article PDF–2.9M

Select item 1014884316.

mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin

Naphat Chantaravisoot, Piriya Wongkongkathep, Nuttiya Kalpongnukul, Narawit Pacharakullanon, Pornchai Kaewsapsak, Chaiyaboot Ariyachet, Joseph A. Loo, Fuyuhiko Tamanoi, Trairak Pisitkun

Sci Rep. 2023; 13: 7037. Published online 2023 Apr 29. doi: 10.1038/s41598-023-33872-y