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Select item 112037231.

Unique Splicing of Lrp5 in the Brain: A New Player in Neurodevelopment and Brain Maturation

Aureli Luquero, Noelia Pimentel, Gemma Vilahur, Lina Badimon, Maria Borrell-Pages

Int J Mol Sci. 2024 Jun; 25(12): 6763. Published online 2024 Jun 20. doi: 10.3390/ijms25126763

PMCID:: PMC11203723

Abstract Article PDF–1.7M

Select item 110041782.

Wenwen Tang, Yi Luan, Qianying Yuan, Ao Li, Song Chen, Stanley Menacherry, Lawrence Young, Dianqing Wu

Nat Commun. 2024; 15: 3068. Published online 2024 Apr 9. doi: 10.1038/s41467-024-47262-z

PMCID:: PMC11004178

Abstract Article PDF–14M

Select item 103303843.

The LRP5 high-bone-mass mutation causes alveolar bone accrual with minor craniofacial alteration

Hakan Turkkahraman, Shannan Flanagan, Tianli Zhu, Teresita M. Bellido, Xue Yuan

J Periodontal Res. Author manuscript; available in PMC 2024 Aug 1.

Published in final edited form as: J Periodontal Res. 2023 Aug; 58(4): 723–732. Published online 2023 May 2. doi: 10.1111/jre.13130

PMCID:: PMC10330384

Abstract Article PDF–1.9M

Select item 101194194.

Balancing WNT signalling in early forebrain development: The role of LRP4 as a modulator of LRP6 function

Shuang Geng, Fabian Paul, Izabela Kowalczyk, Sandra Raimundo, Anje Sporbert, Tamrat Meshka Mamo, Annette Hammes

Front Cell Dev Biol. 2023; 11: 1173688. Published online 2023 Apr 7. doi: 10.3389/fcell.2023.1173688

PMCID:: PMC10119419

Abstract Article PDF–5.2M

Select item 97774115.

In Adult Skeletal Muscles, the Co-Receptors of Canonical Wnt Signaling, Lrp5 and Lrp6, Determine the Distribution and Size of Fiber Types, and Structure and Function of Neuromuscular Junctions

Lea Gessler, Christopher Kurtek, Mira Merholz, Yongzhi Jian, Said Hashemolhosseini

Cells. 2022 Dec; 11(24): 3968. Published online 2022 Dec 8. doi: 10.3390/cells11243968

PMCID:: PMC9777411

Abstract Article PDF–3.1M

Select item 97149716.

Amino acid transporter SLC38A5 regulates developmental and pathological retinal angiogenesis

Zhongxiao Wang, Felix Yemanyi, Alexandra K Blomfield, Kiran Bora, Shuo Huang, Chi-Hsiu Liu, William R Britton, Steve S Cho, Yohei Tomita, Zhongjie Fu, Jian-xing Ma, Wen-hong Li, Jing Chen

eLife. 2022; 11: e73105. Published online 2022 Dec 1. doi: 10.7554/eLife.73105

PMCID:: PMC9714971

Abstract Article PDF–15M

Select item 90978347.

LRP5 regulates cardiomyocyte proliferation and neonatal heart regeneration by the AKT/P21 pathway

Huixing Zhou, Fulei Zhang, Yahan Wu, Hongyu Liu, Ran Duan, Yuanyuan Liu, Yan Wang, Xiaoyu He, Yuemei Zhang, Xiue Ma, Yi Guan, Yi Liu, Dandan Liang, Liping Zhou, Yi‐Han Chen

J Cell Mol Med. 2022 May; 26(10): 2981–2994. Published online 2022 Apr 16. doi: 10.1111/jcmm.17311

PMCID:: PMC9097834

Abstract Article PDF–6.3M

Select item 88623088.

Germline saturation mutagenesis induces skeletal phenotypes in mice

Jonathan J Rios, Kristin Denton, Jamie Russell, Julia Kozlitina, Carlos R Ferreira, Amy F Lewanda, Joshua E Mayfield, Eva Moresco, Sara Ludwig, Miao Tang, Xiaohong Li, Stephen Lyon, Anas Khanshour, Nandina Paria, Aysha Khalid, Yang Li, Xudong Xie, Jian Q Feng, Qian Xu, Yongbo Lu, Robert E Hammer, Carol A Wise, Bruce Beutler

J Bone Miner Res. Author manuscript; available in PMC 2022 Aug 1.

Published in final edited form as: J Bone Miner Res. 2021 Aug; 36(8): 1548–1565. Published online 2021 May 10. doi: 10.1002/jbmr.4323

PMCID:: PMC8862308

Abstract Article PDF–2.5M

Select item 88048549.

The Effect of Overexpression of Lrp5 on the Temporomandibular Joint

Achint Utreja, Hengameh Motevasel, Carol Bain, Robert Holland, Alexander Robling

Cartilage. 2021 Dec; 13(2 Suppl): 419S–426S. Published online 2020 Oct 30. doi: 10.1177/1947603520968875

PMCID:: PMC8804854

Abstract Article PDF–5.9M

Select item 875979410.

RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis

Zhiying Yue, Xin Niu, Zengjin Yuan, Qin Qin, Wenhao Jiang, Liang He, Jingduo Gao, Yi Ding, Yanxi Liu, Ziwei Xu, Zhenxi Li, Zhengfeng Yang, Rong Li, Xiwen Xue, Yankun Gao, Fei Yue, Xiang H.-F. Zhang, Guohong Hu, Yi Wang, Yi Li, Geng Chen, Stefan Siwko, Alison Gartland, Ning Wang, Jianru Xiao, Mingyao Liu, Jian Luo

J Clin Invest. 2022 Jan 18; 132(2): e144579. Published online 2022 Jan 18. doi: 10.1172/JCI144579

PMCID:: PMC8759794

Abstract Article PDF–9.4M

Select item 836008711.

Gain‐of‐Function Lrp5 Mutation Improves Bone Mass and Strength and Delays Hyperglycemia in a Mouse Model of Insulin‐Deficient Diabetes

Giulia Leanza, Francesca Fontana, Seung‐Yon Lee, Maria S. Remedi, Céline Schott, Mathieu Ferron, Malcolm Hamilton‐Hall, Yael Alippe, Rocky Strollo, Nicola Napoli, Roberto Civitelli

J Bone Miner Res. 2021 Jul; 36(7): 1403–1415. Published online 2021 May 5. doi: 10.1002/jbmr.4303

PMCID:: PMC8360087

Abstract Article PDF–6.5M

Select item 831323912.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 829230513.

Loss of endothelial glucocorticoid receptor promotes angiogenesis via upregulation of Wnt/β-catenin pathway

Bing Liu, Han Zhou, Tiening Zhang, Xixiang Gao, Bo Tao, Hao Xing, Zhenwu Zhuang, Alan Dardik, Themis R. Kyriakides, Julie E. Goodwin

Angiogenesis. 2021; 24(3): 631–645. Published online 2021 Mar 2. doi: 10.1007/s10456-021-09773-x

PMCID:: PMC8292305

Abstract Article PDF–6.5M

Select item 825603614.

Stat3 loss in mesenchymal progenitors causes Job syndrome–like skeletal defects by reducing Wnt/β-catenin signaling

Prem Swaroop Yadav, Shuhao Feng, Qian Cong, Hanjun Kim, Yuchen Liu, Yingzi Yang

Proc Natl Acad Sci U S A. 2021 Jun 29; 118(26): e2020100118. Published online 2021 Jun 25. doi: 10.1073/pnas.2020100118

PMCID:: PMC8256036

Abstract Article PDF–3.8M

Select item 824504115.

Lacrimal gland budding requires PI3K-dependent suppression of EGF signaling

Qian Wang, Chenqi Tao, Abdul Hannan, Sungtae Yoon, Xuanyu Min, John Peregrin, Xiuxia Qu, Hongge Li, Honglian Yu, Jean Zhao, Xin Zhang

Sci Adv. 2021 Jul; 7(27): eabf1068. Published online 2021 Jun 30. doi: 10.1126/sciadv.abf1068

PMCID:: PMC8245041

Abstract Article PDF–1.8M

Select item 811454416.

Nrarp Coordinates Endothelial Notch and Wnt Signaling to Control Vessel Density in Angiogenesis

Li-Kun Phng, Michael Potente, Jonathan D. Leslie, Jane Babbage, Daniel Nyqvist, Ivan Lobov, Jennifer K. Ondr, Sujata Rao, Richard A. Lang, Gavin Thurston, Holger Gerhardt

Dev Cell. Author manuscript; available in PMC 2021 May 12.

Published in final edited form as: Dev Cell. 2009 Jan; 16(1): 70–82. doi: 10.1016/j.devcel.2008.12.009

PMCID:: PMC8114544

Abstract Article PDF–3.0M

Select item 795460117.

Catenin α 1 mutations cause familial exudative vitreoretinopathy by overactivating Norrin/β-catenin signaling

Xianjun Zhu, Mu Yang, Peiquan Zhao, Shujin Li, Lin Zhang, Lulin Huang, Yi Huang, Ping Fei, Yeming Yang, Shanshan Zhang, Huijuan Xu, Ye Yuan, Xiang Zhang, Xiong Zhu, Shi Ma, Fang Hao, Periasamy Sundaresan, Weiquan Zhu, Zhenglin Yang

J Clin Invest. 2021 Mar 15; 131(6): e139869. Published online 2021 Mar 15. doi: 10.1172/JCI139869

PMCID:: PMC7954601

Abstract Article PDF–31M

Select item 793877018.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 793646819.

Augmented BMP signaling commits cranial neural crest cells to a chondrogenic fate by suppressing autophagic β-catenin degradation

Jingwen Yang, Megumi Kitami, Haichun Pan, Masako Toda Nakamura, Honghao Zhang, Fei Liu, Lingxin Zhu, Yoshihiro Komatsu, Yuji Mishina

Sci Signal. Author manuscript; available in PMC 2021 Jul 12.

Published in final edited form as: Sci Signal. 2021 Jan 12; 14(665): eaaz9368. Published online 2021 Jan 12. doi: 10.1126/scisignal.aaz9368

PMCID:: PMC7936468

Abstract Article PDF–4.0M

Select item 777008420.

Co-deletion of Lrp5 and Lrp6 in the skeleton severely diminishes bone gain from sclerostin antibody administration

Kyung-Eun Lim, Whitney A. Bullock, Daniel J. Horan, Bart O. Williams, Matthew L. Warman, Alexander G. Robling

Bone. Author manuscript; available in PMC 2022 Feb 1.

Published in final edited form as: Bone. 2021 Feb; 143: 115708. Published online 2020 Oct 24. doi: 10.1016/j.bone.2020.115708

PMCID:: PMC7770084

Abstract Article PDF–1.7M

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