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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 109062332.

Hedgehog activation promotes osteogenic fates of growth plate resting zone chondrocytes through transient clonal competency

Shion Orikasa, Yuki Matsushita, Hiroaki Manabe, Michael Fogge, Zachary Lee, Koji Mizuhashi, Naoko Sakagami, Wanida Ono, Noriaki Ono

JCI Insight. 2024 Jan 23; 9(2): e165619. Published online 2024 Jan 23. doi: 10.1172/jci.insight.165619

PMCID:: PMC10906233

Abstract Article PDF–279M

Select item 108285493.

Non-canonical Hedgehog signaling mediates profibrotic hematopoiesis-stroma crosstalk in myeloproliferative neoplasms

Jessica E. Pritchard, Juliette E. Pearce, Inge A.M. Snoeren, Stijn N.R. Fuchs, Katrin Götz, Fabian Peisker, Silke Wagner, Adam Benabid, Niklas Lutterbach, Vanessa Klöker, James S. Nagai, Monica T. Hannani, Anna K. Galyga, Ellen Sistemich, Bella Banjanin, Niclas Flosdorf, Eric Bindels, Kathrin Olschok, Katharina Biaesch, Nicolas Chatain, Neha Bhagwat, Andrew Dunbar, Rita Sarkis, Olaia Naveiras, Marie-Luise Berres, Steffen Koschmieder, Ross L. Levine, Ivan G. Costa, Hélène F.E. Gleitz, Rafael Kramann, Rebekka K. Schneider

Cell Rep. 2024 Jan 23; 43(1): 113608. Published online 2023 Dec 20. doi: 10.1016/j.celrep.2023.113608

PMCID:: PMC10828549

Abstract Article

Select item 107626774.

BMP7 expression in mammalian cortical radial glial cells increases the length of the neurogenic period

Zhenmeiyu Li, Guoping Liu, Lin Yang, Mengge Sun, Zhuangzhi Zhang, Zhejun Xu, Yanjing Gao, Xin Jiang, Zihao Su, Xiaosu Li, Zhengang Yang

Protein Cell. 2024 Jan; 15(1): 21–35. Published online 2023 Jun 10. doi: 10.1093/procel/pwad036

PMCID:: PMC10762677

Abstract Article PDF–55M

Select item 106564275.

GATA6 is a crucial factor for Myocd expression in the visceral smooth muscle cell differentiation program of the murine ureter

Jennifer Kurz, Anna-Carina Weiss, Timo H.-W. Lüdtke, Lena Deuper, Mark-Oliver Trowe, Hauke Thiesler, Herbert Hildebrandt, Joerg Heineke, Stephen A. Duncan, Andreas Kispert

Development. 2022 Aug 1; 149(15): dev200522. Published online 2022 Jul 29. doi: 10.1242/dev.200522

PMCID:: PMC10656427

Abstract Article

Select item 106562856.

Ligand-dependent hedgehog signaling maintains an undifferentiated, malignant osteosarcoma phenotype

Vijesh G. Vaghjiani, Catherine R. Cochrane, W. Samantha N. Jayasekara, Wai Chin Chong, Anette Szczepny, Beena Kumar, Luciano G. Martelotto, Andrew McCaw, Kirstyn Carey, Maya Kansara, David M. Thomas, Carl Walkley, Stuart Mudge, Daniel J. Gough, Peter A. Downie, Craig D. Peacock, William Matsui, D. Neil Watkins, Jason E. Cain

Oncogene. 2023; 42(47): 3529–3541. Published online 2023 Oct 16. doi: 10.1038/s41388-023-02864-7

PMCID:: PMC10656285

Abstract Article PDF–4.5M

Select item 105519047.

Hedgehog signaling is required for endometrial remodeling and myometrial homeostasis in the cycling mouse uterus

Elle C. Roberson, Ngan Kim Tran, Anushka N. Godambe, Harrison Mark, Michelle Nguimtsop, Trinity Rust, Elizabeth Ung, LeCaine J. Barker, Rebecca D. Fitch, John B. Wallingford

iScience. 2023 Oct 20; 26(10): 107993. Published online 2023 Sep 20. doi: 10.1016/j.isci.2023.107993

PMCID:: PMC10551904

Abstract Article PDF–5.1M

Select item 102344438.

Niche-mediated repair of airways is directed in an occupant-dependent manner

Handeng Lyu, Rachel Warren, Shan Gao, Kylie Klinkhammer, Tingting Yuan, Jin-San Zhang, Douglas Brownfield, Xiaokun Li, Stijn P. De Langhe

Cell Rep. Author manuscript; available in PMC 2023 Jun 1.

Published in final edited form as: Cell Rep. 2022 Dec 20; 41(12): 111863. doi: 10.1016/j.celrep.2022.111863

PMCID:: PMC10234443

Abstract Article PDF–3.2M

Select item 100825049.

IGFBP2 promotes proliferation and cell migration through STAT3 signaling in Sonic hedgehog medulloblastoma

Haritha Kunhiraman, Leon McSwain, Shubin W. Shahab, Timothy R. Gershon, Tobey J. MacDonald, Anna Marie Kenney

Acta Neuropathol Commun. 2023; 11: 62. Published online 2023 Apr 8. doi: 10.1186/s40478-023-01557-2

PMCID:: PMC10082504

Abstract Article PDF–9.9M

Select item 1001765710.

Mesenchyme-derived vertebrate lonesome kinase controls lung organogenesis by altering the matrisome

Salome M. Brütsch, Elizabeta Madzharova, Sophia Pantasis, Till Wüstemann, Selina Gurri, Heiko Steenbock, Amiq Gazdhar, Gisela Kuhn, Peter Angel, Saverio Bellusci, Jürgen Brinckmann, Ulrich auf dem Keller, Sabine Werner, Mattia R. Bordoli

Cell Mol Life Sci. 2023 Apr; 80(4): 89. Published online 2023 Mar 15. doi: 10.1007/s00018-023-04735-6

PMCID:: PMC10017657

Abstract Article PDF–5.2M

Select item 991045811.

Follistatin regulates the specification of the apical cochlea responsible for low-frequency hearing in mammals

Hei Yeun Koo, Min-A Kim, Hyehyun Min, Jae Yeon Hwang, Meenakshi Prajapati-DiNubila, Kwan Soo Kim, Martin M. Matzuk, Juw Won Park, Angelika Doetzlhofer, Un-Kyung Kim, Jinwoong Bok

Proc Natl Acad Sci U S A. 2023 Jan 3; 120(1): e2213099120. Published online 2022 Dec 28. doi: 10.1073/pnas.2213099120

PMCID:: PMC9910458

Abstract Article PDF–11M

Select item 971853212.

Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis

Xiaodong Li, Patrick J Gordon, John A Gaynes, Alexandra W Fuller, Randy Ringuette, Clayton P Santiago, Valerie Wallace, Seth Blackshaw, Pulin Li, Edward M Levine

eLife. 2022; 11: e78342. Published online 2022 Dec 2. doi: 10.7554/eLife.78342

PMCID:: PMC9718532

Abstract Article PDF–14M

Select item 928129313.

Cell-autonomous Hedgehog signaling controls Th17 polarization and pathogenicity

Joachim Hanna, Flavio Beke, Louise M. O’Brien, Chrysa Kapeni, Hung-Chang Chen, Valentina Carbonaro, Alexander B. Kim, Kamal Kishore, Timon E. Adolph, Mikkel-Ole Skjoedt, Karsten Skjoedt, Marc de la Roche, Maike de la Roche

Nat Commun. 2022; 13: 4075. Published online 2022 Jul 14. doi: 10.1038/s41467-022-31722-5

PMCID:: PMC9281293

Abstract Article PDF–3.8M

Select item 925059114.

Hedgehog (HH) pathway endogenous antagonist HHIP: unique lingual expression in filiform papillae during homeostasis and ectopic in fungiform papillae during HH signaling inhibition

Archana Kumari, Libo Li, Alexandre N. Ermilov, Nicole E. Franks, Andrzej A. Dlugosz, Benjamin L. Allen, Charlotte M. Mistretta

Dev Dyn. Author manuscript; available in PMC 2023 Jul 1.

Published in final edited form as: Dev Dyn. 2022 Jul; 251(7): 1175–1195. Published online 2022 Feb 18. doi: 10.1002/dvdy.456

PMCID:: PMC9250591

Abstract Article PDF–2.7M

Select item 905090915.

Decomposing a deterministic path to mesenchymal niche formation by two intersecting morphogen gradients

Rihao Qu, Khusali Gupta, Danni Dong, Yiqun Jiang, Boris Landa, Charles Saez, Gwendolyn Strickland, Pei-lun Weng, M. Mark Taketo, Yuval Kluger, Peggy Myung

Dev Cell. Author manuscript; available in PMC 2023 Apr 25.

Published in final edited form as: Dev Cell. 2022 Apr 25; 57(8): 1053–1067.e5. Published online 2022 Apr 13. doi: 10.1016/j.devcel.2022.03.011

PMCID:: PMC9050909

Abstract Article PDF–3.4M

Select item 904270816.

Ankmy2 Prevents Smoothened-Independent Hyperactivation of the Hedgehog Pathway via Cilia-Regulated Adenylyl Cyclase Signaling

Bandarigoda Nipunika Somatilaka, Sun-Hee Hwang, Vivek Reddy Palicharla, Kevin Andrew White, Hemant Badgandi, John Michael Shelton, Saikat Mukhopadhyay

Dev Cell. Author manuscript; available in PMC 2022 Apr 27.

Published in final edited form as: Dev Cell. 2020 Sep 28; 54(6): 710–726.e8. Published online 2020 Jul 22. doi: 10.1016/j.devcel.2020.06.034

PMCID:: PMC9042708

Abstract Article PDF–3.9M

Select item 900005917.

TMED2 binding restricts SMO to the ER and Golgi compartments

Giulio Di Minin, Markus Holzner, Alice Grison, Charles E. Dumeau, Wesley Chan, Asun Monfort, Loydie A. Jerome-Majewska, Henk Roelink, Anton Wutz

PLoS Biol. 2022 Mar; 20(3): e3001596. Published online 2022 Mar 30. doi: 10.1371/journal.pbio.3001596

PMCID:: PMC9000059

Abstract Article PDF–4.1M

Select item 891878918.

An essential function for autocrine hedgehog signaling in epithelial proliferation and differentiation in the trachea

Wenguang Yin, Andreas Liontos, Janine Koepke, Maroua Ghoul, Luciana Mazzocchi, Xinyuan Liu, Chunyan Lu, Haoyu Wu, Athanasios Fysikopoulos, Alexandros Sountoulidis, Werner Seeger, Clemens Ruppert, Andreas Günther, Didier Y. R. Stainier, Christos Samakovlis

Development. 2022 Feb 1; 149(3): dev199804. Published online 2022 Feb 7. doi: 10.1242/dev.199804

PMCID:: PMC8918789

Abstract Article

Select item 886474819.

Smoothened and ARL13B are critical in mouse for superior cerebellar peduncle targeting

Sarah K Suciu, Alyssa B Long, Tamara Caspary

Genetics. 2021 Aug; 218(4): iyab084. Published online 2021 Jun 16. doi: 10.1093/genetics/iyab084

PMCID:: PMC8864748

Abstract Article PDF–1.0M

Select item 884798720.

STAT3 is required for Smo‐dependent signaling and mediates Smo‐targeted treatment resistance and tumorigenesis in Shh medulloblastoma

Liangping Yuan, Hongying Zhang, Jingbo Liu, Anshu Malhotra, Abhinav Dey, Bing Yu, Kishore Kumar Jella, Leon F. McSwain, Matthew J. Schniederjan, Tobey J. MacDonald

Mol Oncol. 2022 Feb; 16(4): 1009–1025. Published online 2021 Sep 25. doi: 10.1002/1878-0261.13097

PMCID:: PMC8847987

Abstract Article PDF–2.0M

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