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Items: 1 to 20 of 125

1.
ADAR1 Is Essential for Smooth Muscle Homeostasis and Vascular Integrity
Dunpeng Cai, Shi-You Chen
Cells. 2024 Aug; 13(15): 1257. Published online 2024 Jul 26. doi: 10.3390/cells13151257
PMCID:
PMC11311430
AbstractArticlePDF–17M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
Aberrant RNA sensing in regulatory T cells causes systemic autoimmunity
Domnica Luca, Sumin Lee, Keiji Hirota, Yasutaka Okabe, Junji Uehori, Kazushi Izawa, Anna-Lisa Lanz, Verena Schütte, Burcu Sivri, Yuta Tsukamoto, Fabian Hauck, Rayk Behrendt, Axel Roers, Takashi Fujita, Ryuta Nishikomori, Min Ae Lee-Kirsch, Hiroki Kato
Sci Adv. 2024 Mar 1; 10(9): eadk0820. Published online 2024 Mar 1. doi: 10.1126/sciadv.adk0820
PMCID:
PMC10906915
AbstractArticlePDF–4.5M
4.
ADAR1 protects pulmonary macrophages from sepsis-induced pyroptosis and lung injury through miR-21/A20 signaling
Xiaojun Zhao, Jiangang Xie, Chujun Duan, Linxiao Wang, Yi Si, Shanshou Liu, Qianmei Wang, Dan Wu, Yifan Wang, Wen Yin, Ran Zhuang, Junjie Li
Int J Biol Sci. 2024; 20(2): 464–485. Published online 2024 Jan 1. doi: 10.7150/ijbs.86424
PMCID:
PMC10758098
AbstractArticlePDF–13M
5.
ADAR1 Zα domain P195A mutation activates the MDA5-dependent RNA-sensing signaling pathway in brain without decreasing overall RNA editing
Xinfeng Guo, Silvia Liu, Yi Sheng, Mazen Zenati, Timothy Billiar, Alan Herbert, Qingde Wang
Cell Rep. Author manuscript; available in PMC 2023 Dec 1.
Published in final edited form as: Cell Rep. 2023 Jul 25; 42(7): 112733. Published online 2023 Jul 6. doi: 10.1016/j.celrep.2023.112733
PMCID:
PMC10691306
AbstractArticlePDF–2.3M
6.
ADAR1 links R-loop homeostasis to ATR activation in replication stress response
Biao Zhang, Yi Li, Jieyou Zhang, Yuejiao Wang, Can Liang, Ting Lu, Chunyong Zhang, Ling Liu, Yan Qin, Jiahuan He, Xiangnan Zhao, Jia Yu, Jihui Hao, Jie Yang, Mulin Jun Li, Zhi Yao, Shuai Ma, Hui Cheng, Tao Cheng, Lei Shi
Nucleic Acids Res. 2023 Nov 27; 51(21): 11668–11687. Published online 2023 Oct 13. doi: 10.1093/nar/gkad839
PMCID:
PMC10681745
AbstractArticlePDF–3.8M
7.
Loss of ADAR1 in macrophages in combination with interferon gamma suppresses tumor growth by remodeling the tumor microenvironment
Weiwei Lin, Yikai Luo, Jie Wu, Haowan Zhang, Ge Jin, Chahua Guo, Hang Zhou, Han Liang, Xiaoyan Xu
J Immunother Cancer. 2023; 11(11): e007402. Published online 2023 Nov 7. doi: 10.1136/jitc-2023-007402
PMCID:
PMC10649901
AbstractArticlePDF–14M
8.
Generation of a new Adar1p150−/− mouse demonstrates isoform-specific roles in embryonic development and adult homeostasis
Zhen Liang, Ankita Goradia, Carl R. Walkley, Jacki E. Heraud-Farlow
RNA. 2023 Sep; 29(9): 1325–1338. doi: 10.1261/rna.079509.122
PMCID:
PMC10573302
AbstractArticlePDF–2.0M
9.
ADAR1 exacerbates ischemic brain injury via astrocyte-mediated neuron apoptosis
Dunpeng Cai, Mikayla Fraunfelder, Ken Fujise, Shi-You Chen
Redox Biol. 2023 Nov; 67: 102903. Published online 2023 Sep 29. doi: 10.1016/j.redox.2023.102903
PMCID:
PMC10570147
AbstractArticlePDF–4.5M
10.
RNA editing of AZIN1 coding sites is catalyzed by ADAR1 p150 after splicing
Yanfang Xing, Taisuke Nakahama, Yuke Wu, Maal Inoue, Jung In Kim, Hiroyuki Todo, Toshiharu Shibuya, Yuki Kato, Yukio Kawahara
J Biol Chem. 2023 Jul; 299(7): 104840. Published online 2023 May 18. doi: 10.1016/j.jbc.2023.104840
PMCID:
PMC10404624
AbstractArticlePDF–2.2M
11.
ADAR1 non-editing function in macrophage activation and abdominal aortic aneurysm
Dunpeng Cai, Chenming Sun, Takashi Murashita, Xingyi Que, Shi-You Chen
Circ Res. Author manuscript; available in PMC 2024 Feb 17.
Published in final edited form as: Circ Res. 2023 Feb 17; 132(4): e78–e93. Published online 2023 Jan 23. doi: 10.1161/CIRCRESAHA.122.321722
PMCID:
PMC10316962
AbstractArticlePDF–3.6M
12.
The ADAR1 editome reveals drivers of editing-specificity for ADAR1-isoforms
Renata Kleinova, Vinod Rajendra, Alina F Leuchtenberger, Claudio Lo Giudice, Cornelia Vesely, Utkarsh Kapoor, Andrea Tanzer, Sophia Derdak, Ernesto Picardi, Michael F Jantsch
Nucleic Acids Res. 2023 May 22; 51(9): 4191–4207. Published online 2023 Apr 7. doi: 10.1093/nar/gkad265
PMCID:
PMC10201426
AbstractArticlePDF–2.9M
13.
An essential role of adenosine deaminase acting on RNA 1 in coeliac disease mucosa
Davide Di Fusco, Maria Teresa Segreto, Andrea Iannucci, Claudia Maresca, Eleonora Franzè, Giulia Di Maggio, Antonio Di Grazia, Siro Boccanera, Federica Laudisi, Irene Marafini, Omero Alessandro Paoluzi, Alessandro Michienzi, Giovanni Monteleone, Ivan Monteleone
Front Immunol. 2023; 14: 1175348. Published online 2023 May 8. doi: 10.3389/fimmu.2023.1175348
Correction in:
Front Immunol. 2023; 14: 1235641.
PMCID:
PMC10200931
AbstractArticlePDF–4.2M
14.
The phenotype of the most common human ADAR1p150 Zα mutation P193A in mice is partially penetrant
Zhen Liang, Alistair M Chalk, Scott Taylor, Ankita Goradia, Jacki E Heraud‐Farlow, Carl R Walkley
EMBO Rep. 2023 May; 24(5): e55835. Published online 2023 Mar 28. doi: 10.15252/embr.202255835
PMCID:
PMC10157378
AbstractArticlePDF–5.6M
15.
Adar1 deletion causes degeneration of the exocrine pancreas via Mavs-dependent interferon signaling
Dhwani N. Rupani, Fredrik I. Thege, Vidhi Chandra, Hajar Rajaei, Robert W. Cowan, Sonja M. Wörmann, Olivereen Le Roux, Prerna Malaney, Sara L. Manning, Jack Hashem, Jennifer Bailey-Lundberg, Andrew D. Rhim, Florencia McAllister
Development. 2023 Jan 15; 150(2): dev201097. Published online 2023 Jan 16. doi: 10.1242/dev.201097
PMCID:
PMC10110501
AbstractArticle
16.
ADAR1-dependent miR-3144-3p editing simultaneously induces MSI2 expression and suppresses SLC38A4 expression in liver cancer
Hyung Seok Kim, Min Jeong Na, Keun Hong Son, Hee Doo Yang, Sang Yean Kim, Eunbi Shin, Jin Woong Ha, Soyoung Jeon, Keunsoo Kang, Kiho Moon, Won Sang Park, Suk Woo Nam
Exp Mol Med. 2023 Jan; 55(1): 95–107. Published online 2023 Jan 4. doi: 10.1038/s12276-022-00916-8
PMCID:
PMC9898302
AbstractArticlePDF–10M
17.
Ablation of Adar1 in myeloid cells imprints a global antiviral state in the lung and heightens early immunity against SARS-CoV-2
Julia Z. Adamska, Rohit Verma, Shakti Gupta, Thomas Hagan, Florian Wimmers, Katharine Floyd, Qin Li, Erika V. Valore, Yanli Wang, Meera Trisal, José G. Vilches-Moure, Shankar Subramaniam, Carl R. Walkley, Mehul S. Suthar, Jin Billy Li, Bali Pulendran
Cell Rep. 2023 Jan 31; 42(1): 112038. Published online 2023 Jan 17. doi: 10.1016/j.celrep.2023.112038
PMCID:
PMC9842623
AbstractArticlePDF–7.8M
18.
ADAR1 downregulation by autophagy drives senescence independently of RNA editing by enhancing p16INK4a levels
Xue Hao, Yusuke Shiromoto, Masayuki Sakurai, Martina Towers, Qiang Zhang, Shuai Wu, Aaron Havas, Lu Wang, Shelley Berger, Peter D. Adams, Bin Tian, Kazuko Nishikura, Andrew V. Kossenkov, Pingyu Liu, Rugang Zhang
Nat Cell Biol. Author manuscript; available in PMC 2023 Feb 1.
Published in final edited form as: Nat Cell Biol. 2022 Aug; 24(8): 1202–1210. Published online 2022 Jul 18. doi: 10.1038/s41556-022-00959-z
PMCID:
PMC9757154
AbstractArticlePDF–4.8M
19.
ADAR1 promotes systemic sclerosis via modulating classic macrophage activation
Chenming Sun, Dunpeng Cai, Shi-You Chen
Front Immunol. 2022; 13: 1051254. Published online 2022 Dec 1. doi: 10.3389/fimmu.2022.1051254
PMCID:
PMC9751044
AbstractArticlePDF–5.4M
20.
An AGS-associated mutation in ADAR1 catalytic domain results in early-onset and MDA5-dependent encephalopathy with IFN pathway activation in the brain
Xinfeng Guo, Richard A. Steinman, Yi Sheng, Guodong Cao, Clayton A. Wiley, Qingde Wang
J Neuroinflammation. 2022; 19: 285. Published online 2022 Dec 1. doi: 10.1186/s12974-022-02646-0
PMCID:
PMC9714073
AbstractArticlePDF–5.3M

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