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Select item 95684631.

HERC2 deficiency activates C-RAF/MKK3/p38 signalling pathway altering the cellular response to oxidative stress

Joan Sala-Gaston, Leonardo Pedrazza, Juanma Ramirez, Arturo Martinez-Martinez, Lettie E. Rawlins, Emma L. Baple, Andrew H. Crosby, Ugo Mayor, Francesc Ventura, Jose Luis Rosa

Cell Mol Life Sci. 2022; 79(11): 548. Published online 2022 Oct 14. doi: 10.1007/s00018-022-04586-7

PMCID:: PMC9568463

Abstract Article PDF–7.5M

Select item 86297852.

Identification by proximity labeling of novel lipidic and proteinaceous potential partners of the dopamine transporter

Dolores Piniella, Elena Martínez-Blanco, David Bartolomé-Martín, Ana B. Sanz-Martos, Francisco Zafra

Cell Mol Life Sci. 2021 Dec; 78(23): 7733–7756. Published online 2021 Oct 28. doi: 10.1007/s00018-021-03998-1

PMCID:: PMC8629785

Abstract Article PDF–10M

Select item 79387703.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 72950334.

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant

Meagan A. Quinlan, Matthew J. Robson, Ran Ye, Kristie L. Rose, Kevin L. Schey, Randy D. Blakely

Front Mol Neurosci. 2020; 13: 89. Published online 2020 Jun 8. doi: 10.3389/fnmol.2020.00089

PMCID:: PMC7295033

Abstract Article PDF–2.7M

Select item 66927705.

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics

Joel D. Federspiel, Todd M. Greco, Krystal K. Lum, Ileana M. Cristea

Mol Cell Proteomics. 2019 Aug 9; 18(8 Suppl 1): S92–S113. Published online 2019 Apr 30. doi: 10.1074/mcp.RA118.001253

PMCID:: PMC6692770

Abstract Article PDF–7.7M

Select item 61245306.

Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL/6J

Steven Timmermans, Claude Libert

JCI Insight. 2018 Jul 12; 3(13): e121758. Published online 2018 Jul 12. doi: 10.1172/jci.insight.121758

PMCID:: PMC6124530

Abstract Article PDF–358K

Select item 56683707.

RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain

Pamela Valnegri, Ju Huang, Tomoko Yamada, Yue Yang, Luis A. Mejia, Ha Y. Cho, Anna Oldenborg, Azad Bonni

Nat Commun. 2017; 8: 1271. Published online 2017 Nov 2. doi: 10.1038/s41467-017-01333-6

PMCID:: PMC5668370

Abstract Article PDF–2.2M

Select item 56450828.

Spatio-temporal profile of postynaptic interactomes integrates components of complex brain disorders

Jing Li, Wangshu Zhang, Hui Yang, Daniel P. Howrigan, Brent Wilkinson, Tade Souaiaia, Oleg V. Evgrafov, Giulio Genovese, Veronica A. Clementel, Jennifer C. Tudor, Ted Abel, James A. Knowles, Benjamin M. Neale, Kai Wang, Fengzhu Sun, Marcelo P. Coba

Nat Neurosci. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: Nat Neurosci. 2017 Aug; 20(8): 1150–1161. Published online 2017 Jun 26. doi: 10.1038/nn.4594

PMCID:: PMC5645082

Abstract Article PDF–2.3M

Select item 53028989.

The HERC2 ubiquitin ligase is essential for embryonic development and regulates motor coordination

Monica Cubillos-Rojas, Taiane Schneider, Ouadah Hadjebi, Leonardo Pedrazza, Jarbas Rodrigues de Oliveira, Francina Langa, Jean-Louis Guénet, Joan Duran, Josep Maria de Anta, Soledad Alcántara, Rocio Ruiz, Eva María Pérez-Villegas, Francisco J. Aguilar, Ángel M. Carrión, Jose Angel Armengol, Emma Baple, Andrew H. Crosby, Ramon Bartrons, Francesc Ventura, Jose Luis Rosa

Oncotarget. 2016 Aug 30; 7(35): 56083–56106. Published online 2016 Aug 12. doi: 10.18632/oncotarget.11270

PMCID:: PMC5302898

Abstract Article PDF–15M

Select item 499213810.

Novel gene function revealed by mouse mutagenesis screens for models of age-related disease

Paul K. Potter, Michael R. Bowl, Prashanthini Jeyarajan, Laura Wisby, Andrew Blease, Michelle E. Goldsworthy, Michelle M. Simon, Simon Greenaway, Vincent Michel, Alun Barnard, Carlos Aguilar, Thomas Agnew, Gareth Banks, Andrew Blake, Lauren Chessum, Joanne Dorning, Sara Falcone, Laurence Goosey, Shelley Harris, Andy Haynes, Ines Heise, Rosie Hillier, Tertius Hough, Angela Hoslin, Marie Hutchison, Ruairidh King, Saumya Kumar, Heena V. Lad, Gemma Law, Robert E. MacLaren, Susan Morse, Thomas Nicol, Andrew Parker, Karen Pickford, Siddharth Sethi, Becky Starbuck, Femke Stelma, Michael Cheeseman, Sally H. Cross, Russell G. Foster, Ian J. Jackson, Stuart N. Peirson, Rajesh V. Thakker, Tonia Vincent, Cheryl Scudamore, Sara Wells, Aziz El-Amraoui, Christine Petit, Abraham Acevedo-Arozena, Patrick M. Nolan, Roger Cox, Anne-Marie Mallon, Steve D. M. Brown

Nat Commun. 2016; 7: 12444. Published online 2016 Aug 18. doi: 10.1038/ncomms12444

PMCID:: PMC4992138

Abstract Article PDF–2.2M

Select item 456567211.

The Parkinson’s Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway

Yuzuru Imai, Yoshito Kobayashi, Tsuyoshi Inoshita, Hongrui Meng, Taku Arano, Kengo Uemura, Takeshi Asano, Kenji Yoshimi, Chang-Liang Zhang, Gen Matsumoto, Toshiyuki Ohtsuka, Ryoichiro Kageyama, Hiroshi Kiyonari, Go Shioi, Nobuyuki Nukina, Nobutaka Hattori, Ryosuke Takahashi

PLoS Genet. 2015 Sep; 11(9): e1005503. Published online 2015 Sep 10. doi: 10.1371/journal.pgen.1005503

PMCID:: PMC4565672

Abstract Article PDF–11M

Select item 409408812.

Degradation of the Deubiquitinating Enzyme USP33 Is Mediated by p97 and the Ubiquitin Ligase HERC2

Nickie C. Chan, Willem den Besten, Michael J. Sweredoski, Sonja Hess, Raymond J. Deshaies, David C. Chan

J Biol Chem. 2014 Jul 11; 289(28): 19789–19798. Published online 2014 May 22. doi: 10.1074/jbc.M114.569392

PMCID:: PMC4094088

Abstract Article PDF–1.5M

Select item 407349413.

The Central Role of EED in the Orchestration of Polycomb Group Complexes

Qi Cao, Xiaoju Wang, Meng Zhao, Rendong Yang, Rohit Malik, Yuanyuan Qiao, Anton Poliakov, Anastasia K. Yocum, Yong Li, Wei Chen, Xuhong Cao, Xia Jiang, Arun Dahiya, Clair Harris, Felix Y. Feng, Sundeep Kalantry, Zhaohui S. Qin, Saravana M. Dhanasekaran, Arul M. Chinnaiyan

Nat Commun. Author manuscript; available in PMC 2014 Jul 24.

Published in final edited form as: Nat Commun. 2014; 5: 3127. doi: 10.1038/ncomms4127

PMCID:: PMC4073494

Abstract Article PDF–2.1M

Select item 403153314.

The E3 Ubiquitin Protein Ligase HERC2 Modulates the Activity of Tumor Protein p53 by Regulating Its Oligomerization

Monica Cubillos-Rojas, Fabiola Amair-Pinedo, Roser Peiró-Jordán, Ramon Bartrons, Francesc Ventura, Jose Luis Rosa

J Biol Chem. 2014 May 23; 289(21): 14782–14795. Published online 2014 Apr 9. doi: 10.1074/jbc.M113.527978

PMCID:: PMC4031533

Abstract Article PDF–3.6M

Select item 317805915.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 310331916.

Physical and Functional Interaction of the HECT Ubiquitin-protein Ligases E6AP and HERC2

Simone Kühnle, Ulrike Kogel, Sandra Glockzin, Andreas Marquardt, Aaron Ciechanover, Konstantin Matentzoglu, Martin Scheffner

J Biol Chem. 2011 Jun 3; 286(22): 19410–19416. Published online 2011 Apr 14. doi: 10.1074/jbc.M110.205211

PMCID:: PMC3103319

Abstract Article PDF–1.9M

Select item 302253417.

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio

PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582

PMCID:: PMC3022534

Abstract Article PDF–3.8M

Select item 255627018.

Large-scale gene trapping in C57BL/6N mouse embryonic stem cells

Gwenn M. Hansen, Diane C. Markesich, Michael B. Burnett, Qichao Zhu, Karen M. Dionne, Lizabeth J. Richter, Richard H. Finnell, Arthur T. Sands, Brian P. Zambrowicz, Alejandro Abuin

Genome Res. 2008 Oct; 18(10): 1670–1679. doi: 10.1101/gr.078352.108

PMCID:: PMC2556270

Abstract Article PDF–493K

Select item 121363319.

Effects on Sperm Morphology by Alleles at the Pink-Eyed Dilution Locus in Mice

H. Glenn Wolfe, Robert P. Erickson, Linda C. Schmidt

Genetics. 1977 Feb; 85(2): 303–308. doi: 10.1093/genetics/85.2.303

PMCID:: PMC1213633

Summary PDF–340K

Select item 120688720.

Molecular Analysis of 36 Mutations at the Mouse Pink-Eyed Dilution (P) Locus

D. K. Johnson, L. J. Stubbs, C. T. Culiat, C. S. Montgomery, L. B. Russell, E. M. Rinchik

Genetics. 1995 Dec; 141(4): 1563–1571. doi: 10.1093/genetics/141.4.1563

PMCID:: PMC1206887

Summary PDF–894K

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