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Select item 110769891.

Inhibition of ADORA3 promotes microglial phagocytosis and alleviates chronic ischemic white matter injury

Yuhao Xu, Limoran Tang, Chao Zhou, Liang Sun, Yujie Hu, Zhi Zhang, Shengnan Xia, Xinyu Bao, Haiyan Yang, Yun Xu

CNS Neurosci Ther. 2024 May; 30(5): e14742. Published online 2024 May 7. doi: 10.1111/cns.14742

PMCID:: PMC11076989

Abstract Article PDF–20M

Select item 107759502.

Targeted deletion of adenosine A₃ receptors augments adenosine-induced coronary flow in isolated mouse heart

M. A. HASSAN TALUKDER, R. RAY MORRISON, MARLENE A. JACOBSON, KENNETH A. JACOBSON, CATHERINE LEDENT, S. JAMAL MUSTAFA

Am J Physiol Heart Circ Physiol. Author manuscript; available in PMC 2024 Jan 9.

Published in final edited form as: Am J Physiol Heart Circ Physiol. 2002 Jun; 282(6): H2183–H2189. doi: 10.1152/ajpheart.00964.2001

PMCID:: PMC10775950

Abstract Article PDF–644K

Select item 85330733.

The Histamine H₄ Receptor Participates in the Anti-Neuropathic Effect of the Adenosine A₃ Receptor Agonist IB-MECA: Role of CD4⁺ T Cells

Laura Micheli, Mariaconcetta Durante, Elena Lucarini, Silvia Sgambellone, Laura Lucarini, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Emanuela Masini

Biomolecules. 2021 Oct; 11(10): 1447. Published online 2021 Oct 2. doi: 10.3390/biom11101447

PMCID:: PMC8533073

Abstract Article PDF–1.7M

Select item 84936384.

Genetic ablation of adenosine receptor A3 results in articular cartilage degeneration

Ruzanna Shkhyan, Siyoung Lee, Francesca Gullo, Lei Li, Maria Peleli, Mattias Carlstrom, Andrei S. Chagin, Nicholas W. Banks, Sean Limfat, Nancy Q. Liu, Denis Evseenko

J Mol Med (Berl) Author manuscript; available in PMC 2021 Oct 6.

Published in final edited form as: J Mol Med (Berl). 2018 Oct; 96(10): 1049–1060. Published online 2018 Aug 7. doi: 10.1007/s00109-018-1680-3

PMCID:: PMC8493638

Abstract Article PDF–1.7M

Select item 81982345.

Dual Actions of A_2A and A₃ Adenosine Receptor Ligand Prevents Obstruction-Induced Kidney Fibrosis in Mice

Eun Seon Pak, Lak Shin Jeong, Xiyan Hou, Sushil K. Tripathi, Jiyoun Lee, Hunjoo Ha

Int J Mol Sci. 2021 Jun; 22(11): 5667. Published online 2021 May 26. doi: 10.3390/ijms22115667

PMCID:: PMC8198234

Abstract Article PDF–3.6M

Select item 80118996.

Adenosine A₃ agonists reverse neuropathic pain via T cell–mediated production of IL-10

Mariaconcetta Durante, Silvia Squillace, Filomena Lauro, Luigino Antonio Giancotti, Elisabetta Coppi, Federica Cherchi, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Grant Kolar, Carrie Wahlman, Adeleye Opejin, Cuiying Xiao, Marc L. Reitman, Dilip K. Tosh, Daniel Hawiger, Kenneth A. Jacobson, Daniela Salvemini

J Clin Invest. 2021 Apr 1; 131(7): e139299. Published online 2021 Apr 1. doi: 10.1172/JCI139299

PMCID:: PMC8011899

Abstract Article PDF–1.9M

Select item 74041377.

Adenosine A_2A and A₃ Receptors Are Able to Interact with Each Other. A Further Piece in the Puzzle of Adenosine Receptor-Mediated Signaling

Alejandro Lillo, Eva Martínez-Pinilla, Irene Reyes-Resina, Gemma Navarro, Rafael Franco

Int J Mol Sci. 2020 Jul; 21(14): 5070. Published online 2020 Jul 17. doi: 10.3390/ijms21145070

PMCID:: PMC7404137

Abstract Article PDF–1.5M

Select item 68446368.

The A3 adenosine receptor agonist, namodenoson, ameliorates non-alcoholic steatohepatitis in mice

Pnina Fishman, Shira Cohen, Inbal Itzhak, Johnny Amer, Ahmad Salhab, Faina Barer, Rifaat Safadi

Int J Mol Med. 2019 Dec; 44(6): 2256–2264. Published online 2019 Oct 3. doi: 10.3892/ijmm.2019.4364

PMCID:: PMC6844636

Abstract Article PDF–753K

Select item 66220389.

CXCL16 Orchestrates Adenosine A₃ Receptor and MCP-1/CCL2 Activity to Protect Neurons from Excitotoxic Cell Death in the CNS

Maria Rosito, Cristina Deflorio, Cristina Limatola, Flavia Trettel

J Neurosci. 2012 Feb 29; 32(9): 3154–3163. doi: 10.1523/JNEUROSCI.4046-11.2012

PMCID:: PMC6622038

Abstract Article PDF–1.7M

Select item 641587310.

Physiology and effects of nucleosides in mice lacking all four adenosine receptors

Cuiying Xiao, Naili Liu, Kenneth A. Jacobson, Oksana Gavrilova, Marc L. Reitman

PLoS Biol. 2019 Mar; 17(3): e3000161. Published online 2019 Mar 1. doi: 10.1371/journal.pbio.3000161

PMCID:: PMC6415873

Abstract Article PDF–9.2M

Select item 630990011.

Protective roles of adenosine A₁, A_2A, and A₃ receptors in skeletal muscle ischemia and reperfusion injury

Jingang Zheng, Rubio Wang, Edward Zambraski, Dan Wu, Kenneth A. Jacobson, Bruce T. Liang

Am J Physiol Heart Circ Physiol. Author manuscript; available in PMC 2018 Dec 28.

Published in final edited form as: Am J Physiol Heart Circ Physiol. 2007 Dec; 293(6): H3685–H3691. Published online 2007 Oct 5. doi: 10.1152/ajpheart.00819.2007

PMCID:: PMC6309900

Abstract Article PDF–935K

Select item 616819512.

Beneficial Role of Erythrocyte Adenosine A2B Receptor-Mediated AMPK Activation in High Altitude Hypoxia

Hong Liu, Yujin Zhang, Hongyu Wu, Angelo D’Alessandro, Gennady G. Yegutkin, Anren Song, Kaiqi Sun, Jessica Li, Ning-Yuan Cheng, Aji Huang, Yuan Edward Wen, Ting Ting Weng, Fayong Luo, Travis Nemkov, Hong Sun, Rodney E. Kellems, Harry Karmouty-Quintana, Kirk C. Hansen, Bihong Zhao, Andrew W. Subudhi, Sonja Jameson-Van Houten, Colleen G. Julian, Andrew T. Lovering, Holger K. Eltzschig, Michael R Blackburn, Robert C. Roach, Yang Xia

Circulation. Author manuscript; available in PMC 2018 Oct 2.

Published in final edited form as: Circulation. 2016 Aug 2; 134(5): 405–421. doi: 10.1161/CIRCULATIONAHA.116.021311

PMCID:: PMC6168195

Abstract Article PDF–1.9M

Select item 588839713.

Adenosine receptors differentially regulate type 2 cytokine production by IL-33–activated bone marrow cells, ILC2s, and macrophages

Balázs Csóka, Zoltán H. Németh, Claudia U. Duerr, Jörg H. Fritz, Pál Pacher, György Haskó

FASEB J. 2018 Feb; 32(2): 829–837. Published online 2017 Oct 5. doi: 10.1096/fj.201700770R

PMCID:: PMC5888397

Abstract Article

Select item 530969814.

Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent

Anren Song, Yujin Zhang, Leng Han, Gennady G. Yegutkin, Hong Liu, Kaiqi Sun, Angelo D'Alessandro, Jessica Li, Harry Karmouty-Quintana, Takayuki Iriyama, Tingting Weng, Shushan Zhao, Wei Wang, Hongyu Wu, Travis Nemkov, Andrew W. Subudhi, Sonja Jameson-Van Houten, Colleen G. Julian, Andrew T. Lovering, Kirk C. Hansen, Hong Zhang, Mikhail Bogdanov, William Dowhan, Jianping Jin, Rodney E. Kellems, Holger K. Eltzschig, Michael Blackburn, Robert C. Roach, Yang Xia

Nat Commun. 2017; 8: 14108. Published online 2017 Feb 7. doi: 10.1038/ncomms14108

PMCID:: PMC5309698

Abstract Article PDF–1.4M

Select item 520650015.

Resetting microbiota by Lactobacillus reuteri inhibits T reg deficiency–induced autoimmunity via adenosine A_2A receptors

Baokun He, Thomas K. Hoang, Ting Wang, Michael Ferris, Christopher M. Taylor, Xiangjun Tian, Meng Luo, Dat Q. Tran, Jain Zhou, Nina Tatevian, Fayong Luo, Jose G. Molina, Michael R. Blackburn, Thomas H. Gomez, Stefan Roos, J. Marc Rhoads, Yuying Liu

J Exp Med. 2017 Jan; 214(1): 107–123. doi: 10.1084/jem.20160961

PMCID:: PMC5206500

Abstract Article PDF–3.2M

Select item 518355216.

Hypothermia in mouse is caused by adenosine A₁ and A₃ receptor agonists and AMP via three distinct mechanisms

Jesse Lea Carlin, Shalini Jain, Elizabeth Gizewski, Tina C. Wan, Dilip K. Tosh, Cuiying Xiao, John A. Auchampach, Kenneth A. Jacobson, Oksana Gavrilova, Marc L. Reitman

Neuropharmacology. Author manuscript; available in PMC 2018 Mar 1.

Published in final edited form as: Neuropharmacology. 2017 Mar 1; 114: 101–113. Published online 2016 Nov 30. doi: 10.1016/j.neuropharm.2016.11.026

PMCID:: PMC5183552

Abstract Article PDF–4.3M

Select item 501541117.

Genetic Abrogation of Adenosine A₃ Receptor Prevents Uninephrectomy and High Salt–Induced Hypertension

Ting Yang, Christa Zollbrecht, Malin E. Winerdal, Zhengbing Zhuge, Xing‐Mei Zhang, Niccolo Terrando, Antonio Checa, Johan Sällström, Craig E. Wheelock, Ola Winqvist, Robert A. Harris, Erik Larsson, A. Erik G. Persson, Bertil B. Fredholm, Mattias Carlström

J Am Heart Assoc. 2016 Jul; 5(7): e003868. Published online 2016 Jul 18. doi: 10.1161/JAHA.116.003868

PMCID:: PMC5015411

Abstract Article PDF–4.8M

Select item 483839218.

Detrimental effects of adenosine signaling in sickle cell disease

Yujin Zhang, Yingbo Dai, Jiaming Wen, Weiru Zhang, Almut Grenz, Hong Sun, Lijian Tao, Guangxiu Lu, Danny C Alexander, Michael V Milburn, Louvenia Carter-Dawson, Dorothy E Lewis, Wenzheng Zhang, Holger K Eltzschig, Rodney E Kellems, Michael R Blackburn, Harinder S Juneja, Yang Xia

Nat Med. Author manuscript; available in PMC 2016 Apr 20.

Published in final edited form as: Nat Med. 2011 Jan; 17(1): 79–86. Published online 2010 Dec 19. doi: 10.1038/nm.2280

PMCID:: PMC4838392

Abstract Article PDF–556K

Select item 478613719.

Specific Activation of A₃, A_2A and A₁ Adenosine Receptors in CD73-Knockout Mice Affects B16F10 Melanoma Growth, Neovascularization, Angiogenesis and Macrophage Infiltration

Patrycja Koszałka, Monika Gołuńska, Aleksandra Urban, Grzegorz Stasiłojć, Marcin Stanisławowski, Marceli Majewski, Andrzej C. Składanowski, Jacek Bigda

PLoS One. 2016; 11(3): e0151420. Published online 2016 Mar 10. doi: 10.1371/journal.pone.0151420

PMCID:: PMC4786137

Abstract Article PDF–2.1M

Select item 460125820.

Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A₁R A_2AR and A₃R

Silvia Di Angelantonio, Cristina Bertollini, Sonia Piccinin, Maria Rosito, Flavia Trettel, Francesca Pagani, Cristina Limatola, Davide Ragozzino

Front Cell Neurosci. 2015; 9: 409. Published online 2015 Oct 12. doi: 10.3389/fncel.2015.00409

PMCID:: PMC4601258

Abstract Article PDF–1.8M

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