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Select item 102755231.

Antisense oligonucleotides targeting basal forebrain ATXN2 enhances spatial memory and ameliorates sleep deprivation‐induced fear memory impairment in mice

Tao Ma, Long Feng, Shi‐Nan Wei, Ying‐Ying Wang, Guan‐Hua Li, Yan Lu, Ying‐Xin Zhang, Yang Chu, Wei Wang, Hao Zhang

Brain Behav. 2023 Jun; 13(6): e3013. Published online 2023 Apr 18. doi: 10.1002/brb3.3013

PMCID:: PMC10275523

Abstract Article PDF–4.5M

Select item 90156992.

The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery

Kiren Baines, Kazuaki Yoshioka, Yoh Takuwa, Jon D. Lane

Autophagy Rep. 2022; 1(1): 88–118. Published online 2022 Apr 7. doi: 10.1080/27694127.2022.2042054

PMCID:: PMC9015699

Abstract Article PDF–3.3M

Select item 87442573.

The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins

Mickaële Hémono, Alexandre Haller, Johana Chicher, Anne-Marie Duchêne, Richard Patryk Ngondo

BMC Biol. 2022; 20: 13. Published online 2022 Jan 10. doi: 10.1186/s12915-021-01213-y

PMCID:: PMC8744257

Abstract Article PDF–6.0M

Select item 87164174.

The RNA-binding protein and stress granule component ATAXIN-2 is expressed in mouse and human tissues associated with glaucoma pathogenesis

Chad A. Sundberg, Monika Lakk, Sharan Paul, Karla P. Figueroa, Daniel R. Scoles, Stefan M. Pulst, David Križaj

J Comp Neurol. Author manuscript; available in PMC 2023 Feb 1.

Published in final edited form as: J Comp Neurol. 2022 Feb; 530(2): 537–552. Published online 2021 Aug 18. doi: 10.1002/cne.25228

PMCID:: PMC8716417

Abstract Article PDF–1.2M

Select item 86109745.

Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation

Rin Khang, Areum Jo, Hojin Kang, Hanna Kim, Eunsang Kwag, Ji-Yeong Lee, Okjae Koo, Jinsu Park, Hark Kyun Kim, Dong-Gyu Jo, Inwoo Hwang, Jee-Yin Ahn, Yunjong Lee, Jeong-Yun Choi, Yun-Song Lee, Joo-Ho Shin

Sci Rep. 2021; 11: 22745. Published online 2021 Nov 23. doi: 10.1038/s41598-021-02218-x

PMCID:: PMC8610974

Abstract Article PDF–2.5M

Select item 79387706.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 75943437.

Intracellular dynamics of Ataxin-2 in the human brains with normal and frontotemporal lobar degeneration with TDP-43 inclusions

Ryohei Watanabe, Shinji Higashi, Takashi Nonaka, Ito Kawakami, Kenichi Oshima, Kazuhiro Niizato, Haruhiko Akiyama, Mari Yoshida, Masato Hasegawa, Tetsuaki Arai

Acta Neuropathol Commun. 2020; 8: 176. Published online 2020 Oct 28. doi: 10.1186/s40478-020-01055-9

PMCID:: PMC7594343

Abstract Article PDF–4.0M

Select item 75551828.

Mouse Ataxin-2 Expansion Downregulates CamKII and Other Calcium Signaling Factors, Impairing Granule—Purkinje Neuron Synaptic Strength

Aleksandar Arsović, Melanie Vanessa Halbach, Júlia Canet-Pons, Dilhan Esen-Sehir, Claudia Döring, Florian Freudenberg, Nicoletta Czechowska, Kay Seidel, Stephan L. Baader, Suzana Gispert, Nesli-Ece Sen, Georg Auburger

Int J Mol Sci. 2020 Sep; 21(18): 6673. Published online 2020 Sep 12. doi: 10.3390/ijms21186673

PMCID:: PMC7555182

Abstract Article PDF–4.0M

Select item 73225749.

ALS-associated genes in SCA2 mouse spinal cord transcriptomes

Daniel R Scoles, Warunee Dansithong, Lance T Pflieger, Sharan Paul, Mandi Gandelman, Karla P Figueroa, Frank Rigo, C Frank Bennett, Stefan M Pulst

Hum Mol Genet. 2020 Jun 27; 29(10): 1658–1672. Published online 2020 Apr 20. doi: 10.1093/hmg/ddaa072

PMCID:: PMC7322574

Abstract Article PDF–1.3M

Select item 703775410.

The RNA-Binding Protein ATXN2 is Expressed during Megakaryopoiesis and May Control Timing of Gene Expression

Marten Hansen, Sabrina Zeddies, Marjolein Meinders, Franca di Summa, Ewa Rollmann, Floris P.J. van Alphen, Arjan J. Hoogendijk, Kat S. Moore, Melanie Halbach, Laura Gutiérrez, Maartje van den Biggelaar, Daphne C. Thijssen-Timmer, Georg W.J. Auburger, Emile van den Akker, Marieke von Lindern

Int J Mol Sci. 2020 Feb; 21(3): 967. Published online 2020 Jan 31. doi: 10.3390/ijms21030967

PMCID:: PMC7037754

Abstract Article PDF–4.2M

Select item 692874911.

In Human and Mouse Spino-Cerebellar Tissue, Ataxin-2 Expansion Affects Ceramide-Sphingomyelin Metabolism

Nesli-Ece Sen, Aleksandar Arsovic, David Meierhofer, Susanne Brodesser, Carola Oberschmidt, Júlia Canet-Pons, Zeynep-Ece Kaya, Melanie-Vanessa Halbach, Suzana Gispert, Konrad Sandhoff, Georg Auburger

Int J Mol Sci. 2019 Dec; 20(23): 5854. Published online 2019 Nov 21. doi: 10.3390/ijms20235854

PMCID:: PMC6928749

Abstract Article PDF–4.9M

Select item 669277012.

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics

Joel D. Federspiel, Todd M. Greco, Krystal K. Lum, Ileana M. Cristea

Mol Cell Proteomics. 2019 Aug 9; 18(8 Suppl 1): S92–S113. Published online 2019 Apr 30. doi: 10.1074/mcp.RA118.001253

PMCID:: PMC6692770

Abstract Article PDF–7.7M

Select item 660230013.

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA–protein network and RNA granules

Richa Das, Lukas Schwintzer, Stanislav Vinopal, Eva Aguado Roca, Marc Sylvester, Ana-Maria Oprisoreanu, Susanne Schoch, Frank Bradke, Meike Broemer

J Cell Sci. 2019 Jun 15; 132(12): jcs229252. Published online 2019 Jun 17. doi: 10.1242/jcs.229252

PMCID:: PMC6602300

Abstract Article

Select item 629804014.

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, Bruce M. Spiegelman

Cell. Author manuscript; available in PMC 2019 Dec 13.

Published in final edited form as: Cell. 2018 Dec 13; 175(7): 1756–1768.e17. doi: 10.1016/j.cell.2018.10.025

Correction in:: Cell. 2019 Jul 11; 178(2): 507–508.

PMCID:: PMC6298040

Abstract Article PDF–1.2M

Select item 612885615.

Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration

Sharan Paul, Warunee Dansithong, Karla P. Figueroa, Daniel R. Scoles, Stefan M. Pulst

Nat Commun. 2018; 9: 3648. Published online 2018 Sep 7. doi: 10.1038/s41467-018-06041-3

PMCID:: PMC6128856

Abstract Article PDF–7.3M

Select item 588623216.

Gene co-expression network analysis for identifying modules and functionally enriched pathways in SCA2

Lance T. Pflieger, Warunee Dansithong, Sharan Paul, Daniel R. Scoles, Karla P. Figueroa, Pratap Meera, Thomas S. Otis, Julio C. Facelli, Stefan M. Pulst

Hum Mol Genet. 2017 Aug 15; 26(16): 3069–3080. Published online 2017 May 19. doi: 10.1093/hmg/ddx191

PMCID:: PMC5886232

Abstract Article PDF–741K

Select item 579538817.

The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes

Fan Liu, Philip Lössl, Beverley M. Rabbitts, Robert S. Balaban, Albert J. R. Heck

Mol Cell Proteomics. 2018 Feb; 17(2): 216–232. Published online 2017 Dec 8. doi: 10.1074/mcp.RA117.000470

PMCID:: PMC5795388

Abstract Article PDF–4.4M

Select item 564508218.

Spatio-temporal profile of postynaptic interactomes integrates components of complex brain disorders

Jing Li, Wangshu Zhang, Hui Yang, Daniel P. Howrigan, Brent Wilkinson, Tade Souaiaia, Oleg V. Evgrafov, Giulio Genovese, Veronica A. Clementel, Jennifer C. Tudor, Ted Abel, James A. Knowles, Benjamin M. Neale, Kai Wang, Fengzhu Sun, Marcelo P. Coba

Nat Neurosci. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: Nat Neurosci. 2017 Aug; 20(8): 1150–1161. Published online 2017 Jun 26. doi: 10.1038/nn.4594

PMCID:: PMC5645082

Abstract Article PDF–2.3M

Select item 564204219.

Therapeutic reduction of ataxin 2 extends lifespan and reduces pathology in TDP-43 mice

Lindsay A. Becker, Brenda Huang, Gregor Bieri, Rosanna Ma, David A. Knowles, Paymaan Jafar-Nejad, James Messing, Hong Joo Kim, Armand Soriano, Georg Auburger, Stefan M. Pulst, J. Paul Taylor, Frank Rigo, Aaron D. Gitler

Nature. Author manuscript; available in PMC 2017 Oct 16.

Published in final edited form as: Nature. 2017 Apr 20; 544(7650): 367–371. Published online 2017 Apr 12. doi: 10.1038/nature22038

PMCID:: PMC5642042

Abstract Article PDF–3.2M

Select item 524390420.

Atxn2 Knockout and CAG42-Knock-in Cerebellum Shows Similarly Dysregulated Expression in Calcium Homeostasis Pathway

Melanie Vanessa Halbach, Suzana Gispert, Tanja Stehning, Ewa Damrath, Michael Walter, Georg Auburger

Cerebellum. 2017; 16(1): 68–81. Published online 2016 Feb 11. doi: 10.1007/s12311-016-0762-4

PMCID:: PMC5243904

Abstract Article PDF–4.3M

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