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Items: 1 to 20 of 37

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Unexpected Motherhood-Triggered Hearing Loss in the Two-Pore Channel (TPC) Mutant Mouse
Juliette Royer, José-Manuel Cancela, Jean-Marc Edeline
Biomedicines. 2022 Jul; 10(7): 1708. Published online 2022 Jul 15. doi: 10.3390/biomedicines10071708
PMCID:
PMC9312904
AbstractArticlePDF–1.3M
3.
Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance
Spencer A. Freeman, Stefan Uderhardt, Amra Saric, Richard F. Collins, Catherine M. Buckley, Sivakami Mylvaganam, Parastoo Boroumand, Jonathan Plumb, Ronald N. Germain, Dejian Ren, Sergio Grinstein
Science. Author manuscript; available in PMC 2021 May 13.
Published in final edited form as: Science. 2020 Jan 17; 367(6475): 301–305. Published online 2019 Dec 5. doi: 10.1126/science.aaw9544
PMCID:
PMC8118712
AbstractArticlePDF–1.5M
4.
Genetic Inactivation of Two-Pore Channel 1 Impairs Spatial Learning and Memory
Robert Theodor Mallmann, Norbert Klugbauer
Behav Genet. 2020; 50(6): 401–410. Published online 2020 Sep 5. doi: 10.1007/s10519-020-10011-1
PMCID:
PMC7581579
AbstractArticlePDF–1.9M
5.
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)
Kou Motani, Hidetaka Kosako
J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323
PMCID:
PMC7415991
AbstractArticlePDF–2.0M
6.
NAADP‐regulated two‐pore channels drive phagocytosis through endo‐lysosomal Ca2+ nanodomains, calcineurin and dynamin
Lianne C Davis, Anthony J Morgan, Antony Galione
EMBO J. 2020 Jul 15; 39(14): e104058. Published online 2020 Jun 8. doi: 10.15252/embj.2019104058
PMCID:
PMC7360967
AbstractArticlePDF–4.9M
7.
ORAI1, stromal interaction molecules 1/2, and ryanodine receptor type 1 shape sub-second Ca2+ microdomains upon T cell activation
B.-P. Diercks, R. Werner, P. Weidemüller, F. Czarniak, L. Hernandez, C. Lehmann, A. Rosche, A. Krüger, U. Kaufmann, M. Vaeth, A. V. Failla, B. Zobiak, F. I. Kandil, D. Schetelig, A. Ruthenbeck, C. Meier, D. Lodygin, A. Flügel, D. Ren, I. M.A. Wolf, S. Feske, A. H. Guse
Sci Signal. Author manuscript; available in PMC 2019 Sep 5.
Published in final edited form as: Sci Signal. 2018 Dec 18; 11(561): eaat0358. Published online 2018 Dec 18. doi: 10.1126/scisignal.aat0358
PMCID:
PMC6728084
AbstractArticlePDF–2.3M
8.
Hippocampal mGluR1-dependent long-term potentiation requires NAADP-mediated acidic store Ca2+ signaling
William J. Foster, Henry B. C. Taylor, Zahid Padamsey, Alexander F. Jeans, Antony Galione, Nigel J. Emptage
Sci Signal. Author manuscript; available in PMC 2019 Aug 3.
Published in final edited form as: Sci Signal. 2018 Nov 27; 11(558): eaat9093. Published online 2018 Nov 27. doi: 10.1126/scisignal.aat9093
PMCID:
PMC6679716
AbstractArticlePDF–2.3M
9.
Structural insights into the voltage and phospholipid activation of mammalian TPC1 channel
Ji She, Jiangtao Guo, Qingfeng Chen, Weizhong Zeng, Youxing Jiang, Xiao-chen Bai
Nature. Author manuscript; available in PMC 2018 Sep 21.
Published in final edited form as: Nature. 2018 Apr 5; 556(7699): 130–134. Published online 2018 Mar 21. doi: 10.1038/nature26139
PMCID:
PMC5886804
AbstractArticlePDF–2.4M
10.
The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes
Jan Castonguay, Joachim H. C. Orth, Thomas Müller, Faten Sleman, Christian Grimm, Christian Wahl-Schott, Martin Biel, Robert Theodor Mallmann, Wolfgang Bildl, Uwe Schulte, Norbert Klugbauer
Sci Rep. 2017; 7: 10038. Published online 2017 Aug 30. doi: 10.1038/s41598-017-10607-4
PMCID:
PMC5577145
AbstractArticlePDF–4.1M
11.
Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program
John P. Sundberg, Soheil S. Dadras, Kathleen A. Silva, Victoria E. Kennedy, Gaven Garland, Stephen A. Murray, Beth A. Sundberg, Paul N. Schofield, C. Herbert Pratt
PLoS One. 2017; 12(7): e0180682. Published online 2017 Jul 10. doi: 10.1371/journal.pone.0180682
PMCID:
PMC5503261
AbstractArticlePDF–31M
12.
Endolysosomal two‐pore channels regulate autophagy in cardiomyocytes
Vanessa García‐Rúa, Sandra Feijóo‐Bandín, Diego Rodríguez‐Penas, Ana Mosquera‐Leal, Emad Abu‐Assi, Andrés Beiras, Luisa María Seoane, Pamela Lear, John Parrington, Manuel Portolés, Esther Roselló‐Lletí, Miguel Rivera, Oreste Gualillo, Valentina Parra, Joseph A. Hill, Beverly Rothermel, José Ramón González‐Juanatey, Francisca Lago
J Physiol. 2016 Jun 1; 594(11): 3061–3077. Published online 2016 Feb 4. doi: 10.1113/JP271332
PMCID:
PMC4887684
AbstractArticlePDF–1.1M
13.
Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the Heart
Rebecca A. Capel, Emma L. Bolton, Wee K. Lin, Daniel Aston, Yanwen Wang, Wei Liu, Xin Wang, Rebecca-Ann B. Burton, Duncan Bloor-Young, Kai-Ting Shade, Margarida Ruas, John Parrington, Grant C. Churchill, Ming Lei, Antony Galione, Derek A. Terrar
J Biol Chem. 2015 Dec 11; 290(50): 30087–30098. Published online 2015 Oct 5. doi: 10.1074/jbc.M115.684076
PMCID:
PMC4705968
AbstractArticlePDF–2.3M
14.
GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation
Makoto Shigeto, Reshma Ramracheya, Andrei I. Tarasov, Chae Young Cha, Margarita V. Chibalina, Benoit Hastoy, Koenraad Philippaert, Thomas Reinbothe, Nils Rorsman, Albert Salehi, William R. Sones, Elisa Vergari, Cathryn Weston, Julia Gorelik, Masashi Katsura, Viacheslav O. Nikolaev, Rudi Vennekens, Manuela Zaccolo, Antony Galione, Paul R.V. Johnson, Kohei Kaku, Graham Ladds, Patrik Rorsman
J Clin Invest. 2015 Dec 1; 125(12): 4714–4728. Published online 2015 Nov 16. doi: 10.1172/JCI81975
PMCID:
PMC4665783
AbstractArticlePDF–1.7M
15.
Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore
Sean M. Davidson, Kirsty Foote, Suma Kunuthur, Raj Gosain, Noah Tan, Richard Tyser, Yong Juan Zhao, Richard Graeff, A. Ganesan, Michael R. Duchen, Sandip Patel, Derek M. Yellon
Cardiovasc Res. 2015 Dec 1; 108(3): 357–366. Published online 2015 Sep 22. doi: 10.1093/cvr/cvv226
PMCID:
PMC4648198
AbstractArticlePDF–737K
16.
Spatiotemporal regulation of GLI target genes in the mammalian limb bud
Jordan P. Lewandowski, Fang Du, Shilu Zhang, Marian B. Powell, Kristin N. Falkenstein, Hongkai Ji, Steven A. Vokes
Dev Biol. Author manuscript; available in PMC 2016 Oct 1.
Published in final edited form as: Dev Biol. 2015 Oct 1; 406(1): 92–103. Published online 2015 Jul 31. doi: 10.1016/j.ydbio.2015.07.022
PMCID:
PMC4587286
AbstractArticlePDF–2.0M
17.
Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells
Abdelilah Arredouani, Margarida Ruas, Stephan C. Collins, Raman Parkesh, Frederick Clough, Toby Pillinger, George Coltart, Katja Rietdorf, Andrew Royle, Paul Johnson, Matthias Braun, Quan Zhang, William Sones, Kenju Shimomura, Anthony J. Morgan, Alexander M. Lewis, Kai-Ting Chuang, Ruth Tunn, Joaquin Gadea, Lydia Teboul, Paula M. Heister, Patricia W. Tynan, Elisa A. Bellomo, Guy A. Rutter, Patrik Rorsman, Grant C. Churchill, John Parrington, Antony Galione
J Biol Chem. 2015 Aug 28; 290(35): 21376–21392. Published online 2015 Jul 7. doi: 10.1074/jbc.M115.671248
PMCID:
PMC4571866
AbstractArticlePDF–3.6M
18.
Two pore channels control Ebolavirus host cell entry and are drug targets for disease treatment
Yasuteru Sakurai, Andrey A. Kolokoltsov, Cheng-Chang Chen, Michael W. Tidwell, William E. Bauta, Norbert Klugbauer, Christian Grimm, Christian Wahl-Schott, Martin Biel, Robert A. Davey
Science. Author manuscript; available in PMC 2016 Feb 27.
Published in final edited form as: Science. 2015 Feb 27; 347(6225): 995–998. doi: 10.1126/science.1258758
PMCID:
PMC4550587
AbstractArticlePDF–724K
19.
Expression of Ca2+-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells
Margarida Ruas, Lianne C Davis, Cheng-Chang Chen, Anthony J Morgan, Kai-Ting Chuang, Timothy F Walseth, Christian Grimm, Clive Garnham, Trevor Powell, Nick Platt, Frances M Platt, Martin Biel, Christian Wahl-Schott, John Parrington, Antony Galione
EMBO J. 2015 Jul 2; 34(13): 1743–1758. Published online 2015 Apr 14. doi: 10.15252/embj.201490009
PMCID:
PMC4516428
AbstractArticlePDF–1.8M
20.
TPC1 Has Two Variant Isoforms, and Their Removal Has Different Effects on Endo-Lysosomal Functions Compared to Loss of TPC2
Margarida Ruas, Kai-Ting Chuang, Lianne C. Davis, Areej Al-Douri, Patricia W. Tynan, Ruth Tunn, Lydia Teboul, Antony Galione, John Parrington
Mol Cell Biol. 2014 Nov; 34(21): 3981–3992. doi: 10.1128/MCB.00113-14
PMCID:
PMC4386455
AbstractArticlePDF–2.6M

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