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Select item 114526231.

The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development

Pablo Gómez-del Arco, Joan Isern, Daniel Jimenez-Carretero, Dolores López-Maderuelo, Rebeca Piñeiro-Sabarís, Fadoua El Abdellaoui-Soussi, Carlos Torroja, María Linarejos Vera-Pedrosa, Mercedes Grima-Terrén, Alberto Benguria, Ana Simón-Chica, Antonio Queiro-Palou, Ana Dopazo, Fátima Sánchez-Cabo, José Jalife, José Luis de la Pompa, David Filgueiras-Rama, Pura Muñoz-Cánoves, Juan Miguel Redondo

Nat Commun. 2024; 15: 8602. Published online 2024 Oct 4. doi: 10.1038/s41467-024-52809-1

PMCID:: PMC11452623

Abstract Article PDF–4.1M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 103868873.

K_ATP channels are necessary for glucose-dependent increases in amyloid-β and Alzheimer’s disease–related pathology

John Grizzanti, William R. Moritz, Morgan C. Pait, Molly Stanley, Sarah D. Kaye, Caitlin M. Carroll, Nicholas J. Constantino, Lily J. Deitelzweig, James A. Snipes, Derek Kellar, Emily E. Caesar, Ryan J. Pettit-Mee, Stephen M. Day, Jonathon P. Sens, Noelle I. Nicol, Jasmeen Dhillon, Maria S. Remedi, Drew D. Kiraly, Celeste M. Karch, Colin G. Nichols, David M. Holtzman, Shannon L. Macauley

JCI Insight. 2023 May 22; 8(10): e162454. Published online 2023 May 22. doi: 10.1172/jci.insight.162454

PMCID:: PMC10386887

Abstract Article PDF–6.2M

Select item 91803584.

Peroxisome Metabolism Contributes to PIEZO2-Mediated Mechanical Allodynia

Yi Gong, Fiza Laheji, Anna Berenson, April Qian, Sang-O Park, Rene Kok, Martin Selig, Ryan Hahn, Reza Sadjadi, Stephan Kemp, Florian Eichler

Cells. 2022 Jun; 11(11): 1842. Published online 2022 Jun 4. doi: 10.3390/cells11111842

PMCID:: PMC9180358

Abstract Article PDF–4.6M

Select item 90723205.

K_ATP channel dependent heart multiome atlas

D. Kent Arrell, Sungjo Park, Satsuki Yamada, Alexey E. Alekseev, Armin Garmany, Ryounghoon Jeon, Ivan Vuckovic, Jelena Zlatkovic Lindor, Andre Terzic

Sci Rep. 2022; 12: 7314. Published online 2022 May 5. doi: 10.1038/s41598-022-11323-4

PMCID:: PMC9072320

Abstract Article PDF–2.6M

Select item 88809916.

Blocking Kir6.2 channels with SpTx1 potentiates glucose-stimulated insulin secretion from murine pancreatic β cells and lowers blood glucose in diabetic mice

Yajamana Ramu, Jayden Yamakaze, Yufeng Zhou, Toshinori Hoshi, Zhe Lu

eLife. 2022; 11: e77026. Published online 2022 Feb 25. doi: 10.7554/eLife.77026

PMCID:: PMC8880991

Abstract Article PDF–1.9M

Select item 87190147.

Kir6.2-deficient mice develop somatosensory dysfunction and axonal loss in the peripheral nerves

Hiromi Nakai-Shimoda, Tatsuhito Himeno, Tetsuji Okawa, Emiri Miura-Yura, Sachiko Sasajima, Makoto Kato, Yuichiro Yamada, Yoshiaki Morishita, Shin Tsunekawa, Yoshiro Kato, Yusuke Seino, Rieko Inoue, Masaki Kondo, Susumu Seino, Keiko Naruse, Koichi Kato, Hiroki Mizukami, Jiro Nakamura, Hideki Kamiya

iScience. 2022 Jan 21; 25(1): 103609. Published online 2021 Dec 11. doi: 10.1016/j.isci.2021.103609

PMCID:: PMC8719014

Abstract Article PDF–6.0M

Select item 86512958.

Lactate is an energy substrate for rodent cortical neurons and enhances their firing activity

Anastassios Karagiannis, Thierry Gallopin, Alexandre Lacroix, Fabrice Plaisier, Juliette Piquet, Hélène Geoffroy, Régine Hepp, Jérémie Naudé, Benjamin Le Gac, Richard Egger, Bertrand Lambolez, Dongdong Li, Jean Rossier, Jochen F Staiger, Hiromi Imamura, Susumu Seino, Jochen Roeper, Bruno Cauli

eLife. 2021; 10: e71424. Published online 2021 Nov 12. doi: 10.7554/eLife.71424

PMCID:: PMC8651295

Abstract Article PDF–12M

Select item 85774629.

Kir6.2 is essential to maintain neurite features by modulating PM20D1-reduced mitochondrial ATP generation

Nanshan Song, Yinquan Fang, Hong Zhu, Jiaqi Liu, Siyuan Jiang, Sifan Sun, Rong Xu, Jianhua Ding, Gang Hu, Ming Lu

Redox Biol. 2021 Nov; 47: 102168. Published online 2021 Oct 15. doi: 10.1016/j.redox.2021.102168

PMCID:: PMC8577462

Abstract Article PDF–16M

Select item 798804810.

Structure based analysis of K_ATP channel with a DEND syndrome mutation in murine skeletal muscle

Shoichiro Horita, Tomoyuki Ono, Saul Gonzalez-Resines, Yuko Ono, Megumi Yamachi, Songji Zhao, Carmen Domene, Yuko Maejima, Kenju Shimomura

Sci Rep. 2021; 11: 6668. Published online 2021 Mar 23. doi: 10.1038/s41598-021-86121-5

PMCID:: PMC7988048

Abstract Article PDF–6.2M

Select item 768575611.

Gs/Gq signaling switch in β cells defines incretin effectiveness in diabetes

Okechi S. Oduori, Naoya Murao, Kenju Shimomura, Harumi Takahashi, Quan Zhang, Haiqiang Dou, Shihomi Sakai, Kohtaro Minami, Belen Chanclon, Claudia Guida, Lakshmi Kothegala, Johan Tolö, Yuko Maejima, Norihide Yokoi, Yasuhiro Minami, Takashi Miki, Patrik Rorsman, Susumu Seino

J Clin Invest. 2020 Dec 1; 130(12): 6639–6655. Published online 2020 Nov 16. doi: 10.1172/JCI140046

PMCID:: PMC7685756

Abstract Article PDF–6.7M

Select item 659500112.

Myocardial death and dysfunction after ischemia-reperfusion injury require CaMKIIδ oxidation

Yuejin Wu, Qinchuan Wang, Ning Feng, Jonathan M. Granger, Mark E. Anderson

Sci Rep. 2019; 9: 9291. Published online 2019 Jun 26. doi: 10.1038/s41598-019-45743-6

PMCID:: PMC6595001

Abstract Article PDF–5.4M

Select item 650288713.

The role of membrane excitability in pancreatic β-cell glucotoxicity

Zeenat A. Shyr, Zhiyu Wang, Nathaniel W. York, Colin G. Nichols, Maria S. Remedi

Sci Rep. 2019; 9: 6952. Published online 2019 May 6. doi: 10.1038/s41598-019-43452-8

PMCID:: PMC6502887

Abstract Article PDF–2.9M

Select item 640788814.

High Fat Diet induced Remission of Diabetes in a subset of K_ATP-GOF Insulin Secretory-Deficient mice

Zihan Yan, Zeenat A. Shyr, Manuela Fortunato, Alecia Welscher, Mariana Alisio, Michael Martino, Brian N. Finck, Hannah Conway, Maria S. Remedi

Diabetes Obes Metab. Author manuscript; available in PMC 2019 Nov 1.

Published in final edited form as: Diabetes Obes Metab. 2018 Nov; 20(11): 2574–2584. Published online 2018 Jul 11. doi: 10.1111/dom.13423

PMCID:: PMC6407888

Abstract Article PDF–1.9M

Select item 633696115.

Contribution of systemic inflammation to permanence of K_ATP-induced neonatal diabetes in mice

Christopher H. Emfinger, Zihan Yan, Alecia Welscher, Peter Hung, William McAllister, Paul W. Hruz, Colin G. Nichols, Maria S. Remedi

Am J Physiol Endocrinol Metab. 2018 Dec 1; 315(6): E1121–E1132. Published online 2018 Sep 18. doi: 10.1152/ajpendo.00137.2018

PMCID:: PMC6336961

Abstract Article

Select item 610119616.

A rare mutation in ABCC8/SUR1 leading to altered K_ATP channel activity and β-cell glucose sensing is associated with type 2 diabetes mellitus in adults

Andrei I. Tarasov, Tamara Nicolson, Jean-Pierre Riveline, Tarvinder K. Taneja, Stephen A. Baldwin, Jocelyn M. Baldwin, Guillaume Charpentier, Jean-François Gautier, Philippe Froguel, Martine Vaxillaire, Guy A. Rutter

Diabetes. Author manuscript; available in PMC 2018 Aug 20.

Published in final edited form as: Diabetes. 2008 Jun; 57(6): 1595–1604. Published online 2008 Mar 17. doi: 10.2337/db07-1547