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Items: 1 to 20 of 103

1.
Toll-like receptor signalling via IRAK4 affects epithelial integrity and tightness through regulation of junctional tension
Jesse Peterson, Kinga Balogh Sivars, Ambra Bianco, Katja Röper
Development. 2023 Dec 15; 150(24): dev201893. Published online 2023 Dec 11. doi: 10.1242/dev.201893
PMCID:
PMC10753582
AbstractArticle
2.
Paralog-specific signaling by IRAK1/4 maintains MyD88-independent functions in MDS/AML
Joshua Bennett, Chiharu Ishikawa, Puneet Agarwal, Jennifer Yeung, Avery Sampson, Emma Uible, Eric Vick, Lyndsey C. Bolanos, Kathleen Hueneman, Mark Wunderlich, Amal Kolt, Kwangmin Choi, Andrew Volk, Kenneth D. Greis, Jan Rosenbaum, Scott B. Hoyt, Craig J. Thomas, Daniel T. Starczynowski
Blood. 2023 Sep 14; 142(11): 989–1007. Published online 2023 May 16. doi: 10.1182/blood.2022018718
PMCID:
PMC10517216
AbstractArticle
3.
Neuroinflammation, autoinflammation, splenomegaly and anemia caused by bi-allelic mutations in IRAK4
Samantha Cooray, Fiona Price-Kuehne, Ying Hong, Ebun Omoyinmi, Alice Burleigh, Kimberly C. Gilmour, Bilal Ahmad, Sangdun Choi, Mohammad W. Bahar, Paul Torpiano, Andrey Gagunashvili, Barbara Jensen, Evangelos Bellos, Vanessa Sancho-Shimizu, Jethro A. Herberg, Kshitij Mankad, Atul Kumar, Marios Kaliakatsos, Austen J. J. Worth, Despina Eleftheriou, Elizabeth Whittaker, Paul A. Brogan
Front Immunol. 2023; 14: 1231749. Published online 2023 Sep 6. doi: 10.3389/fimmu.2023.1231749
PMCID:
PMC10516541
AbstractArticlePDF–8.0M
4.
Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity
Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong
Mol Cell. Author manuscript; available in PMC 2023 Apr 4.
Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015
PMCID:
PMC10072906
AbstractArticlePDF–4.2M
5.
Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia
Ana García-García, Rebeca Pérez de Diego, Carlos Flores, Darawan Rinchai, Jordi Solé-Violán, Àngela Deyà-Martínez, Blanca García-Solis, José M. Lorenzo-Salazar, Elisa Hernández-Brito, Anna-Lisa Lanz, Leen Moens, Giorgia Bucciol, Mohamed Almuqamam, Joseph B. Domachowske, Elena Colino, Juan Luis Santos-Perez, Francisco M. Marco, Claudio Pignata, Aziz Bousfiha, Stuart E. Turvey, Stefanie Bauer, Filomeen Haerynck, Javier Gonzalo Ocejo-Vinyals, Francisco Lendinez, Seraina Prader, Nora Naumann-Bartsch, Jana Pachlopnik Schmid, Catherine M. Biggs, Kyla Hildebrand, Alexandra Dreesman, Miguel Ángel Cárdenes, Fatima Ailal, Ibtihal Benhsaien, Giuliana Giardino, Agueda Molina-Fuentes, Claudia Fortuny, Swetha Madhavarapu, Daniel H. Conway, Carolina Prando, Laire Schidlowski, María Teresa Martínez de Saavedra Álvarez, Rafael Alfaro, Felipe Rodríguez de Castro, ESID Registry Working Party, COVID Human Genetic Effort, Isabelle Meyts, Fabian Hauck, Anne Puel, Paul Bastard, Bertrand Boisson, Emmanuelle Jouanguy, Laurent Abel, Aurélie Cobat, Qian Zhang, Jean-Laurent Casanova, Laia Alsina, Carlos Rodríguez-Gallego
J Exp Med. 2023 May 1; 220(5): e20220170. Published online 2023 Mar 3. doi: 10.1084/jem.20220170
PMCID:
PMC9998661
AbstractArticlePDF–2.6M
6.
The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways
Milton Pereira, Danielle F. Durso, Clare E. Bryant, Evelyn A. Kurt-Jones, Neal Silverman, Douglas T. Golenbock, Ricardo T. Gazzinelli
Cell Rep. Author manuscript; available in PMC 2022 Sep 6.
Published in final edited form as: Cell Rep. 2022 Aug 16; 40(7): 111225. doi: 10.1016/j.celrep.2022.111225
PMCID:
PMC9446533
AbstractArticlePDF–2.6M
7.
IRAK4 signaling drives resistance to checkpoint immunotherapy in pancreatic ductal adenocarcinoma
Vikas Somani, Daoxiang Zhang, Paarth B. Dodhiawala, Varintra E. Lander, Xiuting Liu, Liang-I Kang, Hung-Po Chen, Brett L. Knolhoff, Lin Li, Patrick M. Grierson, Mariana B. Ruzinova, David G. DeNardo, Kian-Huat Lim
Gastroenterology. Author manuscript; available in PMC 2023 Jun 1.
Published in final edited form as: Gastroenterology. 2022 Jun; 162(7): 2047–2062. Published online 2022 Mar 7. doi: 10.1053/j.gastro.2022.02.035
PMCID:
PMC9387774
AbstractArticlePDF–3.2M
8.
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery
Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili
Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z
PMCID:
PMC9279285
AbstractArticlePDF–2.5M
9.
Association of the IRAK4 rs4251545 genetic polymorphism with severity of enterovirus‐71 infection in Chinese children
Jie Song, Yedan Liu, Ya Guo, Peipei Liu, Fei Li, Chengqing Yang, Xiaoyu Pan, Liping Yi, Fan Fan, Han Zhao, Zongbo Chen
Immun Inflamm Dis. 2022 May; 10(5): e614. Published online 2022 Apr 19. doi: 10.1002/iid3.614
PMCID:
PMC9017637
AbstractArticlePDF–1.1M
10.
Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors
Yosuke Tanaka, Reina Takeda, Tsuyoshi Fukushima, Keiko Mikami, Shun Tsuchiya, Moe Tamura, Keito Adachi, Terumasa Umemoto, Shuhei Asada, Naoki Watanabe, Soji Morishita, Misa Imai, Masayoshi Nagata, Marito Araki, Hitoshi Takizawa, Tomofusa Fukuyama, Chrystelle Lamagna, Esteban S. Masuda, Ryoji Ito, Susumu Goyama, Norio Komatsu, Tomoiku Takaku, Toshio Kitamura
Nat Commun. 2022; 13: 271. Published online 2022 Jan 12. doi: 10.1038/s41467-021-27928-8
PMCID:
PMC8755781
AbstractArticlePDF–2.4M
11.
IRAK-4 in macrophages contributes to inflammatory osteolysis of wear particles around loosened hip implants
Yang-chun Zhang, Jian-hong Xiao, Shao-jie Deng, Guo-liang Yi
Innate Immun. 2021 Aug; 27(6): 470–482. Published online 2021 Jun 18. doi: 10.1177/17534259211018740
PMCID:
PMC8504263
AbstractArticlePDF–1.2M
12.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
13.
Tumor cell intrinsic RON signaling suppresses innate immune responses in breast cancer through inhibition of IRAK4 signaling.
Jennifer R. Bourn, Sasha J. Ruiz-Torres, Brian G. Hunt, Nancy M. Benight, Susan E. Waltz
Cancer Lett. Author manuscript; available in PMC 2022 Apr 10.
Published in final edited form as: Cancer Lett. 2021 Apr 10; 503: 75–90. Published online 2021 Jan 27. doi: 10.1016/j.canlet.2021.01.019
PMCID:
PMC7981256
AbstractArticlePDF–1.3M
14.
Dimeric Structure of the Pseudokinase IRAK3 Suggests an Allosteric Mechanism for Negative Regulation
Sven M. Lange, Marina I. Nelen, Philip Cohen, Yogesh Kulathu
Structure. 2021 Mar 4; 29(3): 238–251.e4. doi: 10.1016/j.str.2020.11.004
PMCID:
PMC7955167
AbstractArticle
15.
IRAK4 Deficiency Presenting with Anti-NMDAR Encephalitis and HHV6 Reactivation
Shiho Nishimura, Yoshiyuki Kobayashi, Hidenori Ohnishi, Kunihiko Moriya, Miyuki Tsumura, Sonoko Sakata, Yoko Mizoguchi, Hidetoshi Takada, Zenichiro Kato, Vanessa Sancho-Shimizu, Capucine Picard, Sarosh R. Irani, Osamu Ohara, Jean-Laurent Casanova, Anne Puel, Nobutsune Ishikawa, Satoshi Okada, Masao Kobayashi
J Clin Immunol. 2021; 41(1): 125–135. Published online 2020 Oct 20. doi: 10.1007/s10875-020-00885-5
PMCID:
PMC7846526
AbstractArticlePDF–1.2M
16.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases
Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger
Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001
PMCID:
PMC7427327
AbstractArticle
17.
Clinical IRAK4 deficiency caused by homozygosity for the novel IRAK4 (c.1049delG, p.Gly350Glufs*15) variant
Alicia Jia, Elliot James, Henry Y. Lu, Mehul Sharma, Bhavi P. Modi, Catherine M. Biggs, Kyla J. Hildebrand, Alanna Chomyn, Stephanie Erdle, Hasandeep Kular, Stuart E. Turvey
Cold Spring Harb Mol Case Stud. 2020 Jun; 6(3): a005298. doi: 10.1101/mcs.a005298
PMCID:
PMC7304365
AbstractArticlePDF–2.4M
18.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
19.
Human TLR-7-, -8-, and -9-Mediated Induction of IFN-α/β and -λ Is IRAK-4 Dependent and Redundant for Protective Immunity to Viruses
Kun Yang, Anne Puel, Shenying Zhang, Céline Eidenschenk, Cheng-Lung Ku, Armanda Casrouge, Capucine Picard, Horst von Bernuth, Brigitte Senechal, Sabine Plancoulaine, Sami Al-Hajjar, Abdulaziz Al-Ghonaium, László Maródi, Donald Davidson, David Speert, Chaim Roifman, Ben-Zion Garty, Adrian Ozinsky, Franck J. Barrat, Robert L. Coffman, Richard L. Miller, Xiaoxia Li, Pierre Lebon, Carlos Rodriguez-Gallego, Helen Chapel, Frédéric Geissmann, Emmanuelle Jouanguy, Jean-Laurent Casanova
Immunity. 2005 Nov; 23(5): 465–478. Published online 2005 Nov 15. doi: 10.1016/j.immuni.2005.09.016
PMCID:
PMC7111074
AbstractArticlePDF–780K
20.
MyD88 Death-Domain Oligomerization Determines Myddosome Architecture: Implications for Toll-like Receptor Signaling
Martin C. Moncrieffe, Daniel Bollschweiler, Bing Li, Pawel A. Penczek, Lee Hopkins, Clare E. Bryant, David Klenerman, Nicholas J. Gay
Structure. 2020 Mar 3; 28(3): 281–289.e3. doi: 10.1016/j.str.2020.01.003
PMCID:
PMC7054835
AbstractArticle

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