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Select item 113250911.

FcγRIIB expressed on CD8⁺ T cells limits responsiveness to PD-1 checkpoint inhibition in cancer

Kelsey B. Bennion, Marvi Tariq, Megan M. Wyatt, Charlotte Duneton, Kirsten M. Baecher, Chrystal M. Paulos, Ragini R. Kudchadkar, Michael C. Lowe, Mandy L. Ford

Sci Transl Med. Author manuscript; available in PMC 2024 Aug 23.

Published in final edited form as: Sci Transl Med. 2023 Aug 23; 15(710): eadd1868. Published online 2023 Aug 23. doi: 10.1126/scitranslmed.add1868

PMCID:: PMC11325091

Abstract Article PDF–3.7M

Select item 109521872.

Mutation of the TGN1412 anti‐CD28 monoclonal antibody lower hinge confers specific FcγRIIb binding and retention of super‐agonist activity

Alicia M Chenoweth, Sandra Esparon, Bruce D Wines, Janine Schuurman, Aran F Labrijn, P Mark Hogarth

Immunol Cell Biol. 2023 Aug; 101(7): 657–662. Published online 2023 Apr 28. doi: 10.1111/imcb.12646

PMCID:: PMC10952187

Abstract Article PDF–649K

Select item 109117033.

FcγRIIB Is an Immune Checkpoint Limiting the Activity of Treg-Targeting Antibodies in the Tumor Microenvironment

David A. Knorr, Lucas Blanchard, Rom S. Leidner, Shawn M. Jensen, Ryan Meng, Andrew Jones, Carmen Ballesteros-Merino, Richard B. Bell, Maria Baez, Alessandra Marino, David Sprott, Carlo B. Bifulco, Brian Piening, Rony Dahan, Juan C. Osorio, Bernard A. Fox, Jeffrey V. Ravetch

Cancer Immunol Res. 2024 Mar 4; 12(3): 322–333. Published online 2023 Dec 26. doi: 10.1158/2326-6066.CIR-23-0389

PMCID:: PMC10911703

Abstract Article PDF–3.3M

Select item 105828874.

C-reactive protein impairs immune response of CD8⁺ T cells via FcγRIIb-p38MAPK-ROS axis in multiple myeloma

Jinxing Jiang, Ziyi Peng, Junying Wang, Mengping Chen, Yike Wan, Honghui Huang, Zhiqiang Liu, Jingya Wang, Jian Hou

J Immunother Cancer. 2023; 11(10): e007593. Published online 2023 Oct 15. doi: 10.1136/jitc-2023-007593

Correction in:: J Immunother Cancer. 2023; 11(12): e007593corr1.

PMCID:: PMC10582887

Abstract Article PDF–5.1M

Select item 105083925.

FCGR2B as a prognostic and immune microenvironmental marker for gliomas based on transcriptomic analysis

Zhimin Sun, Xiaoli Sun, Yaqin Yuan, Hongsheng Li, Xiaona Li, Zhigang Yao

Medicine (Baltimore) 2023 Sep 15; 102(37): e35084. Published online 2023 Sep 15. doi: 10.1097/MD.0000000000035084

PMCID:: PMC10508392

Abstract Article PDF–5.1M

Select item 100191036.

FCGR2A as one novel potential target for poor survival prognosis of clear cell renal cell carcinoma

Taozhu Fu, Lianfeng Zhang, Meini Zuo, Feng Li, Changjin Shi, Hongrun Chen

Medicine (Baltimore) 2023 Mar 17; 102(11): e33324. Published online 2023 Mar 17. doi: 10.1097/MD.0000000000033324

PMCID:: PMC10019103

Abstract Article PDF–2.1M

Select item 90591707.

Inhibitory Fcγ Receptor and Paired Immunoglobulin Type 2 Receptor Alpha Genotypes in Alzheimer’s Disease

Janardan P. Pandey, Aryan M. Namboodiri, Paul J. Nietert, Lisa L. Barnes, David A. Bennett

J Alzheimers Dis. Author manuscript; available in PMC 2022 May 2.

Published in final edited form as: J Alzheimers Dis. 2021; 84(3): 965–968. doi: 10.3233/JAD-215174

PMCID:: PMC9059170

Abstract Article PDF–302K

Select item 86928948.

FcγRIIB potentiates differentiation of myeloid-derived suppressor cells to mediate tumor immunoescape

Lei Wu, Yanquan Xu, Huakan Zhao, Yu Zhou, Yu Chen, Shuai Yang, Juan Lei, Jiangang Zhang, Jingchun Wang, Yongzhong Wu, Yongsheng Li

Theranostics. 2022; 12(2): 842–858. Published online 2022 Jan 1. doi: 10.7150/thno.66575

PMCID:: PMC8692894

Abstract Article PDF–3.9M

Select item 86840749.

Impacts of FcγRIIB and FcγRIIIA gene polymorphisms on systemic lupus erythematous disease activity index

Mansoor Karimifar, Khosro Akbari, Reza ArefNezhad, Farshid Fathi, Mohammad Moosaeepour, Hossein Motedayyen

BMC Res Notes. 2021; 14: 455. Published online 2021 Dec 18. doi: 10.1186/s13104-021-05868-2

Correction in:: BMC Res Notes. 2022; 15: 246.

PMCID:: PMC8684074

Abstract Article PDF–813K

Select item 865357210.

The association between Fc gamma RIIb expression levels and chronic hepatitis B virus infection progression

Jinglan Jin, Yuwei Liu, Xiaotong Xu, Zhongfeng Wang, Junqi Niu

BMC Infect Dis. 2021; 21: 1235. Published online 2021 Dec 8. doi: 10.1186/s12879-021-06918-7

PMCID:: PMC8653572

Abstract Article PDF–1.5M

Select item 844761611.

Homogeneously high expression of CD32b makes it a potential target for CAR-T therapy for chronic lymphocytic leukemia

Guoling Wang, Xiaolei Sun, Shiyu Zuo, Chuo Li, Qing Niu, Yonghui Xia, Yuan Meng, Min Liu, Zihao Fang, Xi Yang, Yanyu Jiang, Sheng Wang, Haidong Cui, Huifang Huang, Erlie Jiang, Dongming Zhou, Qi Deng, Jing Pan, Xiaoming Feng

J Hematol Oncol. 2021; 14: 149. Published online 2021 Sep 16. doi: 10.1186/s13045-021-01160-9

PMCID:: PMC8447616

Abstract Article PDF–1.4M

Select item 816503012.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 794673113.

Accelerated clearance and degradation of cell free HIV by neutralizing antibodies occurs via FcγRIIb on liver sinusoidal endothelial cells by endocytosis

James M. Turman, Alana M. Cheplowitz, Charu Tiwari, Thushara Thomas, Dhruvi Joshi, Menakshi Bhat, Qian Wu, Erik Pong, Seung Y. Chu, David E. Szymkowski, Amit Sharma, Stephanie Seveau, John M. Robinson, Jesse J. Kwiek, Dennis Burton, Murugesan VS. Rajaram, Jonghan Kim, Lars Hangartner, Latha P. Ganesan

J Immunol. Author manuscript; available in PMC 2022 Mar 15.

Published in final edited form as: J Immunol. 2021 Mar 15; 206(6): 1284–1296. Published online 2021 Feb 10. doi: 10.4049/jimmunol.2000772

PMCID:: PMC7946731

Abstract Article PDF–2.6M

Select item 793491814.

FcγRIIB is a T cell checkpoint in antitumor immunity

Clara R. Farley, Anna B. Morris, Marvi Tariq, Kelsey B. Bennion, Sayalee Potdar, Ragini Kudchadkar, Michael C. Lowe, Mandy L. Ford

JCI Insight. 2021 Feb 22; 6(4): e135623. Published online 2021 Feb 22. doi: 10.1172/jci.insight.135623

PMCID:: PMC7934918

Abstract Article PDF–1.5M

Select item 783217715.

FcγRIIb Expression Is Decreased on Naive and Marginal Zone-Like B Cells From Females With Multiple Sclerosis

Stephanie Trend, Jonatan Leffler, Ingrid Teige, Björn Frendéus, Allan G. Kermode, Martyn A. French, Prue H. Hart

Front Immunol. 2020; 11: 614492. Published online 2021 Jan 11. doi: 10.3389/fimmu.2020.614492

PMCID:: PMC7832177

Abstract Article PDF–3.7M

Select item 744730616.

Overexpression of FcγRIIB regulates downstream protein phosphorylation and suppresses B cell activation to ameliorate systemic lupus erythematosus

Linlin Sheng, Xiuqin Cao, Shuhong Chi, Jing Wu, Huihui Xing, Huiyu Liu, Zhiwei Yang

Int J Mol Med. 2020 Oct; 46(4): 1409–1422. Published online 2020 Aug 7. doi: 10.3892/ijmm.2020.4698

PMCID:: PMC7447306

Abstract Article PDF–1.3M

Select item 743811117.

Human Fcγ-receptor IIb modulates pathogen-specific versus self-reactive antibody responses in lyme arthritis

Heike Danzer, Joachim Glaesner, Anne Baerenwaldt, Carmen Reitinger, Anja Lux, Lukas Heger, Diana Dudziak, Thomas Harrer, André Gessner, Falk Nimmerjahn

eLife. 2020; 9: e55319. Published online 2020 Jul 2. doi: 10.7554/eLife.55319

PMCID:: PMC7438111

Abstract Article PDF–1010K

Select item 732638118.

Signaling through the inhibitory Fc receptor FcγRIIB induces CD8 T cell apoptosis to limit T cell immunity

Anna B. Morris, Clara R. Farley, David F. Pinelli, Layne E. Adams, Mark S. Cragg, Jeremy M. Boss, Christopher D. Scharer, Miguel Fribourg, Paolo Cravedi, Peter S. Heeger, Mandy L. Ford

Immunity. Author manuscript; available in PMC 2021 Jan 14.

Published in final edited form as: Immunity. 2020 Jan 14; 52(1): 136–150.e6. doi: 10.1016/j.immuni.2019.12.006

PMCID:: PMC7326381

Abstract Article PDF–2.7M

Select item 680343719.

The Complex Association of FcγRIIb With Autoimmune Susceptibility

J. Sjef Verbeek, Sachiko Hirose, Hiroyuki Nishimura

Front Immunol. 2019; 10: 2061. Published online 2019 Oct 15. doi: 10.3389/fimmu.2019.02061

PMCID:: PMC6803437

Abstract Article PDF–3.4M

Select item 676469120.

IGFBP2 promotes immunosuppression associated with its mesenchymal induction and FcγRIIB phosphorylation in glioblastoma

Yunmian Liu, Chunyan Song, Faping Shen, Jing Zhang, Sonya Wei Song

PLoS One. 2019; 14(9): e0222999. Published online 2019 Sep 27. doi: 10.1371/journal.pone.0222999

PMCID:: PMC6764691

Abstract Article PDF–2.7M

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