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Select item 91197361.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 87755702.

Functional In Vitro Assessment of VEGFA/NOTCH2 Signaling Pathway and pRB Proteasomal Degradation and the Clinical Relevance of Mucolipin TRPML2 Overexpression in Glioblastoma Patients

Giorgio Santoni, Consuelo Amantini, Massimo Nabissi, Antonietta Arcella, Federica Maggi, Matteo Santoni, Maria Beatrice Morelli

Int J Mol Sci. 2022 Jan; 23(2): 688. Published online 2022 Jan 8. doi: 10.3390/ijms23020688

PMCID:: PMC8775570

Abstract Article PDF–6.6M

Select item 85758853.

Endolysosomal ion channel MCOLN2 (Mucolipin-2) promotes prostate cancer progression via IL-1β/NF-κB pathway

Hongyan Yu, Mingxu Xie, Zhaoyue Meng, Chun-Yin Lo, Franky Leung Chan, Liwen Jiang, Xiangqi Meng, Xiaoqiang Yao

Br J Cancer. 2021 Nov 9; 125(10): 1420–1431. Published online 2021 Sep 21. doi: 10.1038/s41416-021-01537-0

PMCID:: PMC8575885

Abstract Article PDF–3.4M

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 73607745.

NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90

Wenwen Chen, Wei Wang, Xiaoxia Sun, Shanshan Xie, Xiaoyang Xu, Min Liu, Chunxia Yang, Min Li, Wen Zhang, Wei Liu, Liangjing Wang, Tianhua Zhou, Yuehong Yang

Cell Death Dis. 2020 Jul; 11(7): 534. Published online 2020 Jul 14. doi: 10.1038/s41419-020-02739-9

Correction in:: Cell Death Dis. 2024 Dec; 15(12): 886.

PMCID:: PMC7360774

Abstract Article PDF–3.3M

Select item 65811976.

Gain of additional BIRC3 protein functions through 3′UTR-mediated protein complex formation

Shih-Han Lee, Christine Mayr

Mol Cell. Author manuscript; available in PMC 2020 May 16.

Published in final edited form as: Mol Cell. 2019 May 16; 74(4): 701–712.e9. Published online 2019 Apr 1. doi: 10.1016/j.molcel.2019.03.006

PMCID:: PMC6581197

Abstract Article PDF–2.0M

Select item 60777227.

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor–targeted breast cancer therapy

Tengfei Xiao, Wei Li, Xiaoqing Wang, Han Xu, Jixin Yang, Qiu Wu, Ying Huang, Joseph Geradts, Peng Jiang, Teng Fei, David Chi, Chongzhi Zang, Qi Liao, Jonathan Rennhack, Eran Andrechek, Nanlin Li, Simone Detre, Mitchell Dowsett, Rinath M. Jeselsohn, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2018 Jul 31; 115(31): 7869–7878. Published online 2018 Jul 9. doi: 10.1073/pnas.1722617115

PMCID:: PMC6077722

Abstract Article PDF–2.4M

Select item 57909178.

Mucolipin-2 Cation Channel Increases Trafficking Efficiency of Endocytosed Viruses

Nicholas Rinkenberger, John W. Schoggins

mBio. 2018 Jan-Feb; 9(1): e02314-17. Published online 2018 Jan 30. doi: 10.1128/mBio.02314-17

PMCID:: PMC5790917

Abstract Article PDF–2.1M

Select item 55316119.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 519005010.

Overexpression of transient receptor potential mucolipin-2 ion channels in gliomas: role in tumor growth and progression

Maria Beatrice Morelli, Massimo Nabissi, Consuelo Amantini, Daniele Tomassoni, Francesco Rossi, Claudio Cardinali, Matteo Santoni, Antonietta Arcella, Maria Antonietta Oliva, Angela Santoni, Carlo Polidori, Maria Paola Mariani, Giorgio Santoni

Oncotarget. 2016 Jul 12; 7(28): 43654–43668. Published online 2016 May 27. doi: 10.18632/oncotarget.9661

PMCID:: PMC5190050

Abstract Article PDF–5.3M

Select item 461721111.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 427671812.

PAX5 IS THE TRANSCRIPTIONAL ACTIVATOR OF MUCOLIPIN-2 (MCOLN2) GENE

Jessica A. Valadez, Math P. Cuajungco

Gene. Author manuscript; available in PMC 2016 Jan 25.

Published in final edited form as: Gene. 2015 Jan 25; 555(2): 194–202. Published online 2014 Nov 6. doi: 10.1016/j.gene.2014.11.003

PMCID:: PMC4276718

Abstract Article PDF–804K

Select item 419687613.

Lysosomal Localization of TRPML3 Depends on TRPML2 and the Mucolipidosis-associated Protein TRPML1

Kartik Venkatachalam, Thomas Hofmann, Craig Montell

J Biol Chem. Author manuscript; available in PMC 2014 Oct 14.

Published in final edited form as: J Biol Chem. 2006 Jun 23; 281(25): 17517–17527. Published online 2006 Apr 10. doi: 10.1074/jbc.M600807200

PMCID:: PMC4196876

Abstract Article PDF–909K

Select item 339112414.

Constitutive Activity of TRPML2 and TRPML3 Channels versus Activation by Low Extracellular Sodium and Small Molecules

Christian Grimm, Simone Jörs, Zhaohua Guo, Alexander G. Obukhov, Stefan Heller

J Biol Chem. 2012 Jun 29; 287(27): 22701–22708. Published online 2012 May 9. doi: 10.1074/jbc.M112.368876

PMCID:: PMC3391124

Abstract Article PDF–1.9M

Select item 317805915.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 293160516.

Heteromultimeric TRPML channel assemblies play a crucial role in the regulation of cell viability models and starvation-induced autophagy

David A. Zeevi, Shaya Lev, Ayala Frumkin, Baruch Minke, Gideon Bach

J Cell Sci. 2010 Sep 15; 123(18): 3112–3124. Published online 2010 Aug 24. doi: 10.1242/jcs.067330

PMCID:: PMC2931605

Abstract Article

Select item 291355417.

The tissue-specific expression of TRPML2 (MCOLN-2) gene is influenced by the presence of TRPML1

Mohammad A. Samie, Christian Grimm, Jeffrey A. Evans, Cyntia Curcio-Morelli, Stefan Heller, Susan A. Slaugenhaupt, Math P. Cuajungco

Pflugers Arch. Author manuscript; available in PMC 2010 Nov 1.

Published in final edited form as: Pflugers Arch. 2009 Nov; 459(1): 79–91. doi: 10.1007/s00424-009-0716-5

PMCID:: PMC2913554

Abstract Article PDF–1.1M

Select item 289646418.

Personalized Smoking Cessation: Interactions between Nicotine Dose, Dependence and Quit-Success Genotype Score

Jed E Rose, Frédérique M Behm, Tomas Drgon, Catherine Johnson, George R Uhl

Mol Med. 2010 Jul-Aug; 16(7-8): 247–253. Published online 2010 Mar 17. doi: 10.2119/molmed.2009.00159

Correction in:: Mol Med. 2012; 18(1): 729.

PMCID:: PMC2896464

Abstract Article PDF–2.4M

Select item 280733219.

Constitutive Activity of the Human TRPML2 Channel Induces Cell Degeneration

Shaya Lev, David A. Zeevi, Ayala Frumkin, Vered Offen-Glasner, Gideon Bach, Baruch Minke

J Biol Chem. 2010 Jan 22; 285(4): 2771–2782. Published online 2009 Nov 23. doi: 10.1074/jbc.M109.046508

PMCID:: PMC2807332

Abstract Article PDF–2.1M

Select item 13924120.

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences

Mammalian Gene Collection (MGC) Program Team

Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26): 16899–16903. Published online 2002 Dec 11. doi: 10.1073/pnas.242603899

PMCID:: PMC139241

Abstract Article PDF–118K

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