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Select item 111156741.

Inactivation of the proximal NPXY motif impairs early steps in LRP1 biosynthesis

Sara M. Reekmans, Thorsten Pflanzner, Philip L. S. M. Gordts, Simone Isbert, Pascale Zimmermann, Wim Annaert, Sascha Weggen, Anton J. M. Roebroek, Claus U. Pietrzik

Cell Mol Life Sci. 2010 Jan; 67(1): 135–145. Published online 2009 Oct 25. doi: 10.1007/s00018-009-0171-7

PMCID:: PMC11115674

Abstract Article PDF–418K

Select item 111056662.

Low density lipoprotein receptor-related protein 1 couples β1 integrin activation to degradation

Lukasz Wujak, Ralph T. Böttcher, Oleg Pak, Helena Frey, Elie El Agha, Ying Chen, Sigrid Schmitt, Saverio Bellusci, Liliana Schaefer, Norbert ‎Weissmann, Reinhard Fässler, Malgorzata Wygrecka

Cell Mol Life Sci. 2018 May; 75(9): 1671–1685. Published online 2017 Nov 7. doi: 10.1007/s00018-017-2707-6

PMCID:: PMC11105666

Abstract Article PDF–11M

Select item 110587293.

LRP1 in GABAergic neurons is a key link between obesity and memory function

Kellen Cristina da Cruz Rodrigues, Seung Chan Kim, Aaron Aykut Uner, Zhi-Shuai Hou, Jennie Young, Clara Campolim, Ahmet Aydogan, Brendon Chung, Anthony Choi, Won-Mo Yang, Woojin S. Kim, Vincent Prevot, Barbara J. Caldarone, Hyon Lee, Young-Bum Kim

Mol Metab. 2024 Jun; 84: 101941. Published online 2024 Apr 16. doi: 10.1016/j.molmet.2024.101941

PMCID:: PMC11058729

Abstract Article PDF–11M

Select item 109176604.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 107403915.

Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression and Metastasis

Nneoma Adaku, Benjamin N. Ostendorf, Wenbin Mei, Sohail F. Tavazoie

Cancer Res. Author manuscript; available in PMC 2023 Dec 22.

Published in final edited form as: Cancer Res. 2023 Sep 15; 83(18): 3013–3025. doi: 10.1158/0008-5472.CAN-23-1252

PMCID:: PMC10740391

Abstract Article PDF–1.7M

Select item 107333006.

ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated cerebrovascular clearance in brain endothelial cells

Jiyeon Lee, Haeryung Lee, Hyein Lee, Miram Shin, Min-Gi Shin, Jinsoo Seo, Eun Jeong Lee, Sun Ah Park, Soochul Park

Nat Commun. 2023; 14: 8463. Published online 2023 Dec 20. doi: 10.1038/s41467-023-44319-3

Correction in:: Nat Commun. 2024; 15: 3062.

PMCID:: PMC10733300

Abstract Article PDF–6.2M

Select item 106669037.

Thymosin β4 preserves vascular smooth muscle phenotype in atherosclerosis via regulation of low density lipoprotein related protein 1 (LRP1)

Sonali Munshaw, Andia N. Redpath, Benjamin T. Pike, Nicola Smart

Int Immunopharmacol. 2023 Feb; 115: None. doi: 10.1016/j.intimp.2023.109702

PMCID:: PMC10666903

Abstract Article PDF–9.6M

Select item 103486708.

Lrp1 is essential for lethal Rift Valley fever hepatic disease in mice

Madeline M. Schwarz, Safder S. Ganaie, Annie Feng, Griffin Brown, Tenzin Yangdon, J. Michael White, Ryan M. Hoehl, Cynthia M. McMillen, Rachael E. Rush, Kaleigh A. Connors, Xiaoxia Cui, Daisy W. Leung, Takeshi Egawa, Gaya K. Amarasinghe, Amy L. Hartman

Sci Adv. 2023 Jul; 9(28): eadh2264. Published online 2023 Jul 14. doi: 10.1126/sciadv.adh2264

PMCID:: PMC10348670

Abstract Article PDF–1.2M

Select item 102679549.

Loss of LRP1 in Adult Neural Stem Cells Impairs Migration to Ischemic Lesions

Kristi Dietert, Swetha Mahesula, Sheetal Hegde, John Verschelde, II, Pamela Reed, Shane Sprague, Erzsebet Kokovay, Naomi L Sayre

Stem Cells. 2023 Jun; 41(6): 570–577. Published online 2023 Apr 25. doi: 10.1093/stmcls/sxad034

PMCID:: PMC10267954

Abstract Article PDF–62M

Select item 1021749810.

LRP1 Deficiency Promotes Mitostasis in Response to Oxidative Stress: Implications for Mitochondrial Targeting after Traumatic Brain Injury

Gopal V. Velmurugan, W. Brad Hubbard, Paresh Prajapati, Hemendra J. Vekaria, Samir P. Patel, Alexander G. Rabchevsky, Patrick G. Sullivan

Cells. 2023 May; 12(10): 1445. Published online 2023 May 22. doi: 10.3390/cells12101445

PMCID:: PMC10217498

Abstract Article PDF–4.1M

Select item 1019881911.

Peripheral apolipoprotein E proteins and their binding to LRP1 antagonize Alzheimer’s disease pathogenesis in the brain during peripheral chronic inflammation

Hana Na, Jack B. Yang, Zhengrong Zhang, Qini Gan, Hua Tian, Ibraheem M. Rajab, Lawrence A. Potempa, Qiushan Tao, Wei Qiao Qiu

Neurobiol Aging. Author manuscript; available in PMC 2024 Jul 1.

Published in final edited form as: Neurobiol Aging. 2023 Jul; 127: 54–69. Published online 2023 Mar 7. doi: 10.1016/j.neurobiolaging.2023.02.013

PMCID:: PMC10198819

Abstract Article PDF–3.2M

Select item 1013793412.

Contribution of LRP1 in Human Congenital Heart Disease Correlates with Its Roles in the Outflow Tract and Atrioventricular Cushion Development

Angelo B. Arrigo, Wenjuan Zhu, Kylia A. Williams, Carla Guzman-Moreno, Cecilia Lo, Jiuann-Huey I. Lin

Genes (Basel) 2023 Apr; 14(4): 947. Published online 2023 Apr 21. doi: 10.3390/genes14040947

PMCID:: PMC10137934

Abstract Article PDF–31M

Select item 1013215813.

LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4

Hiroshi Oue, Yu Yamazaki, Wenhui Qiao, Chen Yuanxin, Yingxue Ren, Aishe Kurti, Francis Shue, Tammee M. Parsons, Ralph B. Perkerson, Keiji Kawatani, Ni Wang, Skylar C. Starling, Bhaskar Roy, Ioana-Emilia Mosneag, Tomonori Aikawa, Marie-Louise Holm, Chia-Chen Liu, Yasuteru Inoue, Patrick M. Sullivan, Yan W. Asmann, Betty Y.S. Kim, Guojun Bu, Takahisa Kanekiyo

JCI Insight. 2023 Apr 10; 8(7): e163822. Published online 2023 Apr 10. doi: 10.1172/jci.insight.163822

PMCID:: PMC10132158

Abstract Article PDF–1.4M

Select item 1011436214.

Low-density lipoprotein receptor–related protein 1 (LRP1) as an auxiliary host factor for RNA viruses

Stephanie Devignot, Tim Wai Sha, Thomas R Burkard, Patrick Schmerer, Astrid Hagelkruys, Ali Mirazimi, Ulrich Elling, Josef M Penninger, Friedemann Weber

Life Sci Alliance. 2023 Jul; 6(7): e202302005. Published online 2023 Apr 18. doi: 10.26508/lsa.202302005

PMCID:: PMC10114362

Abstract Article PDF–2.8M

Select item 1006962915.

Multi-faceted role of LRP1 in the immune system

Olga Sizova, Lisa St. John, Qing Ma, Jeffrey J. Molldrem

Front Immunol. 2023; 14: 1166189. Published online 2023 Mar 20. doi: 10.3389/fimmu.2023.1166189

PMCID:: PMC10069629

Abstract Article PDF–862K

Select item 1004173916.

FUT2 inhibits the EMT and metastasis of colorectal cancer by increasing LRP1 fucosylation

Lingnan He, Zijun Guo, Weijun Wang, Shuxin Tian, Rong Lin

Cell Commun Signal. 2023; 21: 63. Published online 2023 Mar 27. doi: 10.1186/s12964-023-01060-0

PMCID:: PMC10041739

Abstract Article PDF–7.6M

Select item 997730817.

LRP1 protects against excessive superior mesenteric artery remodeling by modulating angiotensin II–mediated signaling

Jackie M. Zhang, Dianaly T. Au, Hisashi Sawada, Michael K. Franklin, Jessica J. Moorleghen, Deborah A. Howatt, Pengjun Wang, Brittany O. Aicher, Brian Hampton, Mary Migliorini, Fenge Ni, Adam E. Mullick, Mashhood M. Wani, Areck A. Ucuzian, Hong S. Lu, Selen C. Muratoglu, Alan Daugherty, Dudley K. Strickland

JCI Insight. 2023 Jan 24; 8(2): e164751. Published online 2023 Jan 24. doi: 10.1172/jci.insight.164751

PMCID:: PMC9977308

Abstract Article PDF–8.1M

Select item 963235818.

Autosomal recessive LRP1-related syndrome featuring cardiopulmonary dysfunction, bone dysmorphology, and corneal clouding

Paul R. Mark, Stephen A. Murray, Tao Yang, Alexandra Eby, Angela Lai, Di Lu, Jacob Zieba, Surender Rajasekaran, Elizabeth A. VanSickle, Linda Z. Rossetti, Lucia Guidugli, Kelly Watkins, Meredith S. Wright, Caleb P. Bupp, Jeremy W. Prokop

Cold Spring Harb Mol Case Stud. 2022 Oct; 8(6): a006169. doi: 10.1101/mcs.a006169

PMCID:: PMC9632358

Abstract Article PDF–16M

Select item 958505519.

The LRP1/CD91 ligands, tissue-type plasminogen activator, α₂-macroglobulin, and soluble cellular prion protein have distinct co-receptor requirements for activation of cell-signaling

Elisabetta Mantuano, Pardis Azmoon, Michael A. Banki, Cory B. Gunner, Steven L. Gonias

Sci Rep. 2022; 12: 17594. Published online 2022 Oct 20. doi: 10.1038/s41598-022-22498-1

PMCID:: PMC9585055

Abstract Article PDF–2.9M

Select item 947738920.

Heterozygous LRP1 deficiency causes developmental dysplasia of the hip by impairing triradiate chondrocytes differentiation due to inhibition of autophagy

Wenjin Yan, Liming Zheng, Xingquan Xu, Zheng Hao, Yibo Zhang, Jun Lu, Ziying Sun, Jin Dai, Dongquan Shi, Baosheng Guo, Qing Jiang

Proc Natl Acad Sci U S A. 2022 Sep 13; 119(37): e2203557119. Published online 2022 Sep 6. doi: 10.1073/pnas.2203557119

PMCID:: PMC9477389

Abstract Article PDF–2.9M

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