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Items: 1 to 20 of 46

1.
On the genetic basis of tail-loss evolution in humans and apes
Bo Xia, Weimin Zhang, Guisheng Zhao, Xinru Zhang, Jiangshan Bai, Ran Brosh, Aleksandra Wudzinska, Emily Huang, Hannah Ashe, Gwen Ellis, Maayan Pour, Yu Zhao, Camila Coelho, Yinan Zhu, Alexander Miller, Jeremy S. Dasen, Matthew T. Maurano, Sang Y. Kim, Jef D. Boeke, Itai Yanai
Nature. 2024; 626(8001): 1042–1048. Published online 2024 Feb 28. doi: 10.1038/s41586-024-07095-8
PMCID:
PMC10901737
AbstractArticlePDF–5.7M
2.
Human transcription factor protein interaction networks
Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo
Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5
PMCID:
PMC8828895
AbstractArticlePDF–1.7M
3.
Association between TBXT rs2305089 polymorphism and chordoma in Iranian patients identified by a developed T‐ARMS‐PCR assay
Maryam Jalessi, Mohammad Saeed Gholami, Ehsan Razmara, Sajad Hassanzadeh, Alireza Sadeghipour, Amin Jahanbakhshi, Alireza Tabibkhooei, Eshagh Bahrami, Masoumeh Falah
J Clin Lab Anal. 2022 Jan; 36(1): e24150. Published online 2021 Nov 27. doi: 10.1002/jcla.24150
PMCID:
PMC8761424
AbstractArticlePDF–1001K
4.
Recurrent loss of chromosome 22 and SMARCB1 deletion in extra-axial Chordoma: A clinicopathological and molecular analysis
Xiaoyun Wen, Robert Cimera, Ruth Aryeequaye, Mohanty Abhinta, Edward Athanasian, John Healey, Nicola Fabbri, Patrick Boland, Yanming Zhang, Meera Hameed
Genes Chromosomes Cancer. Author manuscript; available in PMC 2022 Dec 1.
Published in final edited form as: Genes Chromosomes Cancer. 2021 Dec; 60(12): 796–807. Published online 2021 Aug 26. doi: 10.1002/gcc.22992
PMCID:
PMC8511200
AbstractArticlePDF–3.0M
5.
Machine learning based tissue analysis reveals Brachyury has a diagnosis value in breast cancer
Kaichun Li, Qiaoyun Wang, Yanyan Lu, Xiaorong Pan, Long Liu, Shiyu Cheng, Bingxiang Wu, Zongchang Song, Wei Gao
Biosci Rep. 2021 Apr 30; 41(4): BSR20203391. Published online 2021 Apr 6. doi: 10.1042/BSR20203391
PMCID:
PMC8024874
AbstractArticlePDF–1.1M
6.
Impact of cytosine methylation on DNA binding specificities of human transcription factors
Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale
Science. Author manuscript; available in PMC 2021 Mar 30.
Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239
PMCID:
PMC8009048
AbstractArticlePDF–2.6M
7.
Brachyury Is Associated with Glioma Differentiation and Response to Temozolomide
Filipe Pinto, Ângela M. Costa, Raquel P. Andrade, Rui Manuel Reis
Neurotherapeutics. 2020 Oct; 17(4): 2015–2027. Published online 2020 Aug 12. doi: 10.1007/s13311-020-00911-9
PMCID:
PMC7851232
AbstractArticlePDF–5.9M
8.
Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity
Hadley E. Sheppard, Alessandra Dall’Agnese, Woojun D. Park, M. Hamza Shamim, Julien Dubrulle, Hannah L. Johnson, Fabio Stossi, Patricia Cogswell, Josh Sommer, Joan Levy, Tanaz Sharifnia, Mathias J. Wawer, Behnam Nabet, Nathanael S. Gray, Paul A. Clemons, Stuart L. Schreiber, Paul Workman, Richard A. Young, Charles Y. Lin
Cell Rep Med. 2021 Jan 19; 2(1): 100188. Published online 2021 Jan 19. doi: 10.1016/j.xcrm.2020.100188
PMCID:
PMC7817874
AbstractArticlePDF–14M
9.
Inhibition of histone H3K27 demethylases inactivates brachyury (TBXT) and promotes chordoma cell death
Lucia Cottone, Adam P Cribbs, Garima Khandelwal, Graham Wells, Lorena Ligammari, Martin Philpott, Anthony Tumber, Patrick Lombard, Edward S Hookway, Tamas Szommer, Catrine Johansson, Paul E Brennan, Nischalan Pillay, Richard G Jenner, Udo Oppermann, Adrienne M Flanagan
Cancer Res. Author manuscript; available in PMC 2024 Dec 8.
Published in final edited form as: Cancer Res. 2020 Oct 15; 80(20): 4540–4551. Published online 2020 Aug 27. doi: 10.1158/0008-5472.CAN-20-1387
PMCID:
PMC7616956
AbstractArticlePDF–4.8M
10.
Characterization of T gene sequence variants and germline duplications in familial and sporadic chordoma
MJ Kelley, J Shi, B Ballew, PL Hyland, WQ Li, M Rotunno, DA Alcorta, NJ Liebsch, J Mitchell, S Bass, D Roberson, J Boland, M Cullen, J He, L Burdette, M Yeager, SJ Chanock, DM Parry, AM Goldstein, XR Yang
Hum Genet. Author manuscript; available in PMC 2019 Dec 31.
Published in final edited form as: Hum Genet. 2014 Oct; 133(10): 1289–1297. Published online 2014 Jul 4. doi: 10.1007/s00439-014-1463-z
PMCID:
PMC6938388
AbstractArticlePDF–353K
11.
Transfection of T-Box Transcription Factor BRACHYURY and SOX2 Synergistically Promote Self-Renewal and Invasive Phenotype in Oral Cancer Cells
Naonari Akimoto, Kodai Nakamura, Hiroshi Hijioka, Kenichi Kume, Yoshiaki Matsumura, Tsuyoshi Sugiura
Int J Mol Sci. 2018 Nov; 19(11): 3620. Published online 2018 Nov 16. doi: 10.3390/ijms19113620
PMCID:
PMC6275038
AbstractArticlePDF–4.5M
12.
An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma
Andrew C Nelson, Nischalan Pillay, Stephen Henderson, Nadège Presneau, Roberto Tirabosco, Dina Halai, Fitim Berisha, Paul Flicek, Derek L Stemple, Claudio D Stern, Fiona C Wardle, Adrienne M Flanagan
J Pathol. Author manuscript; available in PMC 2018 Aug 13.
Published in final edited form as: J Pathol. 2012 Nov; 228(3): 274–285. Published online 2012 Sep 26. doi: 10.1002/path.4082
PMCID:
PMC6089345
AbstractArticlePDF–2.3M
13.
The driver landscape of sporadic chordoma
Patrick S. Tarpey, Sam Behjati, Matthew D. Young, Inigo Martincorena, Ludmil B. Alexandrov, Sarah J. Farndon, Charlotte Guzzo, Claire Hardy, Calli Latimer, Adam P. Butler, Jon W. Teague, Adam Shlien, P. Andrew Futreal, Sohrab Shah, Ali Bashashati, Farzad Jamshidi, Torsten O. Nielsen, David Huntsman, Daniel Baumhoer, Sebastian Brandner, Jay Wunder, Brendan Dickson, Patricia Cogswell, Josh Sommer, Joanna J. Phillips, M. Fernanda Amary, Roberto Tirabosco, Nischalan Pillay, Stephen Yip, Michael R. Stratton, Adrienne M. Flanagan, Peter J. Campbell
Nat Commun. 2017; 8: 890. Published online 2017 Oct 12. doi: 10.1038/s41467-017-01026-0
PMCID:
PMC5638846
AbstractArticlePDF–938K
14.
Spinal column chordoma: prognostic significance of clinical variables and T (brachyury) gene SNP rs2305089 for local recurrence and overall survival
Chetan Bettegowda, Stephen Yip, Sheng-Fu Larry Lo, Charles G. Fisher, Stefano Boriani, Laurence D. Rhines, Joanna Y. Wang, Aron Lazary, Marco Gambarotti, Wei-Lien Wang, Alessandro Luzzati, Mark B. Dekutoski, Mark H. Bilsky, Dean Chou, Michael G. Fehlings, Edward F. McCarthy, Nasir A. Quraishi, Jeremy J. Reynolds, Daniel M. Sciubba, Richard P. Williams, Jean-Paul Wolinsky, Patricia L. Zadnik, Ming Zhang, Niccole M. Germscheid, Vasiliki Kalampoki, Peter Pal Varga, Ziya L. Gokaslan, AOSpine Knowledge Forum Tumor
Neuro Oncol. 2017 Mar; 19(3): 405–413. Published online 2016 Sep 23. doi: 10.1093/neuonc/now156
PMCID:
PMC5464366
AbstractArticlePDF–609K
15.
Regulation of brachyury by fibroblast growth factor receptor 1 in lung cancer
Yunping Hu, Xin Feng, Akiva Mintz, W. Jeffrey Petty, Wesley Hsu
Oncotarget. 2016 Dec 27; 7(52): 87124–87135. Published online 2016 Dec 24. doi: 10.18632/oncotarget.13547
PMCID:
PMC5349976
AbstractArticlePDF–8.5M
16.
Brachyury as a potential modulator of androgen receptor activity and a key player in therapy resistance in prostate cancer
Filipe Pinto, Nelma Pértega-Gomes, José R. Vizcaíno, Raquel P. Andrade, Flavio M. Cárcano, Rui Manuel Reis
Oncotarget. 2016 May 17; 7(20): 28891–28902. Published online 2016 Mar 31. doi: 10.18632/oncotarget.8499
PMCID:
PMC5045364
AbstractArticlePDF–4.9M
17.
Brachyury, a vaccine target, is overexpressed in triple negative breast cancer
Duane H. Hamilton, Mario Roselli, Patrizia Ferroni, Leopoldo Costarelli, Francesco Cavaliere, Mariateresa Taffuri, Claudia Palena, Fiorella Guadagni
Endocr Relat Cancer. Author manuscript; available in PMC 2017 Oct 1.
Published in final edited form as: Endocr Relat Cancer. 2016 Oct; 23(10): 783–796. doi: 10.1530/ERC-16-0037
PMCID:
PMC5010091
AbstractArticlePDF–3.8M
18.
The FGFR/MEK/ERK/brachyury pathway is critical for chordoma cell growth and survival
Yunping Hu, Akiva Mintz, Sagar R. Shah, Alfredo Quinones-Hinojosa, Wesley Hsu
Carcinogenesis. 2014 Jul; 35(7): 1491–1499. Published online 2014 Jan 20. doi: 10.1093/carcin/bgu014
PMCID:
PMC4593008
AbstractArticlePDF–1.8M
19.
Overexpression of the EMT Driver Brachyury in Breast Carcinomas: Association With Poor Prognosis
Claudia Palena, Mario Roselli, Mary T. Litzinger, Patrizia Ferroni, Leopoldo Costarelli, Antonella Spila, Francesco Cavaliere, Bruce Huang, Romaine I. Fernando, Duane H. Hamilton, Caroline Jochems, Kwong-Yok Tsang, Qing Cheng, H. Kim Lyerly, Jeffrey Schlom, Fiorella Guadagni
J Natl Cancer Inst. 2014 May; 106(5): dju054. Published online 2014 May 9. doi: 10.1093/jnci/dju054
PMCID:
PMC4568990
AbstractArticlePDF–810K
20.
NUCLEAR BRACHYURY EXPRESSION IS CONSISTENT IN CHORDOMA, COMMON IN GERM CELL TUMORS AND SMALL CELL CARCINOMAS AND RARE IN OTHER CARCINOMAS AND SARCOMAS. AN IMMUNOHISTOCHEMICAL STUDY OF 5229 CASES
Markku Miettinen, Zengfeng Wang, Jerzy Lasota, Christopher Heery, Jeffrey Schlom, Claudia Palena
Am J Surg Pathol. Author manuscript; available in PMC 2016 Oct 1.
Published in final edited form as: Am J Surg Pathol. 2015 Oct; 39(10): 1305–1312. doi: 10.1097/PAS.0000000000000462
PMCID:
PMC4567944
AbstractArticlePDF–3.9M

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