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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 100831032.

Retinoid therapy restores eye-specific cortical responses in adult mice with retinal degeneration

Carey Y. L. Huh, Henri Leinonen, Taylor Nakayama, Julia R. Tomasello, Jianye Zhang, Jack Zeitoun, John P. Peach, Maximilian Halabi, Jianying Z. Kiser, Krzysztof Palczewski, Philip D. Kiser, Sunil P. Gandhi

Curr Biol. Author manuscript; available in PMC 2023 Oct 24.

Published in final edited form as: Curr Biol. 2022 Oct 24; 32(20): 4538–4546.e5. Published online 2022 Sep 23. doi: 10.1016/j.cub.2022.09.005

PMCID:: PMC10083103

Abstract Article PDF–2.3M

Select item 99873313.

Vitamin A regulates tissue-specific organ remodeling in diet-induced obesity independent of mitochondrial function

Ivanna Shymotiuk, Natali Froese, Christopher Werlein, Lea Naasner, Malgorzata Szaroszyk, Mark P. Kühnel, Danny D. Jonigk, William S. Blaner, Adam R. Wende, E. Dale Abel, Johann Bauersachs, Christian Riehle

Front Endocrinol (Lausanne) 2023; 14: 1118751. Published online 2023 Feb 20. doi: 10.3389/fendo.2023.1118751

PMCID:: PMC9987331

Abstract Article PDF–4.4M

Select item 93651004.

Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis

Hong Gao, Zhongmou Jin, Gautam Bandyopadhyay, Gaowei Wang, Dinghong Zhang, Karina Cunha e Rocha, Xiao Liu, Huayi Zhao, Tatiana Kisseleva, David A. Brenner, Michael Karin, Wei Ying

Cell Metab. Author manuscript; available in PMC 2023 Aug 2.

Published in final edited form as: Cell Metab. 2022 Aug 2; 34(8): 1201–1213.e5. doi: 10.1016/j.cmet.2022.07.006

PMCID:: PMC9365100

Abstract Article PDF–1.8M

Select item 80489135.

Sirt6 Alleviated Liver Fibrosis by Deacetylating Conserved Lysine 54 on Smad2 in Hepatic Stellate Cells

Jinhang Zhang, Yanping Li, Qinhui Liu, Ya Huang, Rui Li, Tong Wu, Zijing Zhang, Jian Zhou, Hui Huang, Qin Tang, Cuiyuan Huang, Yingnan Zhao, Guorong Zhang, Wei Jiang, Li Mo, Jian Zhang, Wen Xie, Jinhan He

Hepatology. 2021 Mar; 73(3): 1140–1157. Published online 2020 Nov 10. doi: 10.1002/hep.31418

PMCID:: PMC8048913

Abstract Article PDF–2.3M

Select item 74842806.

Mycobacterium tuberculosis Infection is Exacerbated in Mice Lacking Lecithin:Retinol Acyltransferase.

Steven E. Trasino, Xiao-Han Tang, Carolina Trujillo, Jaclynn Andres, Sabine Ehrt, Lorraine J. Gudas

Biochim Biophys Acta Mol Basis Dis. Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2020 Nov 1; 1866(11): 165909. Published online 2020 Aug 5. doi: 10.1016/j.bbadis.2020.165909

PMCID:: PMC7484280

Article PDF–517K

Select item 74158947.

All-trans-Retinaldehyde Contributes to Retinal Vascular Permeability in Ischemia Reperfusion

Alyssa Dreffs, Cheng-Mao Lin, Xuwen Liu, Sumathi Shanmugam, Steven F. Abcouwer, Timothy S. Kern, David A. Antonetti

Invest Ophthalmol Vis Sci. 2020 Jun; 61(6): 8. Published online 2020 Jun 3. doi: 10.1167/iovs.61.6.8

PMCID:: PMC7415894

Abstract Article PDF–1.5M

Select item 72270288.

Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss

Gayle B. Collin, Navdeep Gogna, Bo Chang, Nattaya Damkham, Jai Pinkney, Lillian F. Hyde, Lisa Stone, Jürgen K. Naggert, Patsy M. Nishina, Mark P. Krebs

Cells. 2020 Apr; 9(4): 931. Published online 2020 Apr 10. doi: 10.3390/cells9040931

PMCID:: PMC7227028

Abstract Article PDF–5.4M

Select item 68512909.

Mice lacking the epidermal retinol dehydrogenases SDR16C5 and SDR16C6 display accelerated hair growth and enlarged meibomian glands

Lizhi Wu, Olga V. Belyaeva, Mark K. Adams, Alla V. Klyuyeva, Seung-Ah Lee, Kelli R. Goggans, Robert A. Kesterson, Kirill M. Popov, Natalia Y. Kedishvili

J Biol Chem. 2019 Nov 8; 294(45): 17060–17074. Published online 2019 Sep 27. doi: 10.1074/jbc.RA119.010835

PMCID:: PMC6851290

Abstract Article PDF–3.5M

Select item 616673710.

Ciliary neurotrophic factor (CNTF) protects retinal cone and rod photoreceptors by suppressing excessive formation of the visual pigments

Songhua Li, Kota Sato, William C. Gordon, Michael Sendtner, Nicolas G. Bazan, Minghao Jin

J Biol Chem. 2018 Sep 28; 293(39): 15256–15268. Published online 2018 Aug 16. doi: 10.1074/jbc.RA118.004008

PMCID:: PMC6166737

Abstract Article PDF–4.0M

Select item 587867711.

Retinal-chitosan Conjugates Effectively Deliver Active Chromophores to Retinal Photoreceptor Cells in Blind Mice and Dogs

Songqi Gao, Shirin Kahremany, Jianye Zhang, Beata Jastrzebska, Janice Querubin, Simon M. Petersen-Jones, Krzysztof Palczewski

Mol Pharmacol. 2018 May; 93(5): 438–452. Published online 2018 May. doi: 10.1124/mol.117.111294

PMCID:: PMC5878677

Abstract Article PDF–1.7M

Select item 568294812.

Impact of LCA-Associated E14L LRAT Mutation on Protein Stability and Retinoid Homeostasis

Sylwia Chelstowska, Made Airanthi K. Widjaja-Adhi, Josie A. Silvaroli, Marcin Golczak

Biochemistry. Author manuscript; available in PMC 2018 Aug 29.

Published in final edited form as: Biochemistry. 2017 Aug 29; 56(34): 4489–4499. Published online 2017 Aug 15. doi: 10.1021/acs.biochem.7b00451

PMCID:: PMC5682948

Abstract Article PDF–977K

Select item 506318513.

Animal modelling for inherited central vision loss

Corinne Kostic, Yvan Arsenijevic

J Pathol. 2016 Jan; 238(2): 300–310. Published online 2015 Nov 13. doi: 10.1002/path.4641

PMCID:: PMC5063185

Abstract Article PDF–977K

Select item 498781414.

Dimerization of visual pigments in vivo

Tao Zhang, Li-Hui Cao, Sandeep Kumar, Nduka O. Enemchukwu, Ning Zhang, Alyssia Lambert, Xuchen Zhao, Alex Jones, Shixian Wang, Emily M. Dennis, Amrita Fnu, Sam Ham, Jon Rainier, King-Wai Yau, Yingbin Fu

Proc Natl Acad Sci U S A. 2016 Aug 9; 113(32): 9093–9098. Published online 2016 Jul 26. doi: 10.1073/pnas.1609018113

PMCID:: PMC4987814

Abstract Article PDF–2.6M

Select item 493551415.

Effects of vitamin A deficiency in the postnatal mouse heart: role of hepatic retinoid stores

Mary Ann Asson-Batres, Sergey Ryzhov, Oleg Tikhomirov, Christine W. Duarte, Clare Bates Congdon, Craig R. Lessard, Samuel McFarland, Cecile Rochette-Egly, Truc-Linh Tran, Cristi L. Galindo, Amanda J. Favreau-Lessard, Douglas B. Sawyer

Am J Physiol Heart Circ Physiol. 2016 Jun 1; 310(11): H1773–H1789. Published online 2016 Apr 15. doi: 10.1152/ajpheart.00887.2015

PMCID:: PMC4935514

Abstract Article

Select item 475341416.

Microphthalmia-associated transcription factor regulates the visual cycle genes Rlbp1 and Rdh5 in the retinal pigment epithelium

Bin Wen, Shuang Li, Huirong Li, Yu Chen, Xiaoyin Ma, Jing Wang, Fan Lu, Jia Qu, Ling Hou

Sci Rep. 2016; 6: 21208. Published online 2016 Feb 15. doi: 10.1038/srep21208

PMCID:: PMC4753414

Abstract Article PDF–1.6M

Select item 468622017.

QLT091001, a 9-cis-Retinal Analog, Is Well-Tolerated by Retinas of Mice with Impaired Visual Cycles

Tadao Maeda, Zhiqian Dong, Hui Jin, Osamu Sawada, Songqi Gao, Deepank Utkhede, Wendy Monk, Grazyna Palczewska, Krzysztof Palczewski

Invest Ophthalmol Vis Sci. 2013 Jan; 54(1): 455–466. Published online 2013 Jan 17. doi: 10.1167/iovs.12-11152

PMCID:: PMC4686220

Abstract Article PDF–1.0M

Select item 465405218.

Disruption of murine Adamtsl4 results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiation

Gayle B. Collin, Dirk Hubmacher, Jeremy R. Charette, Wanda L. Hicks, Lisa Stone, Minzhong Yu, Jürgen K. Naggert, Mark P. Krebs, Neal S. Peachey, Suneel S. Apte, Patsy M. Nishina

Hum Mol Genet. 2015 Dec 15; 24(24): 6958–6974. Published online 2015 Sep 24. doi: 10.1093/hmg/ddv399

PMCID:: PMC4654052

Abstract Article PDF–1.7M

Select item 457188119.

Retinylamine Benefits Early Diabetic Retinopathy in Mice

Haitao Liu, Jie Tang, Yunpeng Du, Chieh Allen Lee, Marcin Golczak, Arivalagan Muthusamy, David A. Antonetti, Alexander A. Veenstra, Jaume Amengual, Johannes von Lintig, Krzysztof Palczewski, Timothy S. Kern

J Biol Chem. 2015 Aug 28; 290(35): 21568–21579. Published online 2013 Jul 2. doi: 10.1074/jbc.M115.655555

PMCID:: PMC4571881

Abstract Article PDF–1.6M

Select item 443184020.

Diacylglycerol O-Acyltransferase Type-1 Synthesizes Retinyl Esters in the Retina and Retinal Pigment Epithelium

Joanna J. Kaylor, Roxana A. Radu, Nicholas Bischoff, Jacob Makshanoff, Jane Hu, Marcia Lloyd, Shannan Eddington, Tran Bianconi, Dean Bok, Gabriel H. Travis

PLoS One. 2015; 10(5): e0125921. Published online 2015 May 14. doi: 10.1371/journal.pone.0125921

PMCID:: PMC4431840

Abstract Article PDF–1.7M

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