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Select item 105980031.

Control of CD4⁺ T cells to restrain inflammatory diseases via eukaryotic elongation factor 2 kinase

Hao-Yun Peng, Liqing Wang, Jugal Kishore Das, Anil Kumar, Darby J. Ballard, Yijie Ren, Xiaofang Xiong, Paul de Figueiredo, Jin-Ming Yang, Jianxun Song

Signal Transduct Target Ther. 2023; 8: 415. Published online 2023 Oct 24. doi: 10.1038/s41392-023-01648-5

PMCID:: PMC10598003

Abstract Article PDF–4.5M

Select item 97081162.

Eukaryotic Elongation Factor 2 Kinase Activity Is Required for the Phenotypes of the Rpl24^Bst Mouse

John R.P. Knight, Christopher G. Proud, Giovanna Mallucci, Tobias von der Haar, C. Mark Smales, Anne E. Willis, Owen J. Sansom

J Invest Dermatol. 2022 Dec; 142(12): 3346–3348.e1. doi: 10.1016/j.jid.2022.06.019

PMCID:: PMC9708116

Article

Select item 89611753.

eEF2K promotes PD-L1 stabilization through inactivating GSK3β in melanoma

Xisha Chen, Kuansong Wang, Shilong Jiang, Hongyin Sun, Xuanling Che, Minghui Zhang, Jiaying He, Ying Wen, Mengting Liao, Xiangling Li, Xiaoming Zhou, Jianxun Song, Xingcong Ren, Wenjun Yi, Jinming Yang, Xiang Chen, Mingzhu Yin, Yan Cheng

J Immunother Cancer. 2022; 10(3): e004026. Published online 2022 Mar 28. doi: 10.1136/jitc-2021-004026

PMCID:: PMC8961175

Abstract Article PDF–4.1M

Select item 88095364.

Elongation factor-2 kinase is a critical determinant of the fate and antitumor immunity of CD8⁺ T cells

Jugal Kishore Das, Yijie Ren, Anil Kumar, Hao-Yun Peng, Liqing Wang, Xiaofang Xiong, Robert C. Alaniz, Paul de Figueiredo, Xingcong Ren, Xiaoqi Liu, Alexey G. Ryazonov, Jin-Ming Yang, Jianxun Song

Sci Adv. 2022 Feb; 8(5): eabl9783. Published online 2022 Feb 2. doi: 10.1126/sciadv.abl9783

PMCID:: PMC8809536

Abstract Article PDF–4.8M

Select item 87220325.

Rescuing epileptic and behavioral alterations in a Dravet syndrome mouse model by inhibiting eukaryotic elongation factor 2 kinase (eEF2K)

Stefania Beretta, Laura Gritti, Luisa Ponzoni, Paolo Scalmani, Massimo Mantegazza, Mariaelvina Sala, Chiara Verpelli, Carlo Sala

Mol Autism. 2022; 13: 1. Published online 2022 Jan 3. doi: 10.1186/s13229-021-00484-0

PMCID:: PMC8722032

Abstract Article PDF–6.1M

Select item 86681886.

Rpl24^Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K

John RP Knight, Nikola Vlahov, David M Gay, Rachel A Ridgway, William James Faller, Christopher Proud, Giovanna R Mallucci, Tobias von der Haar, Christopher Mark Smales, Anne E Willis, Owen J Sansom

eLife. 2021; 10: e69729. Published online 2021 Dec 13. doi: 10.7554/eLife.69729

PMCID:: PMC8668188

Abstract Article PDF–1.8M

Select item 86110987.

Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance

Patrick R. Smith, Sarah Loerch, Nikesh Kunder, Alexander D. Stanowick, Tzu-Fang Lou, Zachary T. Campbell

Nat Commun. 2021; 12: 6789. Published online 2021 Nov 23. doi: 10.1038/s41467-021-27160-4

PMCID:: PMC8611098

Abstract Article PDF–5.1M

Select item 85904658.

Convergence of distinct signaling pathways on synaptic scaling to trigger rapid antidepressant action

Kanzo Suzuki, Ji-Woon Kim, Elena Nosyreva, Ege T. Kavalali, Lisa M. Monteggia

Cell Rep. Author manuscript; available in PMC 2021 Nov 13.

Published in final edited form as: Cell Rep. 2021 Nov 2; 37(5): 109918. doi: 10.1016/j.celrep.2021.109918

PMCID:: PMC8590465

Abstract Article PDF–2.6M

Select item 82018689.

Suppression of the kinase for elongation factor 2 alleviates mGluR-LTD impairments in a mouse model of Alzheimer’s disease

Wenzhong Yang, Xueyan Zhou, Alexey G. Ryazanov, Tao Ma

Neurobiol Aging. Author manuscript; available in PMC 2022 Feb 1.

Published in final edited form as: Neurobiol Aging. 2021 Feb; 98: 225–230. Published online 2020 Nov 30. doi: 10.1016/j.neurobiolaging.2020.11.016

PMCID:: PMC8201868

Abstract Article PDF–530K

Select item 818565810.

Eef2k is not required for fertility in male mice

Tianhao Feng, Shushu Zhou, Xiaodan Shi, Xin Zhang, Jintao Zhang, Shuqin Zhao, Xiaoyu Yang, Xuhui Meng, Mingxi Liu

Transl Androl Urol. 2021 May; 10(5): 1988–1999. doi: 10.21037/tau-21-18

PMCID:: PMC8185658

Abstract Article PDF–3.2M

Select item 794825711.

Repression of eEF2 kinase improves deficits in novel object recognition memory in aged mice.

Saahj Gosrani, Hannah Jester, Xueyan Zhou, Alexey Ryazanov, Tao Ma

Neurobiol Aging. Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: Neurobiol Aging. 2020 Nov; 95: 154–160. Published online 2020 Jul 25. doi: 10.1016/j.neurobiolaging.2020.07.016

PMCID:: PMC7948257

Abstract Article PDF–620K

Select item 724279012.

D1 Dopamine Receptor Activation Induces Neuronal eEF2 Pathway-Dependent Protein Synthesis

Orit David, Iliana Barrera, Nathaniel Gould, Shunit Gal-Ben-Ari, Kobi Rosenblum

Front Mol Neurosci. 2020; 13: 67. Published online 2020 May 15. doi: 10.3389/fnmol.2020.00067

PMCID:: PMC7242790

Abstract Article PDF–6.2M

Select item 650950913.

Ablation of elongation factor 2 kinase enhances heat-shock protein 90 chaperone expression and protects cells under proteotoxic stress

Jianling Xie, Petra Van Damme, Danielle Fang, Christopher G. Proud

J Biol Chem. 2019 May 3; 294(18): 7169–7176. Published online 2019 Mar 19. doi: 10.1074/jbc.AC119.008036

PMCID:: PMC6509509

Abstract Article PDF–1.9M

Select item 635524214.

Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer’s disease model mice

Brenna C. Beckelman, Wenzhong Yang, Nicole P. Kasica, Helena R. Zimmermann, Xueyan Zhou, C. Dirk Keene, Alexey G. Ryazanov, Tao Ma

J Clin Invest. 2019 Feb 1; 129(2): 820–833. Published online 2019 Jan 22. doi: 10.1172/JCI122954

PMCID:: PMC6355242

Abstract Article PDF–10M

Select item 596382415.

eEF2K/eEF2 Pathway Controls the Excitation/Inhibition Balance and Susceptibility to Epileptic Seizures

Christopher Heise, Elham Taha, Luca Murru, Luisa Ponzoni, Angela Cattaneo, Fabrizia C. Guarnieri, Caterina Montani, Adele Mossa, Elena Vezzoli, Giulio Ippolito, Jonathan Zapata, Iliana Barrera, Alexey G. Ryazanov, James Cook, Michael Poe, Michael Rajesh Stephen, Maksym Kopanitsa, Roberta Benfante, Francesco Rusconi, Daniela Braida, Maura Francolini, Christopher G. Proud, Flavia Valtorta, Maria Passafaro, Mariaelvina Sala, Angela Bachi, Chiara Verpelli, Kobi Rosenblum, Carlo Sala

Cereb Cortex. 2017 Mar; 27(3): 2226–2248. Published online 2016 Mar 21. doi: 10.1093/cercor/bhw075

PMCID:: PMC5963824

Abstract Article PDF–10M

Select item 531105916.

Selective molecular impairment of spontaneous neurotransmission modulates synaptic efficacy

Devon C. Crawford, Denise M. O. Ramirez, Brent Trauterman, Lisa M. Monteggia, Ege T. Kavalali

Nat Commun. 2017; 8: 14436. Published online 2017 Feb 10. doi: 10.1038/ncomms14436

PMCID:: PMC5311059

Abstract Article PDF–2.2M

Select item 501669017.

Paradoxical Roles of Elongation Factor-2 Kinase in Stem Cell Survival

Yi Liao, Hsueh-Ping Chu, Zhixian Hu, Jason J. Merkin, Jianmin Chen, Zuguo Liu, Kurt Degenhardt, Eileen White, Alexey G. Ryazanov

J Biol Chem. 2016 Sep 9; 291(37): 19545–19557. Published online 2016 Jul 27. doi: 10.1074/jbc.M116.724856

PMCID:: PMC5016690

Abstract Article PDF–5.1M

Select item 484395318.

Eukaryotic elongation factor 2 kinase regulates the synthesis of microtubule‐related proteins in neurons

Justin W. Kenney, Maja Genheden, Kyung‐Mee Moon, Xuemin Wang, Leonard J. Foster, Christopher G. Proud

J Neurochem. 2016 Jan; 136(2): 276–284. Published online 2015 Nov 17. doi: 10.1111/jnc.13407

PMCID:: PMC4843953

Abstract Article PDF–393K

Select item 480903119.

Mmu-miR-125b overexpression suppresses NO production in activated macrophages by targeting eEF2K and CCNA2

Zhenbiao Xu, Lianmei Zhao, Xin Yang, Sisi Ma, Yehua Ge, Yanxin Liu, Shilian Liu, Juan Shi, Dexian Zheng

BMC Cancer. 2016; 16: 252. Published online 2016 Mar 28. doi: 10.1186/s12885-016-2288-z

PMCID:: PMC4809031

Abstract Article PDF–2.0M

Select item 476027420.

Elongation factor 2 kinase promotes cell survival by inhibiting protein synthesis without inducing autophagy

Claire E.J. Moore, Xuemin Wang, Jianling Xie, Jo Pickford, John Barron, Sergio Regufe da Mota, Matthias Versele, Christopher G. Proud

Cell Signal. 2016 Apr; 28(4): 284–293. doi: 10.1016/j.cellsig.2016.01.005

PMCID:: PMC4760274

Abstract Article PDF–1.2M

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