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Select item 111271561.

Enhanced Apc^Min/+ adenoma formation after epithelial CUL4B deletion by recruitment of myeloid-derived suppressor cells

Beibei Guo, Yawen Zheng, Yujia Fan, Yang Yang, Yuxing Wang, Liping Qin, Yachun An, Xiaoran Xu, Xiyu Zhang, Gongping Sun, Hao Dou, Changshun Shao, Yaoqin Gong, Baichun Jiang, Huili Hu

Neoplasia. 2024 Jul; 53: 101005. Published online 2024 May 17. doi: 10.1016/j.neo.2024.101005

PMCID:: PMC11127156

Abstract Article PDF–13M

Select item 110613122.

Dynamic role of CUL4B in radiation-induced intestinal injury-regeneration

Beibei Guo, Xiaohan Huo, Xueyong Xie, Xiaohui Zhang, Jiabei Lian, Xiyu Zhang, Yaoqin Gong, Hao Dou, Yujia Fan, Yunuo Mao, Jinshen Wang, Huili Hu

Sci Rep. 2024; 14: 9906. Published online 2024 Apr 30. doi: 10.1038/s41598-024-60704-4

PMCID:: PMC11061312

Abstract Article PDF–7.7M

Select item 108657873.

CRL4B E3 ligase recruited by PRPF19 inhibits SARS-CoV-2 infection by targeting ORF6 for ubiquitin-dependent degradation

Linran Zhang, Pengfei Hao, Xiang Chen, Shuai Lv, Wenying Gao, Chang Li, Zhaolong Li, Wenyan Zhang

mBio. 2024 Feb; 15(2): e03071-23. Published online 2024 Jan 24. doi: 10.1128/mbio.03071-23

PMCID:: PMC10865787

Abstract Article PDF–2.5M

Select item 107344154.

B cell expression of E3 ubiquitin ligase Cul4b promotes chronic gammaherpesvirus infection in vivo

Yiping Wang, Mikayla Manzi, April Feswick, Lindsay Renshaw, Paula M. Oliver, Scott A. Tibbetts, Emily K. Moser

J Virol. 2023 Dec; 97(12): e01008-23. Published online 2023 Nov 14. doi: 10.1128/jvi.01008-23

PMCID:: PMC10734415

Abstract Article PDF–1.9M

Select item 97163225.

CUL4B increases platinum‐based drug resistance in colorectal cancer through EMT: A study in its mechanism

Jian‐Wu Luo, Chun‐Ming Wang, Jian‐Wei Su, Ting‐Zhuang Yi, Shao‐Hui Tang

J Cell Mol Med. 2022 Dec; 26(23): 5767–5778. Published online 2022 Nov 16. doi: 10.1111/jcmm.17585

PMCID:: PMC9716322

Abstract Article PDF–14M

Select item 96840316.

Loss of circSRY reduces γH2AX level in germ cells and impairs mouse spermatogenesis

Yanze Song, Min Chen, Yingfan Zhang, Jiayi Li, Bowen Liu, Na Li, Min Chen, Miaomiao Qiao, Nan Wang, Yuanwei Cao, Shan Lu, Jian Chen, Wen Sun, Fei Gao, Haoyi Wang

Life Sci Alliance. 2023 Feb; 6(2): e202201617. Published online 2022 Nov 22. doi: 10.26508/lsa.202201617

PMCID:: PMC9684031

Abstract Article PDF–3.3M

Select item 94333857.

Cullin 4b-RING ubiquitin ligase targets IRGM1 to regulate Wnt signaling and intestinal homeostasis

Yujia Fan, Xiaohan Huo, Beibei Guo, Xiaohui Zhang, Yang Yang, Jiabei Lian, Xinyuan Meng, Yiwen Shao, Yongxin Zou, Haiyang Guo, Haitao Wang, Gongping Sun, Hao Dou, Jinshen Wang, Changshun Shao, Yaoqin Gong, Huili Hu

Cell Death Differ. 2022 Sep; 29(9): 1673–1688. Published online 2022 Feb 23. doi: 10.1038/s41418-022-00954-9

PMCID:: PMC9433385

Abstract Article PDF–7.1M

Select item 85495368.

STK25 and MST3 Have Overlapping Roles to Regulate Rho GTPases during Cortical Development

Tohru Matsuki, Akio Iio, Masashi Ueda, Yumi Tsuneura, Brian W. Howell, Atsuo Nakayama

J Neurosci. 2021 Oct 27; 41(43): 8887–8903. doi: 10.1523/JNEUROSCI.0523-21.2021

PMCID:: PMC8549536

Abstract Article PDF–6.2M

Select item 85351009.

Cullin4 E3 Ubiquitin Ligases Regulate Male Gonocyte Migration, Proliferation and Blood-Testis Barrier Homeostasis

Yan Yin, Liming Zhu, Qiufang Li, Pengbo Zhou, Liang Ma

Cells. 2021 Oct; 10(10): 2732. Published online 2021 Oct 13. doi: 10.3390/cells10102732

PMCID:: PMC8535100

Abstract Article PDF–4.7M

Select item 831891610.

Roles of the ubiquitin ligase CUL4B and ADP-ribosyltransferase TiPARP in TCDD-induced nuclear export and proteasomal degradation of the transcription factor AHR

Mercedes Paz Rijo, Silvia Diani-Moore, Chenyi Yang, Pengbo Zhou, Arleen B. Rifkind

J Biol Chem. 2021 Aug; 297(2): 100886. Published online 2021 Jun 16. doi: 10.1016/j.jbc.2021.100886

PMCID:: PMC8318916

Abstract Article PDF–1.6M

Select item 808063111.

IP₆-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion

Hong Lin, Yuan Yan, Yifan Luo, Wing Yan So, Xiayun Wei, Xiaozhe Zhang, Xiaoli Yang, Jun Zhang, Yang Su, Xiuyan Yang, Bobo Zhang, Kangjun Zhang, Nan Jiang, Billy Kwok Chong Chow, Weiping Han, Fengchao Wang, Feng Rao

Nat Commun. 2021; 12: 2461. Published online 2021 Apr 28. doi: 10.1038/s41467-021-22941-3

PMCID:: PMC8080631

Abstract Article PDF–3.1M

Select item 802664212.

CUL4B negatively regulates Toll-like receptor-triggered proinflammatory responses by repressing Pten transcription

Yu Song, Peishan Li, Liping Qin, Zhiliang Xu, Baichun Jiang, Chunhong Ma, Changshun Shao, Yaoqin Gong

Cell Mol Immunol. 2021 Feb; 18(2): 339–349. Published online 2019 Nov 15. doi: 10.1038/s41423-019-0323-0

PMCID:: PMC8026642

Abstract Article PDF–2.7M

Select item 793877013.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 788868214.

The E3 ubiquitin ligase Cul4b promotes CD4⁺ T cell expansion by aiding the repair of damaged DNA

Asif A. Dar, Keisuke Sawada, Joseph M. Dybas, Emily K. Moser, Emma L. Lewis, Eddie Park, Hossein Fazelinia, Lynn A. Spruce, Hua Ding, Steven H. Seeholzer, Paula M. Oliver

PLoS Biol. 2021 Feb; 19(2): e3001041. Published online 2021 Feb 1. doi: 10.1371/journal.pbio.3001041

PMCID:: PMC7888682

Abstract Article PDF–4.5M

Select item 741599115.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 688564516.

Aryl hydrocarbon receptor (AhR) regulates adipocyte differentiation by assembling CRL4B ubiquitin ligase to target PPARγ for proteasomal degradation

Hao Dou, Yuyao Duan, Xiaohui Zhang, Qian Yu, Qian Di, Yu Song, Peishan Li, Yaoqin Gong

J Biol Chem. 2019 Nov 29; 294(48): 18504–18515. Published online 2019 Oct 25. doi: 10.1074/jbc.RA119.009282

PMCID:: PMC6885645

Abstract Article PDF–2.8M

Select item 660229217.

Embryonic Cul4b is important for epiblast growth and location of primitive streak layer cells

Chun-Yu Chen, I-Shing Yu, Chen-Hsueh Pai, Chien-Yu Lin, Shu-Rung Lin, You-Tzung Chen, Shu-Wha Lin

PLoS One. 2019; 14(7): e0219221. Published online 2019 Jul 1. doi: 10.1371/journal.pone.0219221

PMCID:: PMC6602292

Abstract Article PDF–6.3M

Select item 646668718.

Abnormal level of CUL4B-mediated histone H2A ubiquitination causes disruptive HOX gene expression

Ye Lin, Juan Yu, Jianxin Wu, Shan Wang, Ting Zhang

Epigenetics Chromatin. 2019; 12: 22. Published online 2019 Apr 16. doi: 10.1186/s13072-019-0268-7

PMCID:: PMC6466687

Abstract Article PDF–3.0M

Select item 633388319.

Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4^DCAF5 ubiquitin ligase

Chunxiao Zhang, Feng Leng, Lovely Saxena, Nam Hoang, Jiekai Yu, Salvador Alejo, Logan Lee, Dandan Qi, Fei Lu, Hong Sun, Hui Zhang

J Biol Chem. 2019 Jan 11; 294(2): 476–489. Published online 2018 Nov 15. doi: 10.1074/jbc.RA118.005336

PMCID:: PMC6333883

Abstract Article PDF–3.1M

Select item 549077020.

A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions

Qing Li, Min Cui, Fan Yang, Na Li, Baichun Jiang, Zhen Yu, Daolai Zhang, Yijing Wang, Xibin Zhu, Huili Hu, Pei-Shan Li, Shang-Lei Ning, Si Wang, Haibo Qi, Hechen Song, Dongfang He, Amy Lin, Jingjing Zhang, Feng Liu, Jiajun Zhao, Ling Gao, Fan Yi, Tian Xue, Jin-Peng Sun, Yaoqin Gong, Xiao Yu

J Clin Invest. 2017 Jun 30; 127(7): 2631–2646. Published online 2017 Jun 12. doi: 10.1172/JCI91348

PMCID:: PMC5490770

Abstract Article PDF–2.8M

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