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Items: 1 to 20 of 67

1.
FOXF1 promotes tumor vessel normalization and prevents lung cancer progression through FZD4
Fenghua Bian, Chinmayee Goda, Guolun Wang, Ying-Wei Lan, Zicheng Deng, Wen Gao, Anusha Acharya, Abid A Reza, Jose Gomez-Arroyo, Nawal Merjaneh, Xiaomeng Ren, Jermaine Goveia, Peter Carmeliet, Vladimir V Kalinichenko, Tanya V Kalin
EMBO Mol Med. 2024 May; 16(5): 1063–1090. Published online 2024 Apr 8. doi: 10.1038/s44321-024-00064-8
PMCID:
PMC11099127
AbstractArticlePDF–18M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
The RNA helicase DDX6 controls early mouse embryogenesis by repressing aberrant inhibition of BMP signaling through miRNA-mediated gene silencing
Jessica Kim, Masafumi Muraoka, Hajime Okada, Atsushi Toyoda, Rieko Ajima, Yumiko Saga
PLoS Genet. 2022 Oct; 18(10): e1009967. Published online 2022 Oct 5. doi: 10.1371/journal.pgen.1009967
PMCID:
PMC9534413
AbstractArticlePDF–3.8M
4.
Integrated analysis of Wnt signalling system component gene expression
Paula Murphy, Chris Armit, Bill Hill, Shanmugasundaram Venkataraman, Patrick Frankel, Richard A. Baldock, Duncan R. Davidson
Development. 2022 Aug 15; 149(16): dev200312. Published online 2022 Aug 15. doi: 10.1242/dev.200312
PMCID:
PMC9481969
AbstractArticle
5.
Norrie disease protein is essential for cochlear hair cell maturation
Yushi Hayashi, Hao Chiang, ChunJie Tian, Artur A. Indzhykulian, Albert S. B. Edge
Proc Natl Acad Sci U S A. 2021 Sep 28; 118(39): e2106369118. Published online 2021 Sep 20. doi: 10.1073/pnas.2106369118
PMCID:
PMC8488680
AbstractArticlePDF–3.2M
6.
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development
Francesco Bedogni, Robert F. Hevner
Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034
PMCID:
PMC8313239
AbstractArticlePDF–1.6M
7.
Catenin α 1 mutations cause familial exudative vitreoretinopathy by overactivating Norrin/β-catenin signaling
Xianjun Zhu, Mu Yang, Peiquan Zhao, Shujin Li, Lin Zhang, Lulin Huang, Yi Huang, Ping Fei, Yeming Yang, Shanshan Zhang, Huijuan Xu, Ye Yuan, Xiang Zhang, Xiong Zhu, Shi Ma, Fang Hao, Periasamy Sundaresan, Weiquan Zhu, Zhenglin Yang
J Clin Invest. 2021 Mar 15; 131(6): e139869. Published online 2021 Mar 15. doi: 10.1172/JCI139869
PMCID:
PMC7954601
AbstractArticlePDF–31M
8.
Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis
Jiali Ru, Dianlei Guo, Jiaying Fan, Jiao Zhang, Rong Ju, Hong Ouyang, Lai Wei, Yizhi Liu, Chunqiao Liu
Invest Ophthalmol Vis Sci. 2020 Nov; 61(13): 6. Published online 2020 Nov 3. doi: 10.1167/iovs.61.13.6
PMCID:
PMC7645213
AbstractArticlePDF–35M
9.
The transcription factor Maz is essential for normal eye development
Olga Medina-Martinez, Meade Haller, Jill A. Rosenfeld, Marisol A. O'Neill, Dolores J. Lamb, Milan Jamrich
Dis Model Mech. 2020 Aug 1; 13(8): dmm044412. Published online 2020 Aug 18. doi: 10.1242/dmm.044412
PMCID:
PMC7449797
AbstractArticle
10.
Deficiency of MFSD7c results in microcephaly-associated vasculopathy in Fowler syndrome
Pazhanichamy Kalailingam, Kai Qi Wang, Xiu Ru Toh, Toan Q. Nguyen, Madhuvanthi Chandrakanthan, Zafrul Hasan, Clair Habib, Aharon Schif, Francesca Clementina Radio, Bruno Dallapiccola, Karin Weiss, Long N. Nguyen
J Clin Invest. 2020 Aug 3; 130(8): 4081–4093. Published online 2020 Jun 22. doi: 10.1172/JCI136727
PMCID:
PMC7410059
AbstractArticlePDF–29M
11.
Progressive Cerebellar, Auditory, and Esophageal Dysfunction Caused by Targeted Disruption of thefrizzled-4 Gene
Yanshu Wang, David Huso, Hugh Cahill, David Ryugo, Jeremy Nathans
J Neurosci. 2001 Jul 1; 21(13): 4761–4771. doi: 10.1523/JNEUROSCI.21-13-04761.2001
PMCID:
PMC6762346
AbstractArticlePDF–2.2M
12.
Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers
Chris Cho, Yanshu Wang, Philip M Smallwood, John Williams, Jeremy Nathans
eLife. 2019; 8: e45542. Published online 2019 May 8. doi: 10.7554/eLife.45542
PMCID:
PMC6506210
AbstractArticlePDF–11M
13.
Molecular determinants of WNT9b responsiveness in nephron progenitor cells
Kyle K. Dickinson, Leah C. Hammond, Courtney M. Karner, Nicholas D. Hastie, Thomas J. Carroll, Paul Goodyer
PLoS One. 2019; 14(4): e0215139. Published online 2019 Apr 12. doi: 10.1371/journal.pone.0215139
PMCID:
PMC6461349
AbstractArticlePDF–2.0M
14.
Beta-catenin signaling regulates barrier-specific gene expression in circumventricular organ and ocular vasculatures
Yanshu Wang, Mark F Sabbagh, Xiaowu Gu, Amir Rattner, John Williams, Jeremy Nathans
eLife. 2019; 8: e43257. Published online 2019 Apr 1. doi: 10.7554/eLife.43257
PMCID:
PMC6443350
AbstractArticlePDF–14M
15.
Interplay of the Norrin and Wnt7a/Wnt7b signaling systems in blood–brain barrier and blood–retina barrier development and maintenance
Yanshu Wang, Chris Cho, John Williams, Philip M. Smallwood, Chi Zhang, Harald J. Junge, Jeremy Nathans
Proc Natl Acad Sci U S A. 2018 Dec 11; 115(50): E11827–E11836. Published online 2018 Nov 26. doi: 10.1073/pnas.1813217115
Correction in:
Proc Natl Acad Sci U S A. 2019 Feb 26; 116(9): 3934.
PMCID:
PMC6294914
AbstractArticlePDF–3.6M
16.
Biophysical and functional characterization of Norrin signaling through Frizzled4
Injin Bang, Hee Ryung Kim, Andrew H. Beaven, Jinuk Kim, Seung-Bum Ko, Gyu Rie Lee, Wei Kan, Hasup Lee, Wonpil Im, Chaok Seok, Ka Young Chung, Hee-Jung Choi
Proc Natl Acad Sci U S A. 2018 Aug 28; 115(35): 8787–8792. Published online 2018 Aug 13. doi: 10.1073/pnas.1805901115
Correction in:
Proc Natl Acad Sci U S A. 2018 Nov 6; 115(45): E10807.
PMCID:
PMC6126767
AbstractArticlePDF–1.3M
17.
The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis
Wenguang Yin, Hyun-Taek Kim, ShengPeng Wang, Felix Gunawan, Lei Wang, Keishi Kishimoto, Hua Zhong, Dany Roman, Jens Preussner, Stefan Guenther, Viola Graef, Carmen Buettner, Beate Grohmann, Mario Looso, Mitsuru Morimoto, Graeme Mardon, Stefan Offermanns, Didier Y. R. Stainier
Nat Commun. 2018; 9: 2815. Published online 2018 Jul 19. doi: 10.1038/s41467-018-05043-5
PMCID:
PMC6052067
AbstractArticlePDF–11M
18.
FZD4 Marks Lateral Plate Mesoderm and Signals with NORRIN to Increase Cardiomyocyte Induction from Pluripotent Stem Cell-Derived Cardiac Progenitors
Charles Yoon, Hannah Song, Ting Yin, Damaris Bausch-Fluck, Andreas P. Frei, Steven Kattman, Nicole Dubois, Alec D. Witty, Johannes A. Hewel, Hongbo Guo, Andrew Emili, Bernd Wollscheid, Gordon Keller, Peter W. Zandstra
Stem Cell Reports. 2018 Jan 9; 10(1): 87–100. Published online 2017 Dec 14. doi: 10.1016/j.stemcr.2017.11.008
PMCID:
PMC5768897
AbstractArticlePDF–2.9M
19.
Planar cell polarity genes frizzled4 and frizzled6 exert patterning influence on arterial vessel morphogenesis
Rene Markovič, Julien Peltan, Marko Gosak, Denis Horvat, Borut Žalik, Benjamin Seguy, Remi Chauvel, Gregoire Malandain, Thierry Couffinhal, Cécile Duplàa, Marko Marhl, Etienne Roux
PLoS One. 2017; 12(3): e0171033. Published online 2017 Mar 2. doi: 10.1371/journal.pone.0171033
PMCID:
PMC5333836
AbstractArticlePDF–2.5M
20.
High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray
Nature. Author manuscript; available in PMC 2017 Mar 14.
Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356
Correction in:
Nature. 2017 Nov 16; 551(7680): 398.
PMCID:
PMC5295821
AbstractArticlePDF–3.0M

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