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Items: 1 to 20 of 119

1.
Presenilin Deficiency Results in Cellular Cholesterol Accumulation by Impairment of Protein Glycosylation and NPC1 Function
Marietta Fabiano, Naoto Oikawa, Anja Kerksiek, Jun-ichi Furukawa, Hirokazu Yagi, Koichi Kato, Ulrich Schweizer, Wim Annaert, Jongkyun Kang, Jie Shen, Dieter Lütjohann, Jochen Walter
Int J Mol Sci. 2024 May; 25(10): 5417. Published online 2024 May 16. doi: 10.3390/ijms25105417
PMCID:
PMC11121565
AbstractArticlePDF–3.7M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
Presenilin‐2 knock‐In mice show severe depressive behavior via DVL3 downregulation
Seung Sik Yoo, Dong Won Lee, Hyeon Joo Ham, In Jun Yeo, Ju Young Chang, Jaesuk Yun, Dong Ju Son, Sang‐Bae Han, Jin Tae Hong
CNS Neurosci Ther. 2024 Feb; 30(2): e14370. Published online 2023 Jul 27. doi: 10.1111/cns.14370
PMCID:
PMC10848049
AbstractArticlePDF–2.9M
4.
Presenilin-1 in smooth muscle cells facilitates hypermuscularization in elastin aortopathy
Junichi Saito, Jui M. Dave, Freddy Duarte Lau, Daniel M. Greif
iScience. 2024 Jan 19; 27(1): 108636. Published online 2023 Dec 13. doi: 10.1016/j.isci.2023.108636
PMCID:
PMC10788461
AbstractArticlePDF–9.4M
5.
Interictal spikes in Alzheimer’s disease: Preclinical evidence for dominance of the dentate gyrus and cholinergic control by the medial septum
Christos Panagiotis Lisgaras, Helen E. Scharfman
Neurobiol Dis. Author manuscript; available in PMC 2023 Oct 31.
Published in final edited form as: Neurobiol Dis. 2023 Oct 15; 187: 106294. Published online 2023 Sep 14. doi: 10.1016/j.nbd.2023.106294
PMCID:
PMC10617404
AbstractArticlePDF–4.6M
6.
Loss of normal Alzheimer's disease-associated Presenilin 2 function alters antiseizure medicine potency and tolerability in the 6-Hz focal seizure model
Leanne M. Lehmann, Melissa Barker-Haliski
Front Neurol. 2023; 14: 1223472. Published online 2023 Aug 1. doi: 10.3389/fneur.2023.1223472
PMCID:
PMC10427874
AbstractArticlePDF–3.1M
7.
Guizhi Fuling capsule relieves memory deficits by inhibition of microglial neuroinflammation through blocking JAK2/STAT3 pathway in presenilin1/2 conditional double knockout mice
Guang Yang, Yuting Tong, Xingyu Wang, Chenyi Zhao, Zongtao Ba, Reaila Ahelijiang, Xinjuan Liu, Waimao Gao, Yan Zhao, Yining Gu, Jianmei Yang, Ying Xu
Front Immunol. 2023; 14: 1185570. Published online 2023 Jul 3. doi: 10.3389/fimmu.2023.1185570
PMCID:
PMC10350565
AbstractArticlePDF–7.1M
8.
Transmembrane BAX inhibitor motif containing 6 suppresses presenilin-2 to preserve mitochondrial integrity after myocardial ischemia-reperfusion injury
Li Ma, Lihan Liao, Na Zhou, Huikang Tao, Hao Zhou, Ying Tan, Weidan Chen, Fan Cao, Xinxin Chen
Int J Biol Sci. 2023; 19(4): 1228–1240. Published online 2023 Feb 13. doi: 10.7150/ijbs.81100
PMCID:
PMC10008687
AbstractArticlePDF–7.2M
9.
Presenilins regulate synaptic plasticity in the perforant pathways of the hippocampus
Sang Hun Lee, Vadim Y. Bolshakov, Jie Shen
Mol Brain. 2023; 16: 17. Published online 2023 Jan 30. doi: 10.1186/s13041-023-01009-x
PMCID:
PMC9885562
AbstractArticlePDF–4.0M
10.
Presenilin 2 N141I mutation induces hyperactive immune response through the epigenetic repression of REV-ERBα
Hyeri Nam, Younghwan Lee, Boil Kim, Ji-Won Lee, Seohyeon Hwang, Hyun-Kyu An, Kyung Min Chung, Youngjin Park, Jihyun Hong, Kyungjin Kim, Eun-Kyoung Kim, Han Kyoung Choe, Seong-Woon Yu
Nat Commun. 2022; 13: 1972. Published online 2022 Apr 13. doi: 10.1038/s41467-022-29653-2
PMCID:
PMC9008044
AbstractArticlePDF–6.8M
11.
JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency
Jui M. Dave, Raja Chakraborty, Aglaia Ntokou, Junichi Saito, Fatima Z. Saddouk, Zhonghui Feng, Ashish Misra, George Tellides, Robert K. Riemer, Zsolt Urban, Caroline Kinnear, James Ellis, Seema Mital, Robert Mecham, Kathleen A. Martin, Daniel M. Greif
J Clin Invest. 2022 Mar 1; 132(5): e142338. Published online 2022 Mar 1. doi: 10.1172/JCI142338
PMCID:
PMC8884911
AbstractArticlePDF–3.3M
12.
Loss of presenilin function enhances tau phosphorylation and aggregation in mice
Carlos M. Soto-Faguás, Paula Sanchez-Molina, Carlos A. Saura
Acta Neuropathol Commun. 2021; 9: 162. Published online 2021 Sep 30. doi: 10.1186/s40478-021-01259-7
PMCID:
PMC8482568
AbstractArticlePDF–3.4M
13.
Calcium Signaling and Mitochondrial Function in Presenilin 2 Knock-Out Mice: Looking for Any Loss-of-Function Phenotype Related to Alzheimer’s Disease
Alice Rossi, Luisa Galla, Chiara Gomiero, Lorena Zentilin, Mauro Giacca, Valentina Giorgio, Tito Calì, Tullio Pozzan, Elisa Greotti, Paola Pizzo
Cells. 2021 Feb; 10(2): 204. Published online 2021 Jan 21. doi: 10.3390/cells10020204
PMCID:
PMC7909802
AbstractArticlePDF–3.7M
14.
Neuron‐specific deletion of presenilin enhancer2 causes progressive astrogliosis and age‐related neurodegeneration in the cortex independent of the Notch signaling
Hui‐Ru Bi, Cui‐Hua Zhou, Yi‐Zhi Zhang, Xu‐Dong Cai, Mu‐Huo Ji, Jian‐Jun Yang, Gui‐Quan Chen, Yi‐Min Hu
CNS Neurosci Ther. 2021 Feb; 27(2): 174–185. Published online 2020 Sep 22. doi: 10.1111/cns.13454
PMCID:
PMC7816208
AbstractArticlePDF–3.9M
15.
Cell-autonomous role of Presenilin in age-dependent survival of cortical interneurons
Jongkyun Kang, Jie Shen
Mol Neurodegener. 2020; 15: 72. Published online 2020 Dec 10. doi: 10.1186/s13024-020-00419-y
PMCID:
PMC7731773
AbstractArticlePDF–8.6M
16.
Loss of Presenilin 2 Age-Dependently Alters Susceptibility to Acute Seizures and Kindling Acquisition
Megan Beckman, Kevin Knox, Zachery Koneval, Carole Smith, Suman Jayadev, Melissa Barker-Haliski
Neurobiol Dis. Author manuscript; available in PMC 2021 Mar 1.
Published in final edited form as: Neurobiol Dis. 2020 Mar; 136: 104719. Published online 2019 Dec 17. doi: 10.1016/j.nbd.2019.104719
PMCID:
PMC7462087
AbstractArticlePDF–934K
17.
Dampened Slow Oscillation Connectivity Anticipates Amyloid Deposition in the PS2APP Mouse Model of Alzheimer’s Disease
Alessandro Leparulo, Mufti Mahmud, Elena Scremin, Tullio Pozzan, Stefano Vassanelli, Cristina Fasolato
Cells. 2020 Jan; 9(1): 54. Published online 2019 Dec 24. doi: 10.3390/cells9010054
PMCID:
PMC7016892
AbstractArticlePDF–5.0M
18.
Presenilin/γ-secretase-dependent EphA3 processing mediates axon elongation through non-muscle myosin IIA
Míriam Javier-Torrent, Sergi Marco, Daniel Rocandio, Maria Pons-Vizcarra, Peter W Janes, Martin Lackmann, Joaquim Egea, Carlos A Saura
eLife. 2019; 8: e43646. Published online 2019 Oct 2. doi: 10.7554/eLife.43646
PMCID:
PMC6774734
AbstractArticlePDF–9.8M
19.
Loss of γ-Secretase Function Impairs Endocytosis of Lipoprotein Particles and Membrane Cholesterol Homeostasis
Irfan Y. Tamboli, Kai Prager, Dietmar R. Thal, Karin M. Thelen, Ilse Dewachter, Claus U. Pietrzik, Peter St. George-Hyslop, Sangram S. Sisodia, Bart De Strooper, Michael T. Heneka, Mikhail A. Filippov, Ulrike Müller, Fred van Leuven, Dieter Lütjohann, Jochen Walter
J Neurosci. 2008 Nov 12; 28(46): 12097–12106. doi: 10.1523/JNEUROSCI.2635-08.2008
PMCID:
PMC6671640
AbstractArticlePDF–591K
20.
Dysregulation of Hypoxia-Inducible Factor by Presenilin/γ-Secretase Loss-of-Function Mutations
Muriel R. Kaufmann, Sandra Barth, Uwe Konietzko, Bei Wu, Sascha Egger, Reiner Kunze, Hugo H. Marti, Meike Hick, Ulrike Müller, Gieri Camenisch, Roland H. Wenger
J Neurosci. 2013 Jan 30; 33(5): 1915–1926. doi: 10.1523/JNEUROSCI.3402-12.2013
PMCID:
PMC6619134
AbstractArticlePDF–1.5M

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