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Select item 111451241.

SIRT1 mediates the excitability of spinal CaMKIIα‐positive neurons and participates in neuropathic pain by controlling Nav1.3

Yuanzeng Wang, Yidan Zhang, Nan Ma, Wen Zhao, Xiuhua Ren, Yanyan Sun, Weidong Zang, Jing Cao

CNS Neurosci Ther. 2024 Jun; 30(6): e14764. Published online 2024 Jun 3. doi: 10.1111/cns.14764

PMCID:: PMC11145124

Abstract Article PDF–24M

Select item 107941512.

Na_v1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis

Wenyu Fu, Dmytro Vasylyev, Yufei Bi, Mingshuang Zhang, Guodong Sun, Asya Khleborodova, Guiwu Huang, Libo Zhao, Renpeng Zhou, Yonggang Li, Shujun Liu, Xianyi Cai, Wenjun He, Min Cui, Xiangli Zhao, Aubryanna Hettinghouse, Julia Good, Ellen Kim, Eric Strauss, Philipp Leucht, Ran Schwarzkopf, Edward X. Guo, Jonathan Samuels, Wenhuo Hu, Mukundan Attur, Stephen G. Waxman, Chuan-ju Liu

Nature. 2024; 625(7995): 557–565. Published online 2024 Jan 3. doi: 10.1038/s41586-023-06888-7

PMCID:: PMC10794151

Abstract Article PDF–85M

Select item 107693503.

Identification of new ciliary signaling pathways in the brain and insights into neurological disorders

Abdelhalim Loukil, Emma Ebright, Akiyoshi Uezu, Yudong Gao, Scott H Soderling, Sarah C. Goetz

Version 1. bioRxiv. Preprint. 2023 Dec 21. doi: 10.1101/2023.12.20.572700

PMCID:: PMC10769350

Abstract Article PDF–11M

Select item 104107614.

Identification and targeting of a unique Na_V1.7 domain driving chronic pain

Kimberly Gomez, Harrison J. Stratton, Paz Duran, Santiago Loya, Cheng Tang, Aida Calderon-Rivera, Liberty François-Moutal, May Khanna, Cynthia L. Madura, Shizhen Luo, Bryan McKiver, Edward Choi, Dongzhi Ran, Lisa Boinon, Samantha Perez-Miller, M. Imad Damaj, Aubin Moutal, Rajesh Khanna

Proc Natl Acad Sci U S A. 2023 Aug 8; 120(32): e2217800120. Published online 2023 Jul 27. doi: 10.1073/pnas.2217800120

PMCID:: PMC10410761

Abstract Article PDF–18M

Select item 101914415.

USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities

Chao Liu, Lingang Sun, Yijun Tan, Qi Wang, Tao Luo, Chenlu Li, Nan Yao, Yuting Xie, Xiao Yi, Yi Zhu, Tiannan Guo, Junfeng Ji

Sci Adv. 2023 May; 9(20): eade3888. Published online 2023 May 17. doi: 10.1126/sciadv.ade3888

PMCID:: PMC10191441

Abstract Article PDF–2.4M

Select item 101713596.

Na_v 1.7 gain-of-function mutation I228M triggers age-dependent nociceptive insensitivity and C-LTMR dysregulation

Nivanthika K. Wimalasena, Daniel G. Taub, Jaehoon Shim, Sara Hakim, Riki Kawaguchi, Lubin Chen, Mahmoud El-Rifai, Daniel H. Geschwind, Sulayman D. Dib-Hajj, Stephen G. Waxman, Clifford J. Woolf

Exp Neurol. Author manuscript; available in PMC 2023 Jun 1.

Published in final edited form as: Exp Neurol. 2023 Jun; 364: 114393. Published online 2023 Mar 30. doi: 10.1016/j.expneurol.2023.114393

PMCID:: PMC10171359

Abstract Article PDF–1.9M

Select item 101479237.

Pain-causing stinging nettle toxins target TMEM233 to modulate Na_V1.7 function

Sina Jami, Jennifer R. Deuis, Tabea Klasfauseweh, Xiaoyang Cheng, Sergey Kurdyukov, Felicity Chung, Andrei L. Okorokov, Shengnan Li, Jiangtao Zhang, Ben Cristofori-Armstrong, Mathilde R. Israel, Robert J. Ju, Samuel D. Robinson, Peng Zhao, Lotten Ragnarsson, Åsa Andersson, Poanna Tran, Vanessa Schendel, Kirsten L. McMahon, Hue N. T. Tran, Yanni K.-Y. Chin, Yifei Zhu, Junyu Liu, Theo Crawford, Saipriyaa Purushothamvasan, Abdella M. Habib, David A. Andersson, Lachlan D. Rash, John N. Wood, Jing Zhao, Samantha J. Stehbens, Mehdi Mobli, Andreas Leffler, Daohua Jiang, James J. Cox, Stephen G. Waxman, Sulayman D. Dib-Hajj, G. Gregory Neely, Thomas Durek, Irina Vetter

Nat Commun. 2023; 14: 2442. Published online 2023 Apr 28. doi: 10.1038/s41467-023-37963-2

PMCID:: PMC10147923

Abstract Article PDF–3.8M

Select item 95865478.

Na_v1.7 is required for normal C-low threshold mechanoreceptor function in humans and mice

Steven J Middleton, Irene Perini, Andreas C Themistocleous, Greg A Weir, Kirsty McCann, Allison M Barry, Andrew Marshall, Michael Lee, Leah M Mayo, Manon Bohic, Georgios Baskozos, India Morrison, Line S Löken, Sarah McIntyre, Saad S Nagi, Roland Staud, Isac Sehlstedt, Richard D Johnson, Johan Wessberg, John N Wood, Christopher G Woods, Aziz Moqrich, Håkan Olausson, David L Bennett

Brain. 2022 Oct; 145(10): 3637–3653. Published online 2021 Dec 27. doi: 10.1093/brain/awab482

PMCID:: PMC9586547

Abstract Article PDF–1.9M

Select item 95368429.

Selective optogenetic activation of Na_V1.7–expressing afferents in Na_V1.7-ChR2 mice induces nocifensive behavior without affecting responses to mechanical and thermal stimuli

Toyoaki Maruta, Kotaro Hidaka, Satoshi Kouroki, Tomohiro Koshida, Mio Kurogi, Yohko Kage, Seiya Mizuno, Tetsuro Shirasaka, Toshihiko Yanagita, Satoru Takahashi, Ryu Takeya, Isao Tsuneyoshi

PLoS One. 2022; 17(10): e0275751. Published online 2022 Oct 6. doi: 10.1371/journal.pone.0275751

PMCID:: PMC9536842

Abstract Article PDF–1.4M

Select item 849743910.

Dissecting the precise nature of itch-evoked scratching

Nivanthika K. Wimalasena, George Milner, Ricardo Silva, Cliff Vuong, Zihe Zhang, Diana M. Bautista, Clifford J. Woolf

Neuron. Author manuscript; available in PMC 2021 Oct 8.

Published in final edited form as: Neuron. 2021 Oct 6; 109(19): 3075–3087.e2. Published online 2021 Aug 18. doi: 10.1016/j.neuron.2021.07.020

PMCID:: PMC8497439

Abstract Article PDF–1.4M

Select item 811930111.

Two independent mouse lines carrying the Nav1.7-I228M gain-of-function variant display DRG neuron hyperexcitability but a minimal pain phenotype

Lubin Chen, Nivanthika K. Wimalasena, Jaehoon Shim, Chongyang Han, Seong-il Lee, Rafael Gonzalez-Cano, Mark Estacion, Catharina G. Faber, Giuseppe Lauria, Sulayman D. Dib-Hajj, Clifford J. Woolf, Stephen G. Waxman

Pain. Author manuscript; available in PMC 2022 Jun 1.

Published in final edited form as: Pain. 2021 Jun 1; 162(6): 1758–1770. doi: 10.1097/j.pain.0000000000002171

PMCID:: PMC8119301

Article PDF–1.3M

Select item 802071712.

Nav1.3 and FGF14 are primary determinants of the TTX-sensitive sodium current in mouse adrenal chromaffin cells

Pedro L. Martinez-Espinosa, Chengtao Yang, Xiao-Ming Xia, Christopher J. Lingle

J Gen Physiol. 2021 Apr 5; 153(4): e202012785. Published online 2021 Mar 2. doi: 10.1085/jgp.202012785

PMCID:: PMC8020717

Abstract Article PDF–8.0M

Select item 793877013.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 771370614.

Phox2a Defines a Developmental Origin of the Anterolateral System in Mice and Humans

R. Brian Roome, Farin B. Bourojeni, Bishakha Mona, Shima Rastegar-Pouyani, Raphael Blain, Annie Dumouchel, Charleen Salesse, W. Scott Thompson, Megan Brookbank, Yorick Gitton, Lino Tessarollo, Martyn Goulding, Jane E. Johnson, Marie Kmita, Alain Chédotal, Artur Kania

Cell Rep. Author manuscript; available in PMC 2020 Dec 3.

Published in final edited form as: Cell Rep. 2020 Nov 24; 33(8): 108425. doi: 10.1016/j.celrep.2020.108425

PMCID:: PMC7713706

Abstract Article PDF–4.9M

Select item 703092615.

Sensory neuron–derived Na_V1.7 contributes to dorsal horn neuron excitability

Sascha R. A. Alles, Filipe Nascimento, Rafael Luján, Ana P. Luiz, Queensta Millet, M. Ali Bangash, Sonia Santana-Varela, Xuelong Zhou, James J. Cox, Andrei L. Okorokov, Marco Beato, Jing Zhao, John N. Wood

Sci Adv. 2020 Feb; 6(8): eaax4568. Published online 2020 Feb 19. doi: 10.1126/sciadv.aax4568

PMCID:: PMC7030926

Abstract Article PDF–3.0M

Select item 692874316.

3’-O-Methylorobol Inhibits the Voltage-Gated Sodium Channel Nav1.7 with Anti-Itch Efficacy in A Histamine-Dependent Itch Mouse Model

Fan Zhang, Ying Wu, Shuwen Xue, Shuangyan Wang, Chunlei Zhang, Zhengyu Cao

Int J Mol Sci. 2019 Dec; 20(23): 6058. Published online 2019 Dec 1. doi: 10.3390/ijms20236058

PMCID:: PMC6928743

Abstract Article PDF–3.4M

Select item 673044617.

Early Expression of Sodium Channel Transcripts and Sodium Current by Cajal-Retzius Cells in the Preplate of the Embryonic Mouse Neocortex

Mireille Albrieux, Jean-Claude Platel, Alain Dupuis, Michel Villaz, William J. Moody

J Neurosci. 2004 Feb 18; 24(7): 1719–1725. doi: 10.1523/JNEUROSCI.3548-02.2004

PMCID:: PMC6730446

Abstract Article PDF–306K

Select item 671140418.

Synergistic regulation of serotonin and opioid signaling contribute to pain insensitivity in Na_v1.7 knockout mice

Jörg Isensee, Leonhardt Krahé, Katharina Moeller, Vanessa Pereira, Jane E. Sexton, Xiaohui Sun, Edward Emery, John N. Wood, Tim Hucho

Sci Signal. Author manuscript; available in PMC 2019 Aug 14.

Published in final edited form as: Sci Signal. 2017 Jan 10; 10(461): eaah4874. Published online 2017 Jan 10. doi: 10.1126/scisignal.aah4874

PMCID:: PMC6711404

Abstract Article PDF–3.1M

Select item 669277019.

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics

Joel D. Federspiel, Todd M. Greco, Krystal K. Lum, Ileana M. Cristea

Mol Cell Proteomics. 2019 Aug 9; 18(8 Suppl 1): S92–S113. Published online 2019 Apr 30. doi: 10.1074/mcp.RA118.001253

PMCID:: PMC6692770

Abstract Article PDF–7.7M

Select item 668750620.

ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons

An-Jing Ren, Kai Wang, Huan Zhang, Anjun Liu, Xianhua Ma, Qing Liang, Dongmei Cao, John N. Wood, David Z. He, Yu-Qiang Ding, Wen-Jun Yuan, Zhifang Xie, Weiping J. Zhang

Nat Commun. Author manuscript; available in PMC 2019 Aug 8.

Published in final edited form as: Nat Commun. 2014 Nov 5; 5: 4984. Published online 2014 Nov 5. doi: 10.1038/ncomms5984

PMCID:: PMC6687506

Abstract Article PDF–3.4M

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