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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 105857522.

Insulin-induced gene 2 protects against hepatic ischemia–reperfusion injury via metabolic remodeling

Yichao Wu, Changbiao Li, Abid Ali Khan, Kangchen Chen, Renyi Su, Shengjun Xu, Yiyang Sun, Fengqiang Gao, Kai Wang, Xiaodong Wang, Zhengxing Lian, Shuo Wang, Mengyuan Yu, Xin Hu, Fan Yang, Shusen Zheng, Nasha Qiu, Zhikun Liu, Xiao Xu

J Transl Med. 2023; 21: 739. Published online 2023 Oct 19. doi: 10.1186/s12967-023-04564-y

PMCID:: PMC10585752

Abstract Article PDF–14M

Select item 88105703.

CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing

Han Zeng, Hong Qin, Meng Liao, Enze Zheng, Xiaoqing Luo, Anhua Xiao, Yiyu Li, Lin Chen, Li Wei, Lei Zhao, Xiong Z. Ruan, Ping Yang, Yaxi Chen

Mol Metab. 2022 Mar; 57: 101428. Published online 2021 Dec 30. doi: 10.1016/j.molmet.2021.101428

PMCID:: PMC8810570

Abstract Article PDF–4.7M

Select item 69691114.

Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2

Zhang-Sen Zhou, Mei-Xin Li, Jie Liu, Hengwu Jiao, Jing-Ming Xia, Xiong-Jie Shi, Huabin Zhao, Liping Chu, Jingrong Liu, Wei Qi, Jie Luo, Bao-Liang Song

Nat Commun. 2020; 11: 379. Published online 2020 Jan 17. doi: 10.1038/s41467-019-14231-w

PMCID:: PMC6969111

Abstract Article PDF–2.3M

Select item 68260395.

Cholesterol metabolism plays a crucial role in the regulation of autophagy for cell differentiation of granular convoluted tubules in male mouse submandibular glands

Akiko Suzuki, Junbo Shim, Kenichi Ogata, Hiroki Yoshioka, Junichi Iwata

Development. 2019 Oct 15; 146(20): dev178335. Published online 2019 Oct 17. doi: 10.1242/dev.178335

PMCID:: PMC6826039

Abstract Article

Select item 60536576.

Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis

Hidetoshi Tsushima, Yuning J. Tang, Vijitha Puviindran, Shu-Hsuan Claire Hsu, Puviindran Nadesan, Chunying Yu, Hongyuan Zhang, Anthony J. Mirando, Matthew J. Hilton, Benjamin A. Alman

Development. 2018 Jul 1; 145(13): dev162396. Published online 2018 Jul 9. doi: 10.1242/dev.162396

PMCID:: PMC6053657

Abstract Article

Select item 60533477.

CRTC2 modulates hepatic SREBP1c cleavage by controlling Insig2a expression during fasting

Yuanyuan Zhang, Yi Liu, Liqun Chen, Yiguo Wang, Jinbo Han

Protein Cell. 2018 Aug; 9(8): 729–732. Published online 2018 Apr 20. doi: 10.1007/s13238-018-0538-3

PMCID:: PMC6053347

Article PDF–556K

Select item 55772468.

PPARα-dependent Insig2a overexpression inhibits SREBP-1c processing during fasting

Jae-Ho Lee, Hye Suk Kang, Hyeon Young Park, Young-Ah Moon, Yu Na Kang, Byung-Chul Oh, Dae-Kyu Song, Jae-Hoon Bae, Seung-Soon Im

Sci Rep. 2017; 7: 9958. Published online 2017 Aug 30. doi: 10.1038/s41598-017-10523-7

PMCID:: PMC5577246

Abstract Article PDF–5.9M

Select item 54541179.

Hypoxia-inducible factor 1α activates insulin-induced gene 2 (Insig-2) transcription for degradation of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase in the liver

Seonghwan Hwang, Andrew D. Nguyen, Youngah Jo, Luke J. Engelking, James Brugarolas, Russell A. DeBose-Boyd

J Biol Chem. 2017 Jun 2; 292(22): 9382–9393. Published online 2017 Apr 17. doi: 10.1074/jbc.M117.788562

PMCID:: PMC5454117

Abstract Article PDF–586K

Select item 502350210.

SETDB2 links glucocorticoid to lipid metabolism through Insig2a regulation

Manuel Roqueta-Rivera, Ryan M Esquejo, Peter E Phelan, Katalin Sandor, Bence Daniel, Fabienne Foufelle, Jun Ding, Xiaoman Li, Sepideh Khorasanizadeh, Timothy F Osborne

Cell Metab. Author manuscript; available in PMC 2017 Sep 13.

Published in final edited form as: Cell Metab. 2016 Sep 13; 24(3): 474–484. Published online 2016 Aug 25. doi: 10.1016/j.cmet.2016.07.025

PMCID:: PMC5023502

Abstract Article PDF–3.1M

Select item 401299311.

Epithelial SCAP/INSIG/SREBP Signaling Regulates Multiple Biological Processes during Perinatal Lung Maturation

James P. Bridges, Angelica Schehr, Yanhua Wang, Liya Huo, Valérie Besnard, Machiko Ikegami, Jeffrey A. Whitsett, Yan Xu

PLoS One. 2014; 9(5): e91376. Published online 2014 May 7. doi: 10.1371/journal.pone.0091376

PMCID:: PMC4012993

Abstract Article PDF–2.5M

Select item 390096112.

Insig Proteins Mediate Feedback Inhibition of Cholesterol Synthesis in the Intestine

Matthew R. McFarlane, Guosheng Liang, Luke J. Engelking

J Biol Chem. 2014 Jan 24; 289(4): 2148–2156. Published online 2013 Dec 11. doi: 10.1074/jbc.M113.524041

PMCID:: PMC3900961

Abstract Article PDF–2.7M

Select item 357241013.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 317805914.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 302253415.

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio

PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582

PMCID:: PMC3022534

Abstract Article PDF–3.8M

Select item 292900416.

Hair Growth Defects in Insig-Deficient Mice Caused by Cholesterol Precursor Accumulation and Reversed by Simvastatin

Bret M. Evers, Midhat S. Farooqi, John M. Shelton, James A. Richardson, Joseph L. Goldstein, Michael S. Brown, Guosheng Liang

J Invest Dermatol. Author manuscript; available in PMC 2010 Nov 1.

Published in final edited form as: J Invest Dermatol. 2010 May; 130(5): 1237–1248. Published online 2010 Jan 21. doi: 10.1038/jid.2009.442

PMCID:: PMC2929004

Abstract Article PDF–3.6M

Select item 272695017.

REV-ERBα Participates in Circadian SREBP Signaling and Bile Acid Homeostasis

Gwendal Le Martelot, Thierry Claudel, David Gatfield, Olivier Schaad, Benoît Kornmann, Giuseppe Lo Sasso, Antonio Moschetta, Ueli Schibler

PLoS Biol. 2009 Sep; 7(9): e1000181. Published online 2009 Sep 1. doi: 10.1371/journal.pbio.1000181

PMCID:: PMC2726950

Abstract Article PDF–565K

Select item 265231118.

Peroxisome Deficiency Causes a Complex Phenotype because of Hepatic SREBP/Insig Dysregulation Associated with Endoplasmic Reticulum Stress

Werner J. Kovacs, Khanichi N. Tape, Janis E. Shackelford, Thomas M. Wikander, Michael J. Richards, Steven J. Fliesler, Skaidrite K. Krisans, Phyllis L. Faust

J Biol Chem. 2009 Mar 13; 284(11): 7232–7245. doi: 10.1074/jbc.M809064200

PMCID:: PMC2652311

Abstract Article PDF–1.4M

Select item 155564219.

Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin

Luke J. Engelking, Bret M. Evers, James A. Richardson, Joseph L. Goldstein, Michael S. Brown, Guosheng Liang

J Clin Invest. 2006 Sep 1; 116(9): 2356–2365. Published online 2006 Sep 1. doi: 10.1172/JCI28988

PMCID:: PMC1555642

Abstract Article PDF–1.0M

Select item 141356820.

BGEM: An In Situ Hybridization Database of Gene Expression in the Embryonic and Adult Mouse Nervous System

Susan Magdaleno, Patricia Jensen, Craig L Brumwell, Anna Seal, Karen Lehman, Andrew Asbury, Tony Cheung, Tommie Cornelius, Diana M Batten, Christopher Eden, Shannon M Norland, Dennis S Rice, Nilesh Dosooye, Sundeep Shakya, Perdeep Mehta, Tom Curran

PLoS Biol. 2006 Apr; 4(4): e86. Published online 2006 Mar 28. doi: 10.1371/journal.pbio.0040086

PMCID:: PMC1413568

Article PDF–99K

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