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Select item 110214671.

Combined and differential roles of ADD domains of DNMT3A and DNMT3L on DNA methylation landscapes in mouse germ cells

Naoki Kubo, Ryuji Uehara, Shuhei Uemura, Hiroaki Ohishi, Kenjiro Shirane, Hiroyuki Sasaki

Nat Commun. 2024; 15: 3266. Published online 2024 Apr 16. doi: 10.1038/s41467-024-47699-2

PMCID:: PMC11021467

Abstract Article PDF–3.6M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 92054023.

The Impact of Activin A on Fetal Gonocytes: Chronic Versus Acute Exposure Outcomes

Sarah C. Moody, Penny A. F. Whiley, Patrick S. Western, Kate L. Loveland

Front Endocrinol (Lausanne) 2022; 13: 896747. Published online 2022 May 31. doi: 10.3389/fendo.2022.896747

PMCID:: PMC9205402

Abstract Article PDF–19M

Select item 86743284.

SWI/SNF chromatin remodeling complex is required for initiation of sex-dependent differentiation in mouse germline

Toshiaki Ito, Atsuki Osada, Masami Ohta, Kana Yokota, Akira Nishiyama, Yuichi Niikura, Tomohiko Tamura, Yoichi Sekita, Tohru Kimura

Sci Rep. 2021; 11: 24074. Published online 2021 Dec 15. doi: 10.1038/s41598-021-03538-8

PMCID:: PMC8674328

Abstract Article PDF–5.3M

Select item 83505465.

NANOS2 suppresses the cell cycle by repressing mTORC1 activators in embryonic male germ cells

Ryuki Shimada, Hiroko Koike, Takamasa Hirano, Yuzuru Kato, Yumiko Saga

iScience. 2021 Aug 20; 24(8): 102890. Published online 2021 Jul 22. doi: 10.1016/j.isci.2021.102890

PMCID:: PMC8350546

Abstract Article PDF–5.7M

Select item 79478616.

Transcriptome Analysis of Dnmt3l Knock-Out Mice Derived Multipotent Mesenchymal Stem/Stromal Cells During Osteogenic Differentiation

Chih-Yi Yang, Rita Jui-Hsien Lu, Ming-Kang Lee, Felix Shih-Hsian Hsiao, Ya-Ping Yen, Chun-Chun Cheng, Pu-Sheng Hsu, Yi-Tzang Tsai, Shih-Kuo Chen, I-Hsuan Liu, Pao-Yang Chen, Shau-Ping Lin

Front Cell Dev Biol. 2021; 9: 615098. Published online 2021 Feb 25. doi: 10.3389/fcell.2021.615098

PMCID:: PMC7947861

Abstract Article PDF–7.4M

Select item 76122477.

SPOCD1 is an essential executor of piRNA-directed de novo DNA methylation

Ansgar Zoch, Tania Auchynnikava, Rebecca V. Berrens, Yuka Kabayama, Theresa Schöpp, Madeleine Heep, Lina Vasiliauskaitė, Yuvia A. Pérez-Rico, Atlanta G. Cook, Alena Shkumatava, Juri Rappsilber, Robin C. Allshire, Dónal O’Carroll

Nature. Author manuscript; available in PMC 2022 Jan 21.

Published in final edited form as: Nature. 2020 Aug 1; 584(7822): 635–639. Published online 2020 Jul 16. doi: 10.1038/s41586-020-2557-5

PMCID:: PMC7612247

Abstract Article PDF–5.7M

Select item 67634488.

Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions

Pawel Nowialis, Katarina Lopusna, Jana Opavska, Staci L. Haney, Ajay Abraham, Peike Sheng, Alberto Riva, Amarnath Natarajan, Olga Guryanova, Melanie Simpson, Ryan Hlady, Mingyi Xie, Rene Opavsky

Nat Commun. 2019; 10: 4374. Published online 2019 Sep 26. doi: 10.1038/s41467-019-12355-7

PMCID:: PMC6763448

Abstract Article PDF–2.4M

Select item 67180069.

Ectopic expression of DNA methyltransferases DNMT3A2 and DNMT3L leads to aberrant hypermethylation and postnatal lethality in mice

Keisuke Sasaki, Satoshi Hara, Reina Yamakami, Yusuke Sato, Saki Hasegawa, Tomohiro Kono, Kanako Morohaku, Yayoi Obata

Mol Reprod Dev. 2019 Jun; 86(6): 614–623. Published online 2019 Mar 4. doi: 10.1002/mrd.23137

PMCID:: PMC6718006

Abstract Article PDF–1.1M

Select item 636456610.

Extensive sex differences at the initiation of genetic recombination

Kevin Brick, Sarah Thibault-Sennett, Fatima Smagulova, Kwan-Wood G. Lam, Yongmei Pu, Florencia Pratto, R. Daniel Camerini-Otero, Galina V. Petukhova

Nature. Author manuscript; available in PMC 2019 Mar 5.

Published in final edited form as: Nature. 2018 Sep; 561(7723): 338–342. Published online 2018 Sep 5. doi: 10.1038/s41586-018-0492-5

PMCID:: PMC6364566

Abstract Article PDF–4.7M

Select item 632678411.

DNMT3L facilitates DNA methylation partly by maintaining DNMT3A stability in mouse embryonic stem cells

Nicolas Veland, Yue Lu, Swanand Hardikar, Sally Gaddis, Yang Zeng, Bigang Liu, Marcos R Estecio, Yoko Takata, Kevin Lin, Mary W Tomida, Jianjun Shen, Debapriya Saha, Humaira Gowher, Hongbo Zhao, Taiping Chen

Nucleic Acids Res. 2019 Jan 10; 47(1): 152–167. Published online 2018 Oct 13. doi: 10.1093/nar/gky947

PMCID:: PMC6326784

Abstract Article PDF–2.2M

Select item 601842912.

Loss of Glis3 causes dysregulation of retrotransposon silencing and germ cell demise in fetal mouse testis

Erica K. Ungewitter, Emmi Rotgers, Hong Soon Kang, Kristin Lichti-Kaiser, Leping Li, Sara A. Grimm, Anton M. Jetten, Humphrey H.-C. Yao

Sci Rep. 2018; 8: 9662. Published online 2018 Jun 25. doi: 10.1038/s41598-018-27843-x

PMCID:: PMC6018429

Abstract Article PDF–6.9M

Select item 569582613.

Testis Determination Requires a Specific FGFR2 Isoform to Repress FOXL2

Stefan Bagheri-Fam, Anthony D. Bird, Liang Zhao, Janelle M. Ryan, Meiyun Yong, Dagmar Wilhelm, Peter Koopman, Veraragavan P. Eswarakumar, Vincent R. Harley

Endocrinology. 2017 Nov 1; 158(11): 3832–3843. Published online 2017 Sep 11. doi: 10.1210/en.2017-00674

PMCID:: PMC5695826

Abstract Article

Select item 554975914.

Switching of dominant retrotransposon silencing strategies from posttranscriptional to transcriptional mechanisms during male germ-cell development in mice

Kota Inoue, Kenji Ichiyanagi, Kei Fukuda, Michael Glinka, Hiroyuki Sasaki

PLoS Genet. 2017 Jul; 13(7): e1006926. Published online 2017 Jul 27. doi: 10.1371/journal.pgen.1006926

PMCID:: PMC5549759

Abstract Article PDF–4.7M

Select item 501597315.

Sexual Fate Change of XX Germ Cells Caused by the Deletion of SMAD4 and STRA8 Independent of Somatic Sex Reprogramming

Quan Wu, Kurumi Fukuda, Yuzuru Kato, Zhi Zhou, Chu-Xia Deng, Yumiko Saga

PLoS Biol. 2016 Sep; 14(9): e1002553. Published online 2016 Sep 8. doi: 10.1371/journal.pbio.1002553

PMCID:: PMC5015973

Abstract Article PDF–24M

Select item 483386716.

Dazl is a target RNA suppressed by mammalian NANOS2 in sexually differentiating male germ cells

Yuzuru Kato, Takeo Katsuki, Hiroki Kokubo, Aki Masuda, Yumiko Saga

Nat Commun. 2016; 7: 11272. Published online 2016 Apr 13. doi: 10.1038/ncomms11272

PMCID:: PMC4833867

Abstract Article PDF–2.2M

Select item 476510617.

De novo DNA methylation drives 5hmC accumulation in mouse zygotes

Rachel Amouroux, Buhe Nashun, Kenjiro Shirane, Shoma Nakagawa, Peter WS Hill, Zelpha D’Souza, Manabu Nakayama, Masashi Matsuda, Aleksandra Turp, Elodie Ndjetehe, Vesela Encheva, Nobuaki R Kudo, Haruhiko Koseki, Hiroyuki Sasaki, Petra Hajkova

Nat Cell Biol. Author manuscript; available in PMC 2016 Jul 11.

Published in final edited form as: Nat Cell Biol. 2016 Feb; 18(2): 225–233. Published online 2016 Jan 11. doi: 10.1038/ncb3296

PMCID:: PMC4765106

Abstract Article PDF–1.8M

Select item 471841418.

Dead end1 is an essential partner of NANOS2 for selective binding of target RNAs in male germ cell development

Atsushi Suzuki, Yuki Niimi, Kaori Shinmyozu, Zhi Zhou, Makoto Kiso, Yumiko Saga

EMBO Rep. 2016 Jan; 17(1): 37–46. Published online 2015 Nov 20. doi: 10.15252/embr.201540828

PMCID:: PMC4718414

Abstract Article PDF–2.0M

Select item 453436919.

The Dnmt3L ADD Domain Controls Cytosine Methylation Establishment during Spermatogenesis

Georgios Vlachogiannis, Chad E. Niederhuth, Salih Tuna, Athanasia Stathopoulou, Keijo Viiri, Dirk G. de Rooij, Richard G. Jenner, Robert J. Schmitz, Steen K.T. Ooi

Cell Rep. 2015 Feb 17; 10(6): 944–956. Published online 2015 Feb 13. doi: 10.1016/j.celrep.2015.01.021

Correction in:: Cell Rep. 2015 May 12; 11(6): 990.

PMCID:: PMC4534369

Abstract Article

Select item 449539720.

DNA methylation restrains transposons from adopting a chromatin signature permissive for meiotic recombination

Natasha Zamudio, Joan Barau, Aurélie Teissandier, Marius Walter, Maté Borsos, Nicolas Servant, Déborah Bourc'his

Genes Dev. 2015 Jun 15; 29(12): 1256–1270. doi: 10.1101/gad.257840.114

PMCID:: PMC4495397

Abstract Article PDF–662K

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