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Select item 115120421.

Regulation of hepatic inclusions and fibrinogen biogenesis by SEL1L-HRD1 ERAD

Zhenfeng Song, Pattaraporn Thepsuwan, Woosuk Steve Hur, Mauricio Torres, Shuangcheng Alivia Wu, Xiaoqiong Wei, Nusrat Jahan Tushi, Juncheng Wei, Francesca Ferraresso, Adrienne W. Paton, James C. Paton, Ze Zheng, Kezhong Zhang, Deyu Fang, Christian J. Kastrup, Sunil Jaiman, Matthew James Flick, Shengyi Sun

Nat Commun. 2024; 15: 9244. Published online 2024 Oct 26. doi: 10.1038/s41467-024-53639-x

PMCID:: PMC11512042

Abstract Article PDF–23M

Select item 111947522.

ER-associated degradation adapter Sel1L is required for CD8⁺ T cell function and memory formation following acute viral infection

Luis O. Correa-Medero, Shayna E. Jankowski, Hanna S. Hong, Nicholas D. Armas, Aditi I. Vijendra, Mack B. Reynolds, Garrett M. Fogo, Dominik Awad, Alexander T. Dils, Kantaro A. Inoki, Reid G. Williams, Annabelle M. Ye, Nadezhda Svezhova, Francisco Gomez-Rivera, Kathleen L. Collins, Mary X. O’Riordan, Thomas H. Sanderson, Costas A. Lyssiotis, Shannon A. Carty

Cell Rep. Author manuscript; available in PMC 2024 Jun 24.

Published in final edited form as: Cell Rep. 2024 May 28; 43(5): 114156. Published online 2024 Apr 29. doi: 10.1016/j.celrep.2024.114156

PMCID:: PMC11194752

Abstract Article PDF–2.8M

Select item 109176603.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108733444.

SEL1L-HRD1 interaction is required to form a functional HRD1 ERAD complex

Liangguang Leo Lin, Huilun Helen Wang, Brent Pederson, Xiaoqiong Wei, Mauricio Torres, You Lu, Zexin Jason Li, Xiaodan Liu, Hancheng Mao, Hui Wang, Linyao Elina Zhou, Zhen Zhao, Shengyi Sun, Ling Qi

Nat Commun. 2024; 15: 1440. Published online 2024 Feb 16. doi: 10.1038/s41467-024-45633-0

Correction in:: Nat Commun. 2024; 15: 3241.

PMCID:: PMC10873344

Abstract Article PDF–7.3M

Select item 105414355.

SEL1L preserves CD8⁺ T-cell survival and homeostasis by fine-tuning PERK signaling and the IL-15 receptor-mediated mTORC1 axis

Yafeng Gao, Wenhui Li, Zhenghao Wang, Cangang Zhang, Yaping He, Xiaowei Liu, Kexin Tang, Weiguo Zhang, Qiaoming Long, Yong Liu, Jinping Zhang, Baojun Zhang, Lianjun Zhang

Cell Mol Immunol. 2023 Oct; 20(10): 1232–1250. Published online 2023 Aug 30. doi: 10.1038/s41423-023-01078-x

PMCID:: PMC10541435

Abstract Article PDF–7.0M

Select item 101854716.

SEL1L–HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool

Yewei Ji, Yuan Luo, Yating Wu, Yao Sun, Lianfeng Zhao, Zhen Xue, Mengqi Sun, Xiaoqiong Wei, Zinan He, Shuangcheng Alivia Wu, Liangguang Leo Lin, You Lu, Lei Chang, Fei Chen, Siyu Chen, Wei Qian, Xiaoxi Xu, Shengnuo Chen, Dongli Pan, Zhangsen Zhou, Sheng Xia, Chih-Chi Andrew Hu, Tingbo Liang, Ling Qi

Nat Cell Biol. 2023; 25(5): 726–739. Published online 2023 May 4. doi: 10.1038/s41556-023-01138-4

PMCID:: PMC10185471

Abstract Article PDF–22M

Select item 97973417.

Integration of ER protein quality control mechanisms defines β cell function and ER architecture

Neha Shrestha, Mauricio Torres, Jason Zhang, You Lu, Leena Haataja, Rachel B. Reinert, Jeffrey Knupp, Yu-Jie Chen, Gunes Parlakgul, Ana Paula Arruda, Billy Tsai, Peter Arvan, Ling Qi

J Clin Invest. 2023 Jan 3; 133(1): e163584. Published online 2023 Jan 3. doi: 10.1172/JCI163584

PMCID:: PMC9797341

Abstract Article PDF–5.5M

Select item 95506108.

SEL1L-HRD1 ER-associated degradation suppresses hepatocyte hyperproliferation and liver cancer

Asmita Bhattacharya, Juncheng Wei, Wenxin Song, Beixue Gao, Chunyan Tian, Shuangcheng Alivia Wu, Jian Wang, Ligong Chen, Deyu Fang, Ling Qi

iScience. 2022 Oct 21; 25(10): 105183. Published online 2022 Sep 24. doi: 10.1016/j.isci.2022.105183

PMCID:: PMC9550610

Abstract Article PDF–6.4M

Select item 90145599.

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat

Nature. Author manuscript; available in PMC 2022 Apr 18.

Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2

PMCID:: PMC9014559

Abstract Article PDF–6.6M

Select item 831579510.

Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β−selection

Xia Liu, Jingjing Yu, Longyong Xu, Katharine Umphred-Wilson, Fanglue Peng, Yao Ding, Brendan M Barton, Xiangdong Lv, Michael Y Zhao, Shengyi Sun, Yuning Hong, Ling Qi, Stanley Adoro, Xi Chen

eLife. 2021; 10: e69975. Published online 2021 Jul 9. doi: 10.7554/eLife.69975

PMCID:: PMC8315795

Abstract Article PDF–3.1M

Select item 793877011.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 788853812.

Protein Quality Control Through Endoplasmic Reticulum-Associated Degradation Maintains Hematopoietic Stem Cell Identity and Niche Interactions

Longyong Xu, Xia Liu, Fanglue Peng, Weijie Zhang, Liting Zheng, Yao Ding, Tianpeng Gu, Kaosheng Lv, Jin Wang, Laura Ortinau, Tianyuan Hu, Xiangguo Shi, Guojun Shi, Ge Shang, Shengyi Sun, Takao Iwawaki, Yewei Ji, Wei Li, Jeffrey M. Rosen, Xiang H.-F. Zhang, Dongsu Park, Stanley Adoro, Andre Catic, Wei Tong, Ling Qi, Daisuke Nakada, Xi Chen

Nat Cell Biol. Author manuscript; available in PMC 2021 Mar 21.

Published in final edited form as: Nat Cell Biol. 2020 Oct; 22(10): 1162–1169. Published online 2020 Sep 21. doi: 10.1038/s41556-020-00581-x

PMCID:: PMC7888538

Abstract Article PDF–2.7M

Select item 777056313.

ER-associated degradation preserves hematopoietic stem cell quiescence and self-renewal by restricting mTOR activity

Lu Liu, Ayaka Inoki, Kelly Fan, Fengbiao Mao, Guojun Shi, Xi Jin, Meiling Zhao, Gina Ney, Morgan Jones, Shengyi Sun, Yali Dou, Ken Inoki, Ling Qi, Qing Li

Blood. 2020 Dec 24; 136(26): 2975–2986. Prepublished online 2020 Nov 4. doi: 10.1182/blood.2020007975

PMCID:: PMC7770563

Abstract Article

Select item 732419114.

Sel1L-Hrd1 ER-associated degradation maintains β cell identity via TGF-β signaling

Neha Shrestha, Tongyu Liu, Yewei Ji, Rachel B. Reinert, Mauricio Torres, Xin Li, Maria Zhang, Chih-Hang Anthony Tang, Chih-Chi Andrew Hu, Chengyang Liu, Ali Naji, Ming Liu, Jiandie D. Lin, Sander Kersten, Peter Arvan, Ling Qi

J Clin Invest. 2020 Jul 1; 130(7): 3499–3510. Published online 2020 May 26. doi: 10.1172/JCI134874

PMCID:: PMC7324191

Abstract Article PDF–18M

Select item 645951015.

Mouse screen reveals multiple new genes underlying mouse and human hearing loss

Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel

PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194

PMCID:: PMC6459510

Abstract Article PDF–5.1M

Select item 629804016.

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, Bruce M. Spiegelman

Cell. Author manuscript; available in PMC 2019 Dec 13.

Published in final edited form as: Cell. 2018 Dec 13; 175(7): 1756–1768.e17. doi: 10.1016/j.cell.2018.10.025

Correction in:: Cell. 2019 Jul 11; 178(2): 507–508.

PMCID:: PMC6298040

Abstract Article PDF–1.2M

Select item 623633117.

Hepatic Sel1L‐Hrd1 ER‐associated degradation (ERAD) manages FGF21 levels and systemic metabolism via CREBH

Asmita Bhattacharya, Shengyi Sun, Heting Wang, Ming Liu, Qiaoming Long, Lei Yin, Sander Kersten, Kezhong Zhang, Ling Qi

EMBO J. 2018 Nov 15; 37(22): e99277. Published online 2018 Nov 2. doi: 10.15252/embj.201899277

PMCID:: PMC6236331

Abstract Article PDF–4.1M

Select item 586069618.

Inflammation arising from obesity reduces taste bud abundance and inhibits renewal

Andrew Kaufman, Ezen Choo, Anna Koh, Robin Dando

PLoS Biol. 2018 Mar; 16(3): e2001959. Published online 2018 Mar 20. doi: 10.1371/journal.pbio.2001959

PMCID:: PMC5860696

Abstract Article PDF–5.1M

Select item 582485519.

Hypothalamic ER–associated degradation regulates POMC maturation, feeding, and age-associated obesity

Geun Hyang Kim, Guojun Shi, Diane R.M. Somlo, Leena Haataja, Soobin Song, Qiaoming Long, Eduardo A. Nillni, Malcolm J. Low, Peter Arvan, Martin G. Myers, Jr., Ling Qi

J Clin Invest. 2018 Mar 1; 128(3): 1125–1140. Published online 2018 Feb 19. doi: 10.1172/JCI96420

PMCID:: PMC5824855

Abstract Article PDF–21M

Select item 561765920.

ER-associated degradation is required for vasopressin prohormone processing and systemic water homeostasis

Guojun Shi, Diane R.M. Somlo, Geun Hyang Kim, Cristina Prescianotto-Baschong, Shengyi Sun, Nicole Beuret, Qiaoming Long, Jonas Rutishauser, Peter Arvan, Martin Spiess, Ling Qi

J Clin Invest. 2017 Oct 2; 127(10): 3897–3912. Published online 2017 Sep 18. doi: 10.1172/JCI94771

PMCID:: PMC5617659

Abstract Article PDF–19M

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