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Select item 109453391.

Dual regulation of NEMO by Nrf2 and miR-125a inhibits ferroptosis and protects liver from endoplasmic reticulum stress-induced injury

Jihoon Tak, Min Sung Joo, Yun Seok Kim, Hyun Woo Park, Chang Hoon Lee, Gil-Chun Park, Shin Hwang, Sang Geon Kim

Theranostics. 2024; 14(5): 1841–1859. Published online 2024 Feb 24. doi: 10.7150/thno.89703

PMCID:: PMC10945339

Abstract Article PDF–12M

Select item 109431972.

Gα12 and endoplasmic reticulum stress-mediated pyroptosis in a single cycle of dextran sulfate-induced mouse colitis

Jihoon Tak, Quanxi An, Sang Gil Lee, Chang Hoon Lee, Sang Geon Kim

Sci Rep. 2024; 14: 6335. Published online 2024 Mar 15. doi: 10.1038/s41598-024-56685-z

PMCID:: PMC10943197

Abstract Article PDF–3.8M

Select item 88255993.

Gα₁₂ overexpression in hepatocytes by ER stress exacerbates acute liver injury via ROCK1-mediated miR-15a and ALOX12 dysregulation

Jihoon Tak, Yun Seok Kim, Tae Hyun Kim, Gil-Chun Park, Shin Hwang, Sang Geon Kim

Theranostics. 2022; 12(4): 1570–1588. Published online 2022 Jan 9. doi: 10.7150/thno.67722

PMCID:: PMC8825599

Abstract Article PDF–5.1M

Select item 72617954.

Knockout mouse models reveal the contributions of G protein subunits to complement C5a receptor–mediated chemotaxis

Esther van den Bos, Benjamin Ambrosy, Markus Horsthemke, Stefan Walbaum, Anne C. Bachg, Nina Wettschureck, Giulio Innamorati, Thomas M. Wilkie, Peter J. Hanley

J Biol Chem. 2020 May 29; 295(22): 7726–7742. Published online 2020 Apr 24. doi: 10.1074/jbc.RA119.011984

PMCID:: PMC7261795

Abstract Article PDF–5.0M

Select item 67779795.

Myogenic vasoconstriction requires G₁₂/G₁₃ and LARG to maintain local and systemic vascular resistance

Ramesh Chennupati, Angela Wirth, Julie Favre, Rui Li, Rémy Bonnavion, Young-June Jin, Astrid Wietelmann, Frank Schweda, Nina Wettschureck, Daniel Henrion, Stefan Offermanns

eLife. 2019; 8: e49374. Published online 2019 Sep 24. doi: 10.7554/eLife.49374

PMCID:: PMC6777979

Abstract Article PDF–4.6M

Select item 67252466.

5-HT₇ Receptor Is Coupled to Gα Subunits of Heterotrimeric G12-Protein to Regulate Gene Transcription and Neuronal Morphology

Elena Kvachnina, Guoquan Liu, Alexander Dityatev, Ute Renner, Aline Dumuis, Diethelm W. Richter, Galina Dityateva, Melitta Schachner, Tatyana A. Voyno-Yasenetskaya, Evgeni G. Ponimaskin

J Neurosci. 2005 Aug 24; 25(34): 7821–7830. doi: 10.1523/JNEUROSCI.1790-05.2005

PMCID:: PMC6725246

Abstract Article PDF–465K

Select item 62646487.

Gα₁₂ ablation exacerbates liver steatosis and obesity by suppressing USP22/SIRT1-regulated mitochondrial respiration

Tae Hyun Kim, Yoon Mee Yang, Chang Yeob Han, Ja Hyun Koo, Hyunhee Oh, Su Sung Kim, Byoung Hoon You, Young Hee Choi, Tae-Sik Park, Chang Ho Lee, Hitoshi Kurose, Mazen Noureddin, Ekihiro Seki, Yu-Jui Yvonne Wan, Cheol Soo Choi, Sang Geon Kim

J Clin Invest. 2018 Dec 3; 128(12): 5587–5602. Published online 2018 Nov 12. doi: 10.1172/JCI97831

PMCID:: PMC6264648

Abstract Article PDF–18M

Select item 62054738.

Translating biased signaling in the ghrelin receptor system into differential in vivo functions

Franziska Mende, Cecilie Hundahl, Bianca Plouffe, Louise Julie Skov, Bjørn Sivertsen, Andreas Nygaard Madsen, Michael Lückmann, Thi Ai Diep, Stefan Offermanns, Thomas Michael Frimurer, Michel Bouvier, Birgitte Holst

Proc Natl Acad Sci U S A. 2018 Oct 23; 115(43): E10255–E10264. Published online 2018 Oct 9. doi: 10.1073/pnas.1804003115

PMCID:: PMC6205473

Abstract Article PDF–1.2M

Select item 57838699.

Gα12 regulates osteoclastogenesis by modulating NFATc1 expression

Min‐Kyoung Song, Cheolkyu Park, Yong Deok Lee, Haemin Kim, Min Kyung Kim, Jun‐Oh Kwon, Ja Hyun Koo, Min Sung Joo, Sang Geon Kim, Hong‐Hee Kim

J Cell Mol Med. 2018 Feb; 22(2): 849–860. Published online 2017 Oct 27. doi: 10.1111/jcmm.13370

PMCID:: PMC5783869

Abstract Article PDF–1.4M

Select item 508765110.

Gα12 is required for renal cystogenesis induced by Pkd1 inactivation

Yong Wu, Jen X. Xu, Wassim El-Jouni, Tzongshi Lu, Suyan Li, Qingyi Wang, Mei Tran, Wanfeng Yu, Maoqing Wu, Ivan E. Barrera, Joseph V. Bonventre, Jing Zhou, Bradley M. Denker, Tianqing Kong

J Cell Sci. 2016 Oct 1; 129(19): 3675–3684. doi: 10.1242/jcs.190496

PMCID:: PMC5087651

Abstract Article

Select item 497189311.

G protein α₁₂ (Gα₁₂) is a negative regulator of kidney injury molecule-1-mediated efferocytosis

Ola Z. Ismail, Xizhong Zhang, Joseph V. Bonventre, Lakshman Gunaratnam

Am J Physiol Renal Physiol. 2016 Apr 1; 310(7): F607–F620. Published online 2015 Dec 23. doi: 10.1152/ajprenal.00169.2015

PMCID:: PMC4971893

Abstract Article

Select item 441920412.

Kidney Injury Molecule-1 Protects against Gα12 Activation and Tissue Damage in Renal Ischemia-Reperfusion Injury

Ola Z. Ismail, Xizhong Zhang, Junjun Wei, Aaron Haig, Bradley M. Denker, Rita S. Suri, Alp Sener, Lakshman Gunaratnam

Am J Pathol. 2015 May; 185(5): 1207–1215. doi: 10.1016/j.ajpath.2015.02.003

PMCID:: PMC4419204

Abstract Article PDF–1.8M

Select item 431307013.

Polycystin-1 and Gα12 regulate the cleavage of E-cadherin in kidney epithelial cells

Jen X. Xu, Tzong-Shi Lu, Suyan Li, Yong Wu, Lai Ding, Bradley M. Denker, Joseph V. Bonventre, Tianqing Kong

Physiol Genomics. 2015 Feb 1; 47(2): 24–32. Published online 2014 Dec 9. doi: 10.1152/physiolgenomics.00090.2014

PMCID:: PMC4313070

Abstract Article

Select item 430276514.

The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Ga_12/13 and RhoA

Sarah D. Ackerman, Cynthia Garcia, Xianhua Piao, David H. Gutmann, Kelly R. Monk

Nat Commun. Author manuscript; available in PMC 2015 Jul 21.

Published in final edited form as: Nat Commun. 2015; 6: 6122. Published online 2015 Jan 21. doi: 10.1038/ncomms7122

PMCID:: PMC4302765

Abstract Article PDF–3.5M

Select item 415435415.

G-protein stimulatory subunit alpha and Gq/11α G-proteins are both required to maintain quiescent stem-like chondrocytes

Andrei S. Chagin, Karuna K. Vuppalapati, Tatsuya Kobayashi, Jun Guo, Takao Hirai, Min Chen, Stefan Offermanns, Lee S. Weinstein, Henry M. Kronenberg

Nat Commun. Author manuscript; available in PMC 2015 Apr 30.

Published in final edited form as: Nat Commun. 2014; 5: 3673. Published online 2014 Apr 30. doi: 10.1038/ncomms4673

PMCID:: PMC4154354

Abstract Article PDF–6.3M

Select item 394956816.

Evidence of a common mechanism of disassembly of adherens junctions through Gα13 targeting of VE-cadherin

Haixia Gong, Xiaopei Gao, Shaoting Feng, M. Rizwan Siddiqui, Alexander Garcia, Marcelo G. Bonini, Yulia Komarova, Stephen M. Vogel, Dolly Mehta, Asrar B. Malik

J Exp Med. 2014 Mar 10; 211(3): 579–591. doi: 10.1084/jem.20131190

PMCID:: PMC3949568

Abstract Article PDF–3.0M

Select item 391664917.

Novel Protein Interactions with Endoglin and Activin Receptor-like Kinase 1: Potential Role in Vascular Networks

Guoxiong Xu, Miriam Barrios-Rodiles, Mirjana Jerkic, Andrei L. Turinsky, Robert Nadon, Sonia Vera, Despina Voulgaraki, Jeffrey L. Wrana, Mourad Toporsian, Michelle Letarte

Mol Cell Proteomics. 2014 Feb; 13(2): 489–502. Published online 2013 Dec 7. doi: 10.1074/mcp.M113.033464

PMCID:: PMC3916649

Abstract Article PDF–4.1M

Select item 389449618.

G protein–dependent basal and evoked endothelial cell vWF secretion

Luiza Rusu, Alexandra Andreeva, David J. Visintine, Kyungho Kim, Stephen M. Vogel, Aleksandra Stojanovic-Terpo, Olga Chernaya, Guoquan Liu, Farnaz R. Bakhshi, Sandra L. Haberichter, Hiroko Iwanari, Osamu Kusano-Arai, Nobuchika Suzuki, Takao Hamakubo, Tohru Kozasa, Jaehyung Cho, Xiaoping Du, Richard D. Minshall

Blood. 2014 Jan 16; 123(3): 442–450. Prepublished online 2013 Sep 30. doi: 10.1182/blood-2013-03-489351