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Items: 1 to 20 of 63

1.
Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity
Andres Canela, Yaakov Maman, Shar-yin N. Huang, Gordana Wutz, Wen Tang, Guido Zagnoli-Vieira, Elsa Callen, Nancy Wong, Amanda Day, Jan-Michael Peters, Keith W. Caldecott, Yves Pommier, André Nussenzweig
Mol Cell. Author manuscript; available in PMC 2021 Jun 2.
Published in final edited form as: Mol Cell. 2019 Jul 25; 75(2): 252–266.e8. Published online 2019 Jun 12. doi: 10.1016/j.molcel.2019.04.030
PMCID:
PMC8170508
AbstractArticlePDF–2.4M
2.
Spatiotemporal Gradient of Cortical Neuron Death Contributes to Microcephaly in Knock-In Mouse Model of Ligase 4 Syndrome
Melody P. Lun, Morgan L. Shannon, Sevgi Keles, Ismail Reisli, Nicole Luche, Douglas Ryan, Kelly Capuder, Luigi D. Notarangelo, Maria K. Lehtinen
Am J Pathol. 2019 Dec; 189(12): 2440–2449. doi: 10.1016/j.ajpath.2019.08.010
PMCID:
PMC6897336
AbstractArticlePDF–2.5M
3.
53BP1/Rif1/Shieldin counteract DSB resection through CST/Polα-dependent fill-in
Zachary Mirman, Francisca Lottersberger, Hiroyuki Takai, Tatsuya Kibe, Yi Gong, Kaori Takai, Alessandro Bianchi, Michal Zimmermann, Daniel Durocher, Titia de Lange
Nature. Author manuscript; available in PMC 2019 Jan 18.
Published in final edited form as: Nature. 2018 Aug; 560(7716): 112–116. Published online 2018 Jul 18. doi: 10.1038/s41586-018-0324-7
PMCID:
PMC6072559
AbstractArticlePDF–1.8M
4.
Involvement of Atm and Trp53 in neural cell loss due to Terf2 inactivation during mouse brain development
Jusik Kim, Inseo Choi, Youngsoo Lee
Histochem Cell Biol. 2017; 148(5): 489–501. Published online 2017 Jun 15. doi: 10.1007/s00418-017-1591-3
PMCID:
PMC5641282
AbstractArticlePDF–12M
5.
Genetic Predisposition for Beta Cell Fragility Underlies Type 1 and Type 2 Diabetes
James Dooley, Lei Tian, Susann Schonefeldt, Viviane Delghingaro-Augusto, Josselyn E Garcia-Perez, Emanuela Pasciuto, Daniele Di Marino, Edward J Carr, Nikolay Oskolkov, Valeriya Lyssenko, Dean Franckaert, Vasiliki Lagou, Lut Overbergh, Jonathan Vandenbussche, Joke Allemeersch, Genevieve Chabot-Roy, Jane E Dahlstrom, D Ross Laybutt, Nikolai Petrovsky, Luis Socha, Kris Gevaert, Anton M Jetten, Diether Lambrechts, Michelle A Linterman, Chris C Goodnow, Christopher J Nolan, Sylvie Lesage, Susan M Schlenner, Adrian Liston
Nat Genet. Author manuscript; available in PMC 2017 Sep 5.
Published in final edited form as: Nat Genet. 2016 May; 48(5): 519–527. Published online 2016 Mar 21. doi: 10.1038/ng.3531
PMCID:
PMC5584070
AbstractArticlePDF–1.0M
6.
Synthetic lethality between PAXX and XLF in mammalian development
Gabriel Balmus, Ana C. Barros, Paul W.G. Wijnhoven, Chloé Lescale, Hélène Lenden Hasse, Katharina Boroviak, Carlos le Sage, Brendan Doe, Anneliese O. Speak, Antonella Galli, Matt Jacobsen, Ludovic Deriano, David J. Adams, Andrew N. Blackford, Stephen P. Jackson
Genes Dev. 2016 Oct 1; 30(19): 2152–2157. doi: 10.1101/gad.290510.116
PMCID:
PMC5088564
AbstractArticlePDF–626K
7.
The DNA ligase IV syndrome R278H mutation impairs B-lymphopoiesis via error-prone non-homologous end-joining
Jihye Park, Robert S. Welner, Mei-Yee Chan, Logan Troppito, Philipp B. Staber, Daniel G. Tenen, Catherine T. Yan
J Immunol. Author manuscript; available in PMC 2017 Jan 1.
Published in final edited form as: J Immunol. 2016 Jan 1; 196(1): 244–255. Published online 2015 Nov 25. doi: 10.4049/jimmunol.1403099
PMCID:
PMC4684978
AbstractArticlePDF–1.0M
8.
Inhibition of non-homologous end joining increases the efficiency of CRISPR/Cas9-mediated precise [TM: inserted] genome editing
Takeshi Maruyama, Stephanie K. Dougan, Matthias Truttmann, Angelina M. Bilate, Jessica R. Ingram, Hidde L. Ploegh
Nat Biotechnol. Author manuscript; available in PMC 2015 Nov 1.
Published in final edited form as: Nat Biotechnol. 2015 May; 33(5): 538–542. Published online 2015 Mar 23. doi: 10.1038/nbt.3190
Correction in:
Nat Biotechnol. 2016 Feb; 34(2): 210.
PMCID:
PMC4618510
AbstractArticlePDF–585K
9.
Low levels of endogenous or X-ray-induced DNA double-strand breaks activate apoptosis in adult neural stem cells
Lara Barazzuol, Nicole Rickett, Limei Ju, Penny A. Jeggo
J Cell Sci. 2015 Oct 1; 128(19): 3597–3606. doi: 10.1242/jcs.171223
PMCID:
PMC4610209
AbstractArticle
10.
Polynucleotide kinase–phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability
Mikio Shimada, Lavinia C Dumitrache, Helen R Russell, Peter J McKinnon
EMBO J. 2015 Oct 1; 34(19): 2465–2480. Published online 2015 Aug 19. doi: 10.15252/embj.201591363
PMCID:
PMC4601665
AbstractArticlePDF–7.3M
11.
Pot1a Prevents Telomere Dysfunction and ATM-Dependent Neuronal Loss
Youngsoo Lee, Eric J. Brown, Sandy Chang, Peter J. McKinnon
J Neurosci. 2014 Jun 4; 34(23): 7836–7844. doi: 10.1523/JNEUROSCI.4245-13.2014
PMCID:
PMC4044246
AbstractArticlePDF–4.0M
12.
G1 checkpoint establishment in vivo during embryonic liver development
Xiao Qi Wang, Kwok Kin Chan, Xiaoyan Ming, Vincent CH Lui, Randy YC Poon, Chung Mau Lo, Chris Norbury, Ronnie TP Poon
BMC Dev Biol. 2014; 14: 23. Published online 2014 May 19. doi: 10.1186/1471-213X-14-23
PMCID:
PMC4031160
AbstractArticlePDF–2.9M
13.
Myelodysplastic Syndrome: an inability to appropriately respond to damaged DNA?
Ting Zhou, Paul Hasty, Christi A. Walter, Alexander J.R. Bishop, Linda M. Scott, Vivienne I. Rebel
Exp Hematol. Author manuscript; available in PMC 2014 Aug 1.
Published in final edited form as: Exp Hematol. 2013 Aug; 41(8): 665–674. Published online 2013 Apr 30. doi: 10.1016/j.exphem.2013.04.008
PMCID:
PMC3729593
AbstractArticlePDF–1000K
14.
Fate Mapping for Activation-Induced Cytidine Deaminase (AID) Marks Non-Lymphoid Cells During Mouse Development
Philipp C. Rommel, David Bosque, Alexander D. Gitlin, Gist F. Croft, Nathaniel Heintz, Rafael Casellas, Michel C. Nussenzweig, Skirmantas Kriaucionis, Davide F. Robbiani
PLoS One. 2013; 8(7): e69208. Published online 2013 Jul 8. doi: 10.1371/journal.pone.0069208
PMCID:
PMC3704518
AbstractArticlePDF–1.7M
15.
Role of 53BP1 oligomerization in regulating double-strand break repair
Francisca Lottersberger, Anne Bothmer, Davide F. Robbiani, Michel C. Nussenzweig, Titia de Lange
Proc Natl Acad Sci U S A. 2013 Feb 5; 110(6): 2146–2151. Published online 2013 Jan 23. doi: 10.1073/pnas.1222617110
PMCID:
PMC3568336
AbstractArticlePDF–876K
16.
Removal of Shelterin Reveals the Telomere End-Protection Problem
Agnel Sfeir, Titia de Lange
Science. Author manuscript; available in PMC 2012 Oct 22.
Published in final edited form as: Science. 2012 May 4; 336(6081): 593–597. doi: 10.1126/science.1218498
PMCID:
PMC3477646
AbstractArticlePDF–2.9M
17.
Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors
Youngsoo Lee, Sachin Katyal, Susanna M. Downing, Jingfeng Zhao, Helen R. Russell, Peter J. McKinnon
Nat Neurosci. Author manuscript; available in PMC 2012 Dec 1.
Published in final edited form as: Nat Neurosci. 2012 Jun; 15(6): 819–826. doi: 10.1038/nn.3097
PMCID:
PMC3404252
AbstractArticlePDF–3.3M
18.
Cell cycle- and DNA repair pathway-specific effects of apoptosis on tumor suppression
Steven S. Foster, Saurav De, Linda K. Johnson, John H. J. Petrini, Travis H. Stracker
Proc Natl Acad Sci U S A. 2012 Jun 19; 109(25): 9953–9958. Published online 2012 Jun 5. doi: 10.1073/pnas.1120476109
PMCID:
PMC3382548
AbstractArticlePDF–1.5M
19.
X-ray repair cross-complementing protein 1 (XRCC1) deficiency enhances class switch recombination and is permissive for alternative end joining
Li Han, Weifeng Mao, Kefei Yu
Proc Natl Acad Sci U S A. 2012 Mar 20; 109(12): 4604–4608. Published online 2012 Mar 5. doi: 10.1073/pnas.1120743109
PMCID:
PMC3311337
AbstractArticlePDF–671K
20.
Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1)
Cristian Boboila, Valentyn Oksenych, Monica Gostissa, Jing H. Wang, Shan Zha, Yu Zhang, Hua Chai, Cheng-Sheng Lee, Mila Jankovic, Liz-Marie Albertorio Saez, Michel C. Nussenzweig, Peter J. McKinnon, Frederick W. Alt, Bjoern Schwer
Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7): 2473–2478. Published online 2012 Jan 30. doi: 10.1073/pnas.1121470109
Correction in:
Proc Natl Acad Sci U S A. 2013 Apr 2; 110(14): 5731.
PMCID:
PMC3289296
AbstractArticlePDF–426K

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