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Select item 96737341.

Protein Kinase D1 Regulates Cardiac Hypertrophy, Potassium Channel Remodeling, and Arrhythmias in Heart Failure

Julie Bossuyt, Johanna M. Borst, Marie Verberckmoes, Logan R. J. Bailey, Donald M. Bers, Bence Hegyi

J Am Heart Assoc. 2022 Oct 4; 11(19): e027573. Published online 2022 Sep 29. doi: 10.1161/JAHA.122.027573

PMCID:: PMC9673734

Abstract Article PDF–11M

Select item 81431292.

Novel Autosomal Recessive Splice-Altering Variant in PRKD1 Is Associated with Congenital Heart Disease

Salam Massadeh, Maha Albeladi, Nour Albesher, Fahad Alhabshan, Kapil Dev Kampe, Farah Chaikhouni, Mohamed S. Kabbani, Christian Beetz, Manal Alaamery

Genes (Basel) 2021 May; 12(5): 612. Published online 2021 Apr 21. doi: 10.3390/genes12050612

PMCID:: PMC8143129

Abstract Article PDF–7.6M

Select item 67340903.

Protein kinase D increases maximal Ca²⁺-activated tension of cardiomyocyte contraction by phosphorylation of cMyBP-C-Ser³¹⁵

Ellen Dirkx, Olivier Cazorla, Robert W. Schwenk, Ilka Lorenzen-Schmidt, Sakthivel Sadayappan, Johan Van Lint, Lucie Carrier, Guillaume J. J. M. van Eys, Jan F. C. Glatz, Joost J. F. P. Luiken

Am J Physiol Heart Circ Physiol. 2012 Aug 1; 303(3): H323–H331. Published online 2012 May 25. doi: 10.1152/ajpheart.00749.2011

PMCID:: PMC6734090

Abstract Article

Select item 59880374.

Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing

Alejandro Sifrim, Marc-Phillip Hitz, Anna Wilsdon, Jeroen Breckpot, Saeed H. Al Turki, Bernard Thienpont, Jeremy McRae, Tomas W Fitzgerald, Tarjinder Singh, Ganesh Jawahar Swaminathan, Elena Prigmore, Diana Rajan, Hashim Abdul-Khaliq, Siddharth Banka, Ulrike M. M. Bauer, Jamie Bentham, Felix Berger, Shoumo Bhattacharya, Frances Bu'Lock, Natalie Canham, Irina-Gabriela Colgiu, Catherine Cosgrove, Helen Cox, Ingo Daehnert, Allan Daly, John Danesh, Alan Fryer, Marc Gewillig, Emma Hobson, Kirstin Hoff, Tessa Homfray, The INTERVAL Study, Anne-Karin Kahlert, Ami Ketley, Hans-Heiner Kramer, Katherine Lachlan, Anne Katrin Lampe, Jacoba J. Louw, Ashok Kumar Manickara, Dorin Manase, Karen P. McCarthy, Kay Metcalfe, Carmel Moore, Ruth Newbury-Ecob, Seham Osman Omer, Willem H. Ouwehand, Soo-Mi Park, Michael J. Parker, Thomas Pickardt, Martin O. Pollard, Leema Robert, David J. Roberts, Jennifer Sambrook, Kerry Setchfield, Brigitte Stiller, Chris Thornborough, Okan Toka, Hugh Watkins, Denise Williams, Michael Wright, Seema Mital, Piers E. F. Daubeney, Bernard Keavney, Judith Goodship, The UK10K Consortium, Riyadh Mahdi Abu-Sulaiman, Sabine Klaassen, Caroline F. Wright, Helen V. Firth, Jeffrey C. Barrett, Koenraad Devriendt, David R. FitzPatrick, J. David Brook, The Deciphering Developmental Disorders Study, Matthew Hurles

Nat Genet. Author manuscript; available in PMC 2018 Jun 5.

Published in final edited form as: Nat Genet. 2016 Sep; 48(9): 1060–1065. Published online 2016 Aug 1. doi: 10.1038/ng.3627

PMCID:: PMC5988037

Abstract Article PDF–1.1M

Select item 54305425.

Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop

Mathias Cobbaut, Rita Derua, Heike Döppler, Hua Jane Lou, Sandy Vandoninck, Peter Storz, Benjamin E. Turk, Thomas Seufferlein, Etienne Waelkens, Veerle Janssens, Johan Van Lint

Sci Rep. 2017; 7: 887. Published online 2017 Apr 20. doi: 10.1038/s41598-017-00800-w

PMCID:: PMC5430542

Abstract Article PDF–5.0M

Select item 50806146.

Functional kinomics establishes a critical node of volume-sensitive cation-Cl⁻ cotransporter regulation in the mammalian brain

Jinwei Zhang, Geng Gao, Gulnaz Begum, Jinhua Wang, Arjun R. Khanna, Boris E. Shmukler, Gerrit M. Daubner, Paola de los Heros, Paul Davies, Joby Varghese, Mohammad Iqbal H. Bhuiyan, Jinjing Duan, Jin Zhang, Daniel Duran, Seth L. Alper, Dandan Sun, Stephen J. Elledge, Dario R. Alessi, Kristopher T. Kahle

Sci Rep. 2016; 6: 35986. Published online 2016 Oct 26. doi: 10.1038/srep35986

PMCID:: PMC5080614

Abstract Article PDF–2.9M

Select item 50161867.

Biphasic Regulation of Yes-associated Protein (YAP) Cellular Localization, Phosphorylation, and Activity by G Protein-coupled Receptor Agonists in Intestinal Epithelial Cells: A NOVEL ROLE FOR PROTEIN KINASE D (PKD)

Jia Wang, James Sinnett-Smith, Jan V. Stevens, Steven H. Young, Enrique Rozengurt

J Biol Chem. 2016 Aug 19; 291(34): 17988–18005. Published online 2016 Jul 1. doi: 10.1074/jbc.M115.711275

PMCID:: PMC5016186

Abstract Article PDF–3.5M

Select item 49738498.

Heat shock protein 20 (HSP20) is a novel substrate for protein kinase D1 (PKD1)

Yuan Yan Sin, George S. Baillie

Cell Biochem Funct. 2015 Oct; 33(7): 421–426. Published online 2015 Oct 6. doi: 10.1002/cbf.3147

PMCID:: PMC4973849

Abstract Article PDF–619K

Select item 48805419.

An Evolutionarily Conserved PLC-PKD-TFEB Pathway for Host Defense

Mehran Najibi, Sid Ahmed Labed, Orane Visvikis, Javier Elbio Irazoqui

Cell Rep. Author manuscript; available in PMC 2016 May 31.

Published in final edited form as: Cell Rep. 2016 May 24; 15(8): 1728–1742. Published online 2016 May 12. doi: 10.1016/j.celrep.2016.04.052

PMCID:: PMC4880541

Abstract Article PDF–1.3M

Select item 458732710.

Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth

Joseph Mertz, Haiyan Tan, Vishwajeeth Pagala, Bing Bai, Ping-Chung Chen, Yuxin Li, Ji-Hoon Cho, Timothy Shaw, Xusheng Wang, Junmin Peng

Mol Cell Proteomics. 2015 Jul; 14(7): 1898–1910. Published online 2015 Apr 30. doi: 10.1074/mcp.M114.045898

PMCID:: PMC4587327

Abstract Article PDF–2.6M

Select item 444310111.

Compatibility of Astragalus and Salvia extract inhibits myocardial fibrosis and ventricular remodeling by regulation of protein kinase D1 protein

Bingyu Mao, Liu Nuan, Lei Yang, Xiaotao Zeng

Int J Clin Exp Med. 2015; 8(3): 3716–3724. Published online 2015 Mar 15.

PMCID:: PMC4443101

Abstract Article PDF–1.0M

Select item 435613512.

Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy

Yuan Yan Sin, Tamara P Martin, Lauren Wills, Susan Currie, George S Baillie

Cell Commun Signal. 2015; 13: 16. Published online 2015 Mar 7. doi: 10.1186/s12964-015-0094-x

PMCID:: PMC4356135

Abstract Article PDF–3.7M

Select item 425927113.

Angiotensin II Stimulates Protein Kinase D–Dependent Histone Deacetylase 5 Phosphorylation and Nuclear Export Leading to Vascular Smooth Muscle Cell Hypertrophy

Xiangbin Xu, Chang-Hoon Ha, Chelsea Wong, Weiye Wang, Angelika Hausser, Klaus Pfizenmaier, Eric N. Olson, Timothy A. McKinsey, Zheng-Gen Jin

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2014 Dec 8.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2007 Nov; 27(11): 2355–2362. Published online 2007 Sep 6. doi: 10.1161/ATVBAHA.107.151704

PMCID:: PMC4259271

Abstract Article PDF–1.6M

Select item 423219214.

Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca²⁺ channels through PKD1

Bong Sook Jhun, Jin O-Uchi, Weiye Wang, Chang Hoon Ha, Jinjing Zhao, Ji Young Kim, Chelsea Wong, Robert T. Dirksen, Coeli M.B. Lopes, Zheng Gen Jin

Circ Res. Author manuscript; available in PMC 2014 Nov 14.

Published in final edited form as: Circ Res. 2012 Jan 6; 110(1): 59–70. Published online 2011 Nov 10. doi: 10.1161/CIRCRESAHA.111.254672

PMCID:: PMC4232192

Abstract Article PDF–2.4M

Select item 407449315.

The C-terminus of the long AKAP13 isoform (AKAP-Lbc) is critical for development of compensatory cardiac hypertrophy

Domenico M. Taglieri, Keven R. Johnson, Brian T. Burmeister, Michelle M. Monasky, Matthew J. Spindler, Jaime DeSantiago, Kathrin Banach, Bruce R. Conklin, Graeme K. Carnegie

J Mol Cell Cardiol. Author manuscript; available in PMC 2015 Jan 1.

Published in final edited form as: J Mol Cell Cardiol. 2014 Jan; 66: 27–40. Published online 2013 Oct 23. doi: 10.1016/j.yjmcc.2013.10.010