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Items: 1 to 20 of 64

1.
TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models
Ramanath Narayana Hegde, Anass Chiki, Lara Petricca, Paola Martufi, Nicolas Arbez, Laurent Mouchiroud, Johan Auwerx, Christian Landles, Gillian P Bates, Malvindar K Singh‐Bains, Mike Dragunow, Maurice A Curtis, Richard LM Faull, Christopher A Ross, Andrea Caricasole, Hilal A Lashuel
EMBO J. 2020 Sep 1; 39(17): e104671. Published online 2020 Aug 5. doi: 10.15252/embj.2020104671
PMCID:
PMC7459410
AbstractArticlePDF–3.0M
2.
Interaction of Huntingtin-Associated Protein with Dynactin P150Glued
Shi-Hua Li, Claire-Anne Gutekunst, Steven M. Hersch, Xiao-Jiang Li
J Neurosci. 1998 Feb 15; 18(4): 1261–1269. doi: 10.1523/JNEUROSCI.18-04-01261.1998
PMCID:
PMC6792727
AbstractArticlePDF–357K
3.
Neurons Lacking Huntingtin Differentially Colonize Brain and Survive in Chimeric Mice
Anton Reiner, Nobel Del Mar, Christopher A. Meade, Huaitao Yang, Ioannis Dragatsis, Scott Zeitlin, Daniel Goldowitz
J Neurosci. 2001 Oct 1; 21(19): 7608–7619. doi: 10.1523/JNEUROSCI.21-19-07608.2001
PMCID:
PMC6762912
AbstractArticlePDF–2.6M
4.
Early Motor Dysfunction and Striosomal Distribution of Huntingtin Microaggregates in Huntington's Disease Knock-In Mice
Liliana B. Menalled, Jessica D. Sison, Ying Wu, Melisa Olivieri, Xiao-Jiang Li, He Li, Scott Zeitlin, Marie-Françoise Chesselet
J Neurosci. 2002 Sep 15; 22(18): 8266–8276. doi: 10.1523/JNEUROSCI.22-18-08266.2002
PMCID:
PMC6758087
AbstractArticlePDF–663K
5.
The Induction Levels of Heat Shock Protein 70 Differentiate the Vulnerabilities to Mutant Huntingtin among Neuronal Subtypes
Kazuhiko Tagawa, Shigeki Marubuchi, Mei-Ling Qi, Yasushi Enokido, Takuya Tamura, Reina Inagaki, Miho Murata, Ichiro Kanazawa, Erich E. Wanker, Hitoshi Okazawa
J Neurosci. 2007 Jan 24; 27(4): 868–880. doi: 10.1523/JNEUROSCI.4522-06.2007
PMCID:
PMC6672912
AbstractArticlePDF–836K
6.
Brain-Derived Neurotrophic Factor Restores Synaptic Plasticity in a Knock-In Mouse Model of Huntington's Disease
Gary Lynch, Eniko A. Kramar, Christopher S. Rex, Yousheng Jia, Danielle Chappas, Christine M. Gall, Danielle A. Simmons
J Neurosci. 2007 Apr 18; 27(16): 4424–4434. doi: 10.1523/JNEUROSCI.5113-06.2007
PMCID:
PMC6672319
AbstractArticlePDF–723K
7.
Longitudinal Evaluation of the Hdh(CAG)150 Knock-In Murine Model of Huntington's Disease
Mary Y. Heng, Sara J. Tallaksen-Greene, Peter J. Detloff, Roger L. Albin
J Neurosci. 2007 Aug 22; 27(34): 8989–8998. doi: 10.1523/JNEUROSCI.1830-07.2007
PMCID:
PMC6672210
AbstractArticlePDF–442K
8.
Expression of Normal and Mutant Huntingtin in the Developing Brain
Pradeep G. Bhide, Michelle Day, Ellen Sapp, Cordula Schwarz, Ami Sheth, Johnny Kim, Anne B. Young, John Penney, Jeffrey Golden, Neil Aronin, Marian DiFiglia
J Neurosci. 1996 Sep 1; 16(17): 5523–5535. doi: 10.1523/JNEUROSCI.16-17-05523.1996
PMCID:
PMC6578889
AbstractArticlePDF–2.2M
9.
N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting
Sean M. DeGuire, Francesco S. Ruggeri, Mohamed-Bilal Fares, Anass Chiki, Urszula Cendrowska, Giovanni Dietler, Hilal A. Lashuel
J Biol Chem. 2018 Nov 30; 293(48): 18540–18558. Published online 2018 Sep 5. doi: 10.1074/jbc.RA118.004621
PMCID:
PMC6290154
AbstractArticlePDF–5.0M
10.
Heat shock promotes inclusion body formation of mutant huntingtin (mHtt) and alleviates mHtt-induced transcription factor dysfunction
Justin Y. Chen, Miloni Parekh, Hadear Seliman, Dariya Bakshinskaya, Wei Dai, Kelvin Kwan, Kuang Yu Chen, Alice Y. C. Liu
J Biol Chem. 2018 Oct 5; 293(40): 15581–15593. Published online 2018 Aug 24. doi: 10.1074/jbc.RA118.002933
PMCID:
PMC6177601
AbstractArticlePDF–3.4M
11.
BACHD rats expressing full-length mutant huntingtin exhibit differences in social behavior compared to wild-type littermates
Giuseppe Manfré, Arianna Novati, Ilaria Faccini, Andrea C. Rossetti, Kari Bosch, Raffaella Molteni, Marco A. Riva, Johanneke E. Van der Harst, Huu Phuc Nguyen, Judith R. Homberg
PLoS One. 2018; 13(2): e0192289. Published online 2018 Feb 7. doi: 10.1371/journal.pone.0192289
PMCID:
PMC5802907
AbstractArticlePDF–6.1M
12.
Mutant Huntingtin Is Secreted via a Late Endosomal/Lysosomal Unconventional Secretory Pathway
Katarina Trajkovic, Hyunkyung Jeong, Dimitri Krainc
J Neurosci. 2017 Sep 13; 37(37): 9000–9012. doi: 10.1523/JNEUROSCI.0118-17.2017
PMCID:
PMC5597981
AbstractArticlePDF–3.3M
13.
Distinct cellular toxicity of two mutant huntingtin mRNA variants due to translation regulation
Haifei Xu, Juan Ji An, Baoji Xu
PLoS One. 2017; 12(5): e0177610. Published online 2017 May 11. doi: 10.1371/journal.pone.0177610
PMCID:
PMC5426682
AbstractArticlePDF–16M
14.
Intrinsically disordered proteins as molecular shields
Sohini Chakrabortee, Rashmi Tripathi, Matthew Watson, Gabriele S. Kaminski Schierle, Davy P. Kurniawan, Clemens F. Kaminski, Michael J. Wise, Alan Tunnacliffe
Mol Biosyst. Author manuscript; available in PMC 2017 Mar 24.
Published in final edited form as: Mol Biosyst. 2012 Jan; 8(1): 210–219. Published online 2011 Sep 9. doi: 10.1039/c1mb05263b
PMCID:
PMC5365143
AbstractArticlePDF–1.3M
15.
Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract
Koning Shen, Barbara Calamini, Jonathan A Fauerbach, Boxue Ma, Sarah H Shahmoradian, Ivana L Serrano Lachapel, Wah Chiu, Donald C Lo, Judith Frydman
eLife. 2016; 5: e18065. Published online 2016 Oct 18. doi: 10.7554/eLife.18065
PMCID:
PMC5135392
AbstractArticlePDF–5.3M
16.
Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer
Bankanidhi Sahoo, Irene Arduini, Kenneth W. Drombosky, Ravindra Kodali, Laurie H. Sanders, J. Timothy Greenamyre, Ronald Wetzel
PLoS One. 2016; 11(6): e0155747. Published online 2016 Jun 6. doi: 10.1371/journal.pone.0155747
PMCID:
PMC4894636
AbstractArticlePDF–2.3M
17.
siRNA screen identifies QPCT as a druggable target for Huntington’s disease
Maria Jimenez-Sanchez, Wun Lam, Michael Hannus, Birte Sönnichsen, Sara Imarisio, Angeleen Fleming, Alessia Tarditi, Fiona Menzies, Teresa Ed Dami, Catherine Xu, Eduardo Gonzalez-Couto, Giulia Lazzeroni, Freddy Heitz, Daniela Diamanti, Luisa Massai, Venkata P. Satagopam, Guido Marconi, Chiara Caramelli, Arianna Nencini, Matteo Andreini, Gian Luca Sardone, Nicola P. Caradonna, Valentina Porcari, Carla Scali, Reinhard Schneider, Giuseppe Pollio, Cahir J. O’Kane, Andrea Caricasole, David C. Rubinsztein
Nat Chem Biol. Author manuscript; available in PMC 2015 Dec 30.
Published in final edited form as: Nat Chem Biol. 2015 May; 11(5): 347–354. Published online 2015 Apr 6. doi: 10.1038/nchembio.1790
PMCID:
PMC4696152
AbstractArticlePDF–2.4M
18.
A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity
Yuwei Yao, Xiaotian Cui, Ismael Al-Ramahi, Xiaoli Sun, Bo Li, Jiapeng Hou, Marian Difiglia, James Palacino, Zhi-Ying Wu, Lixiang Ma, Juan Botas, Boxun Lu
eLife. 2015; 4: e05449. Published online 2015 Mar 4. doi: 10.7554/eLife.05449
PMCID:
PMC4372774
AbstractArticlePDF–4.5M
19.
Huntingtin Functions as a Scaffold for Selective Macroautophagy
Yan-Ning Rui, Zhen Xu, Bindi Patel, Zhihua Chen, Dongsheng Chen, Antonio Tito, Gabriela David, Yamin Sun, Erin F. Stimming, Hugo Bellen, Ana Maria Cuervo, Sheng Zhang
Nat Cell Biol. Author manuscript; available in PMC 2015 Sep 1.
Published in final edited form as: Nat Cell Biol. 2015 Mar; 17(3): 262–275. Published online 2015 Feb 16. doi: 10.1038/ncb3101
PMCID:
PMC4344873
AbstractArticlePDF–2.8M
20.
Transgenic Rat Model of Huntington's Disease: A Histopathological Study and Correlations with Neurodegenerative Process in the Brain of HD Patients
Yvona Mazurová, Miroslava Anderova, Ivana Němečková, Aleš Bezrouk
Biomed Res Int. 2014; 2014: 291531. Published online 2014 Aug 3. doi: 10.1155/2014/291531
PMCID:
PMC4137602
AbstractArticlePDF–6.2M

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