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Select item 112833621.

NLRC5 senses NAD⁺ depletion to form a PANoptosome driving PANoptosis and inflammation

Balamurugan Sundaram, Nagakannan Pandian, Hee Jin Kim, Hadia M. Abdelaal, Raghvendra Mall, Omkar Indari, Roman Sarkar, Rebecca E. Tweedell, Emily Q. Alonzo, Jonathon Klein, Shondra M. Pruett-Miller, Peter Vogel, Thirumala-Devi Kanneganti

Cell. Author manuscript; available in PMC 2024 Jul 28.

Published in final edited form as: Cell. 2024 Jul 25; 187(15): 4061–4077.e17. Published online 2024 Jun 14. doi: 10.1016/j.cell.2024.05.034

PMCID:: PMC11283362

Abstract Article PDF–2.8M

Select item 110725092.

Arid2-IR promotes NF-κB-mediated renal inflammation by targeting NLRC5 transcription

Puhua Zhang, Chaolun Yu, Jianwen Yu, Zhijian Li, Hui-yao Lan, Qin Zhou

Cell Mol Life Sci. 2021 Mar; 78(5): 2387–2404. Published online 2020 Oct 22. doi: 10.1007/s00018-020-03659-9

PMCID:: PMC11072509

Abstract Article PDF–2.3M

Select item 104877753.

NLRC5 Deficiency Reduces LPS-Induced Microglial Activation via Inhibition of NF-κB Signaling and Ameliorates Mice’s Depressive-like Behavior

Chen Sun, Yuqing Shen, Piaopiao Liu, Yi Shen, Yue Hu, Ping Li, Ying Zhang, Fengqin Miao, Jianqiong Zhang

Int J Mol Sci. 2023 Sep; 24(17): 13265. Published online 2023 Aug 26. doi: 10.3390/ijms241713265

PMCID:: PMC10487775

Abstract Article PDF–4.1M

Select item 101385884.

NLRC5-CIITA Fusion Protein as an Effective Inducer of MHC-I Expression and Antitumor Immunity

Madanraj Appiya Santharam, Akhil Shukla, Dominique Levesque, Thomas A. Kufer, François-Michel Boisvert, Sheela Ramanathan, Subburaj Ilangumaran

Int J Mol Sci. 2023 Apr; 24(8): 7206. Published online 2023 Apr 13. doi: 10.3390/ijms24087206

PMCID:: PMC10138588

Abstract Article PDF–2.8M

Select item 101117535.

NOD-like receptor NLRC5 promotes neuroinflammation and inhibits neuronal survival in Parkinson’s disease models

Zhaolin Liu, Chenye Shen, Heng Li, Jiabin Tong, Yufei Wu, Yuanyuan Ma, Jinghui Wang, Zishan Wang, Qing Li, Xiaoshuang Zhang, Hongtian Dong, Yufang Yang, Mei Yu, Jian Wang, Renyuan Zhou, Jian Fei, Fang Huang

J Neuroinflammation. 2023; 20: 96. Published online 2023 Apr 18. doi: 10.1186/s12974-023-02755-4

PMCID:: PMC10111753

Abstract Article PDF–11M

Select item 100344706.

NLRC5 affects diet-induced adiposity in female mice and co-regulates peroxisome proliferator-activated receptor PPARγ target genes

Sarah Bauer, Vanessa Aeissen, Alena M. Bubeck, Ioannis Kienes, Kornelia Ellwanger, Mona Scheurenbrand, Fjolla Rexhepi, Sheela Ramanathan, Philip Rosenstiel, W. Florian Fricke, Thomas A. Kufer

iScience. 2023 Apr 21; 26(4): 106313. Published online 2023 Mar 2. doi: 10.1016/j.isci.2023.106313

PMCID:: PMC10034470

Abstract Article PDF–4.0M

Select item 85462067.

NLRC5 Deficiency Deregulates Hepatic Inflammatory Response but Does Not Aggravate Carbon Tetrachloride-Induced Liver Fibrosis

Akouavi Julite I. Quenum, Akhil Shukla, Fjolla Rexhepi, Maryse Cloutier, Amit Ghosh, Thomas A. Kufer, Sheela Ramanathan, Subburaj Ilangumaran

Front Immunol. 2021; 12: 749646. Published online 2021 Oct 12. doi: 10.3389/fimmu.2021.749646

PMCID:: PMC8546206

Abstract Article PDF–7.0M

Select item 77531388.

NLRC5 promotes transcription of BTN3A1-3 genes and Vγ9Vδ2 T cell-mediated killing

Anh Thu Dang, Juliane Strietz, Alessandro Zenobi, Hanif J. Khameneh, Simon M. Brandl, Laura Lozza, Gregor Conradt, Stefan H.E. Kaufmann, Walter Reith, Ivo Kwee, Susana Minguet, Sonia T. Chelbi, Greta Guarda

iScience. 2021 Jan 22; 24(1): 101900. Published online 2020 Dec 7. doi: 10.1016/j.isci.2020.101900

PMCID:: PMC7753138

Abstract Article PDF–3.6M

Select item 72426879.

The USP14–NLRC5 pathway inhibits titanium particle–induced osteolysis in mice by suppressing NF-κB and PI3K/AKT activities

Guibin Fang, Yuan Fu, Shixun Li, Junxiong Qiu, Manyuan Kuang, Sipeng Lin, Changchuan Li, Yue Ding

J Biol Chem. 2020 May 15; 295(20): 7018–7032. Published online 2020 Apr 9. doi: 10.1074/jbc.RA119.012495

PMCID:: PMC7242687

Abstract Article PDF–5.2M

Select item 719360110.

Transcriptional Upregulation of NLRC5 by Radiation Drives STING- and Interferon-Independent MHC-I Expression on Cancer Cells and T Cell Cytotoxicity

Lauren K. Zebertavage, Alejandro Alice, Marka R. Crittenden, Michael J. Gough

Sci Rep. 2020; 10: 7376. Published online 2020 Apr 30. doi: 10.1038/s41598-020-64408-3

PMCID:: PMC7193601

Abstract Article PDF–5.2M

Select item 666039811.

HIV-1 Tat-mediated microglial inflammation involves a novel miRNA-34a-NLRC5-NFκB signaling axis

Palsamy Periyasamy, Annadurai Thangaraj, Venkata Sunil Bendi, Shilpa Buch

Brain Behav Immun. Author manuscript; available in PMC 2020 Aug 1.

Published in final edited form as: Brain Behav Immun. 2019 Aug; 80: 227–237. Published online 2019 Mar 11. doi: 10.1016/j.bbi.2019.03.011

PMCID:: PMC6660398

Abstract Article PDF–1.9M

Select item 660381312.

Effect of NLRC5 on activation and reversion of hepatic stellate cells by regulating the nuclear factor-κB signaling pathway

Yan-Zhen Zhang, Jian-Ning Yao, Lian-Feng Zhang, Chun-Feng Wang, Xue-Xiu Zhang, Bing Gao

World J Gastroenterol. 2019 Jun 28; 25(24): 3044–3055. Published online 2019 Jun 28. doi: 10.3748/wjg.v25.i24.3044

PMCID:: PMC6603813

Abstract Article PDF–9.8M

Select item 659902713.

NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPARγ

Peipei Luan, Weixia Jian, Xu Xu, Wenxin Kou, Qing Yu, Handan Hu, Dali Li, Wei Wang, Mark W. Feinberg, Jianhui Zhuang, Yawei Xu, Wenhui Peng

Nat Commun. 2019; 10: 2882. Published online 2019 Jun 28. doi: 10.1038/s41467-019-10784-y

PMCID:: PMC6599027

Abstract Article PDF–4.0M

Select item 639844714.

Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes

Toru Suzuki, Chisato Kikuguchi, Saori Nishijima, Takeshi Nagashima, Akinori Takahashi, Mariko Okada, Tadashi Yamamoto

Development. 2019 Feb 15; 146(4): dev168146. Published online 2019 Feb 15. doi: 10.1242/dev.168146

PMCID:: PMC6398447

Abstract Article

Select item 568674915.

Novel Role for Interleukin-17 in Enhancing Type 1 Helper T Cell Immunity in the Female Genital Tract following Mucosal Herpes Simplex Virus 2 Vaccination

Puja Bagri, Varun C. Anipindi, Philip V. Nguyen, Danielle Vitali, Martin R. Stämpfli, Charu Kaushic

J Virol. 2017 Dec 1; 91(23): e01234-17. Prepublished online 2017 Sep 27. Published online 2017 Nov 14. doi: 10.1128/JVI.01234-17

PMCID:: PMC5686749

Abstract Article PDF–2.1M

Select item 555318516.

Deficiency of the NOD-Like Receptor NLRC5 Results in Decreased CD8⁺ T Cell Function and Impaired Viral Clearance

Christopher R. Lupfer, Kate L. Stokes, Teneema Kuriakose, Thirumala-Devi Kanneganti

J Virol. 2017 Sep 1; 91(17): e00377-17. Prepublished online 2017 Jun 14. Published online 2017 Aug 10. doi: 10.1128/JVI.00377-17

PMCID:: PMC5553185

Abstract Article PDF–3.9M

Select item 474998117.

NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions

Kristina Ludigs, Camilla Jandus, Daniel T. Utzschneider, Francesco Staehli, Stéphanie Bessoles, Anh Thu Dang, Giorgia Rota, Wilson Castro, Dietmar Zehn, Eric Vivier, Werner Held, Pedro Romero, Greta Guarda

Nat Commun. 2016; 7: 10554. Published online 2016 Feb 10. doi: 10.1038/ncomms10554

PMCID:: PMC4749981

Abstract Article PDF–863K

Select item 456751018.

Canonical inflammasomes drive IFN-γ to prime caspase-11 in defense against a cytosol-invasive bacterium

Youssef Aachoui, Yuji Kajiwara, Irina A Leaf, Dat Mao, Jenny P-Y Ting, Jörn Coers, Alan Aderem, Joseph D Buxbaum, Edward A Miao

Cell Host Microbe. Author manuscript; available in PMC 2016 Sep 9.

Published in final edited form as: Cell Host Microbe. 2015 Sep 9; 18(3): 320–332. Published online 2015 Aug 27. doi: 10.1016/j.chom.2015.07.016

PMCID:: PMC4567510

Abstract Article PDF–1.7M

Select item 437474819.

NLRC5 Exclusively Transactivates MHC Class I and Related Genes through a Distinctive SXY Module

Kristina Ludigs, Queralt Seguín-Estévez, Sylvain Lemeille, Isabel Ferrero, Giorgia Rota, Sonia Chelbi, Chantal Mattmann, H. Robson MacDonald, Walter Reith, Greta Guarda

PLoS Genet. 2015 Mar; 11(3): e1005088. Published online 2015 Mar 26. doi: 10.1371/journal.pgen.1005088