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Items: 1 to 20 of 67

1.
Structural and biochemical basis of interdependent FANCI‐FANCD2 ubiquitination
Kimon Lemonidis, Martin L Rennie, Connor Arkinson, Viduth K Chaugule, Mairi Clarke, James Streetley, Helen Walden
EMBO J. 2023 Feb; 42(3): e111898. Published online 2022 Nov 17. doi: 10.15252/embj.2022111898
PMCID:
PMC9890228
AbstractArticlePDF–6.8M
2.
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization
Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti
Science. Author manuscript; available in PMC 2022 Sep 11.
Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983
PMCID:
PMC9119736
AbstractArticlePDF–3.3M
3.
Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors
Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen
Sci Adv. 2022 May; 8(19): eabm6638. Published online 2022 May 13. doi: 10.1126/sciadv.abm6638
PMCID:
PMC9106303
AbstractArticlePDF–918K
4.
Structure of the FA Core ubiquitin ligase closing the ID clamp on DNA
Shengliu Wang, Renjing Wang, Christopher Peralta, Ayat Yaseen, Nikola P. Pavletich
Nat Struct Mol Biol. Author manuscript; available in PMC 2021 Aug 20.
Published in final edited form as: Nat Struct Mol Biol. 2021 Mar; 28(3): 300–309. Published online 2021 Mar 8. doi: 10.1038/s41594-021-00568-8
PMCID:
PMC8378520
AbstractArticlePDF–8.1M
5.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
6.
DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity
Rajat Gupta, Kumar Somyajit, Takeo Narita, Elina Maskey, Andre Stanlie, Magdalena Kremer, Dimitris Typas, Michael Lammers, Niels Mailand, Andre Nussenzweig, Jiri Lukas, Chunaram Choudhary
Cell. Author manuscript; available in PMC 2021 May 10.
Published in final edited form as: Cell. 2018 May 3; 173(4): 972–988.e23. Published online 2018 Apr 12. doi: 10.1016/j.cell.2018.03.050
PMCID:
PMC8108093
AbstractArticlePDF–3.5M
7.
The interplay of UBE2T and Mule in regulating Wnt/β-catenin activation to promote hepatocellular carcinoma progression
Nicole Pui Yu Ho, Carmen Oi Ning Leung, Tin Lok Wong, Eunice Yuen Ting Lau, Martina Mang Leng Lei, Etienne Ho Kit Mok, Hoi Wing Leung, Man Tong, Irene Oi Lin Ng, Jing Ping Yun, Stephanie Ma, Terence Kin Wah Lee
Cell Death Dis. 2021 Feb; 12(2): 148. Published online 2021 Feb 1. doi: 10.1038/s41419-021-03403-6
PMCID:
PMC7862307
AbstractArticlePDF–4.0M
8.
A founder variant in the South Asian population leads to a high prevalence of FANCL Fanconi anemia cases in India
Frank X. Donovan, Avani Solanki, Minako Mori, Niranjan Chavan, Merin George, Kumar C Selvaa, Yusuke Okuno, Hideki Muramastsu, Kenichi Yoshida, Akira Shimamoto, Akifumi Takaori-Kondo, Hiromasa Yabe, Seishi Ogawa, Seiji Kojima, Miharu Yabe, Ramanagouda Ramanagoudr-Bhojappa, Agata Smogorzewska, Sheila Mohan, Aruna Rajendran, Arleen D Auerbach, Minoru Takata, Settara C. Chandrasekharappa, Babu Rao Vundinti
Hum Mutat. Author manuscript; available in PMC 2021 Jan 1.
Published in final edited form as: Hum Mutat. 2020 Jan; 41(1): 122–128. Published online 2019 Sep 26. doi: 10.1002/humu.23914
PMCID:
PMC7362330
AbstractArticlePDF–508K
9.
Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA
Martin L Rennie, Kimon Lemonidis, Connor Arkinson, Viduth K Chaugule, Mairi Clarke, James Streetley, Laura Spagnolo, Helen Walden
EMBO Rep. 2020 Jul 3; 21(7): e50133. Published online 2020 Jun 8. doi: 10.15252/embr.202050133
PMCID:
PMC7332966
AbstractArticlePDF–2.2M
10.
Characterization of FANCL variants observed in patient cancer cells
Mark G. Frost, Amir Mahdi Mazloumi Aboukheili, Rachel Toth, Helen Walden
Biosci Rep. 2020 Jun 26; 40(6): BSR20191304. Published online 2020 Jun 4. doi: 10.1042/BSR20191304
PMCID:
PMC7273913
AbstractArticlePDF–2.2M
11.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
12.
Preparation and purification of mono-ubiquitinated proteins using Avi-tagged ubiquitin
Winnie Tan, Vincent J. Murphy, Aude Charron, Sylvie van Twest, Michael Sharp, Angelos Constantinou, Michael W. Parker, Wayne Crismani, Rohan Bythell-Douglas, Andrew J. Deans
PLoS One. 2020; 15(2): e0229000. Published online 2020 Feb 24. doi: 10.1371/journal.pone.0229000
PMCID:
PMC7039436
AbstractArticlePDF–1.3M
13.
Allosteric mechanism for site-specific ubiquitination of FANCD2
Viduth K. Chaugule, Connor Arkinson, Martin L. Rennie, Outi Kämäräinen, Rachel Toth, Helen Walden
Nat Chem Biol. Author manuscript; available in PMC 2020 Jun 23.
Published in final edited form as: Nat Chem Biol. 2020 Mar; 16(3): 291–301. Published online 2019 Dec 23. doi: 10.1038/s41589-019-0426-z
PMCID:
PMC7035956
AbstractArticlePDF–2.5M
14.
DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response
Fengshan Liang, Adam S. Miller, Simonne Longerich, Caroline Tang, David Maranon, Elizabeth A. Williamson, Robert Hromas, Claudia Wiese, Gary M. Kupfer, Patrick Sung
Nat Commun. 2019; 10: 2849. Published online 2019 Jun 28. doi: 10.1038/s41467-019-10408-5
PMCID:
PMC6599204
AbstractArticlePDF–1.2M
15.
Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1
Connor Arkinson, Viduth K Chaugule, Rachel Toth, Helen Walden
Life Sci Alliance. 2018 Oct; 1(5): e201800162. Published online 2018 Oct 12. doi: 10.26508/lsa.201800162
PMCID:
PMC6238601
AbstractArticlePDF–2.5M
16.
Identification of UHRF2 as a novel DNA interstrand crosslink sensor protein
Anna Motnenko, Chih-Chao Liang, Di Yang, David Lopez-Martinez, Yasunaga Yoshikawa, Bao Zhan, Katherine E. Ward, Jiayang Tian, Wilhelm Haas, Paolo Spingardi, Benedikt M. Kessler, Skirmantas Kriaucionis, Steven P. Gygi, Martin A. Cohn
PLoS Genet. 2018 Oct; 14(10): e1007643. Published online 2018 Oct 18. doi: 10.1371/journal.pgen.1007643
PMCID:
PMC6193622
AbstractArticlePDF–11M
17.
Estrogen-regulated feedback loop limits the efficacy of estrogen receptor–targeted breast cancer therapy
Tengfei Xiao, Wei Li, Xiaoqing Wang, Han Xu, Jixin Yang, Qiu Wu, Ying Huang, Joseph Geradts, Peng Jiang, Teng Fei, David Chi, Chongzhi Zang, Qi Liao, Jonathan Rennhack, Eran Andrechek, Nanlin Li, Simone Detre, Mitchell Dowsett, Rinath M. Jeselsohn, X. Shirley Liu, Myles Brown
Proc Natl Acad Sci U S A. 2018 Jul 31; 115(31): 7869–7878. Published online 2018 Jul 9. doi: 10.1073/pnas.1722617115
PMCID:
PMC6077722
AbstractArticlePDF–2.4M
18.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M
19.
S. pombe Uba1-Ubc15 structure reveals a novel regulatory mechanism of ubiquitin E2 activity
Zongyang Lv, Kimberly A. Rickman, Lingmin Yuan, Katelyn Williams, Shanmugam Panneer Selvam, Alec N. Woosley, Philip H. Howe, Besim Ogretmen, Agata Smogorzewska, Shaun K. Olsen
Mol Cell. Author manuscript; available in PMC 2018 Feb 16.
Published in final edited form as: Mol Cell. 2017 Feb 16; 65(4): 699–714.e6. Published online 2017 Feb 2. doi: 10.1016/j.molcel.2017.01.008
PMCID:
PMC5319395
AbstractArticlePDF–4.3M
20.
HES1 is a novel interactor of the Fanconi anemia core complex
Cédric S. Tremblay, Feng F. Huang, Ouassila Habi, Caroline C. Huard, Chantal Godin, Georges Lévesque, Madeleine Carreau
Blood. Author manuscript; available in PMC 2016 Dec 13.
Published in final edited form as: Blood. 2008 Sep 1; 112(5): 2062–2070. Published online 2008 Jun 11. doi: 10.1182/blood-2008-04-152710
PMCID:
PMC5154739
AbstractArticlePDF–1.1M

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